• 대한의생명과학회지
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• 제27권3호
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• pp.121-133
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• 2021

Antibody-drug conjugates (ADCs) are drawing much interest due to its great potential to be one of the important options in cancer treatments. ADCs are acting like a magic bullet which delivers cytotoxic drugs specifically to cancerous cells throughout the body, thus attacks these cells, while not harming healthy cells. ADCs are complex molecules that are composed of an antibody having targeting capability and linked-payload or cytotoxic drug killing cancerous cells. The key factors of the success in the development of ADC are selection of appropriate antibody, cytotoxic payload and linker for conjugation. Recently there was considerable progress in ADCs development, and a large number of ADCs gained US FDA approval. About 80 new ADCs are under active clinical studies. In this review we present a brief introduction of the US-FDA approved ADCs and global situation in the clinical studies of ADC pipelines. We address an overview on each component of an ADC design such as target antigens, payloads, linkers, conjugation methods, drug antibody ratio. In addition, we discuss on the trend of ADC market where global big pharmas and domestic biopharmaceutical companies are competing to develop safer and more effective ADCs.

• 한국수소및신에너지학회논문집
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• 제32권6호
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• pp.542-550
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• 2021

As the application of multirotor grows, the demands for multirotor that can fly longer and load more are increasing. Hydrogen has a high energy density, so it can satisfy these demands when used in multirotor. In order to design hydrogen fueled multirotor that satisfies the desired flight time and payload, it is important to calculate the specifications of a fuel cell, battery, and hydrogen storage system. This paper contains detailed information on various energy systems used in multirotor and fuel cell powered multirotor research trends. This study proposed a sizing calculation method that meets the target flight time and payload using thrust and power equations. It has been explained how the two equations derive the particular specifications. The specifications of the multirotor were derived by assuming a payload of 50 kg and a flight time of 1 hour. In addition, the effects of the values of the fuel cell, hydrogen storage system, and motor propeller were analyzed.

• Coupled systems mechanics
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• 제2권1호
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• pp.23-51
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• 2013

An analytical algorithm for the estimation of the resistance forces exerted on the dipper of a cable shovel and the specific energy consumed in the cutting-loading process is presented. Forces due to payload and to cutting of geomaterials under given initial conditions, cutting trajectory of the bucket, bucket's design, and geomaterial properties are analytically computed. The excavation process has been modeled by means of a kinematical shovel model, as well as of dynamic payload and cutting resistance models. For the calculation of the cutting forces, a logsandwich passive failure mechanism of the geomaterial is considered, as has been found by considering that a slip surface propagates like a mixed mode crack. Subsequently, the Upper-Bound theorem of Limit Analysis Theory is applied for the approximate calculation of the maximum reacting forces exerted on the dipper of the cable shovel. This algorithm has been implemented into an Excel$^{TM}$ spreadsheet to facilitate user-friendly, "transparent" calculations and built-in data analysis techniques. Its use is demonstrated with a realistic application of a medium-sized shovel. It was found, among others, that the specific energy of cutting exhibits a size effect, such that it decreases as the (-1)-power of the cutting depth for the considered example application.

• 한국기계가공학회지
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• 제18권5호
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• pp.23-28
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• 2019

In recent years, medium- to large-scale transportation machinery and machine tool manufacturing process lines have shown a trend toward centralization, softening, lightening, and slimming to reduce costs and increase productivity. This has increased the demand for vertical articulated robots. When developing and introducing a heavy weight-handling robot that can be easily applied to existing production lines, it is expected to have a great effect in securing industrial competitiveness by solving industrial issues such as the decreased productivity and increased risk of accidents due to work involving heavy lifting. In this study, we design a 6-axis robot mechanism with a heavy load-handling capacity of 700kg or more for large-sized materials of various types supplied in small quantities.

• 한국군사과학기술학회지
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• 제24권1호
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• pp.70-78
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• 2021

Naval surface ships and submarines could be exposed to non-contact underwater explosion(UNDEX) environment. Equipment installed on the ships and submarines could be damaged by shock load generated by UNDEX environment. Therefore, shock survivability of equipment generally evaluated by shock tests. Ground based shock test machine such as Light weight shock test machine(LVSM) is developed to simulate shock load caused by UNDEX environment. In this study, linear dynamic model of LVSM is proposed and evaluated to improve shock test design procedure. Parameters of the model are decided by optimizing time domain response compared to zero payload experiment. Proposed model is verified by comparing simulation results and test results of maximum payload experiment. Finally, shock test design using the model is described for various test equipment weight.

