• 전기전자학회논문지
• /
• 제13권2호
• /
• pp.140-149
• /
• 2009

최근 인터넷을 통한 각종 침해사고 및 트래픽 폭주와 같은 현상이 급격하게 증가함에 따라 네트워크의 비정상적 상황을 조기에 탐지하기 위한 보다 능동적이고 진보적인 기술이 요구되고 있다. 본 논문에서는 캠퍼스 네트워크와 같이 트래픽이 주기적인 특성을 띠는 환경에서 Fisher 선형 분류법(FLD)을 사용하여 트래픽을 두 개의 그룹으로 분류하고, 네트워크에 유입되는 트래픽이 어떤 그룹에 속하는지를 판별하는 기법을 제안한다. 이를 위해 WISE-Mon이라 불리는 트래픽 분석 시스템을 개발하여 캠퍼스 네트워크의 트래픽을 수집하고 이를 모니터링해서 분석을 수행한다. 생성된 트래픽의 training set을 이용하여 비정상 트래픽의 범위를 판단하기 위한 chi-square distribution을 유도하고, FLD를 적용하여 유입되는 트래픽을 두 그룹으로 분리하기 위한 초평면 (hyperplane)을 만든다. 또한 네트워크 내의 트래픽 패턴이 시간이 지남에 따라 계속적으로 변하는 상황을 반영하기 위하여 self-learning 알고리즘을 적용한다. 캠퍼스 네트워크의 트래픽을 적용한 수학적 결과를 통하여 제안하는 기법의 정확성과 신뢰도를 보여준다.

• Biomolecules & Therapeutics
• /
• 제15권2호
• /
• pp.83-88
• /
• 2007

The roots of Liriope platyphylla (Liliaceae) are widely used in traditional Chinese medicine. In the present study, we investigated the effects of ethanol (70%) extract of the roots of Liriope platyphylla (ELP70) on learning and memory using behavioral and immunohistochemical methods in mice. Control animals were treated with vehicle (10% Tween 80). With sub-chronic treatments of ELP70 (p.o.) for 14 days, the latency time was significantly increased compared with that of the vehicle-treated control group (50, 100 and 200 mg/kg; P<0.05). Moreover, immunopositive cells for brain derived neurotrophic factor (BDNF) were significantly increased in the hippocapmpal dentate gyrus and CA1 regions after ELP70 treatments for 14 days (50, 100 and 200 mg/kg; P < 0.05). In addition, those cells for nerve growth factor (NGF) were also increased in the hippocapmpal dentate gyrus region (50, 100 and 200 mg/kg; P<0.05). These results suggest that the sub-chronic administration of ELP70 improves learning and memory, and that their beneficial effects are mediated, in part, by the enhancement of BDNF or NGF expression.

• Journal of Pharmaceutical Investigation
• /
• 제37권2호
• /
• pp.73-78
• /
• 2007

The aim of this study was to investigate the absorption properties of ketoprofen. The in-situ perfusion model has advantages over in vitro models as it provides intact lymphatic and blood flow circulation. The absorption properties of six different concentrations of ketoprofen have been studied in single pass in-situ rat intestine model. $^{14}C-PEG$ 4000 was used as a permeability marker and the possibility of an energy dependent contribution to ketoprofen absorption was also Investigated using the metabolic inhibitor sodium azide. Three different concentrations of sodium azide were studied to examine its effect on absorption of ketoprofen from the rat intestine. The findings of this study suggest that mono-carboxylic type drugs like ketoprofen cause permeability changes in the intestine. This is shown by the increase in absorption of $^{14}C-PEG$ 4000 as the concentration of ketoprofen is increased. However, the trend for ketoprofen permeability is to decrease over the concentration ranges. It was observed that the Papp values for ketoprofen with sodium azide shows a trend towards reduction in the amount of ketoprofen absorbed from the rat intestine which was significantly different (p<0.05) from that of ketoprofen with sodium azide 3.0mM. This indicates that sodium azide has an affect on the absorption of ketoprofen. The pH of all the perfusion solutions was altered to ${\sim}pH\;6.7$ by the buffering capacity of the small intestine secretions. The results suggest that mechanisms other than passive diffusion may be involved in ketoprofen absorption. This would be consistent with the involvement of active transport or saturatable processes in the absorption of drugs containing monocarboxylic acid group, as has been previously suggested from in vitro data.

