• Title/Summary/Keyword: Penetration control

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Ganoderma lucidum Pharmacopuncture for the Treatment of Acute Gastric Ulcers in Rats

  • Park, Jae-Heung;Jang, Kyung-Jun;Kim, Cheol-Hong;Lee, Yoo-Hwan;Lee, Soo-Jung;Kim, Bum-Hoi;Yoon, Hyun-Min
    • Journal of Pharmacopuncture
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    • v.17 no.3
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    • pp.40-49
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    • 2014
  • Objectives: The gastric ulcer is a common disorder of the stomach and duodenum. The basic physiopathology of a gastric ulcer results from an imbalance between some endogenous aggressive and cytoprotective factors. This study examined whether Ganoderma lucidum pharmacopuncture (GLP) would provide protection against acute gastric ulcers in rats. Methods: Sprague-Dawley rats were divided randomly into 4 groups of 8 rats each: normal, control, normal saline (NP) and GLP groups. The experimental acute gastric ulcer was induced by using an EtOH/HCl solution and the normal group received the same amount of normal saline instead of ethanol. The NP and the GLP groups were treated once with injections of saline and GLP, respectively. Two local acupoints were used: CV12 (中脘) which is the alarm point of the Stomach Meridian, and ST36 (足三里), which is the sea point of the Stomach Meridian. The stomachs from the rats in each group were collected and analyzed for gross appearance and histology. Also, immunohistochemistry staining for BAX, Bcl-2 and TGF-${\beta}1$ was performed. Results: Histological observations of the gastric lesions in the control group showed comparatively extensive damage of the gastric mucosa and necrotic lesions had penetrated deeply into the mucosa. The lesions were long, hemorrhagic, and confined to the glandular portions. The lesions were measured microscopically by using the clear depth of penetration into the gastric mucosal surface. The length and the width of the ulcer were measured and the inhibition percentage was calculated. Wound healing of the acute gastric ulcer was promoted by using GLP, and significant alterations of indices in gastric mucosa were observed. Such protection was shown by gross appearance, histology and immunohistochemistry staining for BAX, Bcl-2 and TGF-${\beta}1$. Conclusion: These results suggest that GLP administered at CV12 and ST36 can provide significant protection to the gastric mucosa against an ethanol-induced acute gastric ulcer.

Effect of Long Period Usage of Polyolefin Film on Growth and Fruit Quality in Korea Melon(Cucumis melo L. var makuwa Makino) (폴리올레핀계 필름 장기사용이 참외의 생육 및 품질에 미치는 영향)

  • Shin, Yong-Seub;Yeon, Il-Kweon;Lee, Ji-Eun;Cheong, Jong-Do;Choi, Seong-Yong;Chung, Doo-Seok
    • Journal of Bio-Environment Control
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    • v.18 no.1
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    • pp.9-14
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    • 2009
  • This experiment was conducted to investigate the difference among 3-years-used Polyolefin films which were J-1, J-2 and J-3 having differences in film thickness, infrared absorption and ultraviolet penetration from Jan. 16,2006. And 1-year-used Polyethylene film K-1 used from Jan. 16,2008, for covering film of greenhouse for korea melon cultivation. J-2, J-3 and J-1 films were better for keeping heat in order, and J-2 film was the best in plant growth at early stage. The first blooming and harvesting days in J-2 film were earlier 10 days than those in K-1 film. Chromaticity and soluble solid of harvested fruit in J-3, J-1 and J-2 films were higher than those in K-1 film. Marketable yields in J-2, J-1 and J-3 films were higher in order.

