• Title/Summary/Keyword: Pilot City

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Changes in expression of the autophagy-related genes microtubule-associated protein 1 light chain 3β and autophagy related 7 in skeletal muscle of fattening Japanese Black cattle: a pilot study

  • Nakanishi, Tomonori;Tokunaga, Tadaaki;Ishida, Takafumi;Kobayashi, Ikuo;Katahama, Yuta;Yano, Azusa;Erickson, Laurie;Kawahara, Satoshi
    • Asian-Australasian Journal of Animal Sciences
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    • v.32 no.4
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    • pp.592-598
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    • 2019
  • Objective: Autophagy is a bulk degradation system for intracellular proteins which contributes to skeletal muscle homeostasis, according to previous studies in humans and rodents. However, there is a lack of information on the physiological role of autophagy in the skeletal muscle of meat animals. This study was planned as a pilot study to investigate changes in expression of two major autophagy-related genes, microtubule-associated protein 1 light chain $3{\beta}$ (MAP1LC3B) and autophagy related 7 (ATG7) in fattening beef cattle, and to compare them with skeletal muscle growth. Methods: Six castrated Japanese Black cattle (initial body weight: $503{\pm}20kg$) were enrolled in this study and fattened for 7 months. Three skeletal muscles, M. longissimus, M. gluteus medius, and M. semimembranosus, were collected by needle biopsy three times during the observation period, and mRNA levels of MAP1LC3B and ATG7 were determined by quantitative reverse-transcription polymerase chain reaction. The expression levels of genes associated with the ubiquitin-proteasome system, another proteolytic mechanism, were also analyzed for comparison with autophagy-related genes. In addition, ultrasonic scanning was repeatedly performed to measure M. longissimus area as an index of muscle growth. Results: Our results showed that both MAP1LC3B and ATG7 expression increased over the observation period in all three skeletal muscles. Interestingly, the increase in expression of these two genes in M. longissimus was highly correlated with ultrasonic M. longissimus area and body weight. On the other hand, the expression of genes associated with the ubiquitin-proteasome system was unchanged during the same period. Conclusion: These findings suggest that autophagy plays an important role in the growth of skeletal muscle of fattening beef cattle and imply that autophagic activity affects meat productivity.

A Case Study on Electronic Recognition Sensor for Underground Facility Management System (지중 매설물 이력 관리 시스템 개발을 위한 전자인식기의 현장 적용성 검증 연구)

  • Jung, YooSeok;Kim, Soullam;Kim, Byungkon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.22 no.1
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    • pp.777-785
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    • 2021
  • Many utility lines are buried underground to provide various functions of the city. Because historical records are not managed systematically, damage has occurred during excavation. In addition, the demand for an underground facility management system is increasing as the aerial underground project is progressing. By attaching an electronic recognition sensor to an underground facility, such as pipelines, the management history and site conditions can be carefully managed. Therefore, in this study, electronic recognition sensors, such as BLE Beacon, UHF RFID, geomagnetic sensor, and commercial marker, were tested to analyze the strengths, weaknesses, and field applicability through a pilot project. According to the limited research results collected through two pilot projects, the installation depth is most important to demonstrate the performance of the electronic reader. In addition, because it should be used in urban areas, the influence of environmental interference should be minimized, and there should be no performance degradation over time. In the case of the geomagnetic recognizer, the effect of environmental interference was large, and performance degradation occurred over time using the BLE Beacon. In the field situation, where the installation depth can be controlled to less than 40cm, the utility of the battery-free UHF RFID was the best.

A Pilot Study on Installation Criteria of Speed Change Lanes according to the Implementation of Safety Speed "5030" in the Urban Area (도심내 안전속도 "5030"시행에 따른 변속차로 설치기준에 관한 기초연구)

  • Oh, Seok-Jin;Ha, Tae-Jun;Jin, Tae-Hee;Shin, Kwang-Min;Lee, Gang-Seok
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.41 no.1
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    • pp.57-64
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    • 2021
  • The speed change lane is installed at the point where the roads are connected on the urban roads, reducing the relative speed to facilitate traffic communication. However, in the case of the speed limit of 30 km/h in accordance with the implementation of the safe speed "5030" in the city, the standard is ambiguous, and there are criticisms about the installation of the transmission lane. This study conducted a pilot study on the traffic patterns of the speed change lanes, focusing on the section where the safe speed "5030" policy was scheduled to be implemented after theoretical consideration of the speed change lanes. After on-site investigation, as a result of analyzing the traffic pattern according to the travel speed of the main road according to road conditions and traffic conditions, the effectiveness of the speed change lane according to the safety speed "5030" was analyzed. In this study, the installation criteria for speed change lane by speed were presented. The criteria is that "speed change lanes should not be installed when the speed limit is 30 km/h, and speed change lanes should be installed when the speed limit is 50 km/h." The criteria will be considered as a reference when establishing engineering standards for connection of other facilities in urban areas in the future. It is expected that unnecessary restrictions on individuals' exercise of private property rights will be minimized, smooth traffic flow and secure safety by the installation of speed change lanes and expansion of turning radius.

