• Title/Summary/Keyword: Postnatal

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Insulin-like growth factor가 소장 점막 세포 증식에 미치는 영향

  • 윤정한
    • 한국영양학회:학술대회논문집
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    • 한국영양학회 1995년도 추계학술대회 초록
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    • pp.11-34
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    • 1995
  • Growth hormone (GH) plays a key role in regulating postnatal growth and can stimulate growth of animals by acting directly on specific receptors on the plasma membrane of tissues or indirectly through stimulating insulin-like growth factor (IGF)-I synthesis and secretion by the liver and other tissues. IGF-I and IGF-Ⅱ are polypeptides with structural similarity with proinsulin that stimulate cell proliferation by endocrine, paracrine and autocrine mechanisms. The initial event in the metabolic action of IGFs on target cells appears to be their binding to specific receptors on the plasma membrane. Current evidence indicates that the mitogenic actions of both IGFs are mediated primarily by binding to the type I IGF receptors, and that IGF action is also mediated by interactions with IGF-binding proteins (IGFBPs). Six distinct IGFBPs have been identified that are characterized by cell-specific interaction, transcriptional and post-translational regulation by many different effectors, and the ability to either potentiate or inhibit IGF actions. Nutritional deficiencies can have their devastating consequence during growth. Although IGF-I is the major mediator of GH's action on somatic growth, nutritional status of an organism is a critical regulator of IGF-I and IGFBPs. Various nutrient deficiencies result in decreased serum IGF-I levels and altered IGFBP levels, but the blood levels of GH are generally unchanged or elevated in malnutrition. Effects of protein, energy, vitamin C and D, and zinc on serum IGF and IGFBP levels and tissue mRNA levels were reviewed in the text. Multiple factors are involved in the regulation of intestinal epithelial cell growth and differentiation. Among these factors the nutritional status of individuals is the most important. The intestinal epithelium is an important site for mitogenic action of the IGFs in vivo, with exogenous IGF-I stimulating mucosal hyperplasia. Therefore, the IGF system appears to provide and important mechanism linking nutrition and the proliferation of intestinal epithelial cells. In order to study the detailed mechanisms by which intestinal mucosa is regulated, we have utilized IEC-6 cells, an intestinal epithelial cell line and Caco-2 cells, a human colon adenocarcinoma cell line. Like intestinal crypt cells analyzed in vivo or freshly isolated intestinal epithelial cells, IEC-6 cells and Caco-2 cells possess abundant quatities of both type Ⅰ and type Ⅱ IGF receptors. Exogenous IGFs stimulate, whereas addition of IGFBP-2 inhibits IEC-6 cell proliferation. To investigate whether endogenously secreted IGFBP-2 inhibit proliferation, IEC-6 cells were transfected with a full-length rat IGFBP-2 cDNA anti-sense expression construct. IEC-6 cells transfected with anti-sense IGFBP-2 protein in medium. These cells grew at a rate faster than the control cells indicating that endogenous IGFBP-2 inhibits proliferation of IEC-6 cells, probably by sequestering IGFs. IEC-6 cells express many characteristics of enterocyte, but do not undergo differentiation. On the other hand, Caco-2 cells undergo a spontaneous enterocyte differentiation. On the other hand, Caco-2 cells undergo a spontaneous enterocyte differentiation after reaching confluency. We have demonstrated that Caco-2 cells produce IGF-Ⅱ, IGFBP-2, IGFBP-3, and an as yet unidentified 31,000 Mr IGFBP, and that both mRNA and peptide secretion of IGFBP-2 and IGFBP-3 increased, but IGFBP-4 mRNA and protein secretion decreased after the cells reached confluency. These changes occurred in parallel to and were coincident with differentiation of the cells, as measured by expression of sucrase-isomaltase. In addition, Caco-2 cell clones forced to overexpress IGFBP-4 by transfection with a rat IGFBP-4 cDNA construct exhibited a significantly slower growth rate under serum-free conditions and had increased expression of sucrase-isomaltase compared with vector control cells. These results indicate that IGFBP-4 inhibits proliferation and stimulates differentiation of Caco-2 cells, probably by inhibiting the mitogenic actions of IGFs.

