• The Korean Journal of Pain
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• v.3 no.2
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• pp.119-124
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• 1990

Reiestad and Stromskag recently introduced the interpleural installation of local anesthetic solutions as a technique for the management of postoperative pain in patients undergoing cholecystectomy, renal surgery, and breast surgery. This study was done to manage postoperative pain in the patients undergoing unilateral upper-abdominal surgery and thoracotomy. Twenty patients received 0.5% bupivacaine 20 ml with epinephrine (Children, received 10 ml). Results were as follows: 1) Analgesic effects appeared in 15.56 minutes; mean analgesic duration from the initial intrapleural injection was 10.5 hours. 2) Blood pressure increased more after the operation than before the operation. Blood pressure before injection of bupivacaine was highest (p<0.01). Heart rate was increased before injection and 10 minutes after injection of 0.5% bupivacaine (p<0.05). 3) The values of $PaCO_2$, were improved from $41.7{\pm}2.02\;mmHg$ ($PaCO_2$), $85.2{\pm}2.41\;mmHg$ ($PaO_2$) to $37.8{\pm}2.41\;mmHg$ ($PaCO_2$), $107.0{\pm}7.86\;mmHg$ ($PaO_2$) respectively (p<0.01). 4) Complication such as pneumothorax, atelectasis and CNS toxicity did not appear. 5) Intrapleural administration of local anesthetics after unilateral upper-abdominal and thoracic surgery provided a satisfactory pain control.

• Korean Journal of Adult Nursing
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• v.20 no.2
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• pp.209-218
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• 2008

Purpose: Regarding the respiratory function of patients with an artificial airway, this study compared the effects between normal saline with chest vibration and normal saline with expectorant mixture, administered before endotracheal suction. Methods: The study was conducted in the ICUs of one university hospital located in Incheon. The experimental group I received normal saline with chest vibration administered before endotracheal suction while the experimental group II received normal saline with expectorant mixture administered before endotracheal suction. For respiratory function, $PaO_2$, $PaCO_2$, and $O_2$ saturation were measured by ABGA at 3 minutes after endotracheal suction for both pre-test and post-test. Results: The two groups were not different significantly regarding $PaO_2$ level and $O_2$ saturation after the treatments, while, the experimental group II had lower $PaCO_2$ level than the experimental group I after the treatments (t = 2.075, p = .042). For experimental group II, post-test score of $PaCO_2$ level was significantly lower than that of the pre-test score (t = 1.842, p = .075). Conclusion: The administration of normal saline with expectorant mixture before endotracheal suction reduced $PaCO_2$ level and improved the respiratory function.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.77-77
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• 2018

