• International Journal of Arrhythmia
• /
• 제18권2호
• /
• pp.66-76
• /
• 2017

Background and Objectives: Although an anterior linear ablation is an effective lesion set in radiofrequency catheter ablation (RFCA) for longstanding persistent atrial fibrillation (L-PeAF), its durability for bidirectional block (BDB) is only about 60% at repeat procedure. We hypothesized that changes in electrocardiogram (ECG) may predict an anterior line block state and the clinical outcome of L-PeAF ablation. Subjects and Methods: We studied 304 L-PeAF patients (77% male, $60{\pm}10yrs$), who consistently underwent RFCA Dallas lesion set (circumferential pulmonary vein isolation, posterior box lesion, and anterior line) protocol with subsequent comparison of pre-procedural and post-procedural P wave axes, and one year follow-up (n=205) sinus rhythm (SR) ECGs. Results: 1. P wave axis shifted inferiorly at immediate post-procedure (p<0.001), and was independently correlated with BDB of anterior line (${\ss}=10.4$, 95% confidence interval [CI] 2.79-17.94, p=0.008). 2. The degree of post-procedural inferior shift of P wave axis did not reflect clinical recurrence within one-year (n=205, p=0.923), potentially due to conduction recovery of an anterior line. However, among 160 patients without clinical recurrence within one-year, P wave axis at one-year ECG was independently associated with very late recurrence of AF after one-year (n=160, hazard ratio [HR] 0.98; 95% CI 0.97-0.99, p=0.001), during $45.6{\pm}16.7$ months of follow-up. 3. Among 22 patients who underwent repeat procedures, P wave axis shift was more significant in patients with maintained BDB of an anterior line than in those without (p=0.015). Conclusion: An inferior shift of P wave axis reflects the achievement and the maintenance of an anterior line BDB, and is associated with better long-term clinical outcome after catheter ablation for L-PeAF based on Dallas lesion set.

• 한국재료학회지
• /
• 제30권8호
• /
• pp.413-420
• /
• 2020

Lu₃Al_5-xGa_xO₁₂:Ce³⁺,Cr³⁺ powders are prepared using a solid-state reaction method. To determine the crystal structure, Rietveld refinement is performed. The results indicate that Ga³⁺ ions preferentially occupied tetrahedral rather than octahedral sites. The lattice constant linearly increases, obeying Vegard's law, despite the strong preference of Ga³⁺ for the tetrahedral sites. Increasing x led to a blue-shift of the Ce³⁺ emission band in the green region and a change in the emission intensity. Persistent luminescence is observed from the powders prepared with x = 2-3, occurring through a trapping and detrapping process between Ce³⁺ and Cr³⁺ ions. The longest persistent luminescence is achieved for x = 2; its lifetime is at least 30 min. The findings are explained using crystal structure refinement, crystal field splitting, optical band gap, and electron trapping mechanism.

• 한국재료학회지
• /
• 제13권10호
• /
• pp.673-676
• /
• 2003

We have investigated $Al_{x}$ $Ga_{l-x}$ N/GaN epilayers (x = 0.08, 0.15) grown by metal organic vapor phase epitaxy on sapphire with photoluminescence(PL), and persistent photoconductivity(PPC) experiments. An anomalous S-shaped shift behavior of temperature dependencies of PL peak energy is observed for the x = 0.15 sample. In PPC measurement, showed that the dark current recovery time of $Al_{x}$$Ga_{l-x}$ N/GaN epilayers mainly depends on the Al content. These behaviors are usually attributed to the presence of carrier localization states. All these phenomena are explained based on the alloy compositional fluctuations in the $Al_{x}$ /$Ga_{l-x}$ N/ epilayers. The photocurrent quenching observed in PPC measurements for $Al_{x}$ $Ga_{l-x}$ N/ epilayers less than 0.2 $\mu\textrm{m}$ thickness indicates that the presence of metastable state in the bandgap of GaN layer, and that the excess holes in the valence band recombine with free electrons.