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어유섭취가 출생후 발달과정의 흰 쥐의 간과 뇌조직의 지질과산화와 그 관련기능에 미치는 영향 (Effect of Dietary Fish Oil on Lipid Peroxidation in Rats Liver and Brain During Postnatal Development)

  • 박명희
    • Journal of Nutrition and Health
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    • 제20권2호
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    • pp.111-121
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    • 1987
  • 어유를 섭취하였을 때, 체내 과산화물 생성과 항산화 기능을 조사하며, 그 결과를 다른 식이지방과 비교하기 위하여, 고등어유, 대두유, 쇠기름, 들기름, 채종유의 5 종의 지방을 먹이의 10% 되게 식이를 조제하여 70g 내외의 암, 수컷의 흰쥐에게 섭취시켰다. 출생후 초기 성장시에 적응도를 관찰하기 위하여, 위의 쥐들을 34일간 조제식이로 사육한후, 교배시켜 출생한 2 대째 쥐들을 수유시기(17일, 26일)과 이유시기(39일)에 희생시키고, 출산, 수유를 마친 어미쥐(나이 123일, 총 식이일수 81일)를 희생하여 간과 뇌조직의 지질과산화물, $\alpha$-tocopherol, glutathione 양을 정량하고, glutathione peroxidase, superoxide dismutase의 활성을 측정하였다. 간조직의 지질과산화물 값은 고등어유를 섭취한 어미쥐와 수유기(17, 26일)의 새끼쥐들에게서 타군에 비해 높았으나 39일의 새끼쥐에서는 채종유보다는 높았으나 대두유, 들기름군과 같은 수준이었다. 뇌조직에서는 간에 차이가 거의없었다. 간조직의 $\alpha$-tocopherol 농도와 환원형의 glutathione(GSH) 의 농도가 어미쥐에서 타군에 비해 현저히 낮았고, 새끼쥐에서도 $\alpha$-tocopherol 경우는 같은경향이나 그 정도가 덜 현저하며, GSH의 경우는 타군들과 차이가 없었다. 산화형 glutathioe (GSSG)의 농도는 어미쥐, 새끼쥐모두에서 식이지방에 따른 차이가 일관성 있게 나타나지 않았다. Glutathione peroxidase 활성은 간장과 뇌조직에서 성장과정중의 새끼쥐들에서 모두 약간씩 증가하였고, 채종유군에서 타군에 비해 증가정도가 낮아 활성이 39일에 현저히 낮았다. Superoxide dismutase 의 활성은 성장기간에 따른 변화는 적었고, 고등어유군이 타군에 비해 비교적 낮은값을 유지하였다. 어미쥐와 17일째 새끼쥐에서는 달리 26일과 39일째 새끼쥐의 간조직 glutathioe peroxidase 의활성이 지질과산화물 농도와 정의 상관관계가 보여져, 출생후 초기 성장과정에서 체내 적응성이 존재함을 나타내주었다.

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초기 산욕부의 간호요구도와 만족도에 관한 연구 (A Study on the Nursing Needs and Satisfactions of Early Postpartum Women)