천마(Gastrodia elata)는 연중생산을 위해 실내시설 재배 시 생육모델을 구죽하고, 생육단계에 따른 온도, 수분, $CO_2$ 등 환경 조건 설정이 필요하다. 본 연구는 천마의 생육단계 중 괴경형성기와 괴경비대기의 수분함량을 설정하여 최적의 환경조건을 찾기 위해 수행하였다. 먼저 괴경형성기 수분함량 공급은 괴경형성기에 -20kPa, -30kPa, -40kPa로 처리하여 120일간 배양한 뒤, 괴경비대기를 -40kPa로 고정하여 60일간 배양하였다. 반면, 괴경비대기 수분함량 공급은 괴경형성기를 -30kPa로 고정하여 120일간 배양한 뒤 괴경비대기에 -20kPa, -30kPa, -40kPa, -50kPa로 처리하여 60일간 배양하였다. Tensiometer(토양수분장력계)기를 설치하여 수분을 공급하였고, FDR센서 (UbiMas, CoCo sensor, Frequency domain reflectometry type)를 배양토의 깊이 5 cm와 15 cm에 2개를 설치하여 평균값으로 수분함량을 측정하였으며, 전체수량, 성마율, 종마율 등을 조사하였다. FDR센서로 수분함량을 측정한 결과, -20 kPa은 43.3%, -30 kPa은 34.7%, -40 kPa은 29.8%, -50 kPa은 25.3%로 측정되었다. 괴경형성기 수분함량 처리 후 수확기의 상자 당 전체수량은 -30 kPa일 때 985 g으로 가장 많았고, -40 kPa일 때 912 g, -20 kPa일 때 703 g으로 처리간의 유의적인 차이를 보였다. 성마율은 수분함량처리별 각각 25, 34, 30% 이었고, 종마율은 수분함량처리별 각각 53, 73, 65%로 나타났다. 따라서 -30 kPa 처리구가 다른 처리구에 비해 전체수량, 성마율, 종마율 등이 유의적으로 우수하였다. 괴경비대기 수분 함량 처리 후 수확기의 상자 당 전체수량은 -40 kPa일 때 992 g으로 가장 많았고, -50 kPa일 때 955 g, -30 kPa일 때 903 g, -20 kPa일 때 686 g 순으로 나타났다. -30 kPa에서 -50 kPa 사이에서는 전체 수량의 유의성 차이는 없었다. 성마율은 수분함량처리별 각각 20, 30, 35, 33%이었고, 종마율은 수분함량처리별 각각 45, 65, 75, 68%로 나타났다. 따라서 -40 kPa 처리구가 다른 처리구에 비해 전체수량, 성마율, 종마율 등이 유의적으로 우수하였다. 반면 -20 kPa 처리구는 과도한 수분으로 천마가 오히려 부패될 수 있는 환경조건이 조성됨에 따라 성마율, 종마율 등 전체적인 수량 감소에 영향을 미친 것으로 판단되었다.

• Journal of Environmental Health Sciences
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• v.22 no.1
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• pp.12-20
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• 1996

This study was carried out to investigate the change of average .specific resistance according to suspension concentration for study phenomena occurring during filtration period. As the results of this study, the following conclusions were obtained. The average specific resistance in 1% $CaCO_3$ suspension was showed power function(R=0.99), whereas in TOYO 5C and TOYO 5A paper were made little difference under high pressure. It represented from results that filtration theory in concord with cake filtration was no affected the average specific resistance of filter medium in cake filtration. In case of 0.1% $CaCO_3$ suspension filtration, the TOYO 5C was showed power function, whereas in TOYO 5A paper differently. In the present study, the $P_1$ value was calculated from the average specific resistance by filtration method. Therefore, $P_1$ value were $1.68\times 10^4Pa$, $4.05\times 10^3Pa$, and $3.15\times 10^3Pa$ in $5.3\times 10^4Pa$, $1.3\times 10^4Pa$, and $8.2\times 10^3Pa$, respectively. We concluded that propriety of new filtration theory was also proved.

• Tuberculosis and Respiratory Diseases
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• v.52 no.1
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• pp.14-23
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• 2002

Background: The opitmal ventilator setting during partial liquid ventilation(PLV) is controversial. This study investigated the effects of various gas exchange parameters during PLV in normal rabbit lungs in order to aid in the development of an optimal ventilator setting during PLV. Methods: Seven New-Zealand white rabbits were ventilated in pressure-controlled mode with the following settings; tidal volume($V_T$) 8 mL/kg, positive end-expiratory pressure(PEEP) 4 $cmH_2O$, inspiratory-to-expiratory ratio(I:E ratio) 1:2, fraction of inspired oxygen($F_TO_2$) 1.0. The respiration rate(RR) was adjusted to keep $PaCO_2$ between 35~45 mmHg. The ventilator settings were changed every 30 min in the following sequence : (1) Baseline, as the basal ventilator setting, (2) Inverse ratio, I:E ratio 2:1, (3) high PEEP, adjust PEEP to achieve the same mean inspiratory pressure (MIP) as in the inverse ratio, (4) High $V_T$, $V_T$ 15 mL/kg, (5) high RR, the same minute ventilation (MV) as in the High $V_T$. Subsequently, the same protocol was repeated after instilling 18 mL/kg of perfluorodecalin for PLV. The parameters of gas exchange, lung mechanics, and hemodynamics were examined. Results: (1) The gas ventilation(GV) group showed no significant changes in the $PaO_2$ at all phases. The $PaCO_2$ was lower and the pH was higher at the high $V_T$ and high RR phases(p<0.05). No significant changes in the lung mechanics and hemodynamics parameters were observed. (2) The baseline $PaO_2$ for the PLV was $312{\pm}$ mmHg. This was significantly lower when decreased compared to the baseline $PaO_2$ for GV which was $504{\pm}81$ mmHg(p=0.001). During PLV, the $PaO_2$, was significantly higher at the high PEEP($452{\pm}38$ mmHg) and high $V_T$ ($461{\pm}53$ mmHg) phases compared with the baseline phase. However, it did not change significantly during the inverse I:E ratio or the high RR phases. (3) The $PaCO_2$ was significantly lower at high $V_T$ and RR phases for both the GV and PLV. During the PLV, $PaCO_2$ were significantly higher compared to the GV (p<0.05). (4) There were no important or significant changes in of baseline and high RR phases lung mechanics and hemodynamics parameters during the PLV. Conclusion: During PLV in the normal lung, adequate $V_T$ and PEEP are important for optimal oxygenation.

