• Archives of Plastic Surgery
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• v.42 no.2
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• pp.179-185
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• 2015

Background Capsular contracture is the most troublesome complication in breast implant surgery. Although capsule formation can be seen as a normal reaction to a foreign body, it can induce pain, hardness, deformity, and other pathologic problems. Surgical intervention is required in severe cases, but even surgery cannot guarantee a successful outcome without recurrence. This experimental study confirms that single topical administration of leukotriene antagonist zafirlukast (Accolate, Astrazeneca) reduces peri-implant capsule formation and prevents capsular contracture. Methods Twelve smooth-surfaced cohesive gel implants were implanted in New Zealand White rabbits. These miniature implants were designed to be identical to currently used products for breast augmentation. The rabbits were divided into 2 groups. In the experimental group (n=6), the implant and normal saline with zafirlukast were inserted in the submuscular pocket. In the control group (n=6), the implant and normal saline alone were used. Two months later, the implants with peri-implant capsule were excised. We evaluated capsule thickness and collagen pattern and performed immunohistochemical staining of myofibroblasts, transforming growth factor $(TGF)-{\beta}1$, 2. Results The thickness of the capsules in the experimental group was reduced in both dorsal and ventral directions. The collagen pattern showed parallel alignment with low density, and the number of myofibroblasts as well as the amounts of $TGF-{\beta}1$ and $TGF-{\beta}2$ were reduced in the experimental group. Conclusions We suggest that single topical administration of leukotriene antagonist zafirlukast can be helpful in reducing capsule formation and preventing capsular contracture via myofibroblast suppression, modulation of fibroblastic cytokines, and anti-inflammatory effect.

• Journal of Korean Academy of Nursing Administration
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• v.5 no.1
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• pp.77-86
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• 1999

The purpose of this study is to look into nurse's legal duty and to analyze influencing factors, by reading through precedents in nursing-related malpractice cases. 157 clinic nurses and 40 head nurses who were working in 3 university hospitals in the area of Seoul and KyongKi province were surveyed with pre-set questionnaires which were based on 20 cases and to compare precedents with nurses' attitudes. Independent variables were demographic characteristics, job characteristics, experience and education, and personal characteristics. Dependent variables were the extents of understanding in their duty. To analyze the extent of duty understanding t-text. ANOVA, and multiple regression were performed according to the characteristics of each study subject. Main findings are as follows; 1. $X^2$ test was performed for each hospitals and job category. The existence of religion and job-related advisers were significantly different according to hospitals and job categories. The existences of the orientation for nursing, education, and meeting were significantly different according to hospitals. 2. The extent of duty understanding according to the subject characteristics was assessed by means of median. Each case was given the median. 12 cases(46%)out of 26 cases demonstrated the median of more than 6 showing high extent of understanding. 3. When $X^2$ test was performed. the extent of duty understanding was significantly different in the areas of marriage status. the existence of meetings. and the experience of having dispute. When multiple regression(stepwise method) was performed, above variables were not statistically significant. 4.As result of comparative analysis on precedents and nurse's attitudes. it is 4 cases that nurse's attitudes is more active than precedents and it is 9 cases that nurse's attitudes is more passive than precedents and it is 4 cases that nurse's attitudes is parallel with precedents. This study does not present statistical model which can integrate all the cases. The significance of this study is in that it generalized and assessed the nurses' understanding of duty based on nursing -care which was legally disputed and compared nurse's attitude with precedents.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.7 no.3
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• pp.89-97
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• 2012

The purpose of this study is to examine service quality elements in China Bank Industry and influence on service value, customer satisfaction and reuse intention. This study is composed one parallel comparison of documentary and evidential researches. To verify research model, the survey about medical institution and hospital services were conducted in Daqing of Heilongjiang Province, in China. Collected data was analyzed and the results are introduced in this paper. The findings ar as followed. This study has modified three-dimensional model of service quality: "interaction quality", "outcome quality" and "physical environment quality". Research was focused on investigating the direct effect of every service quality dimension on customer satisfaction. But "outcome quality "has only direct effect on service value, "interaction quality" and "physical environment quality" have not direct effect on service value in this study. Service value has direct effect on customer satisfaction and reuse intention. And customer satisfaction was the significant mediating role in the relationship of the service value and reuse intention.

