• Natural Product Sciences
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• v.13 no.3
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• pp.186-189
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• 2007

The aerial parts of Verbascum sinaiticum Benth. (Scrophulariaceae) yielded two iridoids that were idenified as ajugol 3 and aucubin 4. Also, investigation of the flavonoid constituents revealed the isolation and identification of luteolin 1 and chrysoeriol-7-glucoside 2. All the isolated compounds were identifid by spectroscopicmethods (UV, MS, $^{1}H-NMR$ and $^{13}C-NMR$) and in comparison with the literature data. Both alcohol and methylene chloride/methanol extracts (1 : 1) exhibited a hepatoprotective effect by $CCl_{4}challenge$ test.

• Natural Product Sciences
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• v.6 no.2
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• pp.91-95
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• 2000

A phytochemical investigation of the aqueous ethanolic flower extract of Tamarix tetragyna led to the isolation and characterization of the hitherto unknown conjugates, kaempheride 3,7-dipotassium sulphate and kaempferol 3,4'-dipotassium sulphate as well. Twelve known flavonol compounds, including kaempheride 3-potassium sulphate and kaempheride $3-O-{\beta}-glucuronide$ were also isolated and identified. $^1H-\;and\;^{13}C-NMR$ spectra for the known kaempheride derivatives have been recorded and assigned for the first time. Structures of all compounds were established by conventional methods of analysis and confirmed by $^1H-,\;^{13}C-NMR$ and mass spectral analysis.

• Natural Product Sciences
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• v.21 no.2
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• pp.71-75
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• 2015

In this study, phytochemical investigation on the aerial parts of Bupleurum falcatum resulted in the isolation of fourteen compounds including three quinic acid derivatives (1 - 3), five flavonoids (4 - 8), three monoterpene glycosides (9 - 11), and three saikosaponins (12 - 14). Compound 1 was first isolated from nature and unambiguously determined to be 3-O-feruloyl 5-O-caffeoylquinic acid on the basis of the extensive spectroscopic evidence. Biological testing revealed that saikosaponin A (12) and saikosaponin D (13) showed moderate antiproliferative effects on HL-60 and HepG2 cancer cell lines.

• Natural Product Sciences
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• v.16 no.4
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• pp.211-216
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• 2010

A new 3-indolyl propionate alkaloid; (-) abrine (1), was isolated from the alcohol extract of Erythrina caffra stem bark together with the alkaloid (-) hypaphorine (2). Phytochemical investigation of the chloroform extract led to the isolation of one fatty alcohol; 1-octacosanol, isolated for the first time from genus Erythrina, two dienoid alkaloids; erythraline and erysodine, and three isoflavonoids; 3S (+) 2'-O-methylphaseollidinisoflavan (3), (6aR, 11aR)- 3-hydroxy-10-dimethylallyl-9-methoxypterocarpan, known as sandwicensin (4) and 3R (-) rythbidin A (5). It is worth mentioning that this is the first report for the isolation of these isoflavonoids from E. caffra. The absolute configuration of 3S (+) 2'-O-methylphaseollidinisoflavan (3) was not previously reported. The isolated isoflavonoids showed promising antibacterial activity against Staphylococcus aureus.

• Natural Product Sciences
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• v.11 no.4
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• pp.240-247
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• 2005

Phytochemical investigation of the berries of Juniperus phoenicea led to the isolation of 4 compounds, namely; scutellarin, isoscutellarin, shikimic acid and the new palmitoyl lactone derivative 16-hydroxy palmitic-1,16-olide. This is the first report for the occurrence of these compounds in the species grown in Libya. The identification of the isolated compounds was based on the application of different spectroscopic techniques. In addition, the antihepatotoxic effect of the aqueous decoction of the berries was investigated.

• Archives of Pharmacal Research
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• v.27 no.9
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• pp.944-946
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• 2004

Phytochemical investigation of the aqueous extract of ~he roots of Agrimania pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agri-monolide (1) and agrimonolide 6-O-$\beta$-D-glucoside (3), and (＋)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC$_{50}$ values of 88.2$\pm$2.8 and 37.7$\pm$1.6 $\mu$M, respectively.y.

• YAKHAK HOEJI
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• v.32 no.4
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• pp.281-286
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• 1988

For the investigation of medicinal resources in Hydrocotyle species, the studies were conducted to evaluate the pharmaco-constituents in Hydrocotyle japonica MAKINO (Umbelliferae), which is used as folk medicine in Korea. From the methyl alcohol extract of the whole plant, $isorhamnetin-3-O-{\beta}-D-galactoside$ ($C_{22}H_{22}O_{12}{\cdot}1/3H_2O$, bright yellow needle crystal, mp $247{\sim}248^{\circ}C$, $[{\alpha}]_D^{28}^{\circ}=-52.27^{\circ}$ in pyridine), one of three flavonol substances in extrat, was isolated and identified by physicochemical properties and spectroscopic evidences (UV, IR, NMR and MS etc.,) in comparison with authentic sample. This flavonoid was appeared from Hydrocotyle japonica MAKINO through phytochemical approaches at the outset.

• Archives of Pharmacal Research
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• v.28 no.1
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• pp.44-48
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• 2005

Phytochemical investigation of the MeOH extract of the root barks of Cudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activity in vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4). All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds 1, 2, and 4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.

• Natural Product Sciences
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• v.9 no.4
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• pp.245-248
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• 2003

A phytochemical investigation on the methanolic extract of Cosmos caudatus has led to the isolation of quercetin $3-O-{\beta}-D-arabinofuranoside$ (1), quercetin $3-O-{\beta}-D-rhamnoside$ (2), quercetin $3-O-{\alpha]-D-glucoside$ (3) and quercetin (4). These compounds were shown to be the antioxidative constituents of the plant when evaluated using the ferric thiocyanate (FTC) and thiobarbituric acid (TBA), and radical scavengers based on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assays.

• Natural Product Sciences
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• v.24 no.2
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• pp.115-118
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• 2018

Herein, we reported the phytochemical investigation of whole thallus Sumatran lichen, Stereocaulon graminosum Schaer, and isolated a mono aromatic compound, ethyl haematommate (1). The structure of compound 1 have been established based on spectroscopic data and confirmed by single crystal X-ray structure analysis.