• 항공우주기술
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• 제4권2호
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• pp.107-116
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• 2005

고도 685km에서 450mm~900mm 파장대역의 한 채널의 흑백영상과 4채널 칼라영상을 이미징하도록 개발된 MSC는 한반도의 정밀 지상관측 등 국가 영상정보 수요충족을 위해 운용예정인 저궤도용 다목적실용위성 2호의 유일한 탑재체로서 마지막 시험단계에 있다. MSC는 우주공간에서 운용되는 위성체 탑재체의 특성상 우주공간에서 경험하게 되는 직,간접의 태양광선, 그리고 극저온의 우주환경 등을 견뎌내도록 설계요구가 주어지는바 이를 위해서는 온도 제어가 불가피하고 또한 한정된 위성본체의 전원용량의 효율적인 사용도 고려되어서 설계되어야 한다. 특히 광학성능에 직접적인 영향을 미치게 되는 EOS의 효율적인 열제어는 MSC 설계요소의 가장 중요한 부분이기도 하다. 본 논문은 먼저 MSC의 전체적인 시스템구성과 열제어 시스템 개념을 소개한 다음, 실제 열제어를 수행하는 THTM(THermal and TeleMetry) 보드를 중심으로 열제어 시스템의 H/W와 S/W의 수행 내용들을 소개하였다.

• 한국항공우주학회지
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• 제33권11호
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• pp.115-120
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• 2005

본 논문에서는 과학기술위성 2호 대용량 메모리 유닛(Mass Memory Unit, MMU)의 시험모델(Engineering Model, EM)을 개발하고 기능 및 성능 시험한 결과를 제시하였다. 성능 구현에 필요한 로직들을 별도의 전용 칩들을 사용하지 않고 하나의 FPGA에 구현함으로써 대용량 메모리 유닛을 소형화, 경량화하고 저전력으로 사용할 수 있도록 하였다. 대용량 메모리는 2Gbits SDRAM 모듈을 사용하였으며 파일 시스템을 운용하여 지상국에서의 데이터 관리가 용이 하도록 하였다. 대용량 메모리에서 발생하는 SEU(Single Event Upset)를 극복하기 위해서 RS(207,187) 코드가 소프트웨어로 구현되어 있어서 187바이트당 10바이트의 에러를 복구할 수 있다. 또한 탑재체 데이터의 수신 성능을 검증하기 위해서 시뮬레이터를 제작 하였다.

• 항공우주기술
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• 제11권2호
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• pp.1-11
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• 2012

본 논문은 우주용 X-대역 능동 위상 배열 레이더를 위한 T/R 모듈에 대하여 기술한다. T/R 모듈은 위상 배열 안테나의 전자적 빔 조향을 가능하게 하는 송수신 RF 반도체 소자가 집적된 모듈이며 SAR 탑재체의 핵심 부품이다. 기존의 T/R 모듈은 수평 편파 또는 수직 편파 신호를 스위치에 의해 선택적으로 수신할 수 있었다. 그러나 현재 기술적 흐름은 수평 편파와 수직 편파 신호를 동시에 수신하는 것이다. 따라서 이중 편파 동시 수신 T/R 모듈에 대한 개발이 활발히 이루어지고 있다. 본 연구는 차세대 SAR 탑재체를 위한 선행 연구로서 능동 위상 배열 레이더 T/R 모듈의 기술 개발 동향과 이중 수신 T/R 모듈의 예비 설계 결과를 정리하였다.

• 한국항공우주학회지
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• 제39권11호
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• pp.1069-1076
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• 2011

인공위성이 궤도상에서 임무를 수행하는 동안 모든 위성 부품이 허용 온도 범위 내에서 존재하도록 하기 위하여 검증된 열모델을 개발하고, 궤도 열해석을 통하여 열적 안정성을 확보하기 위한 열설계를 수행한다. 본 연구에서는 저궤도 위성 광학탑재체의 열진공/열평형 시험 결과를 이용하여 열해석 모델을 보정하고 flight heater의 작동주기를 맞추어 줌으로써 검증된 열모델을 확보하였다. 또한 위성의 열적 안정성을 확보하기 위하여 보정이 완료된 모델을 이용하여 궤도 열해석을 수행함으로써 모든 부품이 허용온도 범위내에 존재하는 것을 확인하였다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2002년도 Proceedings of International Symposium on Remote Sensing
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• pp.229-234
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• 2002

Under the hostile influence of the extreme space environmental conditions due to the deep space and direct solar flux, the thermal control in space applications is especially of major importance. There are tight temperature range restrictions for electro-optical elements while on the other hand there are low power consumption requirements due to the limited energy sources on the spacecraft. So, we usually have strong requirement of thermal and power control module in space applications. In this paper, the design concept of a thermal and power control module in the MSC(Multi-Spectral Camera) system which will be a payload on KOMPSATII is described in terms of H/W & S/W. This thermal and power control module, called THTM(Thermal and Telemetry Module) in MSC, resides inside the PMU(Payload Management Unit) which is responsible for the proper management of the MSC payload for controlling and monitoring the temperature insides the EOS(Electro-Optic System) and gathering all the analog telemetry from all the MSC sub-units, etc. Particularly, the designed heater controller has the special mode of "duty cycle" in addition to normal closed loop control mode as usual. THTM controls heaters in open loop according to on/off set time designed through analysis in duty cycle mode in case of all thermistor failure whereas it controls heaters by comparing the thermistor value to temperature based on closed loop in normal mode. And a designed THTM provides a checking and protection method against the failure in thermal control command using the test pulse in command itself.