Application of Cognitive Enhancement Protocol Based on Information & Communication Technology Program to Improve Cognitive Level of Older Adults Residents in Small-Sized City Community: A Pilot Study (중소도시 지역사회 거주 노인의 치매예방을 위한 Information & Communication Technology 프로그램 기반 인지향상 프로토콜 적용: 파일럿(Pilot) 연구)

  • Yun, Sohyeon;Lee, Hamin;Kim, Mi Kyeong;Park, Hae Yean
    • Therapeutic Science for Rehabilitation
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    • v.12 no.2
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    • pp.69-83
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    • 2023
  • Objective : This study, as a preliminary study, applied an Information & Communication Technology (ICT) home-based program to elderly people aged 65 years or older to confirm the effect of the cognitive enhancement program and to find the possibility of remote rehabilitation. Methods : This study from August to October 2022, three subjects were selected and the intervention was conducted for about 2 months. This intervention was conducted using Korean version of Mini-Mental State Examination, Korean version of Montreal Cognitive Assessment (MoCA-K), Computer Cognitive Senior Assessment System, and the Center for Epidemiologic Studies Depression scale to evaluate cognitive improvement before and after the program. The therapist remotely set the level of cognitive training according to the subject's level through weekly feedback. Results : After the intervention, all subjects showed improved scores in most items of the MoCA-K conducted before and after the intervention. In addition, among the items of Cotras-pro, upper cognition, language ability, attention, visual perception, and memory were improved. Conclusion : Cognitive rehabilitation training using an ICT home-based program not only prevented dementia but also made it habitual. Through this study, it was confirmed that remote rehabilitation for the elderly could be possible.

An Optimization Algorithm of Gypsum Board Loss for Wall Finishing in Modular Construction System (모듈러건축 벽체마감 석고보드 손실 최적화 알고리즘 개발)

  • Lee, Dong-Min;Chin, Sangyoon
    • Korean Journal of Construction Engineering and Management
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    • v.15 no.1
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    • pp.101-110
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    • 2014
  • The ministry of Land, Infrastructure and Transport announced that they launched the pilot project to offer Happy House built with modular construction as part of the major projects of incumbent government in 2013. The market size of modular construction is getting increasingly enlarged together with strong will of government. The major challenges that current modular construction encounters can be summed up as lack of standardization of material on the stage of design and fabrication. The portion of material costs in modular construction marks 16 to 17% higher than the existing other construction method, and account for 60 % of total construction cost, which is why material management is the most important factor. However, the imperfect standardization and specification on design causes high loss of materials on fabrication, which makes the construction wastes and total construction cost increasing in accordance with the increase of material costs. This study has been conducted to verify major modules by developing optimization algorithm on gypsum board material among wall finishing materials. It is expected that this paper contributes not only to eco-friendly construction by minimizing the waste factors of materials through these efforts, but also to removing high cost issues which had been recognized as a setback of current modular construction.

A Descriptive Study on Pain of Elderly (노인의 동통에 관한 조사연구)

