• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8171-8175
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• 2014

Background: To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT). Materials and Methods: The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation. Results: The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. The survival rate was the highest at 87% with a concentration of $30{\mu}g/mL$. Pretreatment with FRT was needed to realize its radioprotective activity in mice at the dose of 60 mg/kg. With the increasing doses of 30 mg/kg, 60 mg/kg and 120 mg/kg, the numbers of CFU-S increased, and were significantly different compared with the control group. Conclusions: Pretreatment with FRT prior to irradiation resulted in significantly higher cell survival at 24 h after 5 Gy radiation, increased 30-day survival in mice after exposure to a potentially lethal dose of 8 Gy, and resulted in a higher number of CFU-S in mice after exposure to a dose of 6 Gy. These results collectively indicate that FRT is an effective radioprotective agent.

• Asian Pacific Journal of Cancer Prevention
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• 제15권19호
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• pp.8391-8394
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• 2014

Purpose: This systematic analysis was conducted to evaluate the efficacy and safety of pemetrexed based salvage chemotherapy for treatment of patients with metastatic colorectal cancer. Methods: Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for patients with colorectal cancer were identified using a predefined search strategy. Pooled response rates (RRs) were calculated. Results: For pemetrexed based regimens, 4 clinical studies including 201 patients with advanced colorectal cancer were considered eligible for inclusion. The analysis suggested that, in all patients, pooled RR was 20.4% (41/201). Major adverse effects were neutropenia, anorexia, fatigue, and anemia. No treatment related death occurred with pemetrexed based treatment. Conclusion: This systematic analysis suggests that pemetrexed based regimens are associated with mild activity with good tolerability in treating patients with metastatic colorectal cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3871-3875
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• 2013

Purpose: MicroRNAs (miRNAs) are small endogenous, non-coding, single-stranded RNAs (approximately 22 nt). Accumulating evidence has shown that aberrant miRNA expression is pronounced and correlated with gastric cancer genesis and progression. Materials and Methods: Expression levels of miR-181a-5p in GC tissues and cell lines were assessed by qRT-PCR and tested for correlation with clinical features. In addition, effects of miR-181a-5p on GC cell growth were investigated. Results: Our findings indicate that miR-181a-5p is upregulated in GC, in correlation with lymph node invasion, nerve invasion and vascular invasion (P<0.05). Enforced expression of miR-181a -5p promoted cell proliferation ability. Conclusions: This study suggested that increased miR-181a-5p is related to GC progression. MiR-181a-5p may represent a potential therapeutic target for GC.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3847-3850
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• 2013

The three homologous members of the p160 SRC family (SRC-1, SRC-2 and SRC-3) mediate the transcriptional functions of nuclear receptors and other transcription factors, and are the most studied of all the transcriptional co-activators. Recent work has indicated that the SRC-3 gene is subject to amplification and overexpression in various human cancers. Some of the molecular mechanisms responsible for SRC overexpression, along with the mechanisms by which SRC-3 promotes breast and prostate cancer cell proliferation and survival, have been identified. However, the function of SRC-3 in bladder cancer remains poorly understood. In the present study, our results indicate that overexpression of SRC-3 promotes bladder cancer cell proliferation whereas knockdown of SRC-3 results in inhibition. At the molecular level, we further established that CXCR4 is a transcriptional target of SRC-3. Therefore, our study first identified that SRC-3 plays a critical role in the bladder cancer, which may be a target beneficial for its prevention and treatment.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권8호
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• pp.3865-3883
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• 2016

Infrastructure as a Service (IaaS) encapsulates computer hardware into a large amount of virtual and manageable instances mainly in the form of virtual machine (VM), and provides rental service for users. Currently, VM anomaly incidents occasionally occur, which leads to performance issues and even downtime. This paper aims at detecting anomalous VMs based on performance metrics data of VMs. Due to the dynamic nature and increasing scale of IaaS, detecting anomalous VMs from voluminous correlated and non-Gaussian monitored performance data is a challenging task. This paper designs an anomaly detection framework to solve this challenge. First, it collects 53 performance metrics to reflect the running state of each VM. The collected performance metrics are testified not to follow the Gaussian distribution. Then, it employs independent components analysis (ICA) instead of principal component analysis (PCA) to extract independent components from collected non-Gaussian performance metric data. For anomaly detection, it employs multi-class Bayesian classification to determine the current state of each VM. To evaluate the performance of the designed detection framework, four types of anomalies are separately or jointly injected into randomly selected VMs in a campus-wide testbed. The experimental results show that ICA-based detection mechanism outperforms PCA-based and LDA-based detection mechanisms in terms of sensitivity and specificity.

