• Journal of Intelligence and Information Systems
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• v.29 no.1
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• pp.397-412
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• 2023

In order for social robots to take root in human life, it is important to consider the technical implementation of social robots and human psychology toward social robots. This study aimed to derive potential social robot clusters based on the emotions consumers feel about social robot appearance design, and to identify and compare important design characteristics and emotional differences of each cluster. In our study, we established a social robot emotion framework to measure and evaluate the emotions consumers feel about social robots, and evaluated the emotions of social robot designs based on the semantic differential method, an kansei engineering approach. We classified 30 social robots into 4 clusters by conducting a multidimensional scaling method and K-means cluster analysis based on the emotion evaluation results, confirmed the characteristics of design elements for each cluster, and conducted a comparative analysis on consumer emotions. We proposed a strategic direction for successful social robot design and development from a human-centered perspective based on the design characteristics and emotional differences derived for each cluster.

• Journal of Ginseng Research
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• v.47 no.1
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• pp.123-132
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• 2023

Background: Pseudotyped virus systems that incorporate viral proteins have been widely employed for the rapid determination of the effectiveness and neutralizing activity of drug and vaccine candidates in biosafety level 2 facilities. We report an efficient method for producing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pseudovirus with dual luciferase and fluorescent protein reporters. Moreover, using the established method, we also aimed to investigate whether Korean Red Ginseng (KRG), a valuable Korean herbal medicine, can attenuate infectivity of the pseudotyped virus. Methods: A pseudovirus of SARS-CoV-2 (SARS-2pv) was constructed and efficiently produced using lentivirus vector systems available in the public domain by the introduction of critical mutations in the cytoplasmic tail of the spike protein. KRG extract was dose-dependently treated to Calu-3 cells during SARS2-pv treatment to evaluate the protective activity against SARS-CoV-2. Results: The use of Calu-3 cells or the expression of angiotensin-converting enzyme 2 (ACE2) in HEK293T cells enabled SARS-2pv infection of host cells. Coexpression of transmembrane protease serine subtype 2 (TMPRSS2), which is the activator of spike protein, with ACE2 dramatically elevated luciferase activity, confirming the importance of the TMPRSS2-mediated pathway during SARS-CoV-2 entry. Our pseudovirus assay also revealed that KRG elicited resistance to SARS-CoV-2 infection in lung cells, suggesting its beneficial health effect. Conclusion: The method demonstrated the production of SARS-2pv for the analysis of vaccine or drug candidates. When KRG was assessed by the method, it protected host cells from coronavirus infection. Further studies will be followed for demonstrating this potential benefit.

• Microbiology and Biotechnology Letters
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• v.50 no.4
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• pp.557-562
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• 2022

In this study we evaluated biohydrogen production potential as operational parameters (substrate, salt concentration, and temperature) using eight inoculum sources. While the volumetric biohydrogen production rate was significantly affected by temperature and inoculum sources, substrate and salt concentration did not have a significant effect on the biohydrogen production. Mesophilic temperature (37℃) was also found more appropriate for the hydrogen production than thermophilic temperature (50℃). Rate, while the eight inoculum sources, anaerobic digestion sludge exhibited the fastest biohydrogen production. The maximum production rate from anaerobic digestion sludge was 2,729 and 1,385 ml-H₂·l^-1·d^-1 at mesophilic and thermophilic temperature, respectively.

• Journal of Food Hygiene and Safety
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• v.38 no.4
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• pp.193-201
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• 2023

Antimicrobials in human medicine are classified by The World Health Organization (WHO) into three groups: critically important antimicrobials (CIA), highly important antimicrobials (HIA), and important antimicrobials (IA). CIA are antibiotic classes that satisfy two main criteria: that they are the sole or the only available limited therapeutic option to effectively treat severe bacterial infections in humans (Criterion 1), and infections where bacteria are transmitted to humans from non-human sources or have the potential to acquire resistance genes from non-human sources (Criterion 2). WHO emphasizes the need for cautious and responsible use of the CIA to mitigate risk and safeguard human health. Specific antimicrobials within the CIA with a high priority for management are reclassified as "highest priority critically important antimicrobials (HP-CIA)" and include the 3^rd generation of cephalosporins and the next generation of macrolides, quinolones, glycopeptides, and polymyxins. The CIA list is the scientific basis for risk assessment and risk management policies that warrant using antimicrobials to reduce antimicrobial resistance in several countries. In addition, the CIA list ensures food safety in the food industry, including for the popular food chain companies McDonald's and KFC. The continuous update of the CIA list reflects the advancement in research and emerging future challenges. Thus, active and deliberate evaluation of antimicrobial resistance and the construction of a list that reflects the specific circumstances of a country are essential to safeguarding food security.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.7 no.2
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• pp.105-111
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• 2021