  • 유연자;이은주
    • 여성건강간호학회지
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    • 제5권3호
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    • pp.389-409
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    • 1999
  • This study was carried out to identify the differences between nursing needs and levels of satisfaction of postpartum women during the early postpartum period. The goal of this study was to obtain needed to develope the nursing quality for postpartum women. The subjects were 87 postpartum women who had vaginal delivery at 2 general hospital and 2 maternity hospital in the Ulsan City. The period for the data collection was from June 1 to 29, 1999. The data was gathered using an 98 items questionnaire which was a modified version of a questionnaire the developed by Y. J. Chun. Results found are as follows : 1. The general characteristics of the subjects : The majority of subjects were 25-29 yrs. (57.5%), high school and college graduates(96.5%), unemployed(75.9%), middle ranged economics(93.1%), had no religion(43.7%), male baby(52.9%), birth weight 3-3.5Kg(49.4%), wanted pregnancy(96.6%), no abortion history(50.6%), had antenatal care(89.7%), had prenatal education(32.2%), postnatal education(42.5%), intended breast feeding (46.0%), had resonable self confidence about self(20.7%), infant care(36.8%) and nuclear family pattern(82.3%). 2. The level of nursing needs of overall nursing care(3.93) and the levels of satisfaction(3.86) was relatively high. The nursing needs by category of nursing care, the highest need was in the emotional and psychological care(4.09), and the lowest need was in physical need(3.73). The satisfactions by category of nursing care, the highest satisfaction was in emotional and psychological care(4.11) and the lowest satisfaction was in education in self care(3.64). The significant differences between nursing needs and satisfactions were found on education in infant care(p=.005), and education in self care(p=.020). 3. Among items of physical care, 'accurate medication and treatment(4.21)', 'control of postpartum hemorrhage(4.13)', 'pain control and care of episiotomy wound (4.12)' and 'regular observation of postpartum conditions(4.09)' showed high nursing needs. 'Accurate medication and treatment(4.31)', 'regular observation of postpartum condition(4.24)', 'control of postpartum hemorrhage(4.22)' and 'pain control and care of episiotomy wound(4.12)' showed high satisfaction levels. 4. Among items of emotional and psychological care, 'personal treatment(4.32)', kind and faithful care(4.30)', 'detailed explanation on the treatment or nursing care(4.25)', 'adequate draping during the care and treatment(4.23)' and detailed explanation on a doubt(4.13)', showed high nursing needs, 'personal treatment(4.52)', 'kind and faithful care(4.45)', 'detailed explanation on a doubt(4.24)', 'detailed explanation on the treatment or nursing care(4.21)' and 'adequate draping during the care and treatment(4.18)' showed high satisfaction of nursing care. Difference between the level of nursing needs and satisfaction was significant except item of 'early contacts with their baby and breast feeding'. 5. Among items of environmental care, the highest level of need and satisfaction were on the items of 'neat bedding and clothes(4.05, 4.21)' and 'room cleansing or care of room(4.01, 4.28)'. Differences between the level of nursing care and satisfaction were 'room cleansing of care of room'. 6. Among items of educational needs on self care, 'sitz bath method(4.22)', 'high risk symptoms to immediate clinic visits(4.13)', 'the timing of tub bath(4.05)' and 'good secretion of breast milk(4.03)', showed high nursing needs, 'sitz bath method(4.22)' showed high satisfaction of nursing care. Differences between the level of nursing care and satisfaction were 'the timing of hair shampoo', 'the timing of tub bath', ' the method of pad change', 'postpartum exercise', 'good secretion of breast milk', 'maintenance of breast figure', 'contraindicated drugs in postpartum women', 'kegel exercise' and 'breast self examination'. 7. Among items of educational needs on infant care, 'immunization of infants(4.36)', 'symptoms of sickness to immediate clinic visits(4.28)'. 'safety and emergency care(4.28)', 'umbilical care(4.26)', 'feeding times and intervals(4.24)', 'normal growth and development of infant(4.24)' and 'infection control(4.22)', showed high level of nursing care, 'immunization of infants(4.21)', 'feeding times and intervals(4.17)', were high satisfaction items showed significant differences between the level of nursing care and satisfaction. 8. Relationship between nursing needs and levels of satisfaction among postpartum women were as follows : 1) Physical area : There were no significant differences in the level of nursing needs, but satisfaction levels were significantly different among 'working mothers', 'baby's weights', 'baby's sex', 'planning of feeding' and 'routes of receiving postpartum informations'. 2) Emotional and psychological area : The level of nursing needs were significantly different in the area of 'confidence in self care'. Satisfaction levels were significantly different among 'baby's sex', 'baby's weights', 'the confidence of infant care' and 'working mother'. 3) Environment area : There were on significant differences in the level of nursing needs, but satisfaction levels were significantly different among 'maternal age' and 'baby's weights'. 4) Education in self care : The level of nursing needs were significantly different among 'parity history' and 'type of family formation'. Satisfaction levels were significantly different among 'working mother', 'baby's sex', 'antenatal care', 'postpartum education', 'planning of feeding', 'routes of receiving postpartum informations'. 5) Education in infant care area : The level of nursing needs were significantly different among 'parity history'. Satisfaction levels were significantly different among 'baby's sex', 'receiving postpartum education or not' and 'working mother'.

