• Journal of the Korean housing association
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• v.20 no.1
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• pp.1-10
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• 2009

This paper documents research carried on the University students who are potential residents of the city to find out their preference for the ubiquitous residential functions, and categorize based on the life style to find out difference of their preference on ubiquitous residential functions. A survey was conducted on 324 university students in Gwangju city. The students were selected through purposive sampling and quota sampling by self-administered questionnaire sheets. The analysis analyzing methods using SPSS/PC 12.0 are frequency, percentage, factor analysis, cluster analysis, $x^2$(chaisquare)-test and one-way ANOVA (analysis of variance). For the survey, lifestyle types were categorized as: These are classified based on the analysis of facts regarding characteristics of student's lifestyles that are divided into nine types of facts and then make the four types through the cluster analysis as below. Energetic life type, Inactive life type, Family-oriented life type, Thrifty and Personality-oriented life type. The residential function of Ubiquitous is classified as Safety, Convenience, Comfortableness, Information, Health, Leisure and the residential space is divided into bedroom, livingroom, kitchen, bathroom. Considering the preference aspects for Ubiquitous residential function, among the bedroom, living room, kitchen, and bathroom, University student seek for safety from the living room, Convenience from the kitchen and Comfortableness from the living room, bedroom and kitchen. For Information, bedroom is most preferred among the bedroom, living room, and kitchen. For Health and Leisure, bedroom is preferred between bedroom and living room. In terms of the difference about the preferences for ubiquitous functions based on the four types of lifestyles; The Thrift-oriented type is commonly preferred to the Inactive type among the bedroom, living room and kitchen. The Family-oriented and the Thrift-oriented type were preferred to the Energetic and Inactive types in the bathroom. Also, in the entire residential space, the Ubiquitous functions is most preferred by the Thrifty and Personality-oriented life type.

• Genomics & Informatics
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• v.14 no.3
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• pp.125-135
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• 2016

Helicobacter pylori is a Gram-negative bacteria that is responsible for gastritis in human. Its spiral flagellated body helps in locomotion and colonization in the host environment. It is capable of living in the highly acidic environment of the stomach with the help of acid adaptive genes. The genome of H. pylori 26695 strain contains 1,555 coding genes that encode 1,445 proteins. Out of these, 340 proteins are characterized as hypothetical proteins (HP). This study involves extensive analysis of the HPs using an established pipeline which comprises various bioinformatics tools and databases to find out probable functions of the HPs and identification of virulence factors. After extensive analysis of all the 340 HPs, we found that 104 HPs are showing characteristic similarities with the proteins with known functions. Thus, on the basis of such similarities, we assigned probable functions to 104 HPs with high confidence and precision. All the predicted HPs contain representative members of diverse functional classes of proteins such as enzymes, transporters, binding proteins, regulatory proteins, proteins involved in cellular processes and other proteins with miscellaneous functions. Therefore, we classified 104 HPs into aforementioned functional groups. During the virulence factors analysis of the HPs, we found 11 HPs are showing significant virulence. The identification of virulence proteins with the help their predicted functions may pave the way for drug target estimation and development of effective drug to counter the activity of that protein.

• Molecules and Cells
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• v.46 no.4
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• pp.219-230
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• 2023

