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Hepatoprotective Constituents of Cudrania tricuspidata  

Tian Yu-Hua (College of Pharmacy and Phytofermentation Research Center, Wonkwang university)
Kim Hyun-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang university)
Cui Jiong-Mo (College of Medicine, Yanbian University)
Kim Youn-Chul (College of Pharmacy and Phytofermentation Research Center, Wonkwang university)
Publication Information
Archives of Pharmacal Research / v.28, no.1, 2005 , pp. 44-48 More about this Journal
Abstract
Phytochemical investigation of the MeOH extract of the root barks of Cudrania tricuspidata Bureau (Moraceae), as guided by hepatoprotective activity in vitro, furnished four isoprenylated xanthones, cudratricusxanthone A (1), cudraxanthone L (2), cudratricusxanthone E (3), and macluraxanthone B (4). All of these compounds showed the significant hepatoprotective effect on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Compounds 1, 2, and 4 also exhibited the significant hepatoprotective effect on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells.
Keywords
Cudrania tricuspidata; Moraceae; Isoprenylated xanthone; Hepatoprotective; Hep G2 cells;
Citations & Related Records

Times Cited By Web Of Science : 13  (Related Records In Web of Science)
Times Cited By SCOPUS : 14
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