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Modern diagnostic capabilities of neonatal screening for primary immunodeficiencies in newborns

  • Khalturina, Evgenia Olegovna;Degtyareva, Natalia Dmitrievna;Bairashevskaia, Anastasiia Vasi'evna;Mulenkova, Alena Valerievna;Degtyareva, Anna Vladimirovna
    • Clinical and Experimental Pediatrics
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    • v.64 no.10
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    • pp.504-510
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    • 2021
  • Population screening of newborns is an extremely important and informative diagnostic approach that allows early identification of babies who are predisposed to the development of a number of serious diseases. Some of these diseases are known and have effective treatment methods. Neonatal screening enables the early diagnosis and subsequent timely initiation of therapy. This helps to prevent serious complications and reduce the percentage of disability and deaths among newborns and young children. Primary immunodeficiency diseases and primary immunodeficiency syndrome (PIDS) are a heterogeneous group of diseases and conditions based on impaired immune system function associated with developmental defects and characterized by various combinations of recurrent infections, development of autoimmune and lymphoproliferative syndromes (genetic defects in apoptosis, gene mutation Fas receptor or ligand), granulomatous process, and malignant neoplasms. Most of these diseases manifest in infancy and lead to serious illness, disability, and high mortality rates. Until recently, it was impossible to identify children with PIDS before the onset of the first clinical symptoms, which are usually accompanied by complications in the form of severe coinfections of a viral-bacterial-fungal etiology. Modern advances in medical laboratory technology have allowed the identification of children with severe PIDS, manifested by T- and/or B-cell lymphopenia and other disorders of the immune system. This review discusses the main existing strategies and directions used in PIDS screening programs for newborns, including approaches to screening based on excision of T-cell receptors and kappa-recombination excision circles, as well as the potential role and place of next-generation sequencing technology to increase the diagnostic accuracy of these diseases.

Factors Affecting Changes in Forest Recreational Activities During the COVID-19 Pandemic (코로나19 팬데믹 이후 산림 휴양 활동의 변화 요인)

  • Chang, Chuyoun;Park, So-Hee;Seol, Ara
    • Journal of Korean Society of Forest Science
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    • v.110 no.4
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    • pp.711-723
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    • 2021
  • During the COVID-19 pandemic, social distancing affected daily life and leisure activities, including forest recreational activities. This study identified changes in people's participation in forest recreational activities and factors affecting their participation. It collected data from 1,000 samples through an online survey and analyzed it using a binary logit model with interaction terms. It was observed that there were decreases in the participation in visits to urban parks and green areas, outdoor activities in forests and mountains, and trips to mountain villages after the COVID-19 outbreak. People in their 40s, 50s, and 60s were more likely to decrease their participation in all kinds of forest recreational activities than those in their 20s. Moreover, higher household income earners were more likely to decrease their involvement in outdoor activities in forests and mountains. With respect to the place of residence, the residents in the Seoul metropolitan area were less likely to decrease their participation in trips to mountain villages than those outside this area. Thus, this study suggests that online forest recreation information services and forest management are needed to meet the demands of forest recreation for young generations and diversify the function of forests and rural areas as a safe leisurely space.

A Study on the Two Big Theories of Music Culture in China's Ancient Times (중국전통시기 양대(兩大) 음악문화 고찰)

  • Lee, Tae Hyoung
    • Cross-Cultural Studies
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    • v.43
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    • pp.355-376
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    • 2016
  • This study looks into the relationship between Chinese philosophy, with a focus on Confucianism and Taoism, and music. Kong zi's Confucius supported, 'Enjoyment without being licentious and grief without being hurtfully excessive', and 'hatred of the music of Zheng'. These ideas do not emphasize the function of music as an expression of emotions, feelings, or desires, and are instead conclusions based on Confucian ideals such as harmony between classes and the spread of benevolent government. Music must coincide with Justice. The hatred of the music of Zheng was a conclusion founded on the idea of a place for Justice in music. Zhuangzi is the source of the spirit of Chinese art; specifically, Zhuangzi's idea of music in relation to its influence on East Asian history of art is extremely influential. In fact, the concept of yuelun is considered the most original and important concept in the history of the East Asian philosophy of art. The most distinctive features of Zhuangzi's theory of music can be summarized as follows. He attempts to liberate music from the restrictions of form and to let music express authentic human feelings and emotions. He also argues that music should not be subjected to politics, as he thinks that the creative mind of an artist can exist only when music is freed from political influence. Confucianism takes a humanistic perspective, while Taoism takes a more naturalistic one. In sum, Confucianism gives weight to the logical and ethical aspects of music, while Taoism emphasizes the intuitional and naturalistic ones.

