Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Age-Related $CD4^+CD25^+Foxp3^+$ Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria

  • Shan, Ying (Department of Immunology, College of Basic Medical Sciences, China Medical University) ;
  • Liu, Jun (Department of Immunology, College of Basic Medical Sciences, China Medical University) ;
  • Pan, Yan-Yan (Department of Immunology, College of Basic Medical Sciences, China Medical University) ;
  • Jiang, Yong-Jun (Department of Laboratory Medicine, the First Hospital of China Medical University) ;
  • Shang, Hong (Department of Laboratory Medicine, the First Hospital of China Medical University) ;
  • Cao, Ya-Ming (Department of Immunology, College of Basic Medical Sciences, China Medical University)
  • Received : 2012.11.20
  • Accepted : 2013.02.26
  • Published : 2013.06.30
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Abstract

Different functions have been attributed to $CD4^+CD25^+Foxp3^+$ regulatory T-cells (Tregs) during malaria infection. Herein, we describe the disparity in Treg response and pro- and anti-inflammatory cytokines during infection with Plasmodium berghei ANKA between young (3-week-old) and middle-aged (8-month-old) C57BL/6 mice. Young mice were susceptible to cerebral malaria (CM), while the middle-aged mice were resistant to CM and succumbed to hyperparasitemia and severe anemia. The levels of pro-inflammatory cytokines, such as TNF-${\alpha}$, in young CM-susceptible mice were markedly higher than in middle-aged CM-resistant mice. An increased absolute number of Tregs 3-5 days post-inoculation, co-occurring with elevated IL-10 levels, was observed in middle-aged CM-resistant mice but not in young CM-susceptible mice. Our findings suggest that Treg proliferation might be associated with the suppression of excessive pro-inflammatory Th1 response during early malaria infection, leading to resistance to CM in the middle-aged mice, possibly in an IL-10-dependent manner.

Keywords

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