• Parasites, Hosts and Diseases
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• 제51권3호
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• pp.289-295
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• 2013

Different functions have been attributed to $CD4^+CD25^+Foxp3^+$ regulatory T-cells (Tregs) during malaria infection. Herein, we describe the disparity in Treg response and pro- and anti-inflammatory cytokines during infection with Plasmodium berghei ANKA between young (3-week-old) and middle-aged (8-month-old) C57BL/6 mice. Young mice were susceptible to cerebral malaria (CM), while the middle-aged mice were resistant to CM and succumbed to hyperparasitemia and severe anemia. The levels of pro-inflammatory cytokines, such as TNF-${\alpha}$, in young CM-susceptible mice were markedly higher than in middle-aged CM-resistant mice. An increased absolute number of Tregs 3-5 days post-inoculation, co-occurring with elevated IL-10 levels, was observed in middle-aged CM-resistant mice but not in young CM-susceptible mice. Our findings suggest that Treg proliferation might be associated with the suppression of excessive pro-inflammatory Th1 response during early malaria infection, leading to resistance to CM in the middle-aged mice, possibly in an IL-10-dependent manner.

• Journal of Korean Biological Nursing Science
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• 제12권3호
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• pp.195-205
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• 2010

Purpose: The purpose of this study was to develop the dietary approaches to stop hypertension (DASH) diet education program tailored to Korean adults and to examine the effect of the DASH diet education program on bone mineral density in middle aged women. Methods: The subjects of this study were 26 middle aged women, pre and post menopause, who attend a church located in Kyung-In district. The DASH group I (n=13) was provided with the DASH diet education program only, while the DASH group II (n=13) was provided with DASH diet education program along with calcium supplements (1 g/day). The DASH diet education program included one lecture on DASH diet, one face to face counseling, and five telephone counseling sessions during the 8 weeks period. Results: The knowledge and subjective compliance level of DASH diet increased significantly in both groups, at 4 and 8 weeks after the intervention. The level of objective compliance of DASH diet in both groups increased over the study period, but it was not significant as compared to those of the baseline. Bone mineral density of both groups decreased at 8weeks as compared to the baseline after the intervention. Conclusion: Although 8weeks of DASH diet education program increased the knowledge and compliance of DASH diet, it was not effective to bring the changes in bone mineral density among the middle aged women.

• 여성건강간호학회지
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• 제20권1호
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• pp.62-71
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• 2014

Purpose: This study investigated the effects of menopausal adaptation and Sanhujori (Korean traditional postnatal care) on the Health-related quality of life in middle-aged women. Methods: Women aged from 45 to 60 completed questionnaires consisting of SF-36 ver. 2 and menopausal adaptation scale between July to Aug, 2013. Two hundred and eighteen participants' data were analyzed using descriptive statistics, t-test, ANOVA, Pearson's correlation coefficient and multiple regression. Results: Physical health ($69.5{\pm}15.1$) was better than mental health ($68.8{\pm}17.1$), and bodily pain and social functioning were the same results as 2009 general U.S. population, with the sub-variables of quality of life being lower. Menopausal adaptation was at moderate level, and correlation of its sub-variables with quality of life were significant: fatigue (r=.60, p<.001), accomplishing feeling (r=.55, p<.001), confidence (r=.54, p<.001), dryness (r=.51, p<.001), flush (r=.38, p<.001), dominance (r=-.36, p<.001), stability (r=.26, p<.001). Fatigue, confidence, stability, period of sanhujori, and dryness revealed as influencing quality of life, while the total variation explained by these components was at 52%. Conclusion: To improve quality of life of middle aged women, health care providers need to provide nursing intervention to relieve fatigue and dryness; and address psychosocial concerns with developing nursing strategies to improve stability and confidence. For post-partum women, enough periods of sanhujori needs to be recommended.

• Journal of Community Nutrition
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• 제8권4호
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• pp.165-170
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• 2006

This study was conducted to develop and apply a computer-based multimedia nutrition education program for preschoolers based on the Dick and Carey model of instructional design. The Dick and Carey model included 4 phases: analysis, design, development, and evaluation. The program's instructional goals, objectives, assessment instruments, content, examples, and practice questions with feedback were written in the design phase. To be familiar with the 5 food groups, 'Nutrition exploration' were programmed using Hyperstudio. 'Nutrition exploration' was designed as a five-session, interactive multimedia game, with each session taking about 5 minutes to complete. Nineteen preschoolers, aged 6, volunteered to participate formative evaluation. The effectiveness of the program was examined using a pre-post test design. Participants were recruited by personal contact at the individual preschool education center. The application was carried out during 4 weeks. The results showed that intervention participants significantly increased knowledge between pre-test and post-test. The results support using IMM (interactive multimedia) to disseminate nutrition education to the target population. This research provides the basis for continuing development of computer-based nutrition education materials.

