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http://dx.doi.org/10.7314/APJCP.2014.15.19.8171

Flavonoids of Rosa roxburghii Tratt Act as Radioprotectors  

Xu, Ping (Department of Pharmacy, Xinxiang Medical University)
Zhang, Wen-Bo (Department of Pharmacy, Xinxiang Medical University)
Cai, Xin-Hua (Department of Pharmacy, Xinxiang Medical University)
Lu, Dan-Dan (Institute of Radiation Medicine, Military Medical Sciences)
He, Xiao-Yang (Institute of Radiation Medicine, Military Medical Sciences)
Qiu, Pei-Yong (Department of Pharmacy, Xinxiang Medical University)
Wu, Jiao (Department of Pharmacy, Xinxiang Medical University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.19, 2014 , pp. 8171-8175 More about this Journal
Abstract
Background: To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT). Materials and Methods: The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation. Results: The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. The survival rate was the highest at 87% with a concentration of $30{\mu}g/mL$. Pretreatment with FRT was needed to realize its radioprotective activity in mice at the dose of 60 mg/kg. With the increasing doses of 30 mg/kg, 60 mg/kg and 120 mg/kg, the numbers of CFU-S increased, and were significantly different compared with the control group. Conclusions: Pretreatment with FRT prior to irradiation resulted in significantly higher cell survival at 24 h after 5 Gy radiation, increased 30-day survival in mice after exposure to a potentially lethal dose of 8 Gy, and resulted in a higher number of CFU-S in mice after exposure to a dose of 6 Gy. These results collectively indicate that FRT is an effective radioprotective agent.
Keywords
FRT; radioprotection; survival rate; AHH-1; CFU-S;
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