• Bulletin of the Korean Chemical Society
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• v.13 no.5
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• pp.553-556
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• 1992

The ${CO}_2$ laser absorption measurement of ${CH}_3{CH}_2Br$ utilizing photoacoustic (PA) technique was performed using a cw and a pulsed ${CO}_2$ lasers. The absorption profile in the ${CO}_2$ laser wavelength region (9-10 ${\mu}$m) and the macroscopic small signal absorption cross section at 10P(20) (10.59 ${\mu}$m, 944 $cm^{-1}$) laser line were measured using a cw ${CO}_2$ laser. The laser fluence dependence on infrared multiphoton absorption (IRMPA) was also studied with a pulsed TEA ${CO}_2$ laser at 10P(20) laser line. In view of monotonic increase of PA signal with the rise of laser fluence, it was suggested that the anharmonicity in pumped vibration mode did not restrict ir multiphoton absorption in ${CH}_3{CH}_2Br$ system as found in large molecular system.

• Tuberculosis and Respiratory Diseases
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• v.45 no.1
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• pp.169-175
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• 1998

Background: Heliox is known to decrease $PaCO_2$ in patients with increased airway resistance by increasing minute ventilation and reducing work of breathing(WOB). Besides these effect, heliox is expected to decrease functional anatomic dead space owing to improvement of peak expiratory flow rate(PEFR) and enhancement of gas distribution. We investigated whether heliox can decrease $PaCO_2$ even at the same minute ventilation (VE) and WOB with $N_2-O_2$ to speculate the effect of the heliox on the anatomic dead space. Material and Method: The subjects were 8 mechanically ventilated patients with asthma or upper airway obstruction(M : F=5 : 3, $68{\pm}10$years) who were under neuromuscular paralysis. The study was consisted of three 15-minutes phases: basal $N_2-O_2$ heliox and washout Heliox was administered via the low pressure inlet of servo 900C, and respiratory parameters were measured by pulmonary monitor(CP-100 pulmonary monitor, Bicore, Irvine, CA, USA). To obtain the same tidal volume(Vt) in heliox phase, the Vt on monitor was adjusted by the factor of relative flow rate of heliox to $N_2-O_2$. Dead space was calculated by Bohr equation. Results: 1) Vt, VE, peak inspiratory pressure(PIP) and peak inspiratory flow rate(PIFR) were not different between $N_2-O_2$ and heliox. 2) PEFR was higher on heliox($0.52{\pm}0.19$L/sec) than $N_2-O_2$($0.44{\pm}0.13$L/sec)(p=0.024). 3) $PaCO_2$(mmHg) were decreased with heliox($56.1{\pm}14.1$) compared to $N_2-O_2$($60.5{\pm}15.9$)(p=0.027). 4) Dead space ventilation(%) were decreased with heliox($73{\pm}9$ with $N_2-O_2$ and $71{\pm}10$ with heliox)(p=0.026). Conclusion: Heliox decreased $PaCO_2$ even at the same VE and WOB with $N_2-O_2$, and the effect was considered to be related with the reduction of anatomic dead space.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2002.02a
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• pp.217-222
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• 2002

