• Journal of Korean Public Health Nursing
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• v.15 no.2
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• pp.262-274
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• 2001

This study was undertaken to grasp the relationship between perceived health status, health conception and health promoting behavior in the elderly. The subjects for this study were 157 old persons in Kyung-ju city. Data were collected by interview with questionnaires from August 24 to October 10, 1999. Analysis of the data was done by SPSS program using descriptive statistics, t-test, ANOVA, Pearson Correlation Coefficient, stepwise multiple regression. The results were summarized as follows 1. For the practice of health promoting behavior. the mean score was 2.52. The factor of the highest mean score was nutrition(3.02) and factor of the lowest mean score was exerciset(2.03). 2. According to age(F=3.35, P=.012), sex(t=2.26, P=.025), marital status (F=5.08, P=.007), education(F=4.22, P=.003), family numbed(F=5.31, P= .006), people living together (F=2.77, P=.044), economic status(F=7.10, P=.00l), average monthly pocket money (F=3.35, P=.012), there were differences of health promoting behavior. 3. According to age(F=3.40, P=.01l), sex(t=4.30, P=.000), education(F=8.55, P=.000), economic status(F=12.59, P=.000), average monthly pocket money(F=4.26, P=.003), present disease(t=-8.41, P=.000), there were differences of perceived health status. According to marital status(F=3.36, P=.037), education(F=2.89, P=.038), there were differences of health conception. 4. Performance in the health promoting behavior was significantly correlated with perceived health status(r=.272, P=.00l), health conception(r=.345, P=.000) 5. The combination of well-being health conception and average monthly pocket money explained $24.7\%$ of the variance of health-promoting behavior. On the basis of the above findings the following recommendations are made; Nursing interventions enhancing exercise or activity, accountability for health, stress management of the elderly must be provided. And Cost-effective health promoting program for the elderly must be developed.

• Journal of the Korean Society for Marine Environment & Energy
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• v.13 no.4
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• pp.296-304
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• 2010

The shoreline change caused by the construction of shore protection structures are discussed based on the example of Youngrang coast, Sokcho where the coastal erosion control system(CECS), three artificial headlands and two submerged breakwaters are being constructed. The study qualitatively analyzed the shoreline changes of Youngrang coast using available satellite/aerial photographs and camera photographs taken during the construction period of 6 years since 2002 for the artificial headlands construction. The main results from the study are as following. (1) Before the installation of the middle artificial headland, longshore drifts along Youngrang coast are transported in the NW-SE direction according to the seasonally different wave characteristics. (2) During the CECS construction the shoreline is continuously changed by altering the local longshore drift budget. Especially, the middle artificial headland induces considerable change of shoreline by blocking the sediment supply from the southern pocket beach to the northern pocket beach and by accelerating the sediment accretion at the wave shadow zone behind its head. It induces the asymmetry on the net longshore drift causing the significant erosion at the center of the southern pocket beach. (3) The study demonstrates that serious unintended erosion/accretion problem are possibly occurred due to local changes on the wave transformation and the sediment transport by the construction of coastal erosion control system.

• Journal of Periodontal and Implant Science
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• v.23 no.3
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• pp.411-421
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• 1993

