Browse > Article

Anti Allergic Effects of Cimicifuga Racemosa on Allergic Models  

Jung, Heung-Sik (Department of Physiology, College of Oriental Medicine, Dongeui University)
Kang, Kyung-Hwa (Department of Physiology, College of Oriental Medicine, Dongeui University)
Choi, Young-Hyun (Department of Biochemistry, College of Oriental Medicine, Dongeui University)
Choi, Byung-Tae (Department of Anatomy, College of Oriental Medicine, Dongeui University)
Lee, Yong-Tae (Department of Physiology, College of Oriental Medicine, Dongeui University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.20, no.2, 2006 , pp. 404-409 More about this Journal
Abstract
Cimicifuga racemosa (Black cohosh) has been used as therapeutics for pain and inflammation in Korean folk medicine. The potential effects of cimicifuga racemosa extract on mast cell dependent allergy reaction, however, have not been well elucidated yet. In the present study, we investigated the effect of cimicifuga racemosa extract on the allergy reaction using mast cell dependent in vivo and in vitro models. The oral administration of cimicifuga racemosa extract showed inhibitory potential on the compound 48/80 induced active systemic anaphylactic shock. cimicifuga racemosa extract also significantly inhibited the anti DNP IgE induced passive cutaneous anaphylaxis (PCA) reaction and acetic acid induced vascular permeability. In addition, cimicifuga racemosa extract inhibited the beta hexosaminidase release and TNF alpha and IL 4 mRNA induction by DNP HSA in rat leukemia mast cells, RBL 2H3. but cimicifuga racemosa extract didn't affected to RBL 2H3 cell viability. These results demonstrated that cimicifuga racemosa extract has an anti allergic potential and it may be due to the inhibition of histamine release and cytokine gene expression in the mast cells.
Keywords
Cimicifuga racemosa; allergy; compound 48/80; anaphylaxis; cytokine;
Citations & Related Records
연도 인용수 순위
  • Reference
1 허준. 대역동의보감. 서울, 법인문화사, pp 1918-1919, 1999
2 Liske, E. Therapeutic efficacy and safety of Cimicifuga racemosa for gynecologic disorders, Adv Ther pp 45-53, 1998
3 S. Katayama, H. Shionoya, S. Ohtake. A new method for extraction of extravasated dye in the skin and the influence of fasting stress on passive cutaneous allergy in guinea pigs and rats. Microbiol. Immunol. 22, 89-101, 1978   DOI
4 김태규 외. 免疫生物學, 서울, 라이프사이언스, pp 31, 40, 81, 493-520, 1998
5 Teshima, R., Saito Y., Ikebuchi, H., De Silva, N..R., Morita, Y., Nakanishi, M., Sawada, J., Kitani, S. J. Immunol. 159, 964-969, 1997
6 Lieberman, S. A review of the effectiveness of Cimicifuga racemosa(black cohosh) for the symptoms of menopause. J Womens Health. 7(5):525-529, 1998   DOI
7 M.R. Allansmith, R.S. Baird, R.N. Ross, N.P. Barney, K.J. Bloch. Ocular anaphylaxis induced in the rat by topical application of compound 48/80. Dose response and time course study. Acta Ophthalmol. 192, 145-153, 1989
8 Shimomura, K. Japan J. Pharmacol. 24, 837, 1972   DOI
9 Ohmori, H., Hikida, M., Takai, T. Prostaglandin E2 as a selective stimulator of antigen-specific IgE response in murine lymphocytes., Eur. J. Immunol. 20(11):2499-2503, 1990   DOI   ScienceOn
10 신민교. 원색임상본초학. 서울, 남산당, pp 540-541, 1996
11 박지현 외. Comparative study on Treatment of postmenopaual Symtoms with Black Cohosh Extract and Hormone Replacement Therapy. 대한산부인과학회지 45권 8호, p 1330
12 Kim, H.M. Antiallergy drugs from Oriental medicines. Int. J. Orient. Med. 1, 1-7, 2000
13 Mistovich, J.J., Limmer, D., Krost, W.S. Anaphylactic and anaphylactoid reactions. Emerg Med Serv. 33(6):48-49, 142, 2004
14 Sheffer, A.L. Anaphylaxis: clinical aspects. Allergy Asthma Proc. 25(1):31-32, 2004
15 盧寬澤. 耳鼻咽喉科學. 서울, 一潮閣, pp 204-208, 1999
16 Duker, E.M., Kopanski, L., Jarry, H., Wuttke, W. Effects of extracts form cimafuga racemosa on gonadotropin release in menopausal women and ovariectomized rats. Planta Med 57(1):420-424, 1991   DOI   ScienceOn
17 Choi, O.H., Kim, J.H., Kinet, J.P. Calcium mobilization via sphingosine kinase in signalling by the FcepsilonRI antigen receptor, Nature (London), 380, 634-635, 1996   DOI   ScienceOn
18 Aketani, S., Teshima, R., Umezawa, Y., Sawada, J., Immunol. Lett. 75, 185-189, 2001   DOI   ScienceOn
19 McKenna, D.J., Jones, K., Humphrey, S., Hughes, K. Black cohosh: efficacy, safety, and use in clinical and preclinical applications. Altern Ther Health Med. 7(3):93-100, 2001
20 강소신의학원 편, 안덕균, 이경순, 신민교, 김창민 역. 중약대사전. 서울, 도서출판 정담, p 2594, 2004
21 白萬基. 最新耳鼻咽喉科學. 서울, 一潮閣, pp 207-215, 1995
22 Stevens, R.L., Austen, K.F. Recent advances in the cellular and molecular biology of mast cells., Immunol. Today, 10, 381-386, 1989   DOI   ScienceOn
23 Teshima, R., Saito, Y., Ikebuchi, H., De Silva, N.R., Morita, Y., Nakanishi, M., Sawada, J., Kitani S., J. Immunol., 159, 964-969, 1997
24 Whittle, B.A. Brit J. Pharmacol. 22, 246, 1964
25 Aketani, S., Teshima, R., Umezawa, Y., Sawada, J., Immunol. Lett., 75, 185-189, 2001   DOI   ScienceOn
26 Foster, S. Black cohosh (Cimicifuga heracleifolia): a literature review. Herbalgram. 45, 35-49, 1999