• 디자인학연구
• /
• 제14권4호
• /
• pp.179-188
• /
• 2001

전시공간은 인간 그리고 전시물에 대해 그 외형과 더불어 내재된 가치의 상호작용까지 고려해야 하므로 건축 및 실내건축의 설계, 전시 프로그램의 기획 조정, 전시공간에의 구체화, 운영 및 관리 등의 여러 가지 작업들이 조화를 이루어 형성되는 결과물이다. 그러므로 박람회의 전시공간은 축적된 가치의 산물들을 보유하는 장소로서의 기능 뿐 아니라 관람자와의 커뮤니케이션을 이룰 수 있는 기능적 역할을 수행하여야 한다. 그러므로 무역박람회 전시의 목적을 달성하기 위해서는 전시물의 특성, 전시내용, 전시 프로그램뿐만 아니라 전시장의 위치와 형태에 따른 효과적인 커뮤니케이tus 계획을 수립해야 한다. 무역박람회 전시매장의 전시공간은 그 위치에 따라 벽형, 모퉁이형, 머리형, 섬형, 양 입구형 5가지로 분류될 수 있으며, 이러한 위치에 따른 커뮤니케이션 계획은 수동적 커뮤니케이션 구역, 능동적 커뮤니케이션 구역, 집약적 커뮤니케이션 구역, 기능수행 구역으로 그 기능을 구분하여 계획해야 한다. 이와 같은 무역박람회 전시공간의 전시형태와 위치에 관련한 커뮤니케이션 계획을 통하여 성공적인 전시를 위한 내용과 방법을 모색할 수 있으며 무역박람회 전시의 목적을 달성할 수 있을 것이다.

• 대한수의학회지
• /
• 제38권2호
• /
• pp.366-370
• /
• 1998

7일령의 송아지 4마리에 실험적으로 크립토스포리디움을 감염시키고 면역혈청, 면역초유 그리고 단크론항체(C6)을 투여하여 이들의 면역요법제로서의 효과를 측정하였다. 크립토스포리디움 감염후 4일째부터 3일간 하루 2회(200~500ml)씩 3종의 면역요법제를 송아지 1마리씩 각각 경구로 투여하였으며, 나머지 한마리의 대조송아지에는 인산 완충액을 경구로 투여하였다. 크립토스포리디움에 감염된 송아지들은 설사를 나타냈는데 대조송아지의 경우 감염후 3일째부터 9일간 설사증상을 나타냈다. 면역혈청, 면역초유 그리고 C6로 치료한 송아지들은 치료후 각각 3일, 2일, 5일째부터 정상에 가까운 분변을 배출하기 시작하였다. 면역혈청과 면역초유로 치료한 송아지들의 경우, 분변으로 배출되는 오시스트의 수가 대조송아지에 비해 현저하게 줄어들었다. 이러한 결과들은 실험에 제공된 면역요법제중 면역초유나 면역혈청이 크립토스포리디움에 감염된 송아지의 설사증상과 오시스트의 배출을 억제하는 효과가 있음을 나타내는 것이다.

• 한국철도학회:학술대회논문집
• /
• 한국철도학회 2007년도 추계학술대회 논문집
• /
• pp.816-823
• /
• 2007

As the South Korean rolling stock industry is developing designs for full compliance with the European Standards, it is fitting to take a look at these two core standards. The paper presents an overview of the load cases and structural requirements developed in Europe for the design of safe and compatible rolling stock vehicles. These load cases and structural requirements have been compiled into two standards namely EN12663 and EN15227. Standard EN12663 was developed as a reference design requirements standard. The work was mandated and sponsored by the European Committee for Standardization and Standard issuing National Institutions. EN12663 specifies a series of proof and fatigue load cases for European rolling stock regulations compliant vehicle designs. As EN12663 does not address the crashworthiness issue, a dedicated crashworthiness standard, EN15227, was therefore developed in a similar manner through industry wide consultations managed by a Trans-European working group of experienced engineers and specialists. In both standards, the vehicle and/or trains are grouped into categories reflecting the vehicle types and/or their indented operational function. EN15227, developed to complement EN12663, addresses the "passive" crashworthiness capability of the vehicles and trains. EN15227 specifies reference crash scenarios similar to those found in the Technical Specification for Interoperability (TSI) of high speed trains operating in Europe. The overview also touches on a general comparison with the corresponding British Group Standard (GM/RT2100) and also the UIC leaflet based load cases. The exercise is extended to pertinent design load cases specified by the Federal Railroad Administration (FRA) in the US.

• 동의생리병리학회지
• /
• 제20권2호
• /
• pp.404-409
• /
• 2006

Cimicifuga racemosa (Black cohosh) has been used as therapeutics for pain and inflammation in Korean folk medicine. The potential effects of cimicifuga racemosa extract on mast cell dependent allergy reaction, however, have not been well elucidated yet. In the present study, we investigated the effect of cimicifuga racemosa extract on the allergy reaction using mast cell dependent in vivo and in vitro models. The oral administration of cimicifuga racemosa extract showed inhibitory potential on the compound 48/80 induced active systemic anaphylactic shock. cimicifuga racemosa extract also significantly inhibited the anti DNP IgE induced passive cutaneous anaphylaxis (PCA) reaction and acetic acid induced vascular permeability. In addition, cimicifuga racemosa extract inhibited the beta hexosaminidase release and TNF alpha and IL 4 mRNA induction by DNP HSA in rat leukemia mast cells, RBL 2H3. but cimicifuga racemosa extract didn't affected to RBL 2H3 cell viability. These results demonstrated that cimicifuga racemosa extract has an anti allergic potential and it may be due to the inhibition of histamine release and cytokine gene expression in the mast cells.