The purpose of this study was to assess the effect of polycaprolactone strip with minocycline on the periodontal pocket in humans and the various clinical parameters in rapidly progressive periodontitis. Nine patients with rapidly progressive periodontitis were selected for the study. They had not taken antibiotics for 6 months and had no history of dental treatment for 6 months before the study. They were in good general health. By the split-mouth method, patients received a supragingival scaling, experimental group (9sites) were subjected to subgingival placement of polycaprolactone strips(1 strip) containg 30% minocyclne and control group (9 site) were subjected to subgingival placement of not polycaprolactone strips(1 strip) containing 30 A Minocycline. Strips were replaced with freshly filled ones at 1 week and 2 week. All strips were removed from pockets at 3 week Clinical examination (plaque index, gingival index, probing pocket depth) and distribution on the bacteria morphology of subgingival plaque were monitored on baseline (0 week), 1, week, 2 week, 4 week and 8 week. The result were as follows : 1. Plaque index in experimental group was not significantly reduced during all weeks(P<0.05), but slightly reduced at 2, 4 and 8 weeks and that in control group was not significantly reduced during monitoring period. 2. Probing pocket depth was significantly reduced at 2, 4 and 8 weeks(P<0.05) in experimental group, but that in control group was not siginificantly changed during monitoring period. 3. Gingival index was significantly improved at 2, 4 and 8 weeks(P<0.05) in experimental group but that in control group was not significantly changed. 4. Percentage of cocci was significantly increased at 2, 4 and 8 weeks in experimental group but that in control group was not significantly changed. 5. Percentage of non-motile rods in both group were not significantly changed when compared with those of baseline(0 week) (P<0.05). 6. Percentage of motile rods was siginificantly reduced at 1, 2 and 4 weeks in experimental group (p<0.05) but that in control group was not significantly changed. 7. Percentage of spirochetes was siginificantly reduced during all weeks(P<0.05) but that in control group was not significantly changed. The result showed that polycaprolactone containing 30% minocycline effect the clinical index and bacterial morphotype.

• Journal of Periodontal and Implant Science
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• v.30 no.1
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• pp.11-27
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• 2000

The purpose of this study was to evaluate the clinical effects of Dipotassium glycyrrhizinate, Allantoin, Hinokitiol, Cetylpyridinium chloride containing gel($Dentheth^{(R)}$) on periodontitis. 41 patients with sites having pocket depth of 4-6mm were selected for the study. We classified 2 groups which consisted of 21 patients in the test group(exp.) and 20 patients in the control(placebo) respectively. Following a baseline examination, plaque and calculus were removed and then the experimental gel were handed out to the patients and topical application regimens were initiated. During the 4-week experimental period, pocket depth, bleeding on probing, gingival index, plaque index as a clinical parameters were measured in the baseline, 2 weeks, 4 weeks respectively. A questionnaire was delivered to each patients in 2 weeks, 4 weeks respectively. The results were as follows : 1. Probing pocket depth showed a significant difference in the Exp. group compared with the control group in the changes from baseline to 2 weeks(p<0.05), but there was no significant difference between the groups in the changes from baseline to 4 weeks, from 2 weeks to 4 weeks(p<0.05). 2. The Exp. group showed a significant difference compared with the control group in the changes from baseline to 2 weeks, from baseline to 4 weeks, from 2 weeks to 4 weeks in bleeding on probing(p<0.05). 3. The gingival index showed a significant difference compared with the control group in the changes from baseline to 2 weeks, from baseline to 4 weeks, from 2 weeks to 4 weeks after 4 weeks use of a gel(p<0.05). 4. The plaque index showed a significant difference in the Exp. group compared with the control group in the changes from baseline to 2 weeks(p<0.05), but there was no significant difference between the groups in the changes from baseline to 4 weeks, from 2 weeks to 4 weeks(p<0.05). 5. A questionnaire was consisted of 5 kinds as to bleeding, pus discharge, pain, burning sensation, patient's satisfaction and all of the questions showed a significant difference compared with the control group in the changes from 2 weeks to 4 weeks(p<0.05). 6. During the 4-week experimental period, important side-effects were not finded out, but each groups had one patient appealed nausea or discomfort respectively. These results indicate that application of periodontitis medical gel was useful as an additional aid of mechanical treatment.

