• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7995-8001
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• 2014

Interferon-gamma (IFN-${\gamma}$) has been used to treat various malignant tumors. However, the molecular mechanisms underlying the direct anti-proliferative activity of IFN-${\gamma}$ are poorly understood. In the present study, we examined the in vitro antitumor activity of IFN-${\gamma}$ on two human non-small-cell lung carcinoma (NSCLC) cell lines, H322M and H226. Our findings indicated that IFN-${\gamma}$ treatment caused a time-dependent reduction in cell viability and induced apoptosis through a FADD-mediated caspase-8/tBid/mitochondria-dependent pathway in both cell lines. Notably, we also postulated that IFN-${\gamma}$ increased indoleamine 2,3-dioxygenase (IDO) expression and enzymatic activity in H322M and H226 cells. In addition, inhibition of IDO activity by the IDO inhibitor 1-MT or tryptophan significantly reduced IFN-${\gamma}$-induced apoptosis and death receptor 5 (DR5) expression, which suggests that IDO enzymatic activity plays an important role in the anti-NSCLC cancer effect of IFN-${\gamma}$. These results provide new mechanistic insights into interferon-${\gamma}$ antitumor activity and further support IFN-${\gamma}$ as a potential therapeutic adjuvant for the treatment of NCSLC.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3143-3147
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• 2012

Background: Previous studies investigating the association of physical activity with risk of lung cancer reported conflicting results. In order to update and improve available evidence on any link, a meta-analysis was performed. Method: We searched the PubMed database for prospective cohort studies investigating the relation of physical activity with risk of lung cancer. The pooled relative risk (RR) with its 95% confidence intervals (95%CI) was used to assess the association. Results: We included 14 prospective studies with a total of 1,644,305 participants, with 14,074 incident lung cancer cases documented during follow-up. Meta-analysis of all 14 studies suggested both high and medium levels of physical activity to be associated with decreased risk of lung cancer compared to the reference group with low level of physical activity (for high level, RR = 0.77, 95%CI 0.73-0.81, P < 0.001; for medium level, RR = 0.87, 95%CI 0.83-0.90, P < 0.001). Subgroup analyses by gender found obvious associations in both men and women. No publication bias was observed. Conclusion: Our findings suggest that high and medium levels of physical activity have a beneficial effect on lung cancer by reducing the overall risk of tumour development among both men and women.

• International Journal of Advanced Culture Technology
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• v.9 no.3
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• pp.334-344
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• 2021

The study has suggested a way to minimize safety accidents found in on-site firefighting activity by analyzing firefighters' [investigation report on accidents to on-sie workers]. The study result is described as follows. First, the result of [investigation report on on-site workers] shows that while accidents are found to most frequently have occurred to low-ranking firefighting officers such as Sobangsa and Sobanggyo and firefighting officers with career of less than 5 years, fire-extinguishing activity proved to be the most prone to accidents in the category of activity. Second, analysis performed to identify variance between injury extent and area based on cause of accident shows statistically significant variance. In addition, the result of verifying difference in cause of accident based on category of activity shows significant difference with 'falling over and sliding' being the highly likely cause of accident in fire containment and rescue activities and 'reckless move' being highly likely case of accident in emergency activities. Third, the result of verifying factors behind the extent of injury done to on-site workers shows that when accident is caused by 'incomplete behavior', it was found that the extent of injury is substantial. It was also found that rescue activity is accompanied by substantial extent of injury. As a solution to this, the study suggested ways to establish, extend and operate safety-specific curriculum for entrants, develop materials regarding risk prognosis training and explicate training-related regulations, set up safety management measure for a single squad team, upgrade performance of private protection equipment, institutionalize SOP by on-site activity stage, materialize and activate swift rescue team and increase objectivity and proficiency of safety accident investigation.

• Journal of Korean Academy of Nursing
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• v.38 no.2
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• pp.217-228
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• 2008

Purpose: This study was conducted to develop and to determine the effects of an integrated symptom management program for prevention of recurrent cardiac events after percutaneous coronary intervention. Methods: Subjects consisted of 58 CAD patients (experimental group: 30, control group: 28). The experimental group participated in an integrated symptom management program for 6 months which was composed of tailored education, stress management, exercise, diet, deep breathing, music therapy, periodical telephone monitoring and a daily log. The control group received the usual care. Results: The experimental group significantly decreased symptom experiences and the level of LDL compared to the control group. The experimental group significantly increased self care activity and quality of life compared to the control group. Although no significant difference was found in cardiac recurrence, the experimental group had fewer recurrences. Conclusion: These results suggest that an integrated symptom management program for prevention of recurrent cardiac events after percutaneous coronary intervention can improve symptom aggravation, recurrent rate, self care activity and quality of life. Nursing interventions are needed to maintain and further enhance the quality of life of these patients and the interventions should be implemented in the overall transition period.

