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An Isocoumarin with Hepatoprotective Activity in Hep G2 and Primary Hepatocytes from Agrimania pilosa  

Park, Eun-Jeon (College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Oh, Hyun-Cheol (Laboratory of Cell Signaling Regulation, Korea Research Institute of Bioscience and Biotechnology)
Kang, Tai-Hyun (College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Sohn, Dong-Hwan (College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Kim, Youn-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang University)
Publication Information
Archives of Pharmacal Research / v.27, no.9, 2004 , pp. 944-946 More about this Journal
Abstract
Phytochemical investigation of the aqueous extract of ~he roots of Agrimania pilosa Ledeb. (Rosaceae), as guided by hepatoprotective activity in vitro, furnished two isocoumarins, agri-monolide (1) and agrimonolide 6-O-$\beta$-D-glucoside (3), and (＋)-catechin (2). Compound 1 showed hepatoprotective effects on both tacrine-induced cytotoxicity in human liver-derived Hep G2 cells and tert-butyl hydroperoxide-induced cytotoxicity in rat primary hepatocytes with EC$_{50}$ values of 88.2$\pm$2.8 and 37.7$\pm$1.6 $\mu$M, respectively.y.
Keywords
Agrimania pilosa; Rosaceae; Isocoumarin; Agrimonolide; Hepatoprotective;
Citations & Related Records

Times Cited By Web Of Science : 11  (Related Records In Web of Science)
Times Cited By SCOPUS : 10
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