• Molecules and Cells
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• v.24 no.1
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• pp.132-138
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• 2007

4-1BB (CD137), a member of the tumor necrosis factor receptor superfamily, is expressed on activated T-cells, and 4-1BB signaling due to interaction with 4-1BB ligand or ligation with anti-4-1BB monoclonal antibody (mAb) costimulates T cells. It has been shown that administration of anti-4-1BB mAb induces anti-tumor immunity in mice, but the nature of the cellular subsets responsible for this immunity is uncertain. In this study we found that anti-4-1BB mAb administration to B16F10 melanoma-bearing mice induced marked expansion of $CD11c^+CD8^+$ T-cells in parallel with suppression of pulmonary tumors. The mAb-treated mice produced higher levels of $IFN-{\gamma}$ in their tumor tissues, spleen and lymph nodes than mice exposed to control antibody. When the $CD11c^+CD8^+$ T-cells were purified and re-stimulated in vitro, they produced high levels of the Th1 cytokines, $IFN-{\gamma}$ and IL-2, but low levels of the Th2 cytokines, IL-4 and IL-10. Furthermore, they expressed high levels of 4-1BB and CD107a, a marker of activated cytotoxic T-lymphocytes. Our results suggest that $CD11c^+CD8^+$ T-cells play a role in the anti-tumor immunity induced by anti-4-1BB mAb.

• Information Systems Review
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• v.9 no.1
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• pp.139-160
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• 2007

Our study focuses on empirical findings of the critical factors which influence the performance of ERP system in business. The study is mainly interested in examining the influence of the characteristics of late process of adopting ERP called "Go-Live" phase with the critical issues like customizing, transformational process of standardization, phased implementation, concurrent operation and use with the current systems on users' ERP satisfaction. The analyses of the data conducted thru moderated regression analysis and subgroup analysis. Using moderated regression analysis, we first examined the effect of moderator variables like customizing, process standardization, sequential use, concurrent use with the current systems. And then, using subgroup analysis is to verify directions of the moderator effects. Having knowledge on the characteristics of ERP Go-Live process can lead to success of ERP system in business. Our results can be beneficial to those organizations who want to adopt and maintain ERP system effectively.

• The Korean Journal of Physiology
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• v.20 no.1
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• pp.43-52
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• 1986

The influences of extracellular $Ca^{2+}\;and\;K^+$ upon the spike action potentials were studied in isolated uterine strips of rat. Regular, rhythmic uterine contractions were induced by the administration of oxytocin$(0.2{\sim}0.5\;I.U.)$, and recorded with force transducer. Spike action potentials were extracellularly measured by use of suction electrode, and compared with those recorded intracellularly by glass microelectrode. The results obtained were as follows : 1) The frequency and duration of spike bursts, and the number of spikes in a burst could be analyzed by use of both methods. But the absolute values of membrane potential were not measurable with the suction electrode. 2) The duration of contraction$(CD_{90};\;the\;duration\;of\;90%\;relaxation)$ was lengthened from the control 17.0 sec to 20.6 sec, in parallel with the increase of spike number from the control 21 to 26, as the increase in $Ca^{2+}$ concentration from 2 to 4 mM. 3) The amplitude and frequency of contractions were gradually decreased, simultaneously with the decrease in the number of spikes in a burst, when the $Ca^{2+}-antagonist$, verapamil was administered cumulatively. 4) The number of spikes was changed from the control 15 to 7, in cabs of the administration of ver)'low dose of verapamil$(10^{-6}\;g/l)$. 5) Increase in the numbers of spike bursts was well matched to the increase in frequency of contractions when extracellular $K^+$ was increased.

