References
- Brodie, B. B. and Hogben, C. A. M., Some physicochemical factors in drug action. J Pharm. Pharmacol., 9, 345-380 (1957) https://doi.org/10.1111/j.2042-7158.1957.tb12289.x
- Hogerle, M. L. and Winne, D., Drug absorption by the rat jejunum perfused in situ. Naunyn Schmiedebergs Arch. Pharmacol., 322, 249-255 (1983) https://doi.org/10.1007/BF00508339
- Rechkemmer, G, Wahl, M., Kuschinsky, W. and von Engelhardt, W., pH-microclimate at the luminal surface of the intestinal mucosa of guinea pig and rat., Pflugers Arch., 407, 3340 (1986)
- Hidalgo, I. J., Ryan, F. M., Marks, G. J. and Smith, P. L., pH-dependent transepithelail transport of cephalexin in rabbit intestinal mucosa, Int. J Pharm., 98, 83-92 (1993) https://doi.org/10.1016/0378-5173(93)90044-G
- T. Shimada, Factors affecting the microclimate pH in rat jejunum, J Physiol., 392, 113-127 (1987) https://doi.org/10.1113/jphysiol.1987.sp016772
- M. lkurna, H. Hanai, E. Kaneko, H. Hayashi and T. Hoshi , Effects of aging on the microclimate pH of the rat jejunum, Biochim. Biophys. Acta, 1280, 1926 (1996)
- Shiau, Y. F., Fernandez, P., Jackson, M. J. and MacMonagle, S., Mechanisms maintaining a low-pH microclimate in the intestine, Am. J hysiol., 248, 608-617 (1985)
- Davies, N. M., Wright, M. R. and Jamali, F., Antiinflammatory drug-induced small intestinal permeability: the rat is a suitable model, Pharm. Res., 11, 1652-1656 (1994) https://doi.org/10.1023/A:1018978308752
- Assessment and prevention of gastrointestinal toxicity of non-steroidal anti-inflammatory drugs, Majella E, Lane and Mi-Jeong Kim, Journal of pharmacy and pharmacology, 58 (10), 1295-1304 (2006) https://doi.org/10.1111/j.2042-7158.2006.tb01645.x
- Tamai, I., Takanaga, H., Maeda, H., Sal, Y., Ogihara, T., Higashida, H. and Tsuji, A., Participation of a protoncotransporter, MCTI, in the intestinal transport of monocarboxylic acids, Biochem. Biophys. Res. Commun., 214, 482-489 (1995) https://doi.org/10.1006/bbrc.1995.2312
- Ogihara, H., Suzuki, T., Nagamachi, Y., Inui, K. and Takata, K., Pepide transporter in the rat small intestine: ultrastructural localization and the effect of starvation and administration of amino acids, Histochem. J., 31, 169-174 (1999) https://doi.org/10.1023/A:1003515413550
- Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid cotransporter., Pharm Res., 17(2), 209-215 (2000) https://doi.org/10.1023/A:1007525616017
- Takagi, M., Taki, Y., Sakane, T., Nadai, T., Sezaki, H., Oku, N. and Yamashita, S., A new interpretation of salicylic acid transport across the lipid bilayer: implications of pH-dependent but not carrier-mediated absorption from the gastrointestinal tract. J. Pharmacol. Exp. Ther., 285, 1175-1180 (1998)
- Legen, I., Zakelj, S. and Kristl, A., Polarised transport of monocarboxylic acid type drugs across rat jejunum in vitro: the effect of mucolysis and ATP-depletion, Int. J. Pharm., 7419, 1-6 (2003)
- I. Komiya, J. Y. Park, A. Kamani, N. H. F. Ho and W. I. Higuchi, Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes., Int. J. Pharm., 4, 249-262 (1980) https://doi.org/10.1016/0378-5173(80)90140-4
-
Sutton, S. C. and Rinaldi, M. T. S., Comaprison of the gravimetric, phenol red, and
$^{14}C$ -PEG-3350 methods to determine water absorption in the rat single-pass intestinal perfusion model, AAPS Pharm. Sci., 3 Article 25 (2001) https://doi.org/10.1208/ps030211 - Swenson E. C. and Curatolo W. J., Intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity, Adv. Drug Del. Rev., 8, 39-92 (1992) https://doi.org/10.1016/0169-409X(92)90015-I
