• Journal of Microbiology and Biotechnology
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• 제27권9호
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• pp.1639-1648
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• 2017

Curcumin is a natural polyphenolic compound, widely acclaimed for its antioxidant, anti-inflammatory, antibacterial, and anticancerous properties. However, its use has been limited due to its low-aqueous solubility and poor bioavailability, rapid clearance, and low cellular uptake. In order to assess the effect of glycosylation on the pharmacological properties of curcumin, one-pot multienzyme (OPME) chemoenzymatic glycosylation reactions with UDP-${\alpha}-{\text\tiny{D}}$-glucose or UDP-${\alpha}-{\text\tiny{D}}$-2-deoxyglucose as donor substrate were employed. The result indicated significant conversion of curcumin to its glycosylated derivatives: curcumin 4'-O-${\beta}$-glucoside, curcumin 4',4"-di-O-${\beta}$-glucoside, curcumin 4'-O-${\beta}$-2-deoxyglucoside, and curcumin 4',4"-di-O-${\beta}$-2-deoxyglucoside. The products were characterized by ultra-fast performance liquid chromatography, high-resolution quadruple-time-of-flight electrospray ionization-mass spectrometry, and NMR analyses. All the products showed improved water solubility and comparable antibacterial activities. Additionally, the curcumin 4'-O-${\beta}$-glucoside and curcumin 4'-O-${\beta}$-2-deoxyglucoside showed enhanced anticancer activities compared with the parent aglycone and diglycoside derivatives. This result indicates that glycosylation can be an effective approach for enhancing the pharmaceutical properties of different natural products, such as curcumin.

• The Plant Pathology Journal
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• 제22권4호
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• pp.364-368
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• 2006

Survival of biocontrol agents and their effective colonization of rhizhosphere are the essential components for successful disease suppression. The effects of hydrogel supplement on bacterial survival and disease control were evaluated in pot and in the field. Addition of 2% hydrogel material to potting soil resulted in significant enhancement of colonization of biocontrol agent Serratia plymuthica A21-4 both in soil and rhizosphere of pepper plants. Rhizosphere colonization of S. plymuthica A21-4 retrieved from 40 days old pepper seedlings indicated 100 times higher bacterial population in hydrogel treated soil than in ordinary pot soil. The pepper plants sown in hydrogelated potting soil showed higher seed germination rate and the better growth of pepper plant than those in ordinary commercial pot soil. Although the suppression of Phytophthora capsid density in the potting soil by treatment of biocontrol agent A21-4 was not significantly different between in hydrogelated soil and ordinary potting soil, the suppression of Phytophthora blight between two treatments was significantly different. A21-4 treatment in hydrogelated potting soil was completely disease-free while same treatment in ordinary potting soil revealed 36% disease incidence. Our field study under natural disease occurrence also showed significantly less disease incidence(12.3%) in the A21-4 treatment in the hydrogelated soil compared to other treatments. Yield promotion of pepper by the A21-4 treatment in the hydrogelated potting soil was also recognized. Our results indicated that hydrogel amendment with biocontrol agent in pot soil would be a good alternative to protect pepper seedlings and increase plant yield.

• 아시안잔디학회지
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• 제19권1호
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• pp.17-25
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• 2005

무궁화의 중요한 식엽성 해충인 무궁화잎밤나방(Anomis mesogona)과 큰붉은잎밤나방(Anomis commoda)에 대한 곤충병원성 선충 Steinernena carpocapsue 포천 계통(ScP)의 병원성을 실내 petri dish와 pot에서 령기별(2령, 3-4령, 5령)로 검정하였다. 큰붉은잎밤나방과 무궁화잎밤나방에 대한 반수치사농도$(LC_{50})$는 령기가 높아질수록 증가하여 선충에 대한 감수성이 감소하였는데, 2령충의 경우 각각 9.7과 4.5였다. 그리고 Pot에서도 ScP의 병원성은 령기에 따라 차이를 보였다. ScP는 큰붉은잎밤나방과 무궁화잎밤나방의 2령충에 대하여 가장 높은 치사율을 보였는데, 90,000마리/pot($=1\times10^9$ 마리/ha) 처리 시 각각 $72.5\%$와 $87.5\%$의 치사율을 보였다. 반면 3-4령충부터는 병원성이 감소하여 큰붉은잎밤나방과 무궁화잎밤나방 5령충에 대해서는 처리 5일 후, 90,000마리/pot 처리 시 각각 $5.0\%$와 $10.0\%$의 치사율만 나타내었다. Pot에 2령충과 3-4령충, 5령충을 각각 10마리씩 접종한 후, ScP를 90,000마리/pot 농도로 처리하였을 때, 큰붉은잎밤나방과 무궁화잎밤나방의 치사율은 각각 $69.2\%$와 $50.0\%$였다.