• Journal of Digital Convergence
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• v.17 no.9
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• pp.349-359
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• 2019

This study investigated the current state of Korean Maker Movement and explored the ways for activating Maker Movement in Korea. To do this purpose, we analyzed the data of 'A survey of the Korea Maker Movement in the second half of 2018', conducted by Korea Foundation for the Advancement of Science & Creativity involved 20's~50's Koreans. As a results, first, awareness, interest and behavior intention of Maker Movement was not high in Korea. Second, there were significant different between participants and non-participants of Maker Community in Maker awareness and Maker activities. Third, the positive relation between Maker Community participation and Maker Orientation is parallel multiple mediated by Maker activating motives such as fun, relieving stress, expressing own idea, saving cost, social recognition. Lastly, based upon the results, we presented several ways to activate Maker Movement in Korea.

• Steel and Composite Structures
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• v.37 no.4
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• pp.447-462
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• 2020

In this paper, a simplified seismic design method for low-rise dual frame-steel plate shear wall (SPSW) structures is proposed in the framework of performance-based seismic design. The dynamic response of a low-rise structure is mainly dominated by the first-mode and the structural system can be simplified to an equivalent single degree-of-freedom (SDOF) oscillator. The dual frame-SPSW structure was decomposed into a frame system and a SPSW system and they were simplified to an equivalent F-SDOF (SDOF for frame) oscillator and an equivalent S-SDOF (SDOF for SPSW) oscillator, respectively. The analytical models of F-SDOF and S-SDOF oscillators were constructed based on the OpenSees platform. The equivalent SDOF oscillator (D-SDOF, dual SDOF) for the frame-SPSW system was developed by combining the F-SDOF and S-SDOF oscillators in parallel. By employing the lateral force resistance coefficients and seismic demands of D-SDOF oscillator, the design approach of SPSW systems was developed. A 7-story frame-SPSW system was adopted to verify the feasibility and demonstrate the design process of the simplified method. The results also show the seismic demands derived by the equivalent dual SDOF oscillator have a good consistence with that by the frame-SPSW structure.

• Journal of Korean Society for Quality Management
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• v.46 no.3
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• pp.717-738
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• 2018

Purpose: This study aims to analyze why surveys of a single set of customer requirement result in different Kano analyses depending on the survey questionnaire designs. Methods: This study singled out 14 common features from four different questionnaires of two studies of Smart Car features and analyzed them using the Kano model. Several methods and devices were used: Group Comparison and Timko Index were applied; Kano Distribution Index, Timko Dispersion and Kano Conformity were newly introduced for the quantitative analysis; Correlations between Timko indices from different Kano questionnaires were conducted; Heuristic Splitting technic for reinforcing attribute categorization is introduced. Results: Correlation Coefficient proved strong positive relations among the three questionnaires, whose agreement degree of the resulting Kano attributes showed less than 10% when Indifferent was ignored. Heuristic Splitting on Timko charts enhanced the degree of the resulting Kano attributes up to 80%. Conclusion: Among the questionnaires the representation of customer requirements tends to move by parallel shifts on the Timko chart maintaining their relative locations. Heuristic Splitting suggests a rational solution to the interpretation of those inexplicable attribute categories resulting from traditional Kano methods.

• Journal of Korean Institute of Industrial Engineers
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• v.36 no.2
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• pp.125-137
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• 2010

This study focuses on the problem of scheduling wafer lots of several product families in the deposition workstation in a semiconductor wafer fabrication facility. There are multiple identical parallel machines in the deposition workstation, and two types of setups, record-dependent setup and family setup, may be required at the deposition machines. A record-dependent setup is needed to find optimal operational conditions for a wafer lot on a machine, and a family setup is needed between processings of different families. We suggest two-phase heuristic algorithms in which a priority-rule-based scheduling algorithm is used to generate an initial schedule in the first phase and the schedule is improved in the second phase. Results of computational tests on randomly generated test problems show that the suggested algorithms outperform a scheduling method used in a real manufacturing system in terms of the sum of weighted flowtimes of the wafer lots.