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The Experimental Study on the Suppression Effect of Asthma and Immune Response Improvement of Platycodi Radix Herbal-acupuncture (길경약침(桔梗藥鍼)의 천식억제(喘息抑制) 및 면역조절효과(免疫調節效果)에 대(對)한 실험적(實驗的) 연구(硏究))

  • Park, Chi-Young;Kim, Young-Il;Hong, Kwon-Eui
    • Journal of Acupuncture Research
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    • v.22 no.6
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    • pp.61-74
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    • 2005
  • Objectives : The aim of this study was to investigate the effect of Asthma-depression and Immunoregulation with PR-HAS(Herbal-acupuncture with Platycodi Radix infusion solution) injection at Joksamni(St36) on ovalbumin-induced asthma in mice. Methods : C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week). The experimental group(OVA-PR-HA) wase treated with concentrations(1%) of PR-HAS at Joksamni(St36) for the later 8 weeks(3times/week). The second experimental group(OVA-Needle prick) was treated with Needle-Prick at Joksamni(St36) for the later 8 weeks(3times/week). Results : 1. The weight and total cells in the mice lung treated with PR-HA decreased significantly compared with that of control group. 2. Total leukocytes and eosinophils in BALF of the mice group treated with PR-HA decreased remarkably compared with those of control group. 3. The sticking of collagen on histological analysis of lung sections, the mice group treated with PR-HA decreased significantly compared with those of control group. 4. The concentrations of IL-4, IL-5, IgE in BALF, and IL-4, IL-5, IL-13 in serum of the mice group treated with PR-HA decreased significantly compared with those of control group. 5. The number of $Gr-1^+/CD11b^+\;and\;CD11b^+$ cells in the lungs of the mice group treated with PR-HA decreased significantly compared with that of control group. 6. The numbers of $CCR3^+\;cells,\;CD4^+\;cells\;and\;CD8^+\;cells$ in the lungs, and $CD3e^+/CD69^+$ in the lungs of the mice group treated with PR-HA decreased significantly compared with those of control group. 7. The mRNA expression of ${\beta}-actin,\;TNF-{\alpha}$, IL-4, IL-5,IL-13 in the mice group treated with PR-HA with RT-PCR decreased significantly compared with those of control group. Conclusion : The concentrations of IL-4, IL-5, IgE in BALF, and IL-4, IL-5, IL-13 in serum of the mice group treated with PR-HA decreased significantly compared with those of control group. The number of $Gr-1^+/CD11b^+\;and\;CD11b^+$ cells in the lungs of the mice group treated with PR-HA decreased significantly compared with that of control group. The numbers of $CCR3^+\;cells,\;CD4^+\;cells\;and\;CD8^+\;cells$ in the lungs, and $CD3e^+/CD69^+$ in the lungs of the mice group treated with PR-HA decreased significantly compared with those of control group. The mRNA expression of ${\beta}-actin,\;TNF-{\alpha}$, IL-4, IL-5, IL-13 in the mice group treated with PR-HA with RT-PCR decreased significantly compared with those of control group. These result suggests that Platycodi Radix Herbal-acupuncture at Joksamni(St36) in C57BL/6mice may be an effictive part to OVA-induced asthma in C57BL/6 mice.

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Extraction & Separation Behavior of Light Rare Earth Elements from the Mixed Solutions by Cyanex 572 (경희토류(La, Ce, Pr, Nd, Sm) 혼합용액에서 Cyanex 572에 의한 추출·분리 거동 고찰)

  • Cho, Yeon-Chul;Lee, Joo-Eun;So, Hong-Il;Ahn, Jae-Woo;Kim, Hong-In;Lee, Jin-Young
    • Resources Recycling
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    • v.26 no.4
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    • pp.79-87
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    • 2017
  • Extraction and separation behaviors of La, Ce, Pr, Nd and Sm from light rare earth multi - component mixed solutions by Cyanex 572 were studied. As extractant concentration increased, the $pH_{50}$ values of all the five components decreased. When extractant concentration was larger than 0.6 M, the separation factor of La and Ce, Nd and Sm was higher than 10, while the separation factor between Ce and Pr, Pr and Nd was as low as 0.5~2.2. Addition of TBP to the 0.6 M Cyanex 572 had little synergistic effect on the phase separation rate and separation factor. From the analysis of experiment results, group separation of [La]/[Pr, Nd, Sm] and [Pr, Nd]/[Sm] could be possible, but in case of the group separation between [La, Ce] and [Pr, Nd] was not available because of the low separation factor between Ce and Pr.