Effect of Long Time Usage of Soft Film on the Growth and Yield in Oriental Melon (Cucumis melo L. var makuwa Makino) (연질필름의 장기사용이 참외의 생육 및 수량에 미치는 영향)

  • Shin, Yong-Seub;Yeon, Il-Kweon;Lee, Ji-Eun;Do, Han-Woo;Cheung, Jong-Do;Park, Jong-Wook;Choi, Seong-Yong;Chung, Doo-Seok
    • Journal of Bio-Environment Control
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    • v.19 no.3
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    • pp.135-139
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    • 2010
  • This experiment was conducted to investigate the difference among 3-years-used polyolefin films which were J-l, J-2 and J-2 having differences in film thickness, infrared absorption and ultraviolet penetration from Jan. 16, 2006. And 1-year-used polyethylene film K-1 used from Jan. 16, 2009, for covering film of greenhouse for oriental melon cultivation. J-2, J-3 and J-1 films were better for keeping heat in order, and J-2 film was the best in plant growth at early stage. The first blooming and harvesting days in J-2 film were earlier 15 days than those in K-1 film. Chromaticity and soluble solid of harvested fruit in J-2, J-3 and J-1 films were higher than whose in K-1 film. Marketable yields in J-2, J-3 and J-1 films were higher in order.

Effects of Geometry of Reactor Pressure Vessel Upper Head Control Rod Drive Mechanism Penetration Nozzles on J-Groove Weld Residual Stress (원자로 상부헤드 제어봉구동장치 관통노즐 형상이 J-Groove 용접잔류응력에 미치는 영향)

  • Kim, Ju-Hee;Kim, Yun-Jae;Lee, Sung-Ho;Hur, Nam-Young;Bae, Hong-Yeol;Oh, Chang-Young;Kim, Ji-Soo;Park, Heung-Bae;Lee, Seung-Geon;Kim, Jong-Sung;Huh, Nam-Su
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.35 no.10
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    • pp.1337-1345
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    • 2011
  • In pressurized water reactors (PWRs), the reactor pressure vessel (RPV) upper head contains numerous control rod drive mechanism (CRDM) nozzles. In the last 10 years, the incidences of cracking in alloy 600 CRDM nozzles and their associated welds has increased significantly. Several axial and circumferential cracks have been found in CRDM nozzles in European PWRs and U.S. nuclear power plants. These cracks are caused by primary water stress corrosion cracking (PWSCC) and have been shown to be driven by welding residual stresses and operational stresses in the weld region. Therefore, detailed finite-element (FE) simulations for the Korea Nuclear Reactor Pressure Vessel have been conducted in order to predict the magnitudes of the weld residual stresses in the tube materials. In particular, the weld residual stress results are compared in terms for nozzle location, geometry factor$r_o$/t, geometry of fillet, and adjacent nozzle.

THE EFFECTS OF ND:YAG LASER AND IRRIGANTS ON CANAL SEALING ABILITY (근관치료시 Nd:YAG Laser 사용과 세척액에 따른 치근단 폐쇄효과의 비교)

  • Kim, Jin-Woon;Lee, Hee-Ju;Hur, Bock
    • Restorative Dentistry and Endodontics
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    • v.26 no.4
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    • pp.307-315
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    • 2001
  • The application of Nd:YAG laser and irrigants to the root surface can change its surface configurations. The purpose of this study was to investigate the effects of Nd:YAG laser and irrigants on the apical seal of obturated canals. In this study, 66 single rooted teeth were randomly assigned to 4 group of 14 teeth each. 8 teeth were served us positive and negative controls. The teeth were divided into 6 groups as follows. Group A: Nd:YAG laser, 5% NaOCl + Rc-prep Group B: Nd:YAG laser, Saline Group C: 5% NaOCl + Rc-prep Group D: Saline Group E: Positive control Group F: Negative control 66 teeth were instrumented using Maillefer ProFile$^{\circledR}$ (Orifice Shapers, .04 taper, .06 taper Dentsply, Switzerland). Two of each group were selected at random, and the canal wall surfaces were examined under a SEM. 12 teeth of each group were obturated using by lateral condensation technique. Specimens were immersed in india ink for 7days, decalcified by 10% nitric acid, dehydrated by 75. 80. 85, 90, 95 and 100% alcohol in order cleared by methyl salicylate and then measured of dye penetration with stereomicroscope($\times$15 magnification) and Image Pro plus. The data were analyzed statistically by one-way ANOVA test and Duncan's Multiple Range test. The results were as follows : 1. The mean leakage was 0.128$\pm$0.376 for group A, 0.237$\pm$0.325 for group B, 0.397$\pm$0.468 for group C, 0.586$\pm$0.402 for group D, and there were statistically significant differences between group A and group D, group B and group D. (p<0.05). 2. Group A had better sealing ability than Group C, but there was statistically no significant differences. (p>0.05). 3. Group B had better sealing ability than Group D and there was statistically significant difference. (p<0.05). 4 Group A had better sealing ability than Group B, but there was statistically no significant difference. (p>0.05). 5. Group C had better sealing ability than Group D, but there was statistically no significant difference. (p>0.05). 6. As a result of observation under SEM, Smear layers were removed in Group A, B. but Smear layers were partially removed and smear plugs were remained in Group C, Smear layers were not removed in Group D. To be specially, Melting of smear layer were showed in Group C. 7. These results suggests that the laser has a potential in reducing the apical microleakage of obturated canals.

