• 대한한방소아과학회지
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• 제35권4호
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• pp.96-111
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• 2021

Objectives The purpose of this study is to look for pathological mechanism of disease development caused by Taedok, by studying whether stress and diet in pregnant ICR mice affect the intestinal flora and IgA (Immunoglobulin A) concentration. Methods The mice were divided into 4 groups (n=5 per group) based on the concept of Taedok: the control group (G1), stress group (G2), capsaicin diet group (G3), high fat diet group (G4). We collected and analyzed intestinal flora from maternal feces and cecal flora from neonatal mice by group. Then, IgA concentration in the maternal feces and sIgA (secretory Immunoglobulin A) concentration in the cecal contents of newborn mice were analyzed. In addition, serum corticosterone was analyzed before and after stress application. Results Changes in maternal intestinal flora and neonatal mice cecal flora by stress and diet were observed. There were no significant changes in the IgA concentration in maternal feces and the sIgA concentration in the cecal contents of neonatal mice. No significant changes compared to the control group were observed between groups before and after applying stress. However, when comparing within one subject, a significant increase was confirmed after stress application in the stress group (G2). Conclusions Based on the results, we observed stress and diet in pregnant mice affect the intestinal flora of maternal and neonatal. We were able to interpret the pathological mechanism of Taedok based on the principle of interaction between mother and newborn intestinal flora.

• Journal of International Society for Simulation Surgery
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• 제3권1호
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• pp.28-32
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• 2016

Background Congenital muscular torticollis (CMT) is a benign condition. With early diagnosis and appropriate management, it can be cured completely, leaving no residual deformity. However, long-standing, untreated CMT can lead to permanent craniofacial deformities and asymmetry.Methods Nineteen patients presented to the author with congenital muscular torticollis. Three dimensional computed tomography (3-D CT) scans was obtained upon patient’s admission. Adjustment of skull’s position to Frankfort horizontal plan was done. Cervical vertebral segmentation was done which allowed a 3D module to be separately created for each vertebra to detect any anatomical or positional changes.Results The segmented vertebrae showed an apparent anatomical changes, which were most noticeable at the level of the atlas and axis vertebrae. These changes decreased gradually till reaching the seventh cervical vertebra, which appeared to be normal in all patients. The changes in the atlas vertebra were mostly due to its intimate relation with the skull base, while the changes of the axis were the most significantConclusion Cervical vertebral segmentation is a reliable tool for isolation and studying cervical vertebral pathological changes of each vertebra separately. The accuracy of the procedures in addition to the availability of many software that can be used for segmentation will allow many surgeons to use segmentation of the vertebrae for diagnosis and even for preoperative simulation planning.

• 대한치과의사협회지
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• 제11권10호
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• pp.643-647
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• 1973

The auther has made the oral examination of 523 pregnant women-such as calculus, gingival disease, periodontal disease, and dental caries-who visit the dental department and obstetric department in National Medical Center in Seoul. After the above studies, results of the changes of the pregnant women's oral condition are following. 1. In creasing of calculus deposition due to the changes of saliva components. 2. Increasing of incidence of gingival and periodontal and pathological changes followed by calculus deposition. 3. Incidence of new cavities are not related to the pregnancy, but old cavities have become more progressive in dental caries.

• 한국임상수의학회지
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• 제16권1호
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• pp.13-18
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• 1999

This study was undertaken to find out the effect of dropwort on histopathological changes of cadmium toxicity in mice. Thirty two mice of BALB/c strain were divided into a control group (A) and three experimental groups (B, C, D). Each group was consisted of four males and four females : group A received tap water and basal diet, group B received tap water and diet supplemented with 100 mg/kg of cadmium, group C received dropwort juice and diet supplemented with 100 mg/kg of cadmium, group D received dropwort juice and basal diet. All mice were dissected on the 35th day. Pathological changes in liver, kidney, spleen, heart, lung, stomach and muscle were observed. Group D showed no significant change as the control group. But group B showed many cytoplasmic vacuoles and necrosis of hepatocytes, glomerular swelling, and degeneration and necrosis of convoluted tubules in kidney, marked congestion and hemorrhage, and a large number of variably sized alveolar macrophages appearance in lung and swelling in some part of muscle fiber. On the other hand, group C showed a little convalescent changes and maintained their normal architectures in liver, kidney, lung and muscle.

• 대한물리치료과학회지
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• 제8권1호
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• pp.727-734
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• 2001

Contracture is defined as the lack of full passive range of motion resulting from pint, muscle or soft tissue limitationprolonged Pint immobilization will result in stress and stretch deprivation and gradual development of contracture. the tissue changes caused by immobilization may be categorized as cellular modeling, ground substance and collagen response, and tissue response. contracture can be divided into three categories according to the anatomical location of pathological changes :arthrogenic, myogenic, soft tissue contractures Therapeutic approach of contracture is thermal or cold agents application, stretch or restoration of length, traction, manipulation, mobilization positioning and restoration of function. The purpose of this article is to review current concepts of mechanical properties and synthesis of collagen tissue and the underlying pathomechanics as it relates to evaluation and treatment of contracture.