• 동의생리병리학회지
• /
• 제25권1호
• /
• pp.37-47
• /
• 2011

This study was aimed to investigate the memory enhancing effect of Jeongjihwan against scopolamine-induced amnesia in C57BL/6 mice. To determine the effect of Jeongjihwan on the memory and cognitive function, we have injected scopolamine (1 mg/kg, i.p.) into C57BL/6 mice 30 min before beginning of behavior tests. We have conducted Y-maze, Morris water-maze, passive avoidance and fear conditioning tests to compare learning and memory functions. Scopolamine-induced behavior changes of memory impairment were significantly restored by oral administration of Jeongjihwan (100 or 200 mg/kg/day). To elucidate the molecular mechanism underlying the memory enhancing effect of Jeongjihwan, we have examined the antioxidant defense system and neurotrophic factors. Jeongjihwan treatment attenuated intracellular accumulation of reactive oxygen species and up-regulated mRNA and protein expression of antioxidant enzymes as assessed by RT-PCR and western blot analysis, respectively. Jeongjihwan also increased protein levels of brain-derived neurotrophic factor (BDNF) compared with those in the scopolamine-treated group. Furthermore, as an upstream regulator, the activation of cAMP response element-binding protein (CREB) via phosphorylation was assessed by Western blot analysis. Jeongjihwan elevated the phosphorylation of CREB (p-CREB), which seemed to be mediated partly by extracellular signal-regulated kinase1/2 (ERK1/2) and protein kinase B/Akt. These findings suggest that Jeongjihwan may have preventive and therapeutic potential in the management of amnesia.

• 한국축산식품학회지
• /
• 제40권2호
• /
• pp.183-196
• /
• 2020

The protective effect of pig skin gelatin water extracts (PSW) and the low molecular weight hydrolysates of PSW generated via enzymatic hydrolysis with Flavourzyme® 1000L (LPSW) against scopolamine-induced impairment of cognitive function in mice was determined. Seventy male ICR mice weighing 20-25 g were randomly assigned to seven groups: Control (CON); scopolamine (SCO, 1 mg/kg B.W., intraperitoneally (i.p.); tetrahydroaminoacridine 10 [THA 10, tacrine; 10 mg/kg B.W. per oral (p.o.) with SCO (i.p.)]; PSW 10 (10 mg/kg B.W. (p.o.) with SCO (i.p.); PSW 40 (40 mg/kg B.W. (p.o.) with SCO (i.p.); LPSW 100 (100 mg/kg B.W. (p.o.) with SCO (i.p.); LPSW 400 (400 mg/kg B.W. (p.o.) with SCO (i.p.). All treatment groups, except CON, received scopolamine on the day of the experiment. The oxygen radical absorbance capacity of LPSW 400 at 1 mg/mL was 154.14 μM Trolox equivalent. Administration of PSW and LPSW for 15 weeks did not significantly affect on physical performance of mice. LPSW 400 significantly increased spontaneous alternation, reaching the level observed for THA and CON. The latency time of animals receiving LPSW 400 was higher than that of mice treated with SCO alone in the passive avoidance test, whereas it was shorter in the water maze test. LPSW 400 increased acetylcholine (ACh) content and decreased ACh esterase activity (p<0.05). LPSW 100 and LPSW 400 reduced monoamine oxidase-B activity. These results indicated that LPSW at 400 mg/kg B.W. is a potentially strong antioxidant and contains novel components for the functional food industry.

• 한국실내디자인학회논문집
• /
• 제13권6호
• /
• pp.184-195
• /
• 2004

The purpose of this study was to clarify the space use pattern and the daily living activities of the elderly with dementia in the common space (dining room, day corner) of nursing home in Japan. The subjects were six units of the 2 nursing homes in Tokyo. For this, researcher visited from September 5 to December 5 and collected data by observations of behavior of the elderly with dementia in common space and interviews with staff for the information about basic characteristics of the elderly with dementia and administration and operation of the facilities. The data were analyzed using the frequency and percentage with SPSS 11 program and recorded in the form of behavior map. The results revealed as follows: first, 6 types (self-concentration type, physical environment-interest type, passive others-interest type, staffs-interaction type, other elderly-interaction type, visitors-interaction type) of the daily living activities of the elderly with dementia in common space were founded. Second, the daily living activities of the elderly with dementia in common space tended to focus on self-concentration type and physical environment-interest type. Third, physical environmental characteristics of common space affected space usage pattern of the elderly with dementia. And it was perceived like as living oriented space, social interaction space, facility space, staff oriented space. Conclusively it was suggested to plan dining space as semi-private space, day comer as semi-public space.