• 한국약용작물학회지
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• 제17권3호
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• pp.217-222
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• 2009

The purpose of this study evaluated the immunoregulatory effect of phellinus linteus ethanol (PLE) extracts on liver damage on carbon tetrachloride ($CCl_4$) induced in rats. Four-week old Male Sprague-Dawley rats were divided into the three experimental groups randomly; Control group, $CCl_4$ group, $CCl_4$ + PLE group. We found that effect of PLE on $IFN-\gamma$, STAT1 and pSTAT1 was decrease in vivo. Several genes were demonstrated to be IL-4 inducible prior to the discovery of STAT6. IL-4, STAT6 and pSTAT6 decreased significantly lower in $CCl_4$ + PLE than the $CCl_4$ group. Our data indicated that cytokine protein production were increased in $CCl_4$ group with $CCl_4$ + PLE group. In our data indicate that IgA levels in MLN lymphocytes were low, while IgE was high in $CCl_4$ + PLE group compared with $CCl_4$ group. Therefore, the results of this study show that PLE can be proposed to protect the liver against $CCl_4$-induced immunoregulatory activity in rats.

• 한국전문물리치료학회지
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• 제18권3호
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• pp.85-93
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• 2011

The purpose of this study was to establish the reliability and validity of the passive lumbar extension (PLE) test and prone instability test (PIT). Thirty-three subjects (14 males, 19 females) with lower back pain enrolled in the study and the subjects were divided into 2 groups (positive and negative instability groups) on the basis of radiographies of flexion and extension. Reliability was determined by the kappa coefficient and validity was examined using calculated sensitivity, specificity, and the likelihood ratio. The results showed that the reliability of the PLE test was higher than the PIT (intra-rater reliability: k=.86 and k=.81, interrater reliability: k=.65 and k=.62) and the validity of the PLE test was also higher than the PIT (sensitivity: 91% and 62%, specificity: 95% and 85% positive likelihood ratio: 20.00 and 4.10, negative likelihood ratio: .10 and .45). In conclusion, we think that the PLE test was a more reliable and valid method for lumbar instability than the PIT.

• IMMUNE NETWORK
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• 제14권2호
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• pp.107-115
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• 2014

Phellinus linteus has been used as a traditional herbal medicine in Asian countries and is known to have anti-tumor, immunomodulatory, anti-inflammatory, and anti-allergic activities. However, the protective effects of P. linteus against experimental asthma have not been fully investigated. The objective of this study was to determine whether P. linteus ethanol extract (PLE) suppresses inflammatory response in an OVA-induced asthma model. As expected, the oral administration of PLE significantly inhibited eosinophilic airway inflammation and airway hyperresponsiveness in OVA-challenged BALB/c mice. Supporting these data, the augmentation of Th2 cytokines (IL-4, IL-5, and IL-13), eotaxin, and adhesion molecules in lung tissues and bronchoalveolar lavage fluid after OVA inhalation was markedly attenuated by PLE. Furthermore, PLE reduced OVA-induced activation of NF-${\kappa}B$ and p38 MAPK in lung tissues. Therefore, our results suggest the potential of P. linteus as a therapeutic agent for asthma.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권1호
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• pp.446-465
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• 2015

In this modern era of technology and information, e-learning approach has become an integral part of teaching and learning using modern technologies. There are different variations or classification of e-learning approaches. One of notable approaches is Personal Learning Environment (PLE). In a PLE system, the contents are presented to the user in a personalized manner (according to the user's needs and wants). The problem arises when a new user enters the system, and due to the lack of information about the new user's needs and wants, the system fails to recommend him/her the personalized e-learning contents accurately. This phenomenon is known as cold-start problem. In order to address this issue, existing researches propose different approaches for recommendation such as preference profile, user ratings and tagging recommendations. In this research paper, the implementation of a novel interaction-based approach is presented. The interaction-based approach improves the recommendation accuracy for the new-user cold-start problem by integrating preferences profile and tagging recommendation and utilizing the interaction among users and system. This research work takes leverage of the interaction of a new user with the PLE system and generates recommendation for the new user, both implicitly and explicitly, thus solving new-user cold-start problem. The result shows the improvement of 31.57% in Precision, 18.29% in Recall and 8.8% in F1-measure.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2000년도 하계학술대회 논문집
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• pp.33-38
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• 2000