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중증 고빌리루빈혈증(혈청 빌리루빈 >25 mg/dL)의 발병 원인과 치료 및 예후 (Etiology, Management, and Prognosis of Severe Hyperbilirubinemia (Serum Bilirubin Level=25 mg/dL) in Newborn)

  • 황종희;이지현;김유진;구수현;이장훈;최창원;장윤실;박원순
    • Clinical and Experimental Pediatrics
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    • 제48권10호
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    • pp.1102-1106
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    • 2005
  • 목 적 : 저자들은 혈청 빌리루빈 25 mg/dL 이상의 중증 고빌리루빈혈증의 발병 원인과 치료 및 예후에 대해 알아보고자 하였다. 방 법 : 1994년 10월부터 2004년 6월까지 성균관대학교 삼성서울병원 신생아 집중치료실에 입원하여 고빌리루빈혈증으로 진단 받은 환아들 중 혈청 빌리루빈치가 25 mg/dL 이상이면서 다른 동반 질환을 가지지 않고 추적관찰이 가능했던 48명을 대상으로 하여 치료 방법에 따라 광선치료군(1군, n=42)과 교환수혈군(2군, n=6)으로 분류하고 인구 통계학적 특징, 발병 시기, 발병 원인 및 치료에 따른 예후의 차이에 대해서 후향적으로 조사하였다. 결 과 : 재태주령은 두 군간(1군; $39{\pm}1$주, 2군; $37{\pm}4$주)에 유의한 차이가 없으며 출생체중은 2군($2,852{\pm}1,085g$)이 1군($3,137{\pm}437g$)에 비해 유의하게 작았으나(P<0.05), 2군에서 820 g의 환아가 포함되어 있어 통계적인 영향을 주었다. 발병 원인으로는 두 군 모두 특발성이 가장 많았으며 황달의 첫 임상적 발현 시기, 첫 혈청 빌리루빈 검사 시기 및 입원 시기는 군간에 유의한 차이가 없었다. 최고 혈청 빌리루빈치는 1군($29{\pm}6mg/dL$)에 비해 2군($45{\pm}16mg/dL$)에서 더 의미 있게 증가하였고(P<0.05), 치료 기간, 치료 후 혈청 빌리루빈의 감소 정도 및 신경학적 예후는 군간에 차이가 없었다. 결 론 : 증증 고빌리루빈혈증의 치료에 있어서 현재의 치료 지침으로도 적절한 치료가 이루어질 수 있으나 조기 진단 및 치료를 위해서는 중증 고빌리루빈혈증의 위험성이 높을 경우 생후 1주일 이내에 황달에 대한 추적 관찰이 필요할 것으로 사료된다.

학령 전기 소아에서 거대세포바이러스 IgG 항체 양성률의 변동 (The alteration of the positive rate of cytomegalovirus IgG antibody among preschool period children)

  • 서세영;박상준;황자영;한승훈;김소영;김현희;이원배
    • Clinical and Experimental Pediatrics
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    • 제49권1호
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    • pp.51-55
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    • 2006
  • 목 적 : 학령 전기 소아에서 연령에 따른 거대세포바이러스 항체 보유율의 조사를 통해 모체로부터 유래된 항체의 소실 시기와 후천적 감염에 의한 항체 양성률이 증가되는 시기를 알아 보기 위해 본 연구를 실시하였다. 방 법 : 2001년 3월부터 2004년 2월까지 가톨릭대학교 성가병원에 내원한 신생아부터 만 5세(60개월)까지 연령의 391명을 대상으로 하였다. 이 중에서 217명은 거대세포바이러스 IgG를 검사하였고, 358명은 거대세포바이러스 IgM를 검사하였다. 결 과 : 학령 전기 소아의 혈청내 거대세포바이러스 IgG 항체양성률은 전체 대상자 217명 중 182명이 양성을 보여 평균 83.9%의 양성률을 보였다. 전체적인 변동은 출생시부터 3개월까지 나이에서 92.9%를 보인 후 생후 4-6개월 사이에서 75.0%로 감소되었으며 생후 7-9개월 사이에서 20.0%로 최저치를 보인 후 차츰 증가하여 생후 22-24개월 사이에 전체 평균인 83.9%에 근접한 수치에 도달하였다. 25개월 이후부터는 전체 평균치보다 높은 양성률을 보였다. 생후 22개월 이후에는 총 114명 중 105명이 양성을 보여 92.1%의 양성률을 보였다. 거대세포바이러스 IgM 항체 양성률은 전체 대상자 358명 중에서 0-1개월의 150명 중 3명이 양성으로 3.3%, 1-2개월의 28명 중 1명이 양성으로 3.6%, 2-3개월의 19명 중 2명이 양성으로 10.5%, 3-4개월의 7명 중 1명이 양성으로 14.3%, 4-5개월의 7명 중 1명이 양성으로 14.3%였고, 이후에는 148명 중 5명만이 양성인데, 22-23개월에 1명, 25-26개월에 1명, 27-28개월에 1명, 28-29개월에 1명, 40-41개월에 1명씩 분포하여 출생 후부터 생후 5개월까지는 지속적으로 발견되었으나, 이후 연령에서는 간헐적으로 발견되었다. 결 론 : 거대세포바이러스 IgG 항체는 모체에서 유래된 IgG 항체는 출생 후부터 감소되어 생후 7-9개월경 급격히 감소되며 주산기 또는 출생 직후부터의 거대세포바이러스 감염에 의해 IgG가 증가되어 생후 22-24개월에 평균 IgG 양성률인 83.9%에 도달한다.