Down syndrome (DS) is the most common autosomal aneuploidy caused by trisomy of chromosome 21. Previous studies demonstrated that DS affected mitochondrial functions, which may be associated with the abnormal development of the nervous system in patients with DS. Runt-related transcription factor 1 (RUNX1) is an encoding gene located on chromosome 21. It has been reported that RUNX1 may affect cell apoptosis via the mitochondrial pathway. The present study investigated whether RUNX1 plays a critical role in mitochondrial dysfunction in DS and explored the mechanism by which RUNX1 affects mitochondrial functions. Expression of RUNX1 was detected in induced pluripotent stem cells of patients with DS (DS-iPSCs) and normal iPSCs (N-iPSCs), and the mitochondrial functions were investigated in the current study. Subsequently, RUNX1 was overexpressed in N-iPSCs and inhibited in DS-iPSCs. The mitochondrial functions were investigated thoroughly, including reactive oxygen species levels, mitochondrial membrane potential, ATP content, and lysosomal activity. Finally, RNA-sequencing was used to explore the global expression pattern. It was observed that the expression levels of RUNX1 in DS-iPSCs were significantly higher than those in normal controls. Impaired mitochondrial functions were observed in DS-iPSCs. Of note, overexpression of RUNX1 in N-iPSCs resulted in mitochondrial dysfunction, while inhibition of RUNX1 expression could improve the mitochondrial function in DS-iPSCs. Global gene expression analysis indicated that overexpression of RUNX1 may promote the induction of apoptosis in DS-iPSCs by activating the PI3K/Akt signaling pathway. The present findings indicate that abnormal expression of RUNX1 may play a critical role in mitochondrial dysfunction in DS-iPSCs.

• Advances in aircraft and spacecraft science
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• v.5 no.1
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• pp.51-71
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• 2018

This work proposes a theoretical and numerical study on the behavior of a tapered shaft rotor made of composite materials by the classical version h and the version p of the finite element method. Hierarchical form functions are used to define the model. The purpose of this paper is to determine the expressions of the kinetic and potential energies of the tree necessary for the results of the equations of motion. A comparison between the version h and the p version of the finite element method of the functions of polynomial and trigonometric hierarchical forms with six degrees of freedom per node, of a composite tapered and cylindrical shaft which rotates at a constant speed about its axis. It is found that when the number of functions of form (the version p) is increased, the solution converges. It is also observed that the conicity of the shaft increases the rigidity with respect to a uniform shaft having the same mechanical properties. The numerical simulation allowed us to determine the natural frequencies and the critical speeds of the composite shaft systems are compared with those available in the literature and the effectiveness of the methods used are discussed.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.22 no.1
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• pp.131-138
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• 1998

Conventional yaw functions are compared with actual response of a hot wire to various yaw angles, and a new function is proposed, which can be applied at large yaw angles and low velocities. To compare the accuracy of the new yaw function with those of the conventional ones, measurements are made for the jet flow at the nozzle exit and at .chi./D=15 with an X hot-wire probe. In the potential core, the flow angles reduced by the present function, ideal angle method and full velocity-angle method are shown to be more accurate than those reduced by the cosine function and Hinze's formula. No matter which yaw functions are used, the profiles of mean velocity and turbulence intensity show little discrepancy at .chi./D=15. However, there is a significant difference between the probability density functions obtained by the present function, ideal angle method and full velocity-angle method and those obtained by the cosine function and Hinze's formula.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.12 no.6
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• pp.931-939
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• 2001

The slot coupling characteristics was analysed in a radial-line slot antenna for its design. The previously proposed waveguide model with a periodic boundary condition on its narrow walls and periodically arranged slots on its wide wall was used. The magnetic field integral equation and two dyadic Green\`s functions for respective regions was derived and the method of moments was used. To maximize the efficiency of numerical analysis and to extract singularities, two different kinds of basis functions, the entire domain basis function and the sub-domain one, are used. In addition, the Ewald sum technique for the rectangular waveguide and the Shanks transform for the half space were used to accelerate the computation of the slowly convergent potential Green\`s functions. Simulation results expressed the effects of the various design parameters on the slot coupling.

• Journal of Korean Society of Steel Construction
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• v.13 no.1
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• pp.41-52
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• 2001

In this paper the analysis of laminate composite folded plates with arbitrary angle connection like box girder is studied by finite strip method Total stiffness of laminated plate is obtained by integration of the stiffness in each layer or lamina through laminate thickness and total stiffness in each layer or lamina through laminate thickness and total tiffness matrix is obtained by substitutionto equilibrium equation derived from the minimum total potential energy theorem. The assumed displacement functions for a finite strip method in plate or box girder analysis are combinations of one-way polynomial functions in the transverse direction and harmonic functions in the span-wise direction. Finite strip method with the merits of the simplification in modeling and the reduction of analytical time is accurate in the analysis of laminate composite folded plates shaped like box firders.