• Asian-Australasian Journal of Animal Sciences
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• 제24권3호
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• pp.429-438
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• 2011

Mastitis is characterized by physical, chemical and bacteriological changes in the milk and pathological changes in the glandular tissue of the udder and affects the quality and quantity of milk. The bacterial contamination of milk from the affected cows render it unfit for human consumption and provides a mechanism of spread of diseases like tuberculosis, sore-throat, Q-fever, brucellosis, leptospirosis etc. and has zoonotic importance. Somatic cell count (SCC) is a useful predictor of intramammary infection (IMI) that includes leucocytes (75%) i.e. neutrophils, macrophages, lymphocytes, erythrocytes and epithelial cells (25%). Leucocytes increase in response to bacterial infection, tissue injury and stress. Somatic cells are protective for the animal body and fight infectious organisms. An elevated SCC in milk has a negative influence on the quality of raw milk. Subclinical mastitis is always related to low milk production, changes to milk consistency (density), reduced possibility of adequate milk processing, low protein and high risk for milk hygiene since it may even contain pathogenic organisms. This review collects and collates relevant publications on the subject.

• 대한의용생체공학회:의공학회지
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• 제26권6호
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• pp.383-391
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• 2005

Age-related White Matter Changes (WMC) on Magnetic Resonance Imaging (MRI) are known to appear frequently in Multiple sclerosis (MS) and Alzheimer's disease and to be related to cognitive impairment. The characterization of these WMC is very important to the study of psychology and aging. These changes consist of periventricular and subcortical types, however it is difficult to detect and segment WMC using only intensity-based methods, because their intensity, level IS similar to th~t of the gray matter (GM). In this paper, we propose a new method of segmenting periventricular WMC using K-means clustering and morphological features.

• 약학회지
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• 제49권3호
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• pp.205-211
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• 2005

The 3' UTR (3' untranslated region) plays important roles in controlling gene expression through regulating 3' polyadenylation, mRNA export, subcellular localization, translational efficiency, and mRNA stability. Changes in the 3' UTR sequence in an expressed transcript can result in functional changes of the genes that are expressed in pathological conditions compared with those genes expressed in normal physiologic conditions. A genome-wide survey of 3' UTR variation was performed for the genes expressed during hematopoietic differentiation from CD34+ stem/progenitor cells to CD 15 + myeloid progenitor cells. Wide-spread differential usage of the 3' UTR was observed from the genes expressed during this cellular transition. This study implies that the 3' UTR can be a highly coordinated region for post-transcriptional regulation of the function of expressed genes.

• 대한치과의료관리학회지
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• 제6권1호
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• pp.1-10
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• 2018

Prior to the end of the 20th century, microorganism research was limited to culture and has since been revolutionized by genetic analysis. Microorganisms, including bacteria, can cause disease, but most of them are commensal microorganisms in our bodies. This knowledge changes the pathological approach to infectious diseases and lends to a new perspective on the effects of gut and oral microorganisms on disease and health. The oral cavity, particularly the periodontal pocket, is considered to be a reservoir of microbes that cause disease, and oral microbial control is becoming more important. In this review, I will examine the changes in the microbiological revolution and the meaning of oral healthcare management based on those changes.

• Parasites, Hosts and Diseases
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• 제33권4호
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• pp.313-322
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• 1995

서을대학교 의과대학 기생충학교실 및 풍토병연구소1). 전남대학교 의과대학 병리학교실f) 요코가와흡충을 실험적으로 마우스(ICR)에 감염시키고 프레드니솔론을 주입하여 마우스의 면역 반응을 저하시킬 때 장의 병변과 충체 침입부위이 변화를 알아보기 위하여 이 연구를 시행하였다 ICR계 마우스를 비감염 대조군 요코가와흡충 감염군(마리당 피낭유충 1.800개 감염). 및 요코가와흡충 감염면역억제군으로 나누고 감염 후 6시간부터 3주까지 관찰하였다. 요코가와흡충 감염군에 있어서는 감염 1일까지 많은 충체가 장 절편내에서 발견되었고. 장 병변은 점막에 국한되어 있었다. 그러나 감염 3일 이후부터는 충체가 거의 발견되지 않았고. 1주 후에는 이미 장 병변이 회복되어 가는 양상을 보였다 한편 면역억제 따우스에 있어서는 감염군과는 달리 장 절편내에서 전기 간동안 충체가 발견되었고 감염이 오랫동안 유지되었다 염증 반응은 전 기간을 통해 미미하였고. 감염 3일까지 장 병변도 융모의 부종이나 상피층의 가벼운 위축 외에는 거의 관찰되지 알았다. 그러나 감염 5일째에는 마우스 십이지장 및 공장의 응모 및 장선이 매우 심하게 파괴되고 장벽으로부터 탈락되는 양상을 보였으며 이때 충체는 점막하 조직을 통과하고 거의 근육층까지 침입하여 장벽을 압박하고 있었다. 이러한 소견은 계속된 면역억제에도 불구하고 감염 7일부터 21일까지 점차 회복되는 양상을 보였다. 이상의 결과는 요코가와흡충을 면역억제 마우스에 감염시키면 짧은 가간 동안 장 점막의 심한 파괴가 일어나고 점막하층까지 충체가 침입할 수 있음을 나타내었다.