• 비료회보
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• 통권498호
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• pp.16-30
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• 1999

• 비료회보
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• 통권501호
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• pp.18-28
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• 1999

• Maxillofacial Plastic and Reconstructive Surgery
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• 제33권3호
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• pp.270-275
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• 2011

Pierre Robin Sequence (PRS) is known as an anomaly consisting of respiratory obstruction with glossoptosis, micrognathia and cleft palate in a newborn. The etiology of PRS is not known, but several factors may be involved simultaneously. Mortality rate of PRS is about 5~30% and the treatment method is divided into both conventional treatments and surgical interventions. If the respiratory obstruction is not resolved by the conventional method, surgical treatment, such as subperiosteal release of the floor of the mouth, tongue-lip adhesion, tracheostomy, distraction osteogenesis may be needed. This study reports a case of PRS in a newborn male at 20 days, with dyspnea and feeding difficulties. Clinical examination showed micrognathia with glossoptosis and cleft palate as the typical PRS triad. We tried surgical intervention with subperiosteal release of the floor of the mouth and tongue-lip adhesion and surgery was successful. At $19^{th}$ months, we also repaired the incomplete cleft palate successfully using 2-Flap palatoplasty.

• 한국자원식물학회지
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• 제26권5호
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• pp.652-657
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• 2013

국내 유통되는 한약재를 이용한 신장질환의 예방 및 치료제 개발을 위한 기초 자료를 제시하고자 경동시장에서 구입한 63종의 한약재 추출물을 이용하여 항산화 활성 및 사구체혈관간 세포의 증식억제능 탐색 활성을 확인하였다. 그 결과 강진향, 고련피, 대풍자, 목향이 RMC 세포의 증식을 50% 이상 억제하는 것으로 나타났고, ORAC와 DPPH assay를 통한 항산화 활성을 확인한 결과 백단향, 백렴이 가장 우수한 ORAC 활성 효능을 보였으며, DPPH 라디칼 소거활성에서는 계혈등, 귀전우, 대풍자, 반대해, 백단향, 백렴이 우수한 효능을 나타냈다. 이 중 대풍자 추출물과 목향 추출물은 항산화 활성과 사구체혈관간세포 증식억제능 모두 뛰어난 효능을 나타냈으나, 목향이 함유하고 있는 aristolochic acid는 임상적으로 신장에 독성을 일으켜 신장질환 치료제에서 제외되는 한약재로 알려져 있다. 따라서, 가장 뛰어난 효능을 보인 대풍자 추출물은 신장질환 치료 및 예방을 위한 한약재 후보물질로서 분획별 항산화 활성과 유효성분 규명의 연구가 요구된다.

• Archives of Plastic Surgery
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• 제38권4호
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• pp.547-551
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• 2011

Purpose: Pierre Robin sequence is a congenital malformation in which micrognathia causes glossoptosis and airway obstruction. If conservative treatment fails, surgical procedures such as tongue-lip adhesion can be performed. However, this procedure remains a subject of debate, with favorable results being countered by reports of complications. To overcome the above limitations, we revised the traditional method of tongue-lip adhesion using an alveolar protector. Methods: Between 1992 and 2011, a total of eight patients were identified with Pierre Robin sequence and were treated with tongue-lip adhesion. Two of these eight tongue-lip adhesion procedures were performed with an alveolar protector. The operative technique for tongue-lip adhesion was similar to that described in other published reports. The alveolar protector was inserted between the ventral surface of the tip of the tongue and the lower labial sulcus. Results: Tongue-lip adhesion failed in two patients because of wound dehiscence. The primary surgical success rate was 66.7%. In the two tongue-lip adhesion procedures performed with the alveolar protector, we observed no postoperative complications. Conclusion: Resistance to traction of the tongue can be encountered with nonunionized symphysis menti, causing loosening of the traction suture through the symphysis menti. This can lead to backward positioning of tongue, resulting in dehiscence of tongue lip adhesion. The alveolar protector is a good adjunct to tongue-lip adhesion because this method avoids postoperative loosening of the traction suture and wound dehiscence. It is a simple and effective auxiliary method that yields functional improvement.

• Imaging Science in Dentistry
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• 제49권4호
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• pp.323-329
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• 2019

Pierre Robin sequence (PRS) is characterized by the triad of micrognathia, glossoptosis, and airway obstruction. PRS does not have a single pathogenesis, but rather is associated with multiple syndromes. This report presents the case of a 35-year-old woman with PRS and scoliosis. Among the syndromes related to PRS, cerebro-costo-mandibular syndrome (CCMS), which is characterized by posterior rib gap defects and vertebral anomalies, was suspected in this patient. However, no posterior rib gap defect was detected on radiological examinations. Although over 80 cases of CCMS have been reported to date, few cases of PRS with scoliosis alone have been reported. Therefore, this report demonstrated the clinical, radiological, and cephalometric characteristics of an adult patient with PRS and scoliosis, but without rib anomalies.

• 천문학회보
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• 제26권1호
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• pp.27.2-27.2
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• 2001

• 원자력산업
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• 제24권6호통권256호
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• pp.62-67
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• 2004

• 한국조명전기설비학회지:조명전기설비
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• 제3권2호
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• pp.12-15
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• 1989

• 한국미생물학회:학술대회논문집
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• 한국미생물학회 2003년도 International Meeting of the Microbiological Society of Korea
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• pp.3-3
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• 2003