- Berggrene S., Hoogstraate J., Fagerholm U. and Lennemas H., Characterization of jejunal absorption and apical efflux of ropivacaine, lidocaine and bupivacaine in the rat using in situ and in vitro absorption models, Eur. J. Pharm. Sci., 21(1), 553-560 (2003) https://doi.org/10.1016/j.ejps.2003.12.004
- Majella E. Lane, Karl Levis, George S. A. McDonald and Owen I. Corrigan, Comparative assessment of two indices of drug induced permeability changes in the perfused rat intestine, International Journal of Pharmaceutics, 312(1-2), 196-199 (2006) https://doi.org/10.1016/j.ijpharm.2005.11.048
- 최선옥, 박기숙, 정성희, 정서정, 엄소영, 장은정, 정수연, 박혜영, 의약품의 생물학적특성분류 및 평가, 식품의약품안전청 연구보고서 8(2), 1703-1708 (2004)
- Lalande, M., Wilson, D. L. and McGilveray, I. J., Rapid high-performance liquid chromatographic determination of ibuprofen in human plasma, J Chromatogr. B, 337, 410-414 (1986)
- Fagerholm, U., Johanssen, M. and Lennemas, H., Comparison between permeability coefficients in rat and human jejunum, Pharm. Res., 13, 1336-1342 (1996) https://doi.org/10.1023/A:1016065715308
- Cioli, V., Putzolu, S., Rossi, V., Barcellona, P. and Corradino, C; The role of direct tissue contact in the production of gastrointestinal ulcers by anti-inflammatory drugs in rats, Toxicol. Appl. Pharmacol., 50, 283-289 (1979) https://doi.org/10.1016/0041-008X(79)90153-4
- Bundgaard, H. and Nielsen, N. M., Glycolamide esters as a novel biolabile prodrug type for non-steroidal anti-inflammatory carboxylic acid drugs, Int. J. Pharm., 43, 101-110 (1988) https://doi.org/10.1016/0378-5173(88)90064-6
- Ford, J., Martin, S. W. and Houston, J. B., Assessment of intestinal permeability changes induced by nonsteroidal antiinflammatory drugs in the rat, J. Pharmacol. Toxicol. Methods, 34, 9-16 (1995) https://doi.org/10.1016/1056-8719(94)00074-E
- Desai, K. J., Biophysical model approach to the study of intestinal transport of drugs., Thesis for Pharmaceutical Chemistry, University of Michigan (1977)
- Iwatsubo, T., Yamazaki, M., Sugiyama, Y., Suzuk, H., Yanai, S., Chool Kim, D., Satoh, H., Miyamoto, Y., Iga, T. and Hanano, M., Epidermal growth factor as a regulatory hormone maintaining a low pH microclimate in the rat small intestine, J. Pharm. Sci., 78, 457-459 (1989) https://doi.org/10.1002/jps.2600780606
- N. Lister, P. D. Bailey, I. D. Collier, C. A. R. Boyd and J. R. Bronk, The influence of luminal pH on transport of neutral and charged dipeptides by rat small intestine, in vitro., Biochim. Biophys. Acta, 1324, 245-250 (1997) https://doi.org/10.1016/S0005-2736(96)00230-1
- H. Lennemas, Does fluid flow across the intestinal mucosa affect quantitative oral drug absorption? Is it time for a reevaluation?, Pharm. Res., 12, 1573-1582 (1995) https://doi.org/10.1023/A:1016220428705
- Chan and B. H. Stewart, Physicochemical and drug-delivery considerations for oral drug bioavailability. Drug Discov. Today 1, 461-473 (1996) https://doi.org/10.1016/1359-6446(96)10039-8
- Satterwhite, J. H. and Boudinot, F. D., Pharmacokinetics of ketoprofen in rats: effect of age and dose, Biopharm. Drug Disp., 13, 197-212 (1992) https://doi.org/10.1002/bdd.2510130306
- Igor Legen and Albin Kristl, pH and energy dependent transport of ketoprofen across rat jejunum in vitro, European Journal of Pharmaceutics and Biopharmaceutics, 56(1), 87-94 (2003) https://doi.org/10.1016/S0939-6411(03)00039-0
- M. A. C. Perez, H. G Diaz, C. F. Teruel, J. Pla-Delfina and M. B. Sanz, A novel approach to determining physicochemical and absorption properties of 6-fluoroquinolone derivatives: experimental assessment, Eur. J. Pharm. Biopharm., 53, 317-325 (2002) https://doi.org/10.1016/S0939-6411(02)00013-9
- Chiou, W., Determination of drug permeability in a flat or distended stirred intestine, Int. J. Clin. Pharmacol. Ther., 32 474-482 (1994)