극소 저체중 출생아에서 뇌백질 병변의 MRI 소견 (Magnetic resonance imagining findings of the white matter abnormalities in the brain of very-low-birth-weight infants)

  • 최재혁;장영표
    • Clinical and Experimental Pediatrics
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    • 제52권10호
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    • pp.1127-1135
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    • 2009
  • 목 적 : 극소 저체중 출생아에서 교정 주수 만삭(40주) 근처에 시행한 뇌 MRI 소견에서 뇌백질 이상 소견을 관찰하고 측뇌실 부위 백질연화증 발생과 관련 있는 임상 위험 인자를 관찰하고자 하였다. 방 법 : 교정 주수 만삭(40주) 근처에 뇌 MRI를 시행한 극소 저체중 출생아 98명을 대상으로 뇌 MRI의 뇌백질 이상 소견을 관찰하였다. 뇌백질 이상 소견 중 낭성 또는 비낭성 측뇌실 부위 백질 연화증 환아들의 임상 소견을 관찰하여 측뇌실 부위 백질연화증의 발생과 관련된 임상 위험 인자를 관찰하고자 하였다. 결 과 : 1) 98명의 환아 중 DEHSI가 74명(75.5%), 뇌실 확장은 17명(17.3%), 국소 백질 음영 증가는 5명(5.1%), 측뇌실 부위 낭성 소견은 11명(11.2%), 종자층 출혈 또는 상의 하 낭종이 9명(9.1%), 뇌실 내 출혈이 3명(3.1%), 출혈 후 뇌수종이 2명(2.0 %), 측뇌실 부위 출혈성 경색이 2명(2.0%) 관찰되었다. 2) 측뇌실 부위 백질연화증 발생과 관련된 임상 위험 인자로는 낭성 측뇌실 부위 백질연화증에서는 재태 기간, 1분 Apgar 점수, CRIB-II 점수, 혈압 상승제 투여가, 비낭성 측뇌실 부위 백질연화증에서는 재태 기간, CRIB-II 점수, 출생 후 스테로이드 투여, 혈압 상승제 투여, 출생 시 비정상적인 백혈구 수치 등이 통계적으로 의미 있었다(P<0.05). 로지스틱 회귀분석에서는 낭성 측뇌실 부위 백질연화증에서는 CRIB-II 점수(odd ratio, 1.63, 95% confidence interval, 1.15, 2.30, P=0.006)가 비낭성 측뇌실 부위 백질연화증에서는 재태 기간(odd ratio 0.90, 95% confidence interval, 0.82, 0.99, P=0.036)이 독립적인 위험 인자였다. 결 론 : 교정 주수 만삭 근처에 시행한 극소 저체중 출생아의 뇌 MRI는 다양한 뇌백질 이상 소견을 보였고, 측뇌실 부위 백질연화증 발생과 연관된 임상 위험 인자로는 CRIB-II 점수와 재태 기간이 의미 있었다.

