[KSCI] Korea Science Citation Index Service

Frequent Changes of 3' UTR Sequences in the Genes Expressed During Hematopoietic Differentiation Implicates the Importance of 3' UTR in Regulation of Gene Function

Lee Sanggyu (Department of Medicine, University of Chicago)

Publication Information

YAKHAK HOEJI / v.49, no.3, 2005 , pp. 205-211 More about this Journal

Abstract

The 3' UTR (3' untranslated region) plays important roles in controlling gene expression through regulating 3' polyadenylation, mRNA export, subcellular localization, translational efficiency, and mRNA stability. Changes in the 3' UTR sequence in an expressed transcript can result in functional changes of the genes that are expressed in pathological conditions compared with those genes expressed in normal physiologic conditions. A genome-wide survey of 3' UTR variation was performed for the genes expressed during hematopoietic differentiation from CD34+ stem/progenitor cells to CD 15 + myeloid progenitor cells. Wide-spread differential usage of the 3' UTR was observed from the genes expressed during this cellular transition. This study implies that the 3' UTR can be a highly coordinated region for post-transcriptional regulation of the function of expressed genes.

Keywords

3' UTR; SAGE; hematopoietic differentiation;

Citations & Related Records

Reference

1	Sonenberg, N. : mRNA translation: influence of the 5' and 3' untranslated regions. Curr. Opin. Genet. Dev. 4, 310 (1994) DOI PUBMED ScienceOn
2	Decker, C. J. and Parker, R. : Diversity of cytoplasmic functions for the 3' untranslated region of eukaryotic transcripts. Curr. Opin. Cell Biol. 7, 386 (1995) DOI ScienceOn
3	Wickens, M., Anderson, P. and Jackson, R. J. : Life and death in the cytoplasm: messages from the 3' end. Curr. Opin. Genet. Dev. 7, 220 (1997) DOI ScienceOn
4	Zhou, G., Chen, J., Lee, S., Clark, T., Rowley, J. D. and Wang, S. M. : The pattern of gene expression in human CD34(+) stem/progenitor cells. Proc. Natl. Acad Sci. USA 98, 13966 (2001)
5	Lynch, K W. and Weiss, A. : A model system for activationinduced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras. Mol. Cell Biol. 20, 70 (2000) DOI ScienceOn
6	Goodall, G. J., Dominguez, F. and Horecker, B. L. : Molecular cloning of cDNA for human prothymosin alpha. Proc. Natl. Acad Sci. USA 83, 8926 (1986)
7	Driessen, C., Bryant, R. A., Lennon-Dumenil, A. M., Villadangos, J. A., Bryant, P. W., Shi, G. P., Chapman, H. A. and Ploegh, H. L. : Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. J. Cell Biol. 147, 775 (1999) DOI ScienceOn
8	Lopez, A. J. : Alternative splicing of pre-mRNA: developmental consequences and mechanisms of regulation. Annu. Rev. Genet. 32, 279 (1998) DOI PUBMED ScienceOn
9	Varani, G. : Delivering messages from the 3' end. Proc. Natl. Acad Sci. USA 98, 4288 (2001)
10	Schuler, G. D., Boguski, M. S., Stewart, E. A., Stein, L. D., Gyapay, G., Rice, K, White, R. E., Rodriguez-Tome, P., Aggarwal, A., Bajorek, E., Bentolila, S., Birren, B. B., Butler, A., Castle, A. B., Chiannilkulchai, N., Chu, A., Clee, C., Cowles, S., Day, P. J., Dibling, T., Drouot, N., Dunham, I., Duprat, S., East, C., Hudson, T. J. and et al. : A gene map of the human genome. Science 274, 540 (1996) DOI ScienceOn
11	Peng, S. S., Chen, C. Y. and Shyu, A. B. : Functional characterization of a non-AUUUA AU-rich element from the cjun proto-oncogene mRNA: evidence for a novel class of AUrich elements. Mol. Cell Biol. 16, 1490 (1996) DOI
12	Zaidi, S. H. and Malter, J. S. : Amyloid precursor protein mRNA stability is controlled by a 29-base element in the 3'-untranslated region. J. Biol. Chem. 269, 24007 (1994)
