• Journal of Pharmaceutical Investigation
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• v.17 no.1
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• pp.1-14
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• 1987

To increase the bioavailability of norfloxacin, inclusion complex of antimicrobial agent norfloxacin with ${\beta}-Cyclodextrin$ was prepared and studied by the solubility method, spectrophotometric methods(UV, IR, $^1H-NMR$), differential thermal analysis, powder X-ray diffractometry, the physical properties, the antimicrobial activity, DNA binding and in situ recirculation technique. The conclusions are summerized as following; 1) The inclusion complexation was identified by means of solubility, spectrophotometry(UV, IR, NMR), DTA and X-ray diffraction. 2) The molar ratio of $norfloxacin-{\beta}-cyclodextrin$ complex was 1 : 1. 3) The stability constant of $norfloxacin-{\beta}-cyclodextrin$ complex was $21.5\;M^{-1}$, and both true and apparent partition coefficients of the inclusion complex were larger than those of norfloxacin. 4) The time required to dissolve 60% $(T_{60}%)$ of the inclusion complex was 120 min. in distilled water and in the artificial intestinal juice, while norfloxacin did not reach to 60% dissolution within 120 min. 5) The antimicrobial activity of the inclusion complex against Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus showed no significant difference compared to that of norfloxacin alone. 6) Studies on binding properties between the inclusion complex and norfloxacin alone to DNA according to equilibrium dialysis showed no significant differency. 7) In situ absorption rates (Ka) of inclusion complex and norfloxacin alone were 0.229 and $0.102hr^{-1}$, respectively.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 1998.06b
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• pp.165-170
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• 1998

This paper presents a new prediction method RBP region-based prediction model where the context used for prediction contains regions instead of individual pixels. There is a meaningful property that RBP can partition a cartoon image into two distinctive types of regions, one containing full-color backgrounds and the other containing boundaries, edges and home-chromatic areas. With the development of computer techniques, synthetic images created with CG (computer graphics) becomes attactive. Like the demand on data compression, it is imperative to efficiently compress synthetic images such as cartoon animation generated with CG for storage of finite capacity and transmission of narrow bandwidth. This paper a lossy compression method to full-color regions and a lossless compression method to homo-chromatic and boundaries regions. Two criteria for partitioning are described, constant criterion and variable criterion. The latter criterion, in form of a linear function, gives the different threshold for classification in terms of contents of the image of interest. We carry out experiments by applying our method to a sequence of cartoon animation. We carry out experiments by applying our method to a sequence of cartoon animation. Compared with the available image compression standard MPEG-1, our method gives the superior results in both compression ratio and complexity.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.23 no.4
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• pp.415-423
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• 2012

This paper specifies on optimized design of wide-band subarray using a Genetic Algorithm. First wide-band radiator was designed at triangle lattice of infinite array structure. It is the radiator of notch type that has a wide-band characteristic of ratio 2:1 between maximum and minimum frequency satisfying active reflection coefficient under -10 dB at boresight. And a Genetic Algorithm was applied to optimize subarray partition of antenna consisting of 1,100 array elements. It was confirmed that an optimized subarray antenna has a 4.5-5.5 dB more improved maximum SLL (Side-Lobe Level) than regular subarray antenna.

• Bulletin of the Korean Chemical Society
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• v.27 no.2
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• pp.231-236
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• 2006

A novel sample pretreatment technique, headspace hanging drop liquid phase microextraction (HS-LPME) was studied and applied to the determination of flavors from solid clove buds by gas chromatography-mass spectrometry (GC-MS). Several parameters affecting on HS-LPME such as organic solvent drop volume, extraction time, extraction temperature and phase ratio were investigated. 1-Octanol was selected as the extracting solvent, drop size was fixed to 0.6 $\mu$L. 60 min extraction time at 25 ${^{\circ}C}$ was chosen. HS-LPME has the good efficiency demonstrated by the higher partition equilibrium constant ($K_{lh}$) values and concentration factor (CF) values. The limits of detection (LOD) were 1.5-3.2 ng. The amounts of eugenol, $\beta$-caryophyllene and eugenol acetate from the clove bud sample were 1.90 mg/g, 1.47 mg/g and 7.0 mg/g, respectively. This hanging drop based method is a simple, fast and easy sample enrichment technique using minimal solvent. HSLPME is an alternative sample preparation method for the analysis of volatile aroma compounds by GC-MS.

• Journal of the Korea Safety Management & Science
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• v.8 no.5
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• pp.17-25
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• 2006

Nowadays most colleges are confronting with a serious problem because many students have left their majors at the colleges. In order to make a countermeasure for reducing major separation rate, many universities are trying to find a proper solution. As a similar endeavor, the objective of this paper Is to find a predicting model of students leaving their majors. The sample for this study was chosen from a university in Kangwon-Do during seven years(2000.3.1 $\sim$ 2006. 6.30). In this study, the ratio of training sample versus testing sample among partition data was controlled as 50% : 50% for a validation test of data division. Also, this study provides values about accuracy, sensitivity, specificity about three kinds of algorithms including CHAID, CART and C4.5. In addition, ROC chart and gains chart were used for classification of students leaving their majors. The analysis results were very informative since those enable us to know the most important factors such as semester taking a course, grade on cultural subjects, scholarship, grade on majors, and total completion of courses which can affect students leaving their majors.