신생아집중치료실 입원아의 혈청 IGF-1과 성장 및 질병 사이의 관련성 (The association between serum IGF-1 and neonatal growth and disease in a NICU)

  • 김정옥;임해리;김행미
    • Clinical and Experimental Pediatrics
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    • 제52권2호
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    • pp.176-180
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    • 2009
  • 목 적 : 신생아의 IGF-1 정상치를 설정하고 신생아 성장 및 질병상태와 IGF-1치의 연관성을 조사하여 신생아 성장 및 질병 경과를 추정하는 지표로 사용할 수 있는지 알아보고자 하였다. 방 법 : 2007년 3월부터 7월까지 5개월 동안 경북대학교 신생아 집중치료실에 입원한 환아들을 대상으로 입원 시 1회 채혈하여 RIA법으로 IGF-1를 측정하였다. 아울러 환아들의 의무 기록을 후향적으로 검토하여 출생 시 체중, 재태 주령, 분만 방법, 동반 질환 등을 조사하였다. 결 과 : 출생 직후 채혈이 가능했던 만삭아 22명과 미숙아 30명의 혈중 IGF-1은 각각 $53.4{\pm}40.0$, $31.6{\pm}27.3$ ng/mL로 미숙아에서 유의하게 낮았다(P<0.05). 건강한 만삭아와 질환을 동반한 만삭아의 IGF-1은 각각 $64.1{\pm}39.5$, $46.0{\pm}40.2$ ng/mL로 질병 동반 시 유의하게 낮았다(P<0.05). 건강한 미숙아와 질환 동반 미숙아의 IGF-1은 각각 $33.2{\pm}23.3$, $30.6{\pm}30.4$ ng/mL로 두군 사이에 유의한 차이를 보이지 않았으나 이들 모두 건강한 만삭아에 비해 의의 있게 낮았다(P<0.05). 출생 8일후 이후 입원, 채혈한 신생아는 27명으로 이들 중 입원 시 체중이 출생체중에 비해 감소한 환아의 IGF-1은 $13.3{\pm}19.9$ ng/mL, 입원 시 체중이 출생체중에 비해 증가한 환아의 IGF-1은 $70.8{\pm}36.2$ ng/mL로 체중 감소군의 IGF-1이 유의하게 낮았다(P<0.001). 성별 및 분만법에 따른 IGF-1의 차이는 관찰되지 않았다. 결 론 : 미숙아는 만삭아에 비해 출생 당일의 IGF-1치가 낮았으며, 출생 후 체중이 감소한 만삭아의 IGF-1은 체중이 증가한 만삭아에 비해 유의하게 낮았다. 이러한 소견으로 보아 신생아의 혈청 IGF-1은 재태 주령, 출생 후 체중 증가와 관련성을 가지는 것으로 보인다.

정상 마우스와 rd/rd 마우스의 망막파형 비교 (Comparison of Retinal Waveform between Normal and rd/rd Mouse)

  • 예장희;서제훈;구용숙
    • 한국의학물리학회지:의학물리
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    • 제19권3호
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    • pp.157-163
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    • 2008
  • 망막색소변성(retinitis pigmentosa: RP)과 연령관련 황반변성(age-related macular Degeneration: AMD)은 망막변성으로 인해 실명에 이르는 대표적인 질환이며 망막이식장치의 개발을 통해 치료될 수 있다고 간주되고 있다. 성공적인 망막이식장치 개발을 위하여 여러 가지 선결요소가 필요하지만 그 중 한 가지가 이식장치에 인가할 전기자극을 최적화하는 것이다. 변성망막의 전기적 특성은 정상 망막과 다르리라 예측되므로 우리는 장차 개발될 망막 이식장치에 인가할 전기자극 최적화를 위한 가이드라인을 제공하기 위해 정상 망막과 변성망막의 망막파형 차이에 관한 연구를 하였다. 망막을 분리한 후 망막절편을 신경절세포 층이 다채널전극의 표면을 향하게 하여 전극에 붙인다. In-vitro 상태에서 망막 신경절세포의 전기신호를 기록하기 위해 전극 직경: $30{\mu}m$, 전극간 거리: $200{\mu}m$, 전극 임피던스 1 kHz에서 50 $k{\Omega}$인 8행 8열의 다채널전극을 사용하였다. 생후 28일된 정상마우스(C57BL/6J 종)에서는 짧은 시간대(<2 ms)의 망막 스파이크만 기록되었다. rd/rd 마우스(C3H/HeJ 종)에서는 정상적인 스파이크뿐만 아니라 약 100 ms 의 시간대를 가지는 느린 파형이 같이 기록되었다. 우리는 rd/rd 마우스에서만 관찰되는 이 느린 파형의 기전을 알아보고자 여러 가지 시냅스억제제를 사용하였다. 이 느린 파형은 rd/rd 마우스에서 양극세포로부터 신경절세포로 들어오는 흥분성입력이 정상마우스보다 강화되었기 때문에 발생한 것으로 보인다. rd/rd 마우스에서 흥분성입력이 강화되는 여러 가능성 중에서 망막변성으로 인해 수평세포로부터 양극세포로 들어오는 억제성 입력이 소실됨으로 인해 결과적으로 양극세포로부터 신경절세포로 들어오는 흥분성입력이 강화되었을 가능성이 가장 높은 것으로 보인다.

