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http://dx.doi.org/10.7314/APJCP.2014.15.19.8391

Pemetrexed is Mildly Active with Good Tolerability for Treatment of Patients with Colorectal Cancer  

Zhang, Hui-Qing (Department of General Surgery, Heping Hospital of Changzhi Medical College)
Lian, Chang-Hong (Department of General Surgery, Heping Hospital of Changzhi Medical College)
Ping, Yao-Dong (Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education))
Song, Wen-Bin (Department of General Surgery, Heping Hospital of Changzhi Medical College)
Lu, Qing-Pu (Department of Pharmacy, Peking University Cancer Hospital & Institute)
Xie, Shu-Zhe (Department of Pharmacy, Peking University Cancer Hospital & Institute)
Lin, Tao (Department of Pharmacy, Peking University Cancer Hospital & Institute)
Cheng, Lin-Zhong (Department of Pharmacy, Heping Hospital of Changzhi Medical College)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.15, no.19, 2014 , pp. 8391-8394 More about this Journal
Abstract
Purpose: This systematic analysis was conducted to evaluate the efficacy and safety of pemetrexed based salvage chemotherapy for treatment of patients with metastatic colorectal cancer. Methods: Clinical studies evaluating the efficacy and safety of pemetrexed based regimens on response and safety for patients with colorectal cancer were identified using a predefined search strategy. Pooled response rates (RRs) were calculated. Results: For pemetrexed based regimens, 4 clinical studies including 201 patients with advanced colorectal cancer were considered eligible for inclusion. The analysis suggested that, in all patients, pooled RR was 20.4% (41/201). Major adverse effects were neutropenia, anorexia, fatigue, and anemia. No treatment related death occurred with pemetrexed based treatment. Conclusion: This systematic analysis suggests that pemetrexed based regimens are associated with mild activity with good tolerability in treating patients with metastatic colorectal cancer.
Keywords
Metastatic colorectal cancer; pemetrexed chemotherapy; response rate;
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