• Journal of Preventive Medicine and Public Health
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• v.53 no.6
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• pp.455-464
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• 2020

Objectives: The distribution of hospitals in Korea is unbalanced in terms of accessibility. Many local public health centers (PHCs) exempt out-of-pocket payments (OOPs) based on local government laws to increase coverage. However, this varies across administrative regions, as many make this exemption for the elderly, while others do not. This study aimed to evaluate the effects of the OOP exemption at local PHCs among elderly individuals. Methods: This study used online data on Korean national law to gather information on individual local governments' regulations regarding OOP exemptions. Individual-level data were gathered from the 2018 Community Health Survey and regional-level data from public online sources. Results: The study analyzed 132 regions and 44 918 elderly people. A statistical analysis of rate differences and 2-level multiple logistic regression were carried out. The rate difference according to whether elderly individuals resided in areas with the OOP exemption was 1.97%p (95% confidence interval [CI], 1.07 to 2.88) for PHC utilization, 1.37%p (95% CI, 0.67 to 2.08) for hypertension treatment, and 2.19%p (95% CI, 0.63 to 3.74) for diabetes treatment. The regression analysis showed that OOP exemption had an effect on hypertension treatment, with a fixed-effect odds ratio of 1.25 (95% CI, 1.05 to 1.48). Conclusions: The OOP exemption at PHCs can affect medical utilization in Korea, especially for hypertension treatment. The OOP exemption should be expanded to improve healthcare utilization in Korea.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.36 no.5
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• pp.192-200
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• 2014

Purpose: The objective of this study was to evaluate the interaction between 4-hexylresorcinol (4HR) and antibody as that affects the performance of a silk-4HR combination graft for soft tissue augmentation in an animal model. Methods: The silk graft materials consisted of four types: silk+10% tricalcium phosphate (TCP) (ST0), silk+10% TCP+1% 4HR (ST1), silk+10% TCP+3% 4HR (ST3), and silk+10% TCP+6% 4-HR (ST6). The antibody binding assay tested the 4HR effect and scanning electron microscopic (SEM) exam was done for silk grafts. The animal experiment used a subcutaneous pocket mouse model. The graft - SH0 or SH1 or SH3 or SH6 - was placed in a subcutaneous pocket. The animals were killed at one, two, and four weeks, postoperatively. The specimens were subjected to histological analysis and lysozyme assay. Results: Groups with 4HR applied showed lower antibody binding affinity to antigen compared to groups without 4HR. In the SEM examination, there was no significant difference among groups. Histological examinations revealed many foreign body giant cells in ST0 and ST1 group at four weeks postoperatively. Both ST3 and ST6 groups developed significantly lower levels of giant cell values compared to ST0 and ST1 groups (P < 0.001) at four weeks postoperatively. In the lysozyme assay, the ST1 and ST3 groups showed denser signals than the other groups. Conclusion: 4HR combined silk implants resulted in high levels of vascular and connective tissue regeneration.

• Journal of the Korean Chemical Society
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• v.42 no.2
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• pp.209-213
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• 1998

The higher order structure of Pseudomonas alcaligenes 5S rRNA has been investigated by using ($\eta^{6}$-mesitylene) manganese (Ⅰ) tricarbonyl hexafluorophosphate[MTH-Mn (Ⅰ)], dimethylpyrocarbonate, potassium permanganate as chemical probes. The sequences cleaved strongly by MTH-Mn (Ⅰ) on the tertiary structure of the 5S rRNA are $G_{12}AUGG_{16}$ of loop a, $G_{51}AAGUGAAGC_{60}$ of the region b-C, $U_{65}-AGCG_{69}$. of the region B-a, and $G_{72}AUGG_{76}$ of loop d. Based on such cleavage patterns of 5S rRNA by MTH-Mn(Ⅰ) and other chemical probes, we presume that the sequences strongly cleaved form pocket-like structure as in the the corner of L structure of $tRNA^{Phe}$. We also presume that the region b-C and loop d together play a role of hinge in forming the pocket-like structure in the 5S rRNA.