  • 김주희;양경희;이현주
    • Journal of Korean Academy of Nursing
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    • v.26 no.4
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    • pp.878-888
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    • 1996
  • The main purpose of this study was getting related to the pain charactristic data of elderly. It contains past and present health status, daily living activity level, pain frequency, causes, pain area, pain intensity, pain worse causes, and pain releave causes, pain management methods. The subject were 79 elderly whose age were over 65 years old. They were lived in their home environment. Half of them were resident of middle range city at province and the others were Seoul city. The data was collected from Dec. 1st. 1995 to Jan. 30th. 1996. Interviews were held with semi-structured questionaire after pilot study by researchers. Pain measurement tool were used graphic rating scale and Abstract of Korean Pain Language Scale. To analize the subject's general characteristics, past and present health status, daily living activity level, characteristics about pain, pain management methods statistical SPSS for win frequency were employed. The findings were as follows ; 1. There were 33(41.8%) male and 46(58.2%) female Below 69 year old were 20(25.3%), 70-79 year old were 42(53.2%), over 80 year old were 17(21.5%), mean age was 74(from 65 to 89). 2. Buddhist were 24(30.4%), Christian were 29(36. 7%), the other religious status or non religians were 26 (32.9%). 3. Past good health status were 63(79.7%), not so good status were 6(7.6%). Present good health status were 19(24.1%), moderated health status were 6(7.6%), not so good status were 14(17.7%). 4. Daily living activity limitation were 39(49.4%), nonlimitation of activity were 5(6.3%). 5. Walking limitation were 3(3.8%), nonlimitation walking were 52(65,8%). 6. Insomnia was 23(29.1%), no difficult were 38(48.1%). 7. Chronic pain complaints were 64(81%), diseases causes of pain were 25(31.6%), bad health behavior causes of pain were 27(34.2%). 8. Most pain area were back 30(29.4%), leg 17(16.7%), knee 16(15.7%), arm 13(12.7%), teeth, chest and head were each 5(4.9%), loin, trunk were each 4(3.9%), the other areas were 3(3%). 9. Pain intensity was 3.49(mean) by Korean Language Scale, 6.59(mean) by graphic rating scale. Sensitive pain was 3.5(47.9%), affective pain was 3(20.8%) It was high pain level and sensitive pain. 10. Most pain worse causes moving was 35(44.3%), pain relieving causes rest was 29(36.7%), 11. Pain management method were medication 40(42.1%), physiotherapy 23(24.2%), hospital 12(12.6%), the others 7(7.4%), none 13(13.7%). The conclusion ; Present health status of eldery was not so good. Almost half of them have some diseases. Most common diseases of eldery were arthristis, respitatory and heart problems. Foully nine percent of elderly had limitation of daily living activities. Eighty one percent of eldely had chronic pain. Most of them was back pain (30%). Pain intensity was high(score over 3.5). The worsening pain causes was moving and releiving causes was rest. Pain management method were pain medication, physiotherapy. Therefore, Nursing care plan for the elderly have to focus on pain because majority of elderly have chronic high level of pain related to the arthritis.

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Isolation and Identification of Opportunist Mycobacteria and Nocardia from Soil Specimens of School Ground in Seoul City (서울시내(布內) 초중고등학교(初中高等學校) 토양(土壤)으로부터 비정형(非定型) Mycobacteria와 Nocardia의 분리(分離) 및 생화학적(生化學的) 동정(同定))

  • Choi, Chul-Soon;Yang, Yong-Tae
    • The Journal of the Korean Society for Microbiology
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    • v.11 no.1
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    • pp.69-78
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    • 1976
  • There have been increasing reports of mycobacterioses in man and animals caused by "atypical" or "opportunist" mycobacteria. At the presnt, "opportunist mycobacterioses" are not generally responsive to antituberculosis drugs, and therefore, create considerable problems with regard to chemotherapy and control measures. In recent years studies have been made to isolate opportunist mycobacteria from soil, house-dusts and tap-water. It seemed quite interesting to define the extent of circumstantial presence of "opportunist" mycobacteria and nocardia in the soils of school-ground of primary schools and middle-high schools. This communication is the results of pilot study to isolate and identify "opportunist" mycobacteria and nocardia from 504 soil specimens of 72 schools in Seoul City. 1. Of a total of 59 isolates from 504 soil specimens tested, 32 strains were identified as opportunist mycobacteria and 27 strains as nocardia. 2. Isolation rates of opportunist mycobacteria by the areas(of specimen collection) were as follows: 36.4% in the southern area of Han-River, 33.3% in the central area, 22.7% in the outskirt area and 16.6% in the intermediate area. There observed no apparent difference in the isolation rates both-between the areas and between primary schools and middle-high schools. However, a significant difference was noted in the isolation rates between the places of soil sampling in a given school(P<0.05), i.e., the highest was the soil of refuge heaps(15.2%), and tap-water pole area(11.1%), the school-lavatory entrance(9.7%), the school gate entrance(5.5%), and iron-bar play ground(2.7%). The soil specimens from the center of school ground and from school building entrance yielded none of mycobacterial isolates. 3. Isolation rates of nocardia by the areas were as follows: 33.3% in the central area, 31.8% in the outskirt area, 27.3% in the southern ares of Han-River and 11.1% in the intermediate area. As in the case of mycobacteral isolates, there observed no apparent differences in the isolation rates both between the areas and between primary schools and middle-high schools, but a significant difference was noted between the places of soil sampling(P<0.05), i.e., the highest was the soil of school building entrance(15.2%), and of school gate entrance(6.9%), refuge heaps(5.5,%), iron-bar play ground(4.1%), the school-lavatory entrance(2.7%) and tap-water pole area(2.7%), respectively. The soil specimens from the center of, school ground yielded none of nocardia isolates. 4. Of the 32 strains of isolated mycobacteria. 15 strains were slow-growing mycobacteria and the remaining 17 strains belonged to the rapid growers. Of the 15 slow-growers. 4 strains were M. scrofulaceum-szulgai complex, 3 M. gordonae, 4 M. terrae-triviale complex, 2 M. avium-intracellulare-xenopi complex, and 2 unclassified schotochromogens. Of the 17 strains of rapid growers, 12 were M. diernhoferi, 2 M. fortuitum-peregrinum complex, 2 M. vaccae and one M. flavescens. 5. Of the 27 strains of nocardia isolated, 11 strains were N. transvalensis, 5 N. convoluta, 5 N. erythropolis, one N. vaccinii, one N. polychromogens-paraffinae complex and 4 untypable strains of orange-pigmented nocardia spp.