• Journal of Information Science Theory and Practice
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• v.8 no.2
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• pp.68-78
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• 2020

This study is a preliminary study to develop an evaluation framework necessary for evaluating the DataON platform. The first objective is to examine expert perceptions of the level of DataON platform construction. The second objective is to evaluate the importance, stability, and usability of DataON platform features over OpenAIRE features. The third objective is to derive weights from the evaluation perspective for future DataON platform evaluation. The fourth objective is to examine the preferences of experts in each evaluation perspective and to derive unbiased evaluation criteria. This study used a survey method for potential stakeholders of the DataON platform. The survey included 12 professionals with at least 10 years of experience in the field. The 57 overall functions and services were measured at 3.1 out of 5 for importance. Stability was -0.07 point and usability was measured as -0.05 point. The 42 features and services scored 3.04 points in importance. Stability was -0.58 points and usability was -0.51 points. In particular, the stability and usability scores of the 42 functions and services provided as of 2018 were higher than the total functions were, which is attributed to the stable and user-friendly improvement after development. In terms of the weight of the evaluation point, the collection quality has the highest weight of 27%. Interface usability is then weighted 22%. Subsequently, service quality is weighted 19%, and finally system performance efficiency and user feedback solicitation are equally weighted 16%.

• Molecules and Cells
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• v.42 no.7
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• pp.546-556
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• 2019

Protein phosphatase 4 (PP4) is a crucial protein complex that plays an important role in DNA damage response (DDR), including DNA repair, cell cycle arrest and apoptosis. Despite the significance of PP4, the mechanism by which PP4 is regulated remains to be elucidated. Here, we identified a novel PP4 inhibitor, protein phosphatase 4 inhibitory protein (PP4IP) and elucidated its cellular functions. PP4IP-knockout cells were generated using the CRISPR/Cas9 system, and the phosphorylation status of PP4 substrates (H2AX, KAP1, and RPA2) was analyzed. Then we investigated that how PP4IP affects the cellular functions of PP4 by immunoprecipitation, immunofluorescence, and DNA double-strand break (DSB) repair assays. PP4IP interacts with PP4 complex, which is affected by DNA damage and cell cycle progression and decreases the dephosphorylational activity of PP4. Both overexpression and depletion of PP4IP impairs DSB repairs and sensitizes cells to genotoxic stress, suggesting timely inhibition of PP4 to be indispensable for cells in responding to DNA damage. Our results identify a novel inhibitor of PP4 that inhibits PP4-mediated cellular functions and establish the physiological importance of this regulation. In addition, PP4IP might be developed as potential therapeutic reagents for targeting tumors particularly with high level of PP4C expression.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.32 no.3
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• pp.93-98
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• 2021

Electroencephalography (EEG) measures neural activation due to various cognitive processes. EEG and event-related potentials (ERPs) are widely used in studies investigating psychopathology and neural substrates of psychiatric diseases in children and adolescents. The present study aimed to review recent ERP studies in child and adolescent psychiatry. ERPs are non-invasive methods for studying synaptic functions in the brain. ERP might be a candidate biomarker in child-adolescent psychiatry, considering its ability to reflect cognitive and behavioral functions in humans. For the EEG study of psychiatric diseases in children and adolescents, several ERP components have been used, such as mismatch negativity, P300, error-related negativity (ERN), and reward positivity (RewP). Regarding executive functions and inhibition in patients with attention-deficit/hyperactivity disorder (ADHD), P300 latency, and ERN were significantly different in patients with ADHD compared to those in the healthy population. ERN showed meaningful changes in patients with anxiety disorders, such as generalized anxiety disorder, separation anxiety disorder, and obsessive-compulsive disorder. Patients with depression showed significantly attenuated RewP compared to the healthy population, which was related to the symptoms of anhedonia.