Characteristics of Red $CaTiO_3$:Pr Phosphors Prepared by Sol-Gel Method (졸-겔법으로 제조된 $CaTiO_3$:Pr 적색형광체의 특성)

  • 강승구;김강덕;은희태;김영진;이기강
    • Journal of the Korean Ceramic Society
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    • v.38 no.3
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    • pp.261-266
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    • 2001
  • 적색 CaTiO$_3$:Pr 형광체 막을 졸-겔법으로 제조하고 형광체의 결정상 및 발광특성에 미치는 열처리 조건 및 Pr 첨가량의 영향에 대하여 연구하였다. CaTiO$_3$:Pr sol로부터 제조된 CaTiO$_3$:Pr 분말은 30~60nm 크기의 입자들이 0.3~0.5$mu extrm{m}$ 크기로 응집된 상태를 나타내었으며, 한편 sol을 borosilicate 기판 위에 4000rpm의 속도로 3회 스핀 코팅하고 열처리하였을 경우 두께 1.2$\mu\textrm{m}$의 CaTiO$_3$:Pr 박막이 형성되었다. CaTiO$_3$:Pr gel 분말을 여러 온도에서 열처리한 경우, $600^{\circ}C$ 이하에서는 비정질이지만, 온도가 증가하면서 erovskite 결정상이 생성되기 시작하여 90$0^{\circ}C$에서는 우수한 perovskite 결정상이 발달되었다. 반면, 박막의 경우에는 80$0^{\circ}C$의 열처리 온도에서는 결정성이 우수한 perovskite 상이 관찰되었으며 이러한 온도는 기존의 분말법의 소결온도에 비하여 300~40$0^{\circ}C$나 낮은 것이다. 0.2 mol% Pr이 첨가되고 90$0^{\circ}C$로 열처리된 분말시편은 최적의 Photoluminescence (PL) 특성을 나타낸 반면, 박막의 경우에는 80$0^{\circ}C$에서 열처리된 시편이 최적의 PL 특성을 나타내었다. 제조된 CaTiO$_3$:Pr 박막에 대하여 Cathodoluminescence (CL) 분석을 행한 결과, 6100$\AA$에서 폭이 좁고 강도가 큰 스펙트럼을 나타냄으로서, 본 실험에서 제조된 박막이 FED(field emission display)등의 적색형광체로 사용될 수 있음을 확인하였다.

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The Effects of Peucedani Radix Herbal Acupuncture at St36 on Ovalbumin-induced Asthma in C57BL Mouse (전호약침(前胡藥鍼)이 Ovalbumin-induced Asthma Mouse Model에 미치는 영향)

  • Roh, Hong-Pyo;Seol, In-Chan;Kim, Yoon-Sik
    • Journal of Acupuncture Research
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    • v.22 no.6
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    • pp.1-15
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    • 2005
  • Objectives : The aim of this study was to investigate the effect of Peucedani Radix herbal acupuncture(PR-HA) at St36(joksamni) on ovalbumin-induced asthma in mice. Methods : C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week) C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (3times a week). One of the two experimental groups was just treated with needle-prick on St36 and the other group was treated with 1% concentrations of PR-HAS at St36, for the later 8 weeks (3times /week). Results : 1. The weight and total cells of lung of the mice group treated with PR-HA decreased significantly compared with those of control group. 2. Total Leukocytes and Eosinophils in BALF of the mice group treated with PR-HA decreased significantly compared with those of control group. 3. Eosinophils in BALF of the mice group treated with PR-HA in Photomicrographs decreased significantly compared with those of control group. 4. According to Histological analysis of lung sections, it decreased significantly adhension of collagen in PR-HA than those of control group 5. The concentration of IgE, IL-4, IL-5, in BALF and IL-4, IL-5, Il-13 in serum of the mice group treated with PR-HA decreased significantly compared with that of control group. 6. The number of Gr-1+/CD11b+, CD11b+, CD3-/CCR3+, CD4+, CD3e+/CD69+ , CD23+B220+ cells in the lungs of the mice group treated with PR-HA decreased significantly compared with those of control group. 7. The cytokine's manifestation of mRNA of the mice group treated with PR-HA with RT-PCR decreased significantly compared with that of control group. Conclusion : We conclude that PR-HA is effective on OVA-induced asthma of C57BL/6 mouse.

