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http://dx.doi.org/10.7732/kjpr.2013.26.5.652

Screening of Traditional Medicines for Antioxidative and Anti-proliferative Effects on Rat Mesangial Cells  

Sohn, Eun-Hwa (Department of Herbal Medicine Resources, Kangwon National University)
Jang, Seon-A (Department of Life Science, Gachon University)
Woo, Han Goo (Department of Life Science, Gachon University)
Koo, Hyun Jung (Department of Life Science, Gachon University)
Han, Hyo-Sang (Department of Health Administration, Joongbu University)
Kang, Se Chan (Department of Life Science, Gachon University)
Publication Information
Korean Journal of Plant Resources / v.26, no.5, 2013 , pp. 652-657 More about this Journal
Abstract
In the present study, anti-oxidative and the RMC proliferation inhibitory propeties of 80% ethanol extracts from 63 kinds of traditional medicines were investigated. Inhibitory effects of RMC proliferation were showed that Dalbergia odorifera T. Chen., Melia azedarach Linn$\acute{e}$ and Hydnocarpus anthelmintica Pierre. Among them Hydnocarpus anthelmintica Pierre had the highest anti-oxidative activity ($ORAC_{PE\;value}=1.6$, DPPH = 81.1), but Dalbergia odorifera T. Chen. and Melia azedarach Linn$\acute{e}$ had no effects. These results suggest that the Hydnocarpus anthelmintica Pierre could prevent or protect from kidney disease as antioxidant and anti-proliferative agent for RMC.
Keywords
Oxygen radical absorbance capacity (ORAC); Hydnocarpus anthelmintica Pierre; Rat mesangial cell (RMC); Renal failure;
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