• 대한물리의학회지
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• 제1권1호
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• pp.93-108
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• 2006

Purpose : To evaluate effects of McKenzie exercise on the functional recovery and forward head posture of chronic neck pain patients. Methods : The subjects were consisted of fifteen patients who had abnormal neck posture, mild neck pain (28 males, 17 females; mean aged 21.9) from 19 to 33 years of age(mean age 21.9). All subjects were received McKenzie exercise for 35 minutes with clinical massage per day three times a week during 4 weeks period. Neck disability index was used to measure functional disability level. Visual analogue scale(VAS) was used to measure subjective pain level. craniovetebral angle(CVA), cranial rotation angle(CRA) was used to measure forward head posture with digital camera. All measurements of each patients were measured at pre-treatment and after 2 week, after 4 week, post-treatment on 2 week. Result : The VAS of McKenzie exercise was significantly reduced between pre-treatment and post-treatment (p<.05) and effects of pain reduce was continued follow 2 weeks. The Neck Disability Index of McKenzie exercise was significantly reduced between pre-treatment and post-treatment (p<.05) and effects of pain reduce was continued follow 2 weeks. The CVA of McKenzie exercise was significantly reduced between pre-treatment and post-treatment (p<.05) and effects of pain reduce was continued follow 2 weeks. The CRA of McKenzie exercise was not significantly reduced between pre-treatment and post-treatment (p<.05). Conclusion : McKenzie exercise improved pain and function of Chronic neck pain patients.

• 대한물리의학회지
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• 제2권2호
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• pp.101-112
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• 2007

Purpose : The purpose of this study was to evaluate influence of sacroiliac joint mobilization on lower extremity muscle strength. Methods : The subjects were consisted of thirty patients who had Leg length inequality(LLI) of more than 10mm(16 females. 14 males) from 21 to 41 years of age(mean aged 24.87). All subjects randomly assigned to sacroiliac joint mobilization group(n=15), control group(n=15). sacroiliac joint mobilization group received sacroiliac joint mobilization about 10 minutes for 3 times per week during 4 weeks period. Control group not received intervention during 4 weeks period. The tape measure method(TMM) was used to measure functional Leg length inequality. Biodex System 3 Pro was used to measure strength of Knee extension & flexion. All measurements of each subjects were measured at pre-test, 2weeks post-test and 4weeks post-test. Results : 1. The LLI of sacroiliac joint mobilization group was significantly reduced according to within treatment period(p<.05), most significantly reduced between pre-test and post-test(p<.05). sacroiliac joint mobilization group significantly more reduced than control group(p<.05). 2. The knee extension strength of sacroiliac joint mobilization group was significantly increased according to within treatment period(p<.05), most significantly increased between pre-test and post-test(p<.05). sacroiliac joint mobilization group significantly more increased than control group(p<.05). 3. The knee flexion strength of sacroiliac joint mobilization group was significantly increased according to within treatment period(p<.05), most significantly increased between pre-test and post-test(p<.05). sacroiliac joint mobilization group significantly more increased than control group(p<.05). Conclusion : sacroiliac joint mobilization can reduce LLI and increased lower extremity muscle strength.

• 대한물리의학회지
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• 제2권2호
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• pp.183-194
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• 2007

Purpose : The purpose of this study was to evaluate influence of therapeutic exercise on functional leg length inequality(LLI). Methods : The subjects were consisted of thirty patients who had Leg length inequality(LLI) of more than 10mm(l6 females. 14 males) from 20 to 35 years of age(mean aged 24.23). All subjects randomly assigned to contract-relax exercise of proprioceptive neuromuscular facilitation(PNF) group(n=15), control group(n=15). Contract-relax exercise group received contract-relax exercise about 10 minutes with therapeutic massage about 15 minutes for 3 times per week during 4 weeks period. Control group not received intervention during 4 weeks period. The tape measure method(TMM) was used to measure functional Leg length inequality. Biodex System 3 Pro was used to measure strength of Knee extension & flexion. All measurements of each subjects were measured at pre-test, 2weeks post-test and 4weeks post-test. Results : 1. The LLI of contract-relax exercise group was significantly reduced according to within treatment period(p<.05), most significantly reduced between pre-test and post-test(p<.05). Contract-relax exercise group significantly more reduced than control group(p<.05). 2. The knee extension strength of contract-relax exercise group was significantly increased according to within treatment period(p<.05), most significantly increased between pre-test and post-test(p<.05). Contract-relax exercise group significantly more increased than control group(p<.05). 3. The knee flexion strength of contract-relax exercise group was significantly increased according to within treatment period(p<.05), most significantly increased between pre-test and post-test(p<.05). Contract-relax exercise group significantly more increased than control group(p<.05). Conclusion : Contract-relax exercise applied with therapeutic massage can reduce LLI and increased lower extremity muscle strength.

