• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2016년도 춘계학술대회
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• pp.715-717
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• 2016

현재 암 환자들을 대상으로 하는 항암치료법은 나노입자, 폴리머 중합체, 지질, 리포솜 등을 치료 전달체로 이용하여 항암치료를 진행하는 방법들이 주로 활발하게 사용되고 있다. 이러한 전달체는 항암 치료제를 직접 암세포로 정확하게 표적 운반하는 정확성, 정확하게 운반한 후 선택적으로 항암 치료제를 방출해야하는 유출제어, 다른 일반 세포들을 약물로부터 안전하게 보호하는 기능 등을 동시에 가지고 있어야 하지만, 대부분 생산과정에서 많은 유해한 화학약품을 사용하며 이로 인한 독성을 유발하는 많은 사례가 빈번하게 발생하고 있다. 따라서 본 논문에서는 겸형 적혈구를 응용한 새로운 항암 전달체로서의 가능성을 타진하고 새로운 항암치료의 방법을 제시하고자 한다.

• 대한두경부종양학회지
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• 제19권1호
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• pp.21-24
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• 2003

Objectives: In this report, we confirmed the distributed pattern of ALA and ALA-methylester in normal and tumor-bearing region. Materials and Methods: ALA and ALA-methylester were administered to nude mouse by intratumoral, subcutaneous and intravenous injection. After injection, the fluorescence in normal and tumor region was measured by LESA (laser electronic spectrum analyzer). Results: The tumor-specificity of ALA and ALA-methylester was shown in the case of intratumoral injection. In all case, the fluorescence caused by ALA and ALA-methylester was maximally increased in 2 hours after injection. Then while the fluorescence level was rapidly decreased to control level in normal region, it was still remained in tumor region. Conclusion: According to this result, The intratumoral injection was more efficient administration method for PDT/PDD than subcutaneous and intravenous injection.

• Bulletin of the Korean Chemical Society
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• 제7권2호
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• pp.120-124
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• 1986

In order to investigate effective solar energy conversion system, the light-induced electron transfer reactions have been examined across single-lamellar liposomes incorporated organic photosensitizers such as anthracene and naphthalene derivatives. We have observed photosensitized reduction of methyl viologen (1,1'-dimethyl-4,4'-$bipyridinium^{2+}$) dissolved in the exterior aqueous phase of the pigmented phospholipid liposomes when EDTA, as electron donor, is dissolved in the enclosed aqueous phase of the liposomes. The anthroyl stearic acid incorporated in the hydrophobic bilayer of liposomes leads to much less quantum yield for the photosensitized reduction of $MV^{2+}$ than the anthracene carboxylate incorporated in the outer hydrophilic layer. However, ${\beta}$-carotene with anthroyl stearic acid incorporated into the bilayer enhances the quantum yield significantly (${\Phi}{\simeq}0.2-0.3$), preventing the reverse reaction of electron transfer ($MV^+_\ {\rightarrow}MV^{2+}$) so that it might be useful for solar energy conversion into chemical energy. A naphthalene derivative, octadecyl naphthylamine sulfonic acid incorporated into the outer layer of liposomes results in less efficiency of $MV^{2+}$ reduction than anthroyl stearic acid. These results have been also tested with respect to lipid components of liposomes.

• Journal of Gastric Cancer
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• 제20권4호
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• pp.355-375
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• 2020

Selective accumulation of a photosensitizer and the subsequent response in only the light-irradiated target are advantages of photodynamic diagnosis and therapy. The limited depth of the therapeutic effect is a positive characteristic when treating surface malignancies, such as peritoneal carcinomatosis. For photodynamic diagnosis (PDD), adjunctive use of aminolevulinic acid- protoporphyrin IX-guided fluorescence imaging detects cancer nodules, which would have been missed during assessment using white light visualization only. Furthermore, since few side effects have been reported, this has the potential to become a vital component of diagnostic laparoscopy. A variety of photosensitizers have been examined for photodynamic therapy (PDT), and treatment protocols are heterogeneous in terms of photosensitizer type and dose, photosensitizer-light time interval, and light source wavelength, dose, and dose rate. Although several studies have suggested that PDT has favorable effects in peritoneal carcinomatosis, clinical trials in more homogenous patient groups are required to identify the true benefits. In addition, major complications, such as bowel perforation and capillary leak syndrome, need to be reduced. In the long term, PDD and PDT are likely to be successful therapeutic options for patients with peritoneal carcinomatosis, with several options to optimize the photosensitizer and light delivery parameters to improve safety and efficacy.