A Study on Current Status and Improvement Tasks of Records Classification in Government-funded Research Institutes (정부출연연구기관의 기록분류 현황과 개선과제)

  • Lee, Mi-Young
    • The Korean Journal of Archival Studies
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    • no.53
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    • pp.229-259
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    • 2017
  • The purpose of this study is to find out the level of the classification system of the government-funded research institutes and to search the future direction of the classification scheme of these research institutes. As a result of analyzing the classification system and regulations of the 23 government-funded research institutes, it is found that the regulations of the records management of most institutions are basically based on other regulations before Public Records Act. In addition, there are not many institutions in which the record production system that reflects the Public Records Act is introduced, and the production and classification of the records are performed separately, and the classification scheme in which the organization classification and the functional classification are mixed is often used only as a reference tool for setting retention period. To overcome this situation, it is necessary to improve the regulation, classification scheme and system. The revision of the law at the national level and establishment of records management regulations at the institutional level should be made. A special classification scheme for 'research' which is a core function of the research institute should be designed and this classification scheme must be applied from the registration stage of records. The fact that the record management obligation is ignored and the production records are not properly managed is to deny the value of the research field records by themselves. I hope that the records management of government-funded research institutes will be moved in place as soon as possible and practical issues will be communicated to academia and good ideas for better development will be returned to the field of practice.

Theatre of Imagination: Study on New Languages in the Theatre Experiment of Ara Kim (상상력의 연극 이미지의 무대구성작업에 관하여 김아라 연출작업에 나타난 새로운 무대언어)

  • Nam, Sangsik
    • Journal of Korean Theatre Studies Association
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    • no.48
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    • pp.261-288
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    • 2012
  • This paper attempts to research on the new language in the directing of Ara Kim. She was cranky on working on the stage to experiment with her own style since the 1980s and so opened a new dawn in modern Korean theatre. She leaded the Korean experimental theatre. The background of this experiment is her idea on theatre. And here, we have to look the subject that she setted for the work in Chuksan: Ritual Past, Ritual Present. To her, the theatre has the function of ritual and fest. The theatre suggests universal tragedy given to human as natural life force and has its own agenda to drive people to healing. For it, Ara Kim explores archetypal forms and languages before the fragmentation of genres of art. Her theatre shows the results of experiments in which such languages are recreated with modernized sensibilities. We here, for example by outdoor performance in Chuksan Human Lear, try to interpret the aesthetic principles that body out her ritual theatre. And what we looked at though, is the base of the 'complex-genre-music-theatre', the methode to 'compose' the stage elements and put it all together. The directing of Ara Kim has, in terms of the composition of the stage elements, much of the indisputable artistic value. Her theatre is, so to speak, theatre of image, and it is theatre of imagination that completed by the audience's imagination. Human Lear which has its own characteristic in image fragments, convert the original Lear into a simple tale. It serves as background of the modern ritual that shows the most basic human instincts. We meet in Human Lear a ritual tale with some list of image for the human instincts. The arrangement of image, the montage of scene shows the performance as a kind of artistic space. In Human Lear the space is the natural one. It centers around the arena stage. The objects installed in the space changes it into the laboratory for 'seeing' the happening. The spectators see the performance and at the same time see themselves in the nature laboratory. They see, and equally, they are visible objects. They see the performance and us in the space in which the performance takes place. That is what Ara Kim with her modern ritual really aims. That aim is to this days still in effect. It is a major driver of her experiments to extend the boundary of the theatre. The ritualistic site-specific performance in Akor Wat, Cambodia, A Song of Mandala is the latest great product from her experiments. On the other hand, she continues on her way to experiment with pure stage elements. The 'Station' series(Station of Water, The Station of Sand, The Station of Wind) she recently showed are the non-verbal performance with all the stage elements: movement, sound, body, light, colour, objects and so on.