• JSTS:Journal of Semiconductor Technology and Science
• /
• 제2권3호
• /
• pp.170-172
• /
• 2002

The epilayer of vertically stacked, self-assembled InAs Quantum Dots (QDs)was grown by MBE with solid sources in non-cracking K-cells, and the sample was fabricated to a FET structure using a conventional technology. The device characteristic and performance were studied. At 77K and room temperature, the threshold voltage shift values are 0.75V and 0.35 V, which are caused by the trapping and detrapping of electrons in the quantum dots. Discharging and charging curves form the part of a hysteresis loop to exhibit memory function. The electrical injection of confined electrons in QDs products the threshold voltage shift and memory function with the persistent electron trapping, which shows the potential use for a room temperature application.

• 생명과학회지
• /
• 제7권3호
• /
• pp.161-166
• /
• 1997

HIV-1 Rev단백질은 바이러스의 구조단백질의 발현조절에 매우 중요한 역할을 하며RNA가 1차발현된 원형대로 또는 일부만이 절단/재조합된 상태로 세포질에 집적되는 것을 가능하게 한다. env gene에 존재하는 Rev-responsive element RNA는 복잡한 RNA구조를 지니면서 Rev의 기능을 위하여 필수적으로 필요시 된다. 그러나 이러한 절차의 완전한 진행을 위해서는 핵단백질이 요구되는 것으로 추정된다. 본 연구에서는 electrophoretic mobility shift, UV-crosslinking 또는 SDS/PAGE등의 실험을 통하여 36/37, 56, 41, 76, 150 kD등의 핵단백질등이 RRE RNA와 결합반응하는 것을 발견하였으며 특히 36/37 과 56 kD 단백질을 5분간의 자외선조사에 의해 특히 RRE RNA에 결합하는 핵단백질들은 gel mobility shift assay에서 Rev RNA인식결합에 경쟁적인 특징을 나타내고 있다.

• 한국산학기술학회논문지
• /
• 제21권9호
• /
• pp.662-671
• /
• 2020

GNSS 상시관측소 고시좌표는 측지기준점으로써의 중요성과 다양한 위성측위 응용 분야의 활용성을 고려할 때 최고의 정확도와 최신성을 갖도록 관리해야 한다. 특히, 지진 등에 따른 지각 변위는 그 크기에 해당하는 만큼 기존 성과에 편의를 유발함으로, 그 영향이 목표 정확도를 초과할 때에는 신속히 새로운 기준 좌표를 산정·제공하는 등 적절한 조치가 필요하다. 본 논문에서는 GNSS 상시관측소 데이터 자동처리 시스템과 연계 구현할 수 있는 칼만 필터에 기반 좌표 시계열의 편의검출 절차와 방법을 연구하였다. 이를 통해 필터 이노베이션과 재추정 시계열에 적용할 수 있는 통계 검정 기법을 구현한 후 과학기술용 GNSS 소프트웨어에 의해 추정한 국내 14개소 상시관측소 2010년~2011년 시계열에 적용해 그 성능과 특징을 파악하였다. 그 결과 통계검정의 오류와 신뢰성을 고려할 때 필터링 시계열에 대한 CUSUM(Cumulative Sum) 검사는 지진 등에 따른 잔류편의 그리고 이노베이션에 대한 광역검정은 특정 에포크에서 발생하는 돌출오차 검출에 효과적인 것으로 분석되었다.

• Journal of Microbiology and Biotechnology
• /
• 제31권10호
• /
• pp.1350-1357
• /
• 2021

Staphylococcus aureus (S. aureus) is a major pathogen that causes human pneumonia, leading to significant morbidity and mortality. S. aureus coagulase (Coa) triggers the polymerization of fibrin by activating host prothrombin, which then converts fibrinogen to fibrin and contributes to S. aureus pathogenesis and persistent infection. In our research, we demonstrate that isovitexin, an active traditional Chinese medicine component, can inhibit the coagulase activity of Coa but does not interfere with the growth of S. aureus. Furthermore, we show through thermal shift and fluorescence quenching assays that isovitexin directly binds to Coa. Dynamic simulation and structure-activity relationship analyses suggest that V191 and P268 are key amino acid residues responsible for the binding of isovitexin to Coa. Taken together, these data indicate that isovitexin is a direct Coa inhibitor and a promising candidate for drug development against S. aureus infection.