The ~1540 nm Er$^{3+}$ photoluminescence (PL) and photoluminescence excitation (PLE) spectra of Er-implanted Mg-codoped GaN (GaN:Er+Mg) exhibit that the excitation efficiency of a specific Er$^{3+}$ center among different Er$^{3+}$ centers existing in Er-implanted GaN is selectively enhanced, compared to Er-implanted undoped GaN (GaN:Er). In GaN:Er+Mg, the 1540 nm PL peaks characteristic of the so-called "violet-pumped" Er$^{3+}$ center and the ~2.8-3.4 eV (violet) PLE band are significantly strengthened by the Mg-doping. The intra-f absorption PLE bands associated with this "violet-pumped" center are also enhanced by this doping. The 1540 nm PL peaks originating from the violet-pumped center dominate the above-gap-excited Er$^{3+}$ PL spectrum of GaN:Er+Mg, whereas it was unobservable under above-gap excitation in GaN:Er. All of these results indicate that Mg doping increases the efficiency of trap-mediated excitation of Er$^{3+}$ emission in Er-implanted GaN.planted GaN.

• Nutrition Research and Practice
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• 제9권1호
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• pp.11-16
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• 2015

BACKGROUND/OBJECTIVES: Perilla frutescens Britton leaves are a commonly consumed vegetable in different Asian countries including Korea. Cancer is a major cause of human death worldwide. The aim of the current study was to investigate the inhibitory effects of ethanol extract of perilla leaf (PLE) against important characteristics of cancer cells, including unrestricted growth, resisted apoptosis, and activated metastasis, using human cancer cells. MATERIALS/METHODS: Two human cancer cell lines were used in this study, HCT116 colorectal carcinoma cells and H1299 non-small cell lung carcinoma cells. Assays using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide were performed for measurement of cell growth. Soft agar and wound healing assays were performed to determine colony formation and cell migration, respectively. Nuclear staining and cell cycle analysis were performed for assessment of apoptosis. Fibronectin-coated plates were used to determine cell adhesion. RESULTS: Treatment of HCT116 and H1299 cells with PLE resulted in dose-dependent inhibition of growth by 52-92% (at the concentrations of 87.5, 175, and $350{\mu}g/ml$) and completely abolished the colony formation in soft agar (at the concentration of $350{\mu}g/ml$). Treatment with PLE at the $350{\mu}g/ml$ concentration resulted in change of the nucleus morphology and significantly increased sub-G1 cell population in both cells, indicating its apoptosis-inducing activity. PLE at the concentration range of 87.5 to $350{\mu}g/ml$ was also effective in inhibiting the migration of H1299 cells (by 52-58%) and adhesion of both HCT116 and H1299 cells (by 25-46%). CONCLUSIONS: These results indicate that PLE exerts anti-cancer activities against colon and lung cancers in vitro. Further studies are needed in order to determine whether similar effects are reproduced in vivo.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제36권3호
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• pp.417-438
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• 2022

본 연구의 목적은 개별화 맞춤형 수학 학습을 지원하는 AI 기반 플랫폼 활용 시 고려해야 할 교수·학습에 관한 시사점을 제안하는 것이다. 이를 위해 국내·외 공교육에서 활용되고 있는 플랫폼 5개(똑똑!수학탐험대, 노리AI스쿨수학, 칸 아카데미, MATHia, CENTURY)를 분석대상으로 선정하여, AI 기반 수학교육 플랫폼이 개별화 맞춤형 학습을 지원하기 위한 세 가지 요소(PLP, PLN, PLE)를 어떻게 반영하고 있는지를 분석하였다. 그 결과, 각 플랫폼에서 구현하고 있는 PLP, PLN, PLE의 특징은 다양했지만, PLP와 PLN을 바탕으로 학습자가 자율적으로 학습에 대한 의사결정을 내릴 수 있는 PLE를 형성할 수 있도록 설계된 것으로 분석되었다. 본 연구의 의의는 AI 기반 수학교육 플랫폼을 활용하는 개별화 맞춤형 수학 학습에 대한 이해도와 실천 가능성을 높였다는 데에서 찾을 수 있다.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2004년도 가을 학술발표논문집 Vol.31 No.2 (2)
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• pp.319-321
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• 2004