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A Study on Non-point Source Pollutants from Pavement of Coastal Area and Guidance for Selecting BMP (연안지역 포장면 비점오염물질 유출 및 최적관리방안 시설의 선정을 위한 가이던스에 관한 연구)

  • Ko, Woong;Park, Kisoo;Chen, Yaoping;Kim, Youngchul
    • Journal of Wetlands Research
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    • v.15 no.4
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    • pp.543-553
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    • 2013
  • In Korea, there have been many studies and progresses on various types of pilot scale or commercialized field scale Best Management Practices(BMP) during the last 10 years. Runoff characteristics of diffuse pollutants from different land uses are well identified and documented. However, for the coastal area connected directly with shoreline, runoff patterns and management schemes of non-point pollution were not fully studied. Recently, coastal area is emerging as a new development axis especially in west coast side of Korea such as Incheon city and Chungnam province, thus urbanized area rapidly increased but there are no buffer zones and BMP facilities to aim at preventing direct discharge of the first flush into coastal sea and beaches. In this study, parking area in Deacheon harbor, Boryeong City in Chungnam Province was selected and rainfall runoff was monitored for two year period in order to examine run-off features from which proper type of BMP suitable for coastal area is proposed. Coastal area usually has a low ground water level and consists of plain land, so that large scale BMP such as storm water retention pond and wetland requiring great excavation works is not best management plan. In addition, monitoring study shows that storm water from the paved parking area has a high salinity compared with those in storm water from the inland. High salinity is detrimental for the vegetation. Therefore, BMP employing least vegetative cover and also in terms of maintenance is a good option such as infiltration trench and porous pavement.

Study for the meaning of facade as media (디지털영상으로써 미디어파사드의 매체적 의미성 연구)

  • Lee, Jong Han
    • Cartoon and Animation Studies
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    • s.31
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    • pp.209-226
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    • 2013
  • With rapidly changing multimedia environment, various artistic changes and digitalized up-to-date social infra, urban environment construction based on culture contents has been activated. The large image in front of urban building that is expressed as media-façade, increasing rapidly in a recent period, is not a new thing at all. In addition, IT technology molten in city space is testing the possibility of new media through the meeting with architecture. However, unlike its infra enlargement, the definition about media-façade is not clear so the system was constructed in a level of night lightscape or outdoor image advertisement. The purpose of this guideline is the regulation from the negative aspect rather than the possibility of various visual, artistic media expressions. Therefore, it could not show essential concept of media-façade. Moreover, most of companies or building owners focus on short-term profit and marketing effect rather than prepare various contents so they can not use constructed infra properly. After all, in many cases, they discolor the meaning of media-façade. This paper is a pilot study to grasp the current definition of media-façade to construct right guideline of media-façade. On the basis of this study, it will prepare academic definition of media-façade and construct the guideline for design evaluation.

Study on System Evaluations the Location Suitability for Urban Mini-Industrial Complex: Case of Seoul Metropolitan Area (미니 산업단지의 입지적합성 평가 연구: 수도권을 중심으로)

  • Lee, Hyeon-joo;Choi, Dae-sik;Song, Youngil;Lee, Eun-yeob;Kim, Tae-gyun;Kwak, Byoung-jo;Ahn, Jae-seong
    • Journal of the Economic Geographical Society of Korea
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    • v.23 no.3
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    • pp.334-348
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    • 2020
  • Recently, the demand for corporate location in the city is increasing. Due to the difficulty of finding a large site in the city, the small-scale 'mini-industrial complex' would be appropriate as a future industrial complex type. In response to this, site suitability indicators was prepared and applied to the metropolitan area as a pilot. To this end, the under-utilized site were assumed as potential candidates for development. After analyzing the importance among indicators through a questionnaire from experts and companies, this was applied as a weight. As a result, candidate sites ranging from Grade 1 to Grade 4 were derived. The indicators that had a great influence on the location identified as a Grade 1 were transport accessibility and urban service conditions when the company weight was applied, whereas advanced knowledge industry and university/research center when applying expert weight. The Seoul-south axis and southwest axis of Gyonggi-Do were identified as the most excellent mini-industrial complex locations among the Seoul metropolitan areas. It means that the already formed knowledge industry clusters will be recognized as competitive future industrial locations.