• 천문학회보
• /
• 제37권2호
• /
• pp.125.1-125.1
• /
• 2012

The wave number 4 (wave-4) and wave number 3 (wave-3) longitudinal structures in the thermospheric neutral mass density are understood as tidal structures driven by diurnal eastward-propagating zonal wave number 3 (DE3) and wave number 2 (DE2) tides, respectively. However, those structures have been identified using data from limited time periods, and the consistency and recurrence of those structures have not yet been examined using long-term observation data. We examine the persistence of those structures by analyzing the neutral mass density data for the years 2001-2008 taken by the CHAllenging Minisatellite Payload (CHAMP) satellite. During years of low solar activity, the amplitude of the wave-4 structure is pronounced during August and September, and the wave-4 phase shows a consistent eastward phase progression of $90^{\circ}$ within 24 h local time in different months and years. During years of high solar activity, the wave-4 amplitude is small and does not show a distinctive annual pattern, but the tendency of the eastward phase shift at a rate of $90^{\circ}$/24 h exists. Thus the DE3 signature in the wave-4 structure is considered as a persistent feature. The wave-3 structure is a weak feature in most months and years. The amplitude and phase of the wave-3 structure do not show a notable solar cycle dependence. Among the contributing tidal modes to the wave-3 structure, the DE2 amplitude is most pronounced. This result may suggest that the DE2 signature, although it is a weak signature, is a perceivable persistent feature in the thermosphere.

• The Korean Journal of Physiology
• /
• 제6권2호
• /
• pp.1-8
• /
• 1972

A study was planned to see if the mammillary bodies have any influence upon orienting response Thirty-nine male rats were divided into two groups. One group of animals received electrolytic lesion of the mammillary bodies through stereotaxically implanted electrodes (mammillary body group), and the other group received the same treatment short of electrolytic lesion(operated control group). All animals were tested for orienting response 3 weeks after surgery. Orienting response was regarded as elicited when an animal in alertness ceased ongoing activity upon 1,000 Hz tone presentation and/or turned head toward the source of stimulus. Weak (momentary and inconspicuous) and strong (marked and more persistent) responses were discriminated. Occurrence and duration of orienting response were measured, and the rate of habituation was estimated in 20 trials. Shift of attention from sound to light stimulus (10 trials) as well as orienting response of thirsty animals to sound stimulus while drinking (5 trials) and while at rest (5 trials) were also tested. 1. Simple orienting respons to sound stimulus tended to occur more often and its duration tended to be shorter in the mammillary body group than in the operated control group. 2. With repetition of trials, the occurrence of orienting response in each trial decreased progressively in both groups (habituation). However, the rate of habituation was significantly less prominent in the mammillary body group than in the operated control group. 3. Under attention·shift situation, orienting response tended to occur less often and its duration tended to be shorter in the mammillary body group than in the operated control group. 4. Orienting response to sound stimulus while drinking to quench thirst tended to occur more often and its duration tended to be shorter in the mammillary body group than in the operated control group. In quiet state, however, there existed no group difference with regard to the occurrence and duration of the orienting response. Although no obvious inference can be drawn from the above results, they may suggest the mammillary bodies being involved in the orienting response as a control mechanism inhibitory to the occurrence and facilitatory to the habituation of the response.

• 한국지능시스템학회논문지
• /
• 제16권1호
• /
• pp.94-100
• /
• 2006

인터넷을 바탕으로 하는 컴퓨팅 패러다임의 변환은 인터넷에서 디지털 정보 교환의 표준으로 확고한 자리를 굳힌 XML의 사용을 가속화시키고 있다. 이로 인해 XML 데이터의 양이 기하급수적으로 증가하고 보다 효율적으로 XML 데이터를 저장하고 질의하기 위한 연구가 활발히 진행되고 있다. 본 논문에서는 대용량의 데이터 중심 XML를 효과적으로 관리하기 위한 방안으로 그래프 중심의 색인 방법을 연구, 제안한다. 논문에서 제안한 XML 색인은 XML 데이터와 XML 구조 정보를 크게 3개의 구성 성분으로 표현한 후, 메인 메모리 자료구조로 표현된 각 그래프들을 노드 아이디를 키로 사용하여 B+트리에 각 노드를 사상하고 B+트리를 디스크에 저장하여 이들 색인 모델에 대해 지속성을 부여하였다. 본 논문에서 제안한 색인 방법을 통해 XML 데이터의 크기에 따라 질의 처리시간이 선형적으로 증가하는 결과를 얻을 수 있었다.