A Study on the Application of the New York Convention in the Recognition and Enforcement of ISDS Arbitral Awards (투자협정중재에 의한 중재판정의 승인·집행에 대한 뉴욕협약 적용에 관한 고찰)

  • Kang, Soo Mi
    • Journal of Arbitration Studies
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    • v.29 no.1
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    • pp.31-52
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    • 2019
  • As international transactions have grown more numerous, situations of disputes related to the transactions are getting more complicated and more diverse. Cost-effective remedies to settle the disputes through traditional methods such as adjudications of a court will be insufficient. There fore, nations are attempting to more efficiently solve investor-state disputes through arbitration under organizations such as the ICSID Convention, the ICSID Additionary Facility Rules, and the UNCITRAL Arbitration Rules by including the provisions on investor-state dispute settlement at the conclusion of an investment agreement. In case of an arbitration under the ICSID Convention, ICSID directly exercises the supervisorial function on arbitral proceedings, and there is no room for the intervention of national courts. In time of the arbitration where the ICSID Convention does not apply, however, the courts have to facilitate the arbitral proceedings. When the recognition and enforcement of an arbitral award under the ICSID Convention are guaranteed by the Convention, it should be considered that the New York Convention does not apply to them under the Convention Article 7 (1) fore-end. In exceptional cases in which an arbitral award under the ICSID Convention cannot be recognized or enforced by the Convention, the New York Convention applies to the recognition and enforcement because the award is not a domestic award of the country in which the recognition or enforcement is sought. It is up to an interpretation of the New York Convention whether the New York Convention applies to ISDS arbitral awards not based on the ICSID Convention or not. Although an act of the host country is about sovereign activities, a host country and the country an investor is in concurring to the investment agreement with the ISDS provisions is considered a surrender of sovereignty immunity, and it will not suffice to exclude the investment disputes from the scope of application of the New York Convention. If the party to the investment agreement has declared commercial reservation at its accession into the New York Convention, it should be viewed that the Convention applies to the recognition and enforcement of the ISDS awards to settle the disputes over an investitive act, inasmuch as the act will be considered as a commercial transaction. When the recognition and enforcement of an arbitral award on investment disputes about a nation's sovereign act have been sought in Korea and Korea has been designated the place of the investment agreement arbitration as a third country, it should be reviewed whether the disputes receive arbitrability under the Korean Arbitration Act or not.

Literary Physiology of an Emotional Ratio Using Sijo (시조를 활용한 감정 비율의 문학생리학)

  • Park, Inkwa
    • The Journal of the Convergence on Culture Technology
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    • v.5 no.2
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    • pp.305-311
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    • 2019
  • Does the healing of life lead to a grave, or can death heal life? The healing in life exists in the emotional circuit of the space of life. So what kind of space does healing in death exist? For now, healing in death exists beyond life. Imje (林悌, 1549-1587) is famous for reciting Sadness Sijo in his beloved Hwang Jin-yi's Grave. For the Literature Therapy, this time we're trying to code the Emotions of Sijo "The Valley Which is Covered With Blue Grass", which Imje is said to have recited in the Hwang Jin-yi's Grave. This Sijo sings the love of Sadness such as Love and Death, Grave and Sadness. That is, how fuse human Emotions, which are caused by conflicting concepts of love and pain or love and separation. Imje's Sijo fuses signifiers such as Grave, Love and Sadness to code 'The Transience of Human Life.' This 'The Transience of Human Life' is a function of this Sijo's Literature Therapy. 'The Transience of Human Life' has a role of healing that relaxes the human body. With the Literature Therapy in place like this, no matter how painful life is, we have some leeway. This is because the sadness of 'The Transience of Human Life' delivered by Sijo conveys the effect of the Literature Therapy, which contemplate and tolerate the entire life. We look forward to continuing this research and achieving Emotion Coding for new life.