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문화간호를 위한 한국인의 민간 돌봄에 대한 연구 : 출생을 중심으로 (Study on Folk Caring in Korea for Cultural Nursing)

  • 고성희;조명옥;최영희;강신표
    • 대한간호학회지
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    • 제20권3호
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    • pp.430-458
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    • 1990
  • Care is a central concept of nursing. Nursing would not exist without caring. Care and quality of life are closely related. Human behavior is a manifestation of culture. We can say that caring and nursing care are expression of culture. The nurse must understand the relationship of culture with care for ensure quality nursing care. But knowledge of cultural factors in nursing is not well developed. Time and in - depth study are needed to find meaningful relationships between culture and care. Nurses recognized the importance of culturally appropriate nursing There are two care systems in culturally based nursing. The folk care system and the professional nursing care system. The folk care system existed long before the professional nursing care system was introduced into this culture. If the discrepancy between these two care systems is great, the client may receive inappropriate nursing care. Culture and subcaltures are diverse and dynamic in nature. Nurses need to know the caring behaviors, patterns, and their meaning in their own culture. In Korea we have taken some first step to study cultural nursing phenomena. It is not our intent necessarily to return to the past and develop a nationalistic of nursing, but to identify the core of traditional caring and relate that to professional nursing care. Our Assumptions are as follows : 1) Care is essential for human growth, well being and survial. 2) 7here are diverse and universal forma, expressions, patterns, and processes of human care that exist transcul - turally. 3) The behaviors and functions of caring differ according to the social structure of each culture. 4) Cultures have folk and professional care values, beliefs, and practices. To promote the quality of nursing care we must understand the folk care value, beliefs, and practices. We undertook this study to understand caring in our traditional culture. The Goals of this study were as follows : 1) To identify patterns in caring behavior, 2) To identify the structural components of caring, and 3) To understand the meaning and some principles of caring. We faised several questions in this study. Who is the care-giver? Who is the care-receipient? Was the woman the major care -giver at any time? What are the patterns in caring behavior? What art the priciples underlying the caring process? We used an interdisciplinary team approach, composed of representatives from nursing and anthropology, to contribute in -depth understanding of caring through a socicaltural perspeetive. A Field study was conducted in Ro-Bong, a small agricultural kinship village. The subjects were nine women and one man aged be or more years of age. Data were collected from january 15 to 21, 1990 through opem-ended in-depth interviews and observations. The interview focused on caring behaviors sorrounding birth, aging, death and child rearing. We analysed these data for meaning, pattern and priciples of caring. In this report we describe caring behaviors surrounding childbirth. The care-givers were primarily mothers- in -low, other women in the family older than the mother - to- be, older neighbor woman, husbands, and mothers of the mother-to- be. The care receivers were the mother-to-be the baby, and the immediate family as a component of kinship. Emerging caring behavior included praying, helping proscribing, giving moral advice(Deug - Dam), showing concern, instructing, protecting, making preparations, showing consideration, touching, trusting, encouraging, giving emotional comfort, being with, worrying about, being patient, preventing problems, showing by an example, looking after bringing up, taking care of postnatal health, streng thening the health condition, entering into another's feelings(empathizing), and sharing food, joy and sorrow The emerging caring component were affection, touching, nurtuing, teaching, praying, comforting, encouraging, sharing. empathizing, self - discipline, protecting, preparing, helping and compassion. Emerging principles of. caring were solidarity, heir- archzeal relationships, sex - role distinction. Caring during birth expresses the valve of life and reflects the valued traditional beliefs that human birth is given by god and a unique unifying family event reaching back to include the ancestors and foreward to later generations. In addition, We found positive and rational foundations for traditionl caring behaviors surrounding birth, these should not be stigmatized as inational or superstitious. The nurse appropriately adopts the rational and positive nature of traditional caring behaviors to promote the quality of nursing care.

