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Distribution Patterns in the Tumor Tissue and Normal Tissue according to the Administration Methods of ALA and ALA-Methylester  

Chung Phil-Sang (Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine)
Jung Sang-Oun (Depatemtne of Medical Laser Reserch Center, Dankook University College of Medicine)
Ahn Jin-Chul (Depatemtne of Medical Laser Reserch Center, Dankook University College of Medicine)
Lee Sang-Joon (Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine)
Yoon Jun-Sik (Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine)
Publication Information
Korean Journal of Head & Neck Oncology / v.19, no.1, 2003 , pp. 21-24 More about this Journal
Abstract
Objectives: In this report, we confirmed the distributed pattern of ALA and ALA-methylester in normal and tumor-bearing region. Materials and Methods: ALA and ALA-methylester were administered to nude mouse by intratumoral, subcutaneous and intravenous injection. After injection, the fluorescence in normal and tumor region was measured by LESA (laser electronic spectrum analyzer). Results: The tumor-specificity of ALA and ALA-methylester was shown in the case of intratumoral injection. In all case, the fluorescence caused by ALA and ALA-methylester was maximally increased in 2 hours after injection. Then while the fluorescence level was rapidly decreased to control level in normal region, it was still remained in tumor region. Conclusion: According to this result, The intratumoral injection was more efficient administration method for PDT/PDD than subcutaneous and intravenous injection.
Keywords
5-Aminolevulatic acid; Photosensitizers; Tumor specificity;
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