본 연구에서는 가연성 폐기물을 이용한 시설원예 난방에너지 공급시스템 개발을 위하여 대형 온실 난방이나 RPC 시설에 이용할 수 있는 왕겨와 중유 겸용연소 시스템에서 중유의 연소 및 성능 특성을 분석하고자 하였다. 중요 인자로는 분사노즐의 크기(2.0, 2.25, 2.5, 3.0 GPH)와 진공압력(375, 500, 625, 750 Pa)을 설정하였으며 이에 대한 결과를 요약하면 다음과 같다. 1.진공압력 500Pa조건에서 연료 공급율이 증가할수록 연소실 벽체 열교환기 효율은 감소하고 폐열회수 열교환기와 사이클론 열교환기의 효율이 증가하였으며, 노즐 2.5GPH에서 진공압력이 커질수록 연소실 하부의 온도가 감소하였고 연소실 상부에서는 비슷한 경향을 보였다. 2, 연소온도특성, 열효율, 배기가스 성분분석 등의 결과로 볼 때 최적의 연소 조건은 노즐 2.5GPH는 진공압력 375Pa, 노즐3.0GPH는 진공압력 500Pa과 625Pa 사이로 판단되었다. 3. 배연가스내의 대기오염 성분은 모든 실험처리에서 CO 함량은 거의 없고 SO$_2$와 NO$_{x}$의 함량 또한 일반 보일러 허용기준을 만족하는 것으로 나타났다.

• Proceedings of the KSPS conference
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• 2007.05a
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• pp.261-264
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• 2007

Five males trained singers (age:25.0${\pm}$1.4years, career:6.8${\pm}$1.1 years) and five female trained singers (age:22.0${\pm}$1.0years, career:5.8${\pm}$1.2 years) participated in this study. SaO2(Oxi Hemoglobin saturation) measured by Oxy-Pulse meter and PAC02 (Pressure Alveolar Co2) measured by Quick et CO2 are compared with pre and post vocal training. As the result, PAC02 was lower than normal range (36-40mmHg) after vocal training, leading to Hypocapnia. This causes headache and dizziness

• Journal of Veterinary Science
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• v.23 no.1
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• pp.4.1-4.15
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• 2022

Background: Flavonoids are natural polyphenols found widely in citrus fruit and peel that possess anti-adipogenic effects. On the other hand, the detailed mechanisms for the antiadipogenic effects of flavonoids are unclear. Objectives: The present study observed the anti-adipogenic effects of five major citrus flavonoids, including hesperidin (HES), narirutin (NAR), nobiletin (NOB), sinensetin (SIN), and tangeretin (TAN), on AMP-activated protein kinase (AMPK) activation in palmitate (PA)-treated HepG2 cells. Methods: The intracellular lipid accumulation and triglyceride (TG) contents were quantified by Oil-red O staining and TG assay, respectively. The glucose uptake was assessed using 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) assay. The levels of AMPK, acetyl-CoA carboxylase (ACC), and glycogen synthase kinase 3 beta (GSK3β) phosphorylation, and levels of sterol regulatory element-binding protein 2 (SREBP-2) and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) expression were analyzed by Western blot analysis. The potential interaction between the flavonoids and the γ-subunit of AMPK was investigated by molecular docking analysis. Results: The flavonoid treatment reduced both intracellular lipid accumulation and TG content in PA-treated HepG2 cells significantly. In addition, the flavonoids showed increased 2-NBDG uptake in an insulin-independent manner in PA-treated HepG2 cells. The flavonoids increased the AMPK, ACC, and GSK3β phosphorylation levels and decreased the SREBP-2 and HMGCR expression levels in PA-treated HepG2 cells. Molecular docking analysis showed that the flavonoids bind to the CBS domains in the regulatory γ-subunit of AMPK with high binding affinities and could serve as potential AMPK activators. Conclusion: The overall results suggest that the anti-adipogenic effect of flavonoids on PA-treated HepG2 cells results from the activation of AMPK by flavonoids.