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http://dx.doi.org/10.3347/kjp.2013.51.3.289

Age-Related $CD4^+CD25^+Foxp3^+$ Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria  

Shan, Ying (Department of Immunology, College of Basic Medical Sciences, China Medical University)
Liu, Jun (Department of Immunology, College of Basic Medical Sciences, China Medical University)
Pan, Yan-Yan (Department of Immunology, College of Basic Medical Sciences, China Medical University)
Jiang, Yong-Jun (Department of Laboratory Medicine, the First Hospital of China Medical University)
Shang, Hong (Department of Laboratory Medicine, the First Hospital of China Medical University)
Cao, Ya-Ming (Department of Immunology, College of Basic Medical Sciences, China Medical University)
Publication Information
Parasites, Hosts and Diseases / v.51, no.3, 2013 , pp. 289-295 More about this Journal
Abstract
Different functions have been attributed to $CD4^+CD25^+Foxp3^+$ regulatory T-cells (Tregs) during malaria infection. Herein, we describe the disparity in Treg response and pro- and anti-inflammatory cytokines during infection with Plasmodium berghei ANKA between young (3-week-old) and middle-aged (8-month-old) C57BL/6 mice. Young mice were susceptible to cerebral malaria (CM), while the middle-aged mice were resistant to CM and succumbed to hyperparasitemia and severe anemia. The levels of pro-inflammatory cytokines, such as TNF-${\alpha}$, in young CM-susceptible mice were markedly higher than in middle-aged CM-resistant mice. An increased absolute number of Tregs 3-5 days post-inoculation, co-occurring with elevated IL-10 levels, was observed in middle-aged CM-resistant mice but not in young CM-susceptible mice. Our findings suggest that Treg proliferation might be associated with the suppression of excessive pro-inflammatory Th1 response during early malaria infection, leading to resistance to CM in the middle-aged mice, possibly in an IL-10-dependent manner.
Keywords
Plasmodium berghei ANKA; cerebral malaria; $CD4^+CD25^+Foxp3^+$ regulatory T cell; age; cytokine;
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