제품 계열 공학(Product Line Engineering, PLE)는 패밀리 멤버들의 공통성과 가변성을 분석하여 만든 핵심 자산을 특화시켜 어플리케이션을 개발함으로써 재사용성과 이용가능성을 증대시키는 접근 방법이다. 핵심 자산은 제품 계열에 속하는 패밀리 멤버들이 어플리케이션을 만드는데 기초가 되는 모든 자산을 포함하며, 아키텍처, 컴포넌트 둥이 포함될 수 있다. 범용 아키텍처는 패밀리 멤버들이 공통적으로 사용할 수 있는 아키텍처로, 제품 계열에 속하는 제품들의 구조를 정의하고 컴포넌트의 인터페이스 명세를 제공하여 컴포넌트만큼 중요한 재사용 단위이다. 본 논문에서는 대표적인 PLE 방법론에서 정의한 제품 계열 아키텍처와 일반 소프트웨어 아키텍처를 비교하여 범용 아키텍처에 포함되는 요소들을 선정하고, 메타 모델을 이용하여 범용 아키텍처 구성요소와 구성요소간 관계를 명확히 정의함으로써, 개념적인 아키텍처를 보다 실용적으로 설계하는데 도움이 되게 하고자 한다.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2004년도 가을 학술발표논문집 Vol.31 No.2 (2)
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• pp.448-450
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• 2004

제품 계열 공학 (Product Line Engineering, PLE)은 유사한 도메인에 속한 제품들로부터 공통성과 가변성을 분석하여 재사용 가능한 핵심 자산 (core asset)을 만들고, 만들어진 핵심 자산을 사용하여 어플리케이션을 개발하는 제품 개발 기술이다. 그러나 아직까지는 표준화된 방법론이 존재하지 않아 산업계와 학계는 해당 제품에 적합한 방법론 또는 프로세스의 일부를 선택하는 과정에서 어려움을 겪고 있다. 본 논문에서는 재사용성을 강조하는 PLE 방법론의 핵심 자산 구성 요소를 비교하여, 산업계나 학계가 핵심 자산을 개발하는 과정에서 효율성을 높일 수 있는 방법론을 선택하는데 도움이 되는 기반 연구를 한다. 나아가 본 논문은 비교 기준이 된 요소들과 비교 결과가 PLE 방법론을 표준화하는 과정에서도 사용될 수 있도록 정보를 제공한다.

• 식물병과 농업
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• 제1권2호
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• pp.18-21
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• 1995

Mycosphaerella nawae, the causal organism, of spotted leaf casing disease of persimmon, was isolated from infected leaves showing typical symptom. The cultural characteristics of the fungus were compared on artificial media. Among 24 different combinations of culture media and supplements, oatmeal agar+persimmon leaf extract (PLE) and PAD+ PLE+streptomycin showed the highest rate of isolating as 57.1%. The best medium for mycelial growth of the fungus was PDA+persimmon leaf powder (PLP). The colony diameter was reached 47mm for 30 days at 2$0^{\circ}C$. PDA+PLE also supported good mcyelial growth showing 46mm of diameter in same condition. The optimum growth temperature of this fungus in PDA was recognized fairly low. The mycelial growth was higher at 2$0^{\circ}C$ than 15$^{\circ}C$. The variation of pH between pH 4 to pH 8 did not affect to the mycelial growth of the pathogen.