• 치위생과학회지
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• 제8권3호
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• pp.109-115
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• 2008

치과용 가시광선 중합형 복합수지의 광중합효율을 높이기 위해 2종의 새로운 액체형 amine 개시제인 MA, MPT와 현재 가장 많이 사용되고 있는 개시제인 AEM을 CQ, PD, DA에 각각 첨가하고 UDMA의 광중합효율을 알아본 결과 다음과 같은 결론을 얻었다. 1. 조사시간이 증가됨에 따라 amine 개시제의 종류에 관계없이 광중합효율이 점차 증가되었으며, 약 60초까지 조사였을 때에는 광중합효율이 급격히 증가되었으나 그 이상 조사하여도 광중합효율이 크게 증가되지 않았다. 2. AEM, MA와 MPT를 사용하였을 경우 모두 CQ > PD > DA의 순으로 광중합효율이 우수하게 나타났으나 AEM을 사용하였을 때 PD와 CQ는 큰 차이를 보이지 않았다. 3. CQ의 광중합효율은 새로운 광개시제인 MA와 MPT를 사용하였을 때가 범용으로 사용되고 있는 amine 개시제인 AEM을 사용하였을 경우보다 중합효율이 증가하는 결과를 보였다. 4. PD의 광중합효율은 MA와 함께 사용하였을 경우가 가장 높게 나타났으나 AEM의 경우와 큰 차이를 보이지는 않았다. 5. 이상의 결과로부터 MA와 CQ 및 PD를 함께 사용한 새로운 광중합시스템이 광중합효율을 높이는데 효율적인 것을 알 수 있었다.

• 한국식품과학회지
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• 제42권3호
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• pp.277-280
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• 2010

내분비교란물질인 BPA는 식품의 포장용기나 젖병 등의 제조에 이용되며, 라이보플라빈 광산화에 의해 안정성이 감소하는 것으로 보고된 바 있다. 본 연구에서는 광산화 시 메틸렌블루, 로즈벵갈, 라이보플라빈, 또는 이산화티타늄 등의 감광제 종류에 따른 BPA안정성을 비교하였고, sodium azide($NaN_3$) 농도에 따른 BPA안정성을 확인하였다. BPA 농도는 라이보플라빈, 로즈벵갈, 메틸렌블루 순서로 유의적으로 감소하였지만(p<0.05), 이산화티타늄 첨가 시료와 대조구인 감광제 무첨가군의 BPA 농도는 유의적인 차이가 없었다(p>0.05). BPA의 안정성은 메틸렌블루 농도 의존적으로 감소하였으며, $NaN_3$ 농도가 증가할수록 BPA 안정성은 증가하였다. 이는 메틸렌블루 광산화에 의한 BPA농도 감소에 일중항산소가 관여함을 의미한다.

• Journal of Periodontal and Implant Science
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• 제44권6호
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• pp.280-287
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• 2014

Purpose: The purpose of this randomized single-blind controlled trial was to elucidate the clinical and antimicrobial effects of daily phototherapy (PT) as an adjunct to scaling and root planing (SRP) in patients with chronic periodontitis. Methods: The study was conducted from December 2013 to May 2014 at Ewha Womans University Mokdong Hospital, Seoul, Korea. Forty-one patients with mild to moderate chronic periodontitis were randomly divided into two therapeutic groups in a 1:1 ratio: SRP+PT and SRP (control) groups. All participants underwent full-mouth SRP. PT was performed thrice a day for a month by using electric toothbrushes with embedded light-emitting diodes. Plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing were assessed before (baseline) and four weeks after (follow-up) the treatment. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia, Fusobacterium nucleatum, Parvimonas micra, Campylobacter rectus, Eikenella corrodens, Streptococcus mutans, and Streptococcus sobrinus levels were detected by a real-time polymerase chain reaction at the same points in time. Results: The clinical parameters improved in both the groups. At the follow-up assessment, PPD was significantly decreased in the SRP+PT group (P=0.00). Further, PPD and CAL showed significantly greater changes in the SRP+PT group than in the SRP group (PPD, P=0.03; CAL, P=0.04). P. gingivalis and T. forsythia levels decreased in this group, but no significant intergroup differences were noted. Conclusions: Adjunctive PT seems to have clinical benefits, but evidence of its antimicrobial effects is not sufficient. Long-term studies are necessary to develop the most effective PT protocol and compare the effectiveness of PT with and without exogenous photosensitizers.