• Pediatric Infection and Vaccine
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• 제18권1호
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• pp.68-79
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• 2011

목 적:본 시판 후 조사(NCT00750360)는 2002년부터 국내에서 사용 허가된 정제불활화 3가 분할 인플루엔자 백신의 안전성 및 반응원성을 평가하기 위하여 시행되었다. 방 법:생후 6개월 이상의 소아 및 성인 피험자 총 883명을 대상으로 평가대상 인플루엔자 백신을 1회 접종하였다. 이전에 인플루엔자에 감염되지 않았거나 인플루엔자 백신을 접종하지 않은 만 9세 미만의 소아의 경우에는 1회의 추가접종을 실시 하였다. 411명의 피험자가 일일 기록카드를 사용하여 안정성 정보를 기록하였으며 본 보고서에는 이들 피험자들로부터 수집된 자료가 포함되어 있다. 전신 및 투여부위에서의 명시된 이상반응 및 명시되지 않은 이상반응의 발생률을 기록하였다(백신접종 후 각각 4일 및 21일 동안 추적 관찰하였음). 또한 연구진행기간 전체에 걸쳐서 중대한 유해사례를 추적 관찰하여 기록하였다. 결 과 : 가장 흔하게 관찰된 전신 및 투여부위에서의 명시된 이상반응은 접종부위 통증(만 6세 미만의 소아: 12.6%, 만 6세 이상의 소아: 34.7%), 발열(만 6세 미만: 1.3%) 그리고 근육통(만 6세 이상: 13.9%) 이었다. 등급 3의 명시된 이상반응은 전체 피험자의 4.0% 이하에서 보고되었다. 한국식품의약품 안전청의 기준에 따라 백신과 인과관계가 없는 중대한 유해사례도 기록하였다. 결 론 : 평가대상 백신의 전 연령대에서의 확립된 면역원성 및 우수한 안정성, 반응원성 프로파일과 국내에서의 높은 접종률을 고려할 때, 본 백신을 국가예방접종사업에 포함시켜 모든 연령대에서 계절성 인플루엔자 예방 접종을 증진시키기 위한 후보백신으로 추천할 수 있을 것이다.

• 대한간호학회지
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• 제36권4호
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• pp.645-651
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• 2006

Purpose. This study investigated changes in attitudes toward elders in general and elders with dementia after students finished a gerontological nursing practicum. Methods. Questionnaires developed for Asian cultures were administered pre practicum, immediately post practicum, and at 8-months follow up to 31 senior students in a baccalaureate nursing program. The 1-week practicum occurred at two adult day care centers: a center for elders with dementia and a center for elders with stroke. Repeated measures ANOVA and Bonferroni correction procedures were used to analyze data. Results. Students' evaluation of elder vitality and flexibility increased significantly at post practicum, however this increase was not sustained at follow up. Score of generosity of elders, the only positively evaluated dimension for elders in general, improved partly at post practicum. Students evaluated flexibility and generosity of elders with dementia more negatively than general elders. All of the decreased attitudes at follow up were not significantly different from those at pre practicum. Conclusions. Students had more negative attitudes toward elders with dementia. Attitudes of students in direct contact with elders with dementia were improved through the practicum regarding generosity and flexibility. However the sustainability of the immediate effect was not observed at follow up.

• 한국초등과학교육학회지:초등과학교육
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• 제23권4호
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• pp.273-278
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• 2004

According to Piaget, children aged 11 are in the middle of concrete operation period and formal operation period. So, it is necessary to adopt the Learning Cycle Model (LCM) which helps students improve their cognitive development. After determining the test for the Science Concept of Matter (SCOM), the experimental group showed higher average than the comparative group in the post-test. In the sound understanding, the experimental group showed higher ratio than the comparative group. And in the ratio of imperfect, wrong understanding and no response, the experimental group was lower than the comparative group. On the questions that were needed the complicated inquiry, many students of both groups still couldn't find the fundamental cause. In forming the scientific conceptualization, there was a meaningful difference (p < .001) after post-test Analysis of Covariance (ANCOVA) with pre-test result. After determining the test for the Test Inquiry Science Process (TISP), the experimental group showed higher average than the comparative group in the post-test. In the category of basic inquiry process which is needed in concrete operation, there was a meaningful difference (p < .05). In the category of unified inquiry process which is needed in formal operation, they showed no meaningful difference (p > .05). Therefore, applying the LCM to the chapter of 'Solution and Dissolving' is more effective on improving the scientific conceptualization and on helping the concrete operation abilities than the teacher centered learning.