⁸⁹Zr is a positron-emitting radioisotope, which has known as well-suited radioisotope for use in a monoclonal antibody-based imaging agent for immuno-PET. The purpose of this study was to quantitatively evaluate the diagnostic ability of general trastuzumab and thio-trastuzumab as HER2 positive receptors based on Df hexadentate iron chelator. Desferrioxamine-p-SCN (Df-Bz-NCS) and desferroixamine-maleimide (Df-Mal) were purchased from Macrocyclics (Dallas, TX, USA). The trastuzumab was purchased from Roche (Schweiz), and thio-trastuzumab was obtained from professor Hyo-Jeong Hong group (Kangwon National University). The radioisotope ⁸⁹Zr was produced by domestic purification system and KIRAMS using medical cyclotron (50 MeV, Scantronix). The conjugates of Df-trastuzumab and Df-thio-trastuzumab were prepared with Df-Bz-NCS and Df-Mal under basic aqueous solution (pH 8-9) at room temperature, respectively. The conjugates purified by PD-10 column were mixed with dried ⁸⁹Zr chloride. ⁸⁹Zr-labeled conjugates were purified and concentrated by Amicon ultra centrifugal filter. The preparation step and time of ⁸⁹Zr-labeled conjugates was shorted as 4 steps within 2 hours. ⁸⁹Zr-labeled conjugates showed the highly radiochemical purity of over 98%, and were very stable until 7 days by the analysis of radio-ITLC method. Each radio-labeled conjugates were also exhibited the highly stability in both PBS buffer and mouse serum. Immuno-PET imaging of ⁸⁹Zr-labeled conjugates in mice bearing gastric cancer xenograft tumors with HER2 expression showed high tumor uptake in the NCI-N87 HER2-expressing. However, ⁸⁹Zr-Df-Mal-thio-trastuzumab showed a relatively lower tumor-to-background ratio than ⁸⁹Zr-Df-Bz-trastuzumab, as well as whole-body distribution. In the results, ⁸⁹Zr-Df-Bz-trastuzumab was evaluated to have a relatively higher HER2 diagnostic ability than ⁸⁹Zr-Df-Mal-thio-trastuzumab.

• Journal of the Korean Society of Marine Environment & Safety
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• v.29 no.5
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• pp.497-504
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• 2023

In this study, Selective catalytic reduction (SCR) + Diesel particulate filter (DPF) system was installed on a ship with a low-speed engine to conduct the on-board test. The target ship (2,881 gross tons, rated power 1,470 kW@240 rpm ×1) is a general cargo ship sailing in the coastal area. Drawing development, approvals and temporary survey of the ship were performed for the installation of the after-treatment system. For performance evaluation, the gaseous emission analyzer was used according to the NOx technical code and ISO-8178 method of measurement. The particulate matter analyzer used a smoke meter to measure black carbon, as discussed by the International Maritime Organization (IMO). Tests were conducted using MGO (0.043%) and LSFO (0.42%) fuels according to the sulfur content. The test conditions were selected by considering the engine rpm (130, 160 and 180). Gaseous emission and particulate matter (smoke) were measured according to the test conditions to confirm the reduction efficiency of the after treatment system. The results of NOx emission and particulate matter (smoke) revealed that reduction efficiency was more than 90%. The exhaust pressure met the allowable back pressure (less than 50 mbar). This study confirms the importance of the on-board test and the potential of SCR + DPF systems as a response technology for reducing nitrogen oxides and particulate matter.