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Physical Characteristic and In vitro Transdermal Delivery of PCL-b-PEG Micelles Containing Quercetin and Rutin (Quercetin과 Rutin을 함유하는 PCL-b-PEG 고분자 미셀의 특성 및 피부 흡수에 관한 In vitro 연구)

  • Lim, Gyu-Nam;Kim, Sun-Young;Kim, Min-Ji;Park, Soo-Nam
    • Polymer(Korea)
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    • v.36 no.4
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    • pp.420-426
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    • 2012
  • In this study, we prepared polymer micelles containing quercetin and rutin, known as antioxidants, using poly(${\varepsilon}$-caprolactone)-b-poly(ethylene glycol), and evaluated in vitro skin permeation of the active materials. Quercetin and rutin loaded micelles were characterized by DSC (differential scanning calorimetry), HPLC (high performance liquid chromatography) and DLS (dynamic light scattering) measurements. The particle size of the polymer micelles increased in a concentration dependent manner (0.5~2.0% PCL-b-PEG). The Zeta potential of quercetin and rutin loaded micelles remained constant. To evaluate the skin penetration of PCL-b-PEG micelles, Franz diffusion cell experiment was performed. The aqueous solutions of quercetin and rutin were used as the control groups. Quercetin and rutin loaded PCL-b-PEG micelles showed more efficient skin permeation than the control groups. Safety assessment (patch test) of quercetin and rutin loaded PCL-b-PEG micelles on skin was performed to test application possibility of the polymer micelles to cosmetics. Any adverse symptoms were not observed.

The Effect of Self Swallowing Exercise Program with Neuromuscular Electrical Stimulation(NMES) on Swallowing Function of Dysphagia (신경근 전기자극치료와 함께 적용된 자가 삼킴 운동 프로그램이 삼킴 장애 환자의 삼킴 기능 향상에 미치는 효과)

  • Yoon, In-Jin;Kim, Du-Ri;Cho, Young-Moon
    • The Journal of Korean society of community based occupational therapy
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    • v.5 no.1
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    • pp.23-34
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    • 2015
  • Objective : The purpose of this study is to investigate the effect of self swallowing exercise program with neuromuscular electrical stimulation(NMES) on swallowing function. Methods : Subjects who were diagnosed in dysphagia were randomly divided into the control group or experimental group. Both group were received NMES during 60 minutes with traditional swallowing therapy during 30 minutes. Additionally the experimental group was received self swallowing exercise during 30 minutes. We invested subject's characteristics through medical chart. We used VDS(Videofluoroscopic Dysphagia Scale) and PAS(Penetration Aspiration Scale) for assessing the swallowing function. Results : There were not significantly different in both group's pre swallowing function. The control group was significantly improved on pyriform sinus residue, aspiration, and VDS total score(p<.05). The experimental group was significantly improved on vallecular residue, pyriform sinus residue, and VDS total score(p<.05). Both group's difference of pre and post swallowing function were not significantly different. Conclusion : Self swallowing exercise and traditional swallowing therapy with NMES and traditional swallowing therapy with NMES are positive effect on swallowing function. The self swallowing exercise is not effective factor.