A Study on the Meaning of School Space: Criticism and Alternatives (학교 공간에 관한 의미 탐색: 비판과 대안)

  • Kim, Dal-Hyo
    • Journal of the Korean Institute of Educational Facilities
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    • v.26 no.4
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    • pp.3-10
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    • 2019
  • In school facilities, space is the basic framework. The structure and arrangement of space will provide the form and feel of school facilities. In order to become a high-quality school facility, it is necessary to focus on the educational, human and ecological aspects of the instructor and learner until the space is conceived, designed and completed. However, even when public education was introduced in the past, it did not become a school space considering this aspect. The school space, which focuses on efficiency and labor production, is a school space that reflects the characteristics of a factory-type school, which has been occupied by a large number until recently. Although efforts to improve the quality of school facilities have been attempted in recent years, there is also a need to pursue more active changes. Future-oriented and progressive school spaces include flexibility, connectivity, individualization, diversity(creativity). In other words, space should be flexible so that it can be used faithfully according to the educational situation, not the fixed and limited school space as in the past. In the future, the school space should be open and securely linked to the place where it is essential to complete community relations with the community. In addition, space should be flexible so that the school can meet the needs of each student as much as possible. And the school space should be transformed from the space design of the past fixed pattern to reflect the close relationship between spatial, psychological, physiological, and behavioral areas. When school space needs to shift away from the past and change in a new future-oriented direction, the remaining tasks should be presented with specific characteristics and content of the direction. And the function of the consignment should be handled by related research. Although the text of this study reveals the characteristics of future-oriented school space, more concrete and empirical research results should be presented by subsequent research at home and abroad. It is necessary to reduce trial and error in creating a future-oriented school space where both professors and learners can be satisfied by analyzing the common points and differences between the results of the study. In order to do this, it is necessary to make efforts to approach such research based on the participation of the subjects who teach and learn directly at the school site.

Orthodontic intrusion treatment of mandibular anterior teeth in a periodontal patient with hyperdivergent skeletal pattern: 8-year follow-up (장안모를 보이는 치주 질환자에서 하악 전치의 압하를 통한 과개 교합 치료: 8년 경과 관찰)

  • Kwon, Eun-Young;Jung, Kyung-Hwa;Park, Soo-Byung;Kim, Seong-sik;Kim, Yong-il;Choi, Youn-kyung
    • Journal of Dental Rehabilitation and Applied Science
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    • v.37 no.1
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    • pp.48-60
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    • 2021
  • Patients who have extruded anterior teeth and deep bite with pathologic tooth migration, it is necessary not only periodontal treatment for reduce inflammation, but also orthodontic treatment for intrusion of anterior teeth. However, it is difficult to place the orthodontic brackets due to the deep bite, and there is a problem that the extrusion of the posterior teeth occurs more easily than the intrusion of the anterior teeth biomechanically. In particular, in patients with long face, relative intrusion of the anterior teeth by extrusion of the posterior teeth causes the clockwise rotation of the mandible and makes the facial profile worse. Therefore the biomechanical consideration and appliance design that can block these problems are required from the treatment plan. This is a patient who had a deep overbite with extruded anterior teeth, treated by periodontal treatment and intrusion of mandibular anterior teeth using cute brackes and miniscrews, and resulted in favorable maintenance during 8-year retention.

Concept and application of implant connection systems: Part I. Placement and restoration of internal conical connection implant (임플란트 연결부의 개념과 적용: Part 1. 원추형 내부연결 임플란트의 식립과 보철)

  • Ko, Kyung-Ho;Kang, Hyeon-Goo;Huh, Yoon-Hyuk;Park, Chan-Jin;Cho, Lee-Ra
    • Journal of Dental Rehabilitation and Applied Science
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    • v.36 no.4
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    • pp.211-221
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    • 2020
  • The typical biomechanical properties of an internal conical connection (ICC) are axial displacement and loss of preload. The axial displacement of an ICC without a vertical stop can cause the loss of preload and a lowered occlusion. The stress of an ICC is concentrated on the contact interface of the abutment and not on the screw, and during placement, it is important to choose a wider coronal wall thickness as much as possible. The ICC should also be placed below the level of the bone crest. During the restoration of an ICC, care should be taken to ensure an appropriate abutment shape and an accurate connection. To get the best clinical results, it is important to select its wall thickness and place it in the appropriate position to restore it adequately.