• ETRI Journal
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• v.33 no.4
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• pp.589-599
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• 2011

This paper presents an image description and matching scheme using synthetic features for a recommendation service. The recommendation service is an example of smart search because it offers something before a user's request. In the proposed extraction scheme, an image is described by synthesized spatial and statistical features. The spatial feature is designed to increase the discriminability by reflecting delicate variations. The statistical feature is designed to increase the robustness by absorbing small variations. For extracting spatial features, we partition the image into concentric circles and extract four characteristics using a spatial relation. To extract statistical features, we adapt three transforms into the image and compose a 3D histogram as the final statistical feature. The matching schemes are designed hierarchically using the proposed spatial and statistical features. The result shows that each feature is better than the compared algorithms that use spatial or statistical features. Additionally, if we adapt the proposed whole extraction and matching scheme, the overall performance will become 98.44% in terms of the correct search ratio.

• Bulletin of the Korean Chemical Society
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• v.5 no.3
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• pp.104-108
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• 1984

The self-diffusion experiment of THO was performed across a series of copolymer hydrogel membranes at different temperatures. Copolymer hydrogel membranes were prepared by copolymerizing 2-hydroxyethyl methacrylate (HEMA) and 2-aminoethyl methacrylate (AEMA) in the presence of the solvent and the crosslinker, ethylene glycol dimethacrylate (EGDMA). By changing the crosslinker content and the ratio of HEMA and AEMA monomer, two series of copolymer hydrogel membranes were synthesized. The tagging material was THO and efflux of THO was counted on a Liquid Sc-intillation Counter. The experimental data show that the permeability decreases as the amount of EGDMA and the mole fraction of HEMA increase, and the permeability is proportional to the temperature. The partition coefficient shows a parallel trend with permeability. Using the relationship between viscosity and diffusivity, the viscosity of water within the membrane was obtained. According to the result, the viscosity of watler within the membrane has the same value with those of supercooling water. And we obtained the activation energy of THO for transport in the membrane by using Arrhenius plotting.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.3
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• pp.1238-1259
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• 2019

Saving energy is a big challenge for Wireless Sensor Networks (WSNs), which becomes even more critical in large-scale WSNs. Most energy waste is communication related, such as collision, overhearing and idle listening, so the schedule-based access which can avoid these wastes is preferred for WSNs. On the other hand, clustering technique is considered as the most promising solution for topology management in WSNs. Hence, providing interference-free clustering is vital for WSNs, especially for large-scale WSNs. However, schedule management in cluster-based networks is never a trivial work, since it requires inter-cluster cooperation. In this paper, we propose a clustering method, called Interference-Free Clustering Protocol (IFCP), to partition a WSN into interference-free clusters, making timeslot management much easier to achieve. Moreover, we model the clustering problem as a multi-objective optimization issue and use non-dominated sorting genetic algorithm II to solve it. Our proposal is finally compared with two adaptive clustering methods, HEED-CSMA and HEED-BMA, demonstrating that it achieves the good performance in terms of delay, packet delivery ratio, and energy consumption.

• Journal of Soil and Groundwater Environment
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• v.27 no.6
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• pp.11-21
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• 2022

Sorption of phenanthrene (PHE) and pyrene (PYR) in several sorbents, i.e., natural soil, BionSoil^®, Pahokee peat, vermicompost and Devonian Ohio Shale and a surfactant (hexadecyltrimethyl ammonium chloride)-modified montmorillonite (HDTMA-M) were investigated. Pyrene exhibited higher sorption tendency than phenanthrene, as predicted by its higher octanol to water partition coefficient (K_ow). Several sorption models: linear, Freundlich, solubility-normalized Freundlich model, and Polanyi-Manes model (PMM) were used to analyze sorption isotherms. Linear isotherms were observed for natural soil, BionSoil^®, Pahokee peat, vermicompost, while nonlinear Freundlich isotherms fitted for Ohio shale and HDTMA-M. The relationship between sorption model parameters, organic carbon content (f_oc), and elemental C/N ratio was studied. In the binary competitive sorption of phenanthrene and pyrene in natural soil, competition between the solutes caused reduction in the sorption of each solute compared with that in the single-solute system. The ideal adsorbed solution theory (IAST) coupled with the single-solute Freundlich model was not successful in describing the binary competitive sorption equilibria. This was due to the inherent nature of linear sorption of phenanthrene and pyrene in natural soil. The result indicates that the applicability of IAST for the prediction of binary competitive sorption is limited when the sorption isotherms are inherently linear.

• Korean Chemical Engineering Research
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• v.54 no.1
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• pp.135-139
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• 2016

We developed a liquid-liquid extraction method using an inorganic salt to dramatically improve the recovery efficiency of the anticancer agent paclitaxel from plant cell cultures. As a result of liquid-liquid extraction using a diverse types of inorganic salt (NaCl, KCl, $K_2HPO_4$, $NaH_2PO_4$, $NaH_2PO_4{\cdot}2H_2O$), NaCl gave the highest yield (~96%) and lowest partition coefficient (0.053) of paclitaxel. The optimal NaCl/solvent ratio, methylene chloride/MeOH ratio, and pure paclitaxel content for liquid-liquid extraction using NaCl were 1% (w/v), 26% (v/v), and 0.066% (w/v), respectively. Under the optimal conditions developed in the present method, most of the paclitaxel (~96%) was recovered from biomass by a single extraction step. In addition, this method facilitated 3-fold higher recovery efficiency of paclitaxel in a shorter extraction number than the conventional liquid-liquid extraction method.