• 대한핵의학회지
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• 제3권2호
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• pp.1-16
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• 1969

The double tracer study on erythrokinetics was carried out experimentally with radioactive iron ($^{59}Fe$) and chromium ($^{51}Cr$) in rabbits. The 0.1% canthalidin solution and 1% pot. perchlomate solution was given subcutaneously to 20 rabbits respectively. 3 and 6 days after injection, the blood chemistry, urine examination, ferrokinetics and apparent half survival time of RBC were ($^{51}Cr\;T\frac{1}{2}$)determined. Following were the results: 1) Red blood cell hematocrit and hemoglobin values were moderately reduced and B.U.N. and serum creatinine values were slight]y inercased in the canthalidin group, while B.U.N. and serum creatinine values were within normal limits in the pot. perchlomate group. Reticulocyte values were slight]y increased in the canthalidin group, while was normal range in the pot. perchlomate group. 2) Blood chemistry finding was not significant statistically in both experimental groups, but serum iron value was moderately reduced in both group. 3) Plasma volume was unchanged in both group, but red cell volume and whole blood volume were slightly reduced in both groups. 4) Results of ferrokinetics were as follows: i) The plasma iron disappearance rate was delayed in both groups. Plasma iron turnover rate, red cell iron utilization and red cell iron turnover rate were decreased in both groups, and then red cell iron turnover rate was more decreased than plasma iron turnover rate in both groups. Circulating red cell iron was slight]y increased in canthalidin group and red cell iron concentration was within normal range in both groups. ii) P.I.T.R.-R.C.I.T. value was moderately increased in the canthalidin group and slightly increased in the pot. perchlomate group. Reticulocyte index, red cell iron turnover index, plasma iron turnover index and effective erythropoiesis index were whole]y reduced in both groups. iii) The red cell life span was slightly shortened in the canthalidin group while was within normal range in pot. perchlomate group. The pathologic finding of renal biopsy of the canthalidin group shows a selective damage in glomerulus, while shows almost normal range or slight damage in tubules. And that of the pot. perchlomate group shows a selective damage in tubules with slight damage of glomerulus.

• 디지털융복합연구
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• 제19권3호
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• pp.363-369
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• 2021

본 연구는 시각장애인과 노약자를 위한 일상생활용품 중 뜨거운 음료를 안전하게 따르고 마실 수 있는 전기 포트와 컵에 대한 디자인을 개선하는 것을 목적으로 한다. 시각장애인이 평소에 사용하는 일반 전기 포트와 컵을 그들의 사용관점을 통해 바라보고 이를 유니버설디자인의 원칙에 의거 사용 시 발생하는 안전에 관한 문제점을 연구, 개선하여 이를 반영한 전기 포트용 안전 클립과 안전 컵 디자인을 제안한다. 이러한 선행연구를 통해 모든 장애인과 사회적 약자가 함께 사용하고 공유할 수 있는 디자인을 연구하고 기존 생활용품 디자인을 개선함으로써 일반 제품의 사용범위를 확대하고 사회적 가치를 새롭게 마련하는 계기로 삼는다. 또한, 이러한 디자인 개선 과정을 통해 모두가 평등하고 윤택한 삶을 추구하는 사회적 분위기 속에 장애인의 현재 위치와 삶의 가치에 대해 다시 한 번 생각해보는 기회로 삼는다.

• Design & Manufacturing
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• 제8권1호
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• pp.27-30
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• 2014

Alloy tool steel such as SKD11 and SKD61 or high speed tool like SKH51 are used as materials for semiconductor dies. Cavities, curl blocks, pot blocks and housings are made from those materials. To make those parts from alloy tool steel or high speed tool, one utilizes discharge machining, and mechanical machining including machining center, milling, drilling, forming grinding and others. In the process of cutting machining and polishing, the die materials become unsuitable for machining owing to bubbles and foreign substances in them, which hinders production process. Therefore, this study focuses on die material selection criteria, and on analysis and comparison of material characteristics to help companies to solve their problems, make die manufacture less burdensome and extend die life.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2006년도 춘계 학술발표회 논문집(II)
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• pp.353-356
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• 2006

Hardening of 2 component adhesive such as epoxy resin used in saturating FRP composite is triggered by mixing each component part within a batch. Chemical reactions occur explosively after a certain time after mixing the batch, viscosity and temperature rapidly increase. As a results, bond performance remarkably decreases and workability declines due to increase in viscosity. Therefore, adhesion should be completed before chemical hardening reaction is rapidly going on. This study examined pot life of structural adhesive for FRP composites by means of change in apparent viscosity and means of exothermic reaction temperature proposing in existing test standards. Result of each test method was compared and analyzed, and reasonable test method and evaluation method are suggested.

• 전기학회논문지
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• 제61권6호
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• pp.916-921
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• 2012

Sealant paste with silica immersed in cross-linked epoxy-acrylate polymer resin was prepared by thermal and UV curing process. The curing mechanism of polymer resin resulted from 2 functional groups of epoxy and acrylic structure. The properties of microstructure, thermal conductivity and mechanical strength were investigated for its various applications. The adhesion strength is increased by increasing the thermal curing time until 15 minutes, and curing efficiency is saturated over 20 minutes. The increase rate per day of pot life and viscosity is 4.8%, indicating it has excellent storage stability. It is found that the formulation of silica pastes can be applied to heavy industries, building materials, display and various industries.

• 대한화학회지
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• 제55권2호
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• pp.240-242
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• 2011

CuCl과 N-methyl-2-pyrrolidone을 이용하여 5-bromoindole을 halogen - halogen 교환반응을 통하여 5-chloroindole계 화합물을 합성하는 one-pot대량합성방법을 개발하였다.

• Bulletin of the Korean Chemical Society
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• 제35권4호
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• pp.994-1000
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• 2014

Synthesis of tetrahydroimidazo[1,2-a]pyridines and tetrahydropyrido[1,2-a] pyrimidines by a one-pot and three component reaction of ${\alpha}$-oxoketenedithioacetals, diamines and DMAD in water has been described. Different routes for accessing the desired compounds were examined and a few specially designed-substrates have been utilized further to afford the new imidazo and pyrido fused [1,8] naphthyridine tetracyclic compound by $S_NAr$ intramolecular cyclization.