13	Siomi, M. C., Siomi, H., Sauer, W. H., Srinivasan, S., Nussbaum, R. L. and Dreyfuss, G. : FXRl, an autosomal homolog of the fragile X mental retardation gene. EMBO J. 14, 2401 (1995)
14	Smith, C. W. and Valcarcel, J. : Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem. Sci. 25, 381 (2000) DOI ScienceOn
15	Beaudoing, E., Freier, S., Wyatt, J. R, Claverie, J. M. and Gautheret, D. : Patterns of variant polyadenylation signal usage in human genes. Genome Res. 10, 1001 (2000) DOI ScienceOn
16	Tanguay, R. L. and Gallie, D. R. : Translational efficiency is regulated by the length of the 3' untranslated region. Mol. Cell Biol. 16, 146 (1996) DOI
17	Gallie, D. R. : A tale of two termini: a functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation. Gene. 216, 1 (1998) DOI PUBMED ScienceOn
18	Davis, B. M., McCurrach, M. E., Taneja, K. L., Singer, R. H. and Housman, D. E. : Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts. Proc. Natl. Acad. Sci. USA 94, 7388 (1997)
19	Mignone, F., Gissi, C., Liuni, S. and Pesole, G. : Untranslated regions of mRNAs. Genome Biol. 3, REVIEWS0004 (2002)
20	Mironov, A. A., Fickett, J. W. and Gelfand, M. S. : Frequent alternative splicing of human genes. Genome Res. 9, 1288 (1999) DOI ScienceOn
21	Brett, D., Hanke, J., Lehmann, G., Haase, S., Delbruck, S., Krueger, S., Reich, J. and Bork, P. : EST comparison indicates 38% of human mRNAs contain possible alternative splice forms. FEBS Lett. 474, 83 (2000) DOI ScienceOn
22	Trowbridge, I. S. : CD45. A prototype for transmembrane protein tyrosine phosphatases. J. Biol. Chem. 266, 23517 (1991) PUBMED
23	Groenen, P. J., Wansink, D. G., Coerwinkel, M., van den Broek, W., Jansen, G. and Wieringa, B. : Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties. Hum. Mol. Genet. 9, 605 (2000) DOI ScienceOn
24	Velculescu, V. E., Zhang, L., Vogelstein, B. and Kinzler, K. W. : Serial analysis of gene expression. Science 270, 484 (1995) DOI ScienceOn
25	Inoue, S. B., Siomi, M. C. and Siomi, H. : Molecular mechanisms of fragile X syndrome. J. Med. Invest. 47, 101 (2000)
26	Ralph, S. J., Thomas, M. L., Morton, C. C. and Trowbridge, I. S. : Structural variants of human T200 glycoprotein (leukocytecommon antigen). EMBO J. 6, 1251 (1987)
27	Rimokh, R., Berger, F., Bastard, C., Klein, B., French, M., Archimbaud, E., Rouault, J. P., Santa Lucia, B., Duret, L., Vuillaume, M. and et al. : Rearrangement of CCND1 (BCL1/PRAD1) 3' untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias. Blood. 83, 3689 (1994)
28	Russell, J. E. and Liebhaber, S. A. : The stability of human beta-globin mRNA is dependent on structural determinants positioned within its 3' untranslated region. Blood. 87, 5314 (1996)
29	Shi, G. P., Villadangos, J. A., Dranoff, G., Small, C., Gu, L., Haley, K. J., Riese, R., Ploegh, H. L. and Chapman, H. A. : Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity 10, 197 (1999) DOI ScienceOn
30	Zaidi, S. H. and Malter, J. S. : Nucleolin and heterogeneous nuclear ribonucleoprotein C proteins specifically interact with the 3'-untranslated region of amyloid protein precursor mRNA. J. Biol. Chem. 270, 17292 (1995) DOI ScienceOn
31	Conne, B., Stutz, A. and Vassalli, J. D. : The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology? Nat. Med. 6, 637 (2000) DOI ScienceOn
32	Lee, S., Zhou, G., Clark, T., Chen, J., Rowley, J. D. and Wang, S. M. : The pattern of gene expression in human CD15+ myeloid progenitor cells. Proc. Natl. Acad Sci. USA 98, 3340 (2001)