Browse > Article

Phytochemical and Biological Studies on Verbascum sinaiticum Growing in Egypt  

Mahmoud, Samia M. (Phytochemistry Dept., National Research Centre)
Abdel-Azim, Nahla S. (Phytochemistry Dept., National Research Centre)
Shahat, Abdelaaty A. (Phytochemistry Dept., National Research Centre)
Ismail, Shams I. (Phytochemistry Dept., National Research Centre)
Hammouda, Faiza M. (Phytochemistry Dept., National Research Centre)
Publication Information
Natural Product Sciences / v.13, no.3, 2007 , pp. 186-189 More about this Journal
Abstract
The aerial parts of Verbascum sinaiticum Benth. (Scrophulariaceae) yielded two iridoids that were idenified as ajugol 3 and aucubin 4. Also, investigation of the flavonoid constituents revealed the isolation and identification of luteolin 1 and chrysoeriol-7-glucoside 2. All the isolated compounds were identifid by spectroscopicmethods (UV, MS, $^{1}H-NMR$ and $^{13}C-NMR$) and in comparison with the literature data. Both alcohol and methylene chloride/methanol extracts (1 : 1) exhibited a hepatoprotective effect by $CCl_{4}challenge$ test.
Keywords
Flavonoids; Hepatoprotection; Iridoides; Verbascum sinaiticum;
Citations & Related Records

Times Cited By SCOPUS : 2
연도 인용수 순위
1 Roberts, E.A., Letarte, M., Squire, J., and Yang, S., Characterization of human hepatocyte lines derived from normal liver tissue. Hepatology, 19(6) 1390-1399 (1994)   DOI   ScienceOn
2 Kiso, Y., Toihkin, M., and Hikino, H., Assay method for antihepatotoxicity using primary cultured hepatocytes. Planta Med., 49, 222-225 (1983)   DOI   ScienceOn
3 Seglen, P.O., Preparation of isolated rat liver cells. Methods Cell Biol., 13, 29-83 (1976)   DOI
4 Seifert, K., Lien, N.T., Schmidt, J., John, S., Popov, S.S., and Porzel, A., Iridoide aus Verbascum pulverulentum. Planta Med. 55(5), 470-473 (1989)   DOI   ScienceOn
5 Chang, I.M., Ryu, J.C., Park, Y.C., Yun-Choi, H.S., and Yang, K.H., Protective Activities of aucubin against carbon tetra chloride-induced liver damage in mice. Drug Chem. Toxicol. 6 (5), 443-453 (1983)   DOI
6 Trim, A.R. and Hill, R., The preparation and properties of aucubin, asperuloside and some related glycosides. Biochem. J. 50, 310-319 (1952)   DOI   PUBMED
7 Agostini, A., Guiso, M., Marini-Bettolo, R., and Martinazzu, G.; 5'- deoxylamioside, a new iridoid glucoside from Lamium amplexicaul L. and reassignment of HO-C (6) configuration of ajugol. Gazz. Chem. Ital. 112, 9-12 (1982)
8 Boulos, L., Flora of Egypt, Al Hadara Publishing, Cairo, Egypt, 3, 55-59 (2002)
9 Vesper, T. and Seifert, K., Iridoids from Verbascum nigrum. Liebigs Ann. Chem. 7, 751-753 (1994)
10 Bianco, A., Guiso, M., Iavarone, C., Passacantilli, P., and Troglo, C., Iridoids XXV. New iridoid glucosides from Rubiaceae. Gazz. Chim. Ital. 108, 13 (1978)
11 Taekholm, V., (ed.) Students Flora of Egypt, pp. 484-486, 1974
12 Klimek, B. 6-0-apiosyl-verbascoside in the flowers of mullein (Verbascum Species) Acta Poloniae Pharmaceutica-Drug Research 53(2) 137-140 (1996)