• Transactions on Electrical and Electronic Materials
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• 제17권6호
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• pp.335-340
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• 2016

The vibrational energy is prevalent in the natural environment, which is studied by energy researchers as a new energy resource in recent years. Vibration generation utilizes electromagnetic induction technology, piezoelectric technology and certain characteristics of smart materials to convert mechanical energy into electrical energy. In this paper, a new method of using MSMA (magnetic shape memory alloy) to generate electricity is proposed and the principle of generating electricity is demonstrated. Martensitic variants and magnetic domain characteristics of MSMA are analyzed. Combining with Gibbs free energy function thermal theory, the mathematics model of MSMA vibration generator is established. The basic structure of MSMA vibration generator is designed and simulation is done to analyze that the effects of generator output voltage when the input amplitude and frequency of vibration stress change. The simulation experiments verify the feasibility of using MSMA to make the micro vibration generators and the correctness of the mathematical model, which lays a good foundation for the further research and application of MSMA vibration generator.

• Journal of Information Processing Systems
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• 제13권3호
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• pp.559-572
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• 2017

Cyberbullying has been an emerging issue in recent years where research has revealed that users generally spend an increasing amount of time in social networks and forums to keep connected with each other. However, issue arises when cyberbullies are able to reach their victims through these social media platforms. There are different types of cyberbullying and like traditional bullying; it causes victims to feel overly selfconscious, increases their tendency to self-harm and generally affects their mental state negatively. Such situations occur due to security issues such as user anonymity and the lack of content restrictions in some social networks or web forums. In this paper, we highlight the existing solutions, which are Intrusion Prevention System and Intrusion Detection System from a number of researchers. However, even with such solutions, cyberbullying acts still occurs at an alarming rate. As such, we proposed an alternative solution that aims to prevent cyberbullying activities at a younger age, e.g., young children. The application would provide an alternative method to preventing cyberbullying activities among the younger generations in the future.

• Geomechanics and Engineering
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• 제13권1호
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• pp.173-194
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• 2017

Access shaft is of critical importance to the construction and operation of underground rock caverns. It usually has a relatively large cross-section and penetrates through fill materials, soil layers, and weathered rocks before reaching the caverns excavated in solid bedrock. In this paper, the design and construction of vertical shafts are reviewed in terms of diameter, depth, geological conditions, and support structure. Three shaft alternatives, namely alternative I: vertical shaft with spiral roads, alternative II: upper shaft with spiral roads & lower tunnels, alternative III: plain shaft, are proposed based on a simplified geological profile of the Jurong formation, Singapore. The advantages and limitations of the three types of shafts are discussed. The key issues relating to shaft design and construction, such as the shaft sinking, water control, support structure, are also discussed with a series of solutions provided, such as the sequential excavation, pre-grouting and diaphragm walls.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.2027-2029
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• 2015

Background: Laparoscope-assisted gastrectomy in treating patients with gastric cancers developed with a background of highly invasive traditional surgery and is being increasingly performed in the Asian Pacific area. This study systemically investigated the technique and clinical results for comparison with traditional radical subtotal gastrectomy for gastric cancers. Methods: Clinical studies evaluating the effectiveness and side effects of laparoscope-assisted gastrectomy in treating patients with gastric cancers were identified using a predefined search strategy. Summary rates of effectiveness and side effects of laparoscope-assisted gastrectomy were calculated. Results: Thirteen clinical studies which including 1,412 patients with gastric cancer treated by laparoscope-assisted gastrectomy were considered eligible for inclusion. Systemic analysis showed that, for all patients, the pooled resection rate was 100%. Major adverse effects were anastomotic stenosis, abdominal abscess, abdominal bleeding, postoperative ileus. Treatment related death occurred in 0. 71% (10/1412). Conclusion: This systemic analysis suggests that laparoscope-assisted gastrectomy in treating patients with gastric cancers is associated with good curative rate and acceptable complications.

• Journal of Power Electronics
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• 제17권2호
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• pp.334-345
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• 2017

In order to meet the increasing needs of the hybrid energy source system for electric vehicles, which demand bidirectional power flow capability with a wide-voltage-conversion range, a bidirectional three-level DC-DC converter and some control strategies for hybrid energy source electric vehicles are proposed. The proposed topology is synthesized from Buck and Boost three-level DC-DC topologies with a high voltage-gain and non-extreme duty cycles, and the bidirectional operation principle is analyzed. In addition, the inductor current ripple can be effectively reduced within the permitted duty cycle range by the coordinated control between the current fluctuation reduction and the non-extreme duty cycles. Furthermore, benefitting from duty cycle disturbance control, series-connected capacitor voltages can also be well balanced, even with the discrepant rise and fall time of power switches and the somewhat unequal capacitances of series-connected capacitors. Finally, experiment results of the bidirectional operations are given to verify the validity and feasibility of the proposed converter and control strategies. It is shown to be suitable for hybrid energy source electric vehicles.