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농촌지역의 일차보건사업 개발을 위한 기초조사 연구 - 경기도 여주군 금사면 산북부락을 중심으로 - (A Baseline Survey on Development of Primary Health Care in the Rural Korea -Sanpuk Village, Kumsa-Myun, Yuju- Gun, Kyunggi-Do-)

  • 김명호;윤석우;이해숙
    • 농촌의학ㆍ지역보건
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    • 제12권1호
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    • pp.5-27
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    • 1987
  • It is widely recognized that primary health care in the community is one of the most important and effective health measures in these days. However, it is reality that unsatisfactory health care system, ineffective utilization of health care by the community people in the rural area are hampering better understanding for primary health care. Therefore promoting health for the rural people and increasing understanding about primary health care, the baseline survey in the community focused in examination for safe community water supply was carried out. The survey was conducted through August 25-31, 1986 in order to find out health problems and relevant factors and to define the demographic characteristics of $^*$Sanpuk village, Kumsa-Myun, Yuju-Gun, Kyunggi-Do, Korea. Household survey was carried out for every home by trained interviewers. The major results are found out as follows : 1) 84.2%(400 houses) of total households were surveyed because 15.8%(75 houses) were unable to survey due to either refusal against interview or absence of family. These 400 households were composed of 1,697 residents(male:830, female 867). Educational level of respondents showed 34.1% as elementary school graduated. Religion distribution showed Buddism(23.8%) as the most dominant. 50.7% of respondents married in the area. 2) Most households(91.5%) have lived in their own house in Sanpuk area. Average family size showed 4.3. More than half of residents(64.2%) have used public supplied water tap. Only 1.5% of the households had a flush toliet. The rest of households have still used primitive insanitary latrines. 3) 32.5% of residents have used gas burner for cooking and for heating in the house, and the coal briquet were used for boiler. Lack of convenient public transportation was the chief complaint for their day life. 4) Each household occupied 1,990 pyungs of rice paddy and 1,170 pyungs of ordinary field in average. Beside farming products, mushroom was the highest product. 5) Sixth percent of households in the survey area regularly participated in community meeting one hand and on the other hand 39.5% never participated. Most of respondents closely contacted with their neighbours and they seemed very friendly each other. 6) The prevalence rate of illness and injury during recent 15 days showed 48.3 per 1,000. The prevalence rate of chronic illnesses during the past one year showed 74 per 1,000. Injury and accident lead the higher portion(22.0%) in the former and in the latter pain(arthritis, back-pain) showed 27.0% as the dominant sickness. 87.8% of the ill residents in the former received medical treatment. As the most frequently utilized medical facility, the clinic or hospital were counted. Among the residents suffering from chronic illnesses, 77.3% in Sanpuk area get some kind of medical treatments and they rarely utilized the clinic or hospital. The reason why the patient did not receive any medical care was found out the fact that symptoms of illness was light or mild and economic problems was serious. 7) Average age of marriage showed 21.6 years old in the women and the average duration of marital period was shown for 15.1 years. The married woman in reproductive age in Sanpuk area had experienced pregnancies 4 times in the aver-age including 0.7 time of pregnancy in average were interrupted by induced abortion and 0.3 time by spontaneous abortion respectively. The practicing rate of the family planning of the married woman during reproductive ages showed 70.7% and the tuballigation was found out as the most frequently used contraceptives. 8) Among woman who has children under 2 years old, 70.0% had received the prenatal care for the last pregnancy. However, the average number of prenatal care visitis per woman showed 3.3 times. Fifty-two % of woman who received the postnatal care for the last delivery showed only 37.5%. 9) Immunization rate of the children under 2 years old showed relatively high and looked successful. The breast feeding for these children showed dominantly in the most. Most of the mothers in Sanpuk area had started the supplementary diet during weaning period of their infants of 6th and 7th month after birth. * : Sanpuk area is a demstration area for community development which has been supported by the Community Development Foundation during the part 10 years. The village is relatively closer to urban area such as Seoul, However, it has a similar characteristics shown as a remote village because of geographical location and inconvenient transportation at present.

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