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http://dx.doi.org/10.4062/biomolther.2007.15.2.083

Neurotrophic Factors Mediate Memory Enhancing Property of Ethanolic Extract of Liriope platyphylla in Mice  

Mun, Jung-Hyun (Department of Oriental Pharmaceutical Science, Kyung Hee East-West Pharmaceutical Research Institute)
Lee, Sang-Gon (Department of Oriental Pharmaceutical Science, Kyung Hee East-West Pharmaceutical Research Institute)
Kim, Dong-Hyun (Department of Life and Nanopharmaceutical Science, Kyung Hee University)
Jung, Ji-Wook (Department of Herbal Medicinal Resource, College of Health and Welfare)
Yoon, Byung-Hoon (Department of Life and Nanopharmaceutical Science, Kyung Hee University)
Shin, Bum-Young (Department of Pharmaceutical Science, Kyung Hee East-West Pharmaceutical Research Institute)
Kim, Sun-Ho (Department of Life and Nanopharmaceutical Science, Kyung Hee University)
Ryu, Jong-Hoon (Department of Oriental Pharmaceutical Science, Department of Life and Nanopharmaceutical Science, Kyung Hee University, Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy)
Publication Information
Biomolecules & Therapeutics / v.15, no.2, 2007 , pp. 83-88 More about this Journal
Abstract
The roots of Liriope platyphylla (Liliaceae) are widely used in traditional Chinese medicine. In the present study, we investigated the effects of ethanol (70%) extract of the roots of Liriope platyphylla (ELP70) on learning and memory using behavioral and immunohistochemical methods in mice. Control animals were treated with vehicle (10% Tween 80). With sub-chronic treatments of ELP70 (p.o.) for 14 days, the latency time was significantly increased compared with that of the vehicle-treated control group (50, 100 and 200 mg/kg; P<0.05). Moreover, immunopositive cells for brain derived neurotrophic factor (BDNF) were significantly increased in the hippocapmpal dentate gyrus and CA1 regions after ELP70 treatments for 14 days (50, 100 and 200 mg/kg; P < 0.05). In addition, those cells for nerve growth factor (NGF) were also increased in the hippocapmpal dentate gyrus region (50, 100 and 200 mg/kg; P<0.05). These results suggest that the sub-chronic administration of ELP70 improves learning and memory, and that their beneficial effects are mediated, in part, by the enhancement of BDNF or NGF expression.
Keywords
Liriope platyphylla; Memory; Passive avoidance test; NGF; BDNF;
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