• The Korea Journal of Herbology
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• v.38 no.5
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• pp.85-95
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• 2023

Objectives : This study was intended to reveal the chemical profiles of aerial(leaf, stem) and underground(rhizome, radix) parts of wild ginseng, and to investigate their anti-aging effects on human skin cells. Methods : Wild ginseng, estimated for over 20 years, was divided into the aerial and underground parts. Total phenolic contents of each extracts were measured using a Folin-ciocalteu method. The contents of 18 amino acids, 8 minerals and 27 ginsenosides were determined by GC-FID, ICP-MS and LC-MS, respectively. The anti-aging effects, including the radical scavenging activity, the activation of mitochondrial function on human fibroblasts, and the proliferation activity on human keratinocyte progenitor cells, for the whole plant and underground part of wild ginseng were evaluated. Results : The total phenolic acids, amino acids, and minerals in the aerial part were more than twice as high as in the underground part. Compared to the cultivated ginseng root, there were various types of ginsenosides in both parts of wild ginseng, and the total amount was more than twice as high. In particular, the aerial part significantly contained ginsenoside F1, F2, C-Mc1, and C-O, and the distinctive patterns that distinguish each parts of wild ginseng from the cultivated ginseng root were derived. The whole plant and underground part of wild ginseng exhibited significant antioxidant effect(14.3-45.6%), activation of mitochondrial membrane potential(105.5-120.1%), and cell proliferation(112.1-125.4%). Conclusions : The entire plant and underground part of wild ginseng are high value-added plants and have beneficial effects on skin anti-aging properties through its abundant metabolites.

• Journal of the Korean earth science society
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• v.43 no.6
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• pp.749-761
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• 2022

As the number of National and UNESCO Global Geoparks has increased, awareness of geological heritage and local government interests have also increased. In this study, data from the geological heritage sites in the Ulsan area were summarized, a practical use plan for geological heritage was prepared based on the assessment results, and the expected effects were also presented. The value for 33 of 112 geological heritage sites identified through literature surveys was evaluated. In terms of the geological heritage types in Ulsan, there were two geological, one geomorphological, and thirty mixed-heritage sites. In the context of the geological heritage of Ulsan, rivers and coastal topography were found to be dominant, and various geomorphological and geological features, such as fossils, folds, faults, shear zones, minerals, and ore deposits are included. Based on the assessment results, there were three, eighteen, nine, and three sites in Classes I, II, III, and IV, respectively. Considering the intrinsic and subsidiary values of geological heritage, the Gangdong Coast, Jujeon Coast, Taehwagang area, Daewangam area, the Daegokri-Cheonjeonri track sites, and Mujechineup are likely to be listed as potential geosites. When the endorsement of the geopark has been promoted alongside these geosites, it can contribute to the sustainable preservation and maintenance of the geosites, satisfy the demand for science education through geo-education, and support the sustainable development of the local economy following the detailed standards for geopark certification in the Natural Parks Act. This is expected to increase the brand value of Ulsan Metropolitan City.

• Journal of the Korea Institute of Building Construction
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• v.23 no.3
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• pp.305-313
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• 2023

With an increasing interest in the commercialization of research results in the present societal climate, especially in the construction industry, preliminary product analysis plays a critical role when introducing a new product to the market. It significantly influences the product's success or failure. In this context, this study aims to investigate the utility of Importance-Performance Analysis (IPA) as a management strategy tool for preliminary analysis in the commercialization of new architectural technologies. The study specifically assesses a smart ball product engineered for pipeline inspection. The evaluation is carried out based on product quality, convenience, and usability categories. Seventeen factors are recognized as sub-items, and a survey is conducted among relevant experts and consumer groups. From the survey, four key items are chosen: "Keep up the good work," "Concentrate here," "Low priority," and "Possible overkill." Suitable strategic measures are derived for each item. By conducting a correlation analysis between product importance and performance, this study offers a method to establish priority directions for future development. This analysis assists in identifying areas that necessitate improvement or additional focus to increase the product's commercial potential. On the whole, this study contributes to understanding and applying Importance-Performance Analysis as a valuable tool in the preliminary analysis and commercialization of novel technologies in the field of architecture.

• Journal of the Korean Geotechnical Society
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• v.23 no.10
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• pp.97-107
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• 2007

Accurate evaluation of the slope stability by assuming failure block as the entire slope is considered to be apposite for the small scale slope, whereas it is not the case for the large scale slope. Hence, appropriate estimation of a failure block size is required since the safety factor and the joint strength parameters are the function of the failure block size. In this paper, the size of failure block was investigated by generating 3-dimensional rock joint system based on statistical data of joints obtained from research slope, such as joint orientation, spacing and 3-dimensional joint intensity. The result indicates that 33 potential failure blocks exist in research slope, as large as 1.4 meters at least and 38.7 meters at most, and average block height is 15.2 meters. In addition, the data obtained from 3 dimensional joint system were directly applicable to the probability analysis and 2 and 3 dimensional discontinuity analysis.