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Developmental Gene Expression of Antimicrobial Peptide PR-39 and Effect of Zinc Oxide on Gene Regulation of PR-39 in Piglets

  • Wang, Y.Z.;Xu, Z.R.;Lin, W.X.;Huang, H.Q.;Wang, Z.Q.
    • Asian-Australasian Journal of Animal Sciences
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    • v.17 no.12
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    • pp.1635-1640
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    • 2004
  • Two experiments were conducted to evaluate developmental gene expression of antimicrobial peptide PR-39 and effect of zinc oxide on gene regulation of PR-39 in piglets using semi-quantitative RT-PCR analysis. In experiment 1, fifteen female Tai-Hu pigs (a local breed in China) in five groups, each of three pigs at 1, 14, 28, 42 and 56 days of age were used to determine effect of age and weaning on mRNA expression of PR-39. In experiment 2, nine groups of pigs (total seventy-two female 36 days-age weanling Tai-Hu piglets) were assigned to three treatments (${ZnO}_0$, ${ZnO}_{100}$ and ${ZnO}_{3000}$). The feeding experimental period lasted 15 days. After feeding experiment, nine pigs with three animals in each treatment were chosen to determine the effect of ZnO on PR-39 mRNA expression of pigs. The results showed that PR-39 mRNA levels increased steadily in postnatal day 1-28 (preweaning), and weaning significantly decreased PR-39 mRNA expression of piglets (p<0.05). ${ZnO}_{3000}$ (3,000 mg zinc/kg diet) significantly increased PR-39 mRNA expression (p<0.05) when piglets were feed ${ZnO}_{3000}$ diet for 15 days. ${ZnO}_{100}$ (100 mg zinc/kg diet) also increased PR-39 gene expression, but the result was not statistically significant (p>0.05). The result was in accordance with the effect of ${ZnO}_{3000}$ and ${ZnO}_{100}$ on weight gain of piglets and prevention of diarrhea.

The study about accelerating Photoresist strip under plasma (플라즈마 약액 활성화 방법을 이용한 Photoresist strip 가속화 연구)

  • Kim, Soo-In;Lee, Chang-Woo
    • Journal of the Korean Vacuum Society
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    • v.17 no.2
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    • pp.113-116
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    • 2008
  • As the integration in semiconductor display develops, semiconductor process becomes multilayer. In order to form several layer patterns, etching process which uses photoresistor (PR) must be performed in multilayer process. Repeated etching processes which take long time and PR residue cause mortal problems in semiconductor. To overcome such problems, we studied about the solution which eliminates PR effectively by using normal dry and wet etching method using plasma activated PR strip solvent in liquid condition. At first, we simulate the device which activates the plasma and make sure whether gas flow in device is uniform or not. Under activated plasma, etching effect is elevated. This improvement reduces etching time as well as display production time of semiconductor process. Generally, increasing etching process increases environmental hazards. Reducing etching process can save the etchant and protect environment as well.