• 한국균학회지
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• 제17권2호
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• pp.99-104
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• 1989

1. 최적광조사 조건, 470 nm에서 15초 동안 빛을 조사한 미토콘드리아성 ATP synthase는 1mmole DCPI에 의하여 그 활성이 85% 증가되었다. 2. 1mmole DNP, $10\;{\mu}mole$ HHQNO 및 $100\;{\mu}g/ml$의 oligomycin은 이 효소의 활성을 각각 61, 41% 및 12% 억제시켰다. 3. 최적 조건의 빛에 의한 $Fe^{3+}$ 및 $Fe^{2+}$ 이온의 유입효과에서, 5mmole $Fe^{3+}$ 및 0.5mmole $Fe^{2+}$ 이온에 의하여 이 효소 활성이 각각 14% 및 12% 증가되었다. 4. 광증감제인 phenazine methosulfate의 존재하에서 470nm의 빛을 조사한 후의 효소의 활성도가 크게 증가되는 것으로 보아, 미토콘드리아성 ATP synthase내에 미지의 흡광물질이 존재함을 추정할 수 있었다.

• Bulletin of the Korean Chemical Society
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• 제30권1호
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• pp.205-213
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• 2009

This study reports on the geometry optimizations and electronic structure calculations for methyl pyropheophorbide (MPPa), tropolonyl methyl pyropheophorbides (TMPPa, ITMPPa), and cationic tropolonyl methyl pyropheophorbides ($TMPPa^+{{\cdot}BF_4}^-,\;ITMPPa^+{{\cdot}BF_4}^-,\;TMPPa^+,\;and\;ITMPPa^+$) using Local Spin Density Approximation (LSDA/ 6-31G*) and the Restricted Hatree-Fock (RHF/6-31G*) level theory. From the calculated results, we found that substituted cationic tropolonyl groups have larger structural effects than those of substituted neutral tropolonyl groups. The order of structural change effects is $ITMPPa^+ > ITMPPa^+{{\cdot}BF_4}^-$ > ITMPPa, as a result of the isopropyl group. Because it is an electron-releasing group, the substituted isopropyl group electronic effect on a 3-position tropolone increases the Highest Occupied Molecular Orbital and Lowest Unoccupied Molecular Orbital (HOMO-LUMO) energy gap. It was constituted that the larger the cationic characters of these photosensitizers, the smaller the HOMOLUMO band gaps are. The orbital energies of the cationic systems and the ions are stronger than those of a neutral system because of a strong electrostatic interaction. However, this stabilization of orbital energies are counteracted by the distortion of chlorin macrocycle, which results in a large destabilization of chlorin-based compound HOMOs and smaller destabilization of LUMOs as shown in TMPPa (ITMPPa), $TMPPa^+{{\cdot}BF_4}^- (ITMPPa^+{{\cdot}BF_4}^-),\;and\;TMPPa^+\;(ITMPPa^+)$ of Figure 6 and Table 6-7. These results are in reasonable agreement with normal-coordinate structural decomposition (NSD) results. The HOMO-LUMO gap is an important factor to consider in the development of photodynamic therapy (PDT).

• 대한약리학회지
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• 제30권3호
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• pp.331-336
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• 1994

본 연구의 목적은 광 유도에 의한 nitric oxide (PIANO)유리가 혈관이완에 대해 cyclic GMP (cGMP)가 관여하는 지의 여부와 아울러 ${\alpha}$-수용체를 통한 수축에 PIANO가 어떻게 작용하는 지를 파악하고자 하였다. In vitro 실험에서 흰쥐의 대동맥을 준 최고농도의 phenylephrine (PE)으로 수축시킨 후 nitric oxide 생성을 변화시키는 약물이나 광민감성 (photosensitizing) 약물에 대한 반응을 등장력 변화로 기록하였다. PIANO에 의한 혈관이완은 광노출 강도와 기간 및 광민감성 약물농도에 비례하여 증가하였고 cGMP의 증가를 수반하였다. PE에 의해 증대되는 phosphatidylinositide(PI) 전환은 PIANO에 의해 억제되었다. 이상의 결과는 cGMP의 증가로 인해 PIANO에 의한 혈관이완이 일어나며 ${\alpha}$-아드레날성 수용체 자극에 의한 PI 전환의 억제현상은 cGMP 증가의 결과로 생각할 수 있다. 결론적으로 PIANO에 의한 혈관이완은 cGMP의 증가로 인함을 확인할 수 있었다.