• Korea Journal of Hospital Management
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• v.19 no.4
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• pp.57-68
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• 2014

Since the introduction of National Health Insurance(NHI) in 1977, it has grown rapidly and contributed to extend patient's access to the health care services. However, limited coverage for health care services of NHI has been ongoing challenge and private health insurance(PHI) has been rising as an alternative source of enhancing coverage and saving out-of-pocket(OOP) expenditure for patients. In this study, after controlling for socio-demographic, economic, health related variables, we identified the patients' healthcare utilization and subsequent OOP expenditure depending on their PHI enrollment and their enrollment types(fixed benefit, indemnity, fixed benefit plus indemnity). Data were collected from the 2010 Korean Health Panel. The unit of analysis was a member of household(n=13,324). Of the 13,324 cases, 70.7% of patients held PHI, in detail, fixed benefit(47.0%), indemnity(3.6%), fixed benefit plus indemnity(20.1%). Major findings showd that patients who enrolled in PHI used more outpatient services(outpatient visit, number of physician visit, number of examination) and spent more OOP expenditure than non-PHI patients. There were also differences of healthcare utilization and OOP expenditure among the types of PHI. In addition, PHI patients used more inpatient services(inpatient use, number of hospitalization, LOS), but there was no significant difference between PHI and non-PHI patients with regard to the OOP expenditure. Thus, we could not find any distinct relationship between the types of PHI and patients' tertiary hospital use. Policy-makers should need careful political deliberation for monitoring the effect of PHI on health care utilization and subsequent expenditure not only to improve patients' coverage but also to save their OOP expenditures.

• Molecules and Cells
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• v.27 no.1
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• pp.99-103
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• 2009

Ribose-5-phosphate isomerase A (RpiA) plays an important role in interconverting between ribose-5-phosphate (R5P) and ribulose-5-phosphate in the pentose phosphate pathway and the Calvin cycle. We have determined the crystal structures of the open form RpiA from Vibrio vulnificus YJ106 (VvRpiA) in complex with the R5P and the closed form with arabinose-5-phosphate (A5P) in parallel with the apo VvRpiA at $2.0{\AA}$ resolution. VvRpiA is highly similar to Escherichia coli RpiA, and the VvRpiA-R5P complex strongly resembles the E. coli RpiA-A5P complex. Interestingly, unlike the E. coli RpiA-A5P complex, the position of A5P in the VvRpiA-A5P complex reveals a different position than the R5P binding mode. VvRpiA-A5P has a sugar ring inside the binding pocket and a phosphate group outside the binding pocket: By contrast, the sugar ring of A5P interacts with the Asp4, Lys7, Ser30, Asp118, and Lys121 residues; the phosphate group of A5P interacts with two water molecules, W51 and W82.

• Progress in Medical Physics
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• v.30 no.4
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• pp.104-111
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• 2019

Purpose: Online magnetic resonance-guided adaptive radiotherapy (MRgART), an emerging technique, is used to address the change in anatomical structures, such as treatment target region, during the treatment period. However, the electron density map used for dose calculation differs from that for daily treatment, owing to the variation in organ location and, notably, air pockets. In this study, we evaluate the dosimetric effect of electron density override on air pockets during online ART for pancreatic cancer cases. Methods: Five pancreatic cancer patients, who were treated with MRgART at the Seoul National University Hospital, were enrolled in the study. Intensity modulated radiation therapy plans were generated for each patient with 60Co beams on a ViewrayTM system, with a 45 Gy prescription dose for stereotactic body radiation therapy. During the treatment, the electron density map was modified based on the daily MR image. We recalculated the dose distribution on the plan, and the dosimetric parameters were obtained from the dose volume histograms of the planning target volume (PTV) and organs at risk. Results: The average dose difference in the PTV was 0.86Gy, and the observed difference at the maximum dose was up to 2.07 Gy. The variation in air pockets during treatment resulted in an under- or overdose in the PTV. Conclusions: We recommend the re-contouring of the air pockets to deliver an accurate radiation dose to the target in MRgART, even though it is a time-consuming method.