Study about PR-VEP Characteristics on Perception Function and Judgement Function of MBTI (MBTI의 인식기능(S/N), 판단기능(T/F)에 대한 PR-VEP 특성연구)

  • Seol, Jee-Yong;Park, Pyong-Woon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.8
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    • pp.5485-5491
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    • 2015
  • The purpose of this study is to investigate PR-VEP characteristics on the perception function(S/N) and the judgement function(T/F) of MBTI. The 136 study participants, over 20 years old adults, were examined by PR-VEP and MBTI test for two months in July and August in 2013. PR-VEP was conducted in O1 and O2 by 32 channels EEG system and MBTI test was measured by Form-M online. We found that the time interval(Duration) between N75 and P100 of PR-VEP was 5.49 ms significantly shorter in the group preferring S indicator. And the latency until N75 was 4.83 ms significantly shorter in O1 and 4.27 ms shorter in O2 in the group preferring F indicator. According to these, the characteristics of groups preferring S and F indicator have influence on visual cognitive function, which is meaningful that the interpretation of brain-science can be used with recognition/judgement function of MBTI.

Recycling of Sintered Nd-Fe-B Magnets Doped with PrNd Nanoparticles

  • Zhang, Xuefeng;Liu, Fei;Liu, Yanli;Ma, Qiang;Li, Yongfeng;Zhao, Qian;Wang, Gaofeng;Li, Zhubai
    • Journal of Magnetics
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    • v.20 no.2
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    • pp.97-102
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    • 2015
  • The waste of sintered Nd-Fe-B magnets was recycled using the method of dopingPrNd nanoparticles. The effect of PrNd nanoparticle doping on the magnetic properties of the regenerated magnets has been studied. As the content of the PrNd nanoparticles increases, the coercivity increases monotonically, whereas both the remanence and the maximum energy products reach the maximum values for 4 wt% PrNd doping. Microstructural observation reveals that the appropriate addition of PrNd nanoparticles improves the magnetic properties and refines the grain. Domain investigation shows that the self-pinning effect of the rare earth (Re)-rich phase is enhanced by PrNd nano-particle doping. Compared to the magnet with 4 wt% PrNd alloy prepared using the dual-alloy method, the regenerated magnet doped with the same number of PrNd nanoparticles exhibits better magnetic properties and a more homogeneous microstructure. Therefore, it is concluded that PrNd nanoparticle doping is an efficient method for recycling the leftover scraps of Nd-Fe-B magnets.

A Study on Estimators of Parameters and Pr[X < Y] in Marshall and Olkin's Bivariate Exponential Model

  • Kim, Jae Joo;Park, Eun Sik
    • Journal of Korean Society for Quality Management
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    • v.18 no.2
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    • pp.101-116
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    • 1990
  • The objectives of this thesis are : first, to estimate the parameters and Pr[X < Y] in the Marshall and Olkin's Bivariate Exponential Distribution ; and secondly, to compare the Bayes estimators of Pr[X < Y] with maximum likelihood estimator of Pr[X < Y] in the Marshall and Olkin's Bivariate Exponential Distribution. Through the Monte Carlo Simulation, we observed that the Bayes estimators of Pr[X < Y] perform better than the maximum likelihood estimator of Pr[X < Y] and the Bayes estimator of Pr[X < Y] with gamma prior distribution performs better than with vague prior distribution with respect to bias and mean squared error in the Marshall and Olkin's Bivariate Exponential Distribution.

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Effect of Pr substitution on the normal-state and superconducting properties of GdBa$_2$(Cu$_{2.9}$Al$_{0.1}$)O$_z$

  • Park, Jung-Rok;Ha, Dong-Han;Lee, Ho-Keum
    • 한국초전도학회:학술대회논문집
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    • v.10
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    • pp.70-75
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    • 2000
  • We report results of a comparative study of the normal-state and superconducting properties in the GdBa$_2$(Cu$_{2.9}$Al$_{0.1}$)O$_z$ system with substitutions by Pr for the Gd and Ba sites. It is observed that, fur both Pr-doped systems, the superconducting transition temperature(T$_c$) decreases almost linearly with the Pr-content, but Pr at Ba sites results in a faster T$_c$ drop than that of Pr at Gd sites. The thermoelectric power measurements indicate that there is a strong correlation between the T$_c$ and the room temperature value of thermoelectric power. The experimental results are discussed in connection with existing models.

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