• Journal of the Korea Safety Management & Science
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• v.14 no.3
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• pp.59-66
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• 2012

Steel industry in Korea is a key national industry that has led economic growth for a long time. And accidents occurred from a variety of causes has endlessly made as much as remarkable achievements of steel industry. It is a fact that research achievements of disaster prevention in steel industry has not been significantly, compared to production technique achievements. And the level of interest on safety management in the steel industry is conspicuously low. Although support activity for a various safety management are provided reasonably to prevent disasters occurring with subcontractors. A method capable of quantitative evaluation, applied to subcontractors in most business places are relatively rare except parent firms-leading places. This study is to make and show safety management activities to purcue in advance in conjunction with a parent firm through development of a more systematic and quantitative evaluation model for disaster prevention with steel industry subcontractors, and to contribute to disaster prevention in domestic steel industry through advanced safety management method, by applying a proposed evaluation model of safety management activities as subcontractors in steel industry.

• Korean Journal of Childcare and Education
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• v.15 no.3
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• pp.39-60
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• 2019

Objective: The purpose of this study was to analyze the Nuri-curriculum daycare programs for 3, 4, and 5-year-olds based on the Child Welfare Act. Methods: Data were analyzed according to the analysis criteria for 195 children's safety education programs in the Nuri-Program. The analyzed data used frequency and percentages. Results: First, life safety education was the most important element. And after looking at the contents category of the Child Welfare Act, the results in order are as follows: "raffic safety"; "Health and hygiene management, including the prevention of contagious diseases and drug abuse"; "Safety measures against disasters"; "Precaution and prevention of disappearance and abduction"; and "Prevention of sexual violence and child abuse." Second, there were many safety education activities in accordance to chronological age (3-to 5-years old). Health and safety by subject, season, and life tools were more frequent. By type of activity, conversation and language activity, fairy tales, and plays were the most common activities. Conclusion/Implications: This suggests the need to systematically plan safety education content through a program that links safety-related laws and elements related to the Nuri curriculum in child care centers.

• Korean Security Journal
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• no.6
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• pp.67-101
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• 2003

This study presents a plan of construction for cooperating crime prevention system between public police and private security to provide positive safety, and crime prevention activity for clients. A method of this study, this paper used statistics analysis and literature study. This study, an introduction is at the chapter I , a role of public police and private security at the Chapter II, the realities of private security industry of korea at the Chapter III, the police service relating with private security and operating realities at the ChapterIV, the problems and a plan of construction for co-operating crime prevention system at the ChapterV, and conclusion at the ChapterVI. In conclusion, It is needed a public information strategy, partnership between the police and guard, establishment of special office for private security, and the improvement of the quality in security corporation.

• Journal of the Ergonomics Society of Korea
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• v.30 no.4
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• pp.517-523
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• 2011

Objective: The purpose were understanding the epidemiological characteristics of work related injuries of the farmer and establishing injury prevention and control activity. Background: Agriculture is one of the most hazardous industry and job in Korea. Method: We reviewed previous reports regarding the agricultural injury, injury prevention and control. Results: In the agricultural total injury, there were 45,342 hospitalized injury to farmers, injury rate was 35.8/1,000 farmers/years. Of these injuries, 52.6 percent were classed as work related injury. The farm-related injury rate was 17.5/1,000 farmers/years by analysis of Safety Aid System of Farm Workers. There were 2.4 times as incidence rate for farmers compared to non-farmers. Conclusion: Several strategies are available for injury prevention and control. They are as follows; social concern, survey of farm related injury, injury prevention, injury surveillance system and injury compensation.

• Research in Community and Public Health Nursing
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• v.4 no.2
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• pp.158-169
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• 1993

Health promotions have been identified as foundamental concepts for nursing practice, especially in community health nursing. Nurses have been regarded as having important role's in health promotion activities. According to a review of literature, the concepts of health promotion consist of prevention services, health protection. Health prevention services have three levels : Primary secondary and tertiary. The objectives of this study are (1) to analyze the health promotion activities in school nursing. (2) to analyze health promotion activities in community health nursing posts. (3) to analyze the health promotion activities in industrial nursing while suggesting future direction for health promotion in community health nursing areas. The major results are first, Prevention services are most actively performed rather than health protection, and health education in three areas: School, industries, and community. Health nursing, secondary prevention services follow emergency care, and ordinary diseases control are especially active. Health promotion can ultimately from changing life be accomplished styles, and health behavior. As a consequence, future directions promoting health in community health nursing are desirable areas. Focusing on health protection, and health education that is not activated presently.

• Journal of the Korea Safety Management & Science
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• v.4 no.4
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• pp.63-71
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• 2002

Accident analyses are used to identify common factors contributing to occupational accidents and to give recommendations for accident prevention. This study concerns with the accident characteristics and prevention in the telecommunication service industry. To investigate the accident characteristics, we used workers' compensation reports and employers' accident analysis reports. Three hundred and forty-five injury accidents which results in more than 4 days absence were surveyed. These data were used to investigate the accident characteristics in terms of company size, injured person's age, work experience, accident time, activity at time of accident, accident type, injured body part, and accident agency. We propose the accident prevention policy based on the accident characteristics. These results can be used to develop more effective occupational safety management policies in the telecommunication service industries.