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Strength of Recycled Concrete with Furnace Slag Cement under Steam Curing Condition (순환골재 및 고로슬래그 시멘트를 사용한 증기양생 콘크리트의 강도 특성)

  • Lee Myung-Kue;Kim Kwang-Seo;Lee Keun-Ho;Jung Sang-Hwa
    • Journal of the Korea Concrete Institute
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    • v.17 no.4 s.88
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    • pp.613-620
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    • 2005
  • There are some problems in utilizing recycled concrete aggregate go structural use because of the difficulties concerning about quality control and durability. It seems to be possible to utilize recycled concrete aggregate for making concrete products because quality control of concrete products is easier than ready-mixed concrete, but there are little studies about the properties of the steam-cured recycled aggregate concrete. In this study, various tests were performed such as compressive strength, flexural strength, splitting tensile strength, bonding strength and chloride ion penetration test to evaluate the effect of substitution of recycled concrete aggregate. The results of strength test showed that the concrete strength decreased with the increase of the substitution ratio of recycled concrete aggregate, but it was in the reasonable range and almost equal to that of normal concrete below the substitution ratio of $50\%$. On the other hand, strength test of furnace slag cement concrete shows that the strength of recycled concrete with furnace slag cement under curing condition lower than that of recycled concrete with ordinary portland cement under same condition. From the result of this study, it can be concluded that recycled concrete aggregate is able to be utilized for structural use but substitution ratio should be decided with care in each case. The result of this study could be used as the basic data for the structural use of recycled concrete aggregate.

Effect of Calcium Chloride Concentration on Roadside Ground Cover Plant Growth (염화칼슘 처리농도가 가로변 지피식물의 생장에 미치는 영향)

  • Lee, Sun-Young;Kim, Won-Tae;Ju, Jin-Hee;Yoon, Yong-Han
    • Journal of the Korean Institute of Landscape Architecture
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    • v.41 no.4
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    • pp.17-23
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    • 2013
  • The purpose of this study was to provide information on management and apply it to a roadside ground cover plant understanding the capacity of calcium chloride in the plant. The experimental group was composed of the ratio control group of calcium chloride, 0.5%, 1.0%, and 3.0% in 500g of soil. Plant materials were selected and measured according to their ecological characteristics such as ground cover plant, Pachysandra terminalis, Hosta plantaginea, Trachelospermum asiaticum, Vitex rotundifolia, Euonymus japonica and Callicarpa japonica. The acidity of the amended soil was increased gradually depending on the treatment and conductivity was continually decreased. The EX-Ca increased after the treatment, but decreased in the middle of the experiment. Pachysandra terminalis, Trachelospermum asiaticum and Euonymus japonica were able to grow and survive at the ratio of 0.5%. Hosta plantaginea and Vitex rotundifolia were able to survive at the ratio of 1.0%. Hosta plantaginea, the possible state can absorb salts due to moisture and, can be applied to ground cover plants in the roadside. The growth and development of Callicarpa japonica was poor and the leaves were open to grow for calcium chloride treatment except the control group. It was concluded that Callicarpa japonica was very sensitive to calcium chloride.

Effects of Floating and Submerged Plants on Important Water Environments of Wetland (부유식물과 침수식물이 습지의 주요 수 환경에 미치는 영향)

  • Lee, Geun-Joo;Sung, Kijune
    • Journal of Wetlands Research
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    • v.15 no.3
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    • pp.289-300
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    • 2013
  • In this study, two types of wetland plants, Eichhornia crassipes (a floating plant) and Ceratophyllum demersum (a submerged plant) were introduced to wetland mesocosms to understand how the water properties of wetlands such as pH, dissolved oxygen content, water temperature, oxidation reduction potential, and nutrient concentrations are affected by different types of wetland plant. The floating plant lives on the water surface and can block light penetration; it exhibited the lowest water temperature and temperature difference between lower and upper layers. After the addition of contaminants, the dissolved oxygen (DO) concentration decreased abruptly but recovered continuously in all mesocosms; especially the submerged plants, which photosynthesize in water, showed the largest increases in DO and diel periodicity DO, as well as in pH value. The oxidation-reduction potential in both water and sediment were affected by the presence of wetland plants and plant type and the results suggest that various aspects of wetland biogeochemistry are affected by the presence and type of wetland plants. The total nitrogen and phosphorous concentrations in water decreased in the following order: Water only < Water + Soil < Floating Plants < Submerged Plants. Although both floating and submerged plants can control algal concentrations, the effect was more prominent for floating plants.