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Immunomodulatory Effects of phellinus linteus Extracts on Liver Damage Induced by Carbon Tetrachloride in Rats.  

An, Chi-Sun (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Choi, Se-Young (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Jin, Hai-Lan (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Jeon, Yun-Hui (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Hur, Sun-Jin (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Kim, Ick-Hee (Department of Surgery, School of Medicine, Konkuk University)
Park, Geum-Duck (Suheung Capsule Company)
Jeoung, Young-Jun (Suheung Capsule Company)
Lim, Beong-Ou (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
Publication Information
Korean Journal of Medicinal Crop Science / v.17, no.3, 2009 , pp. 217-222 More about this Journal
Abstract
The purpose of this study evaluated the immunoregulatory effect of phellinus linteus ethanol (PLE) extracts on liver damage on carbon tetrachloride ($CCl_4$) induced in rats. Four-week old Male Sprague-Dawley rats were divided into the three experimental groups randomly; Control group, $CCl_4$ group, $CCl_4$ + PLE group. We found that effect of PLE on $IFN-\gamma$, STAT1 and pSTAT1 was decrease in vivo. Several genes were demonstrated to be IL-4 inducible prior to the discovery of STAT6. IL-4, STAT6 and pSTAT6 decreased significantly lower in $CCl_4$ + PLE than the $CCl_4$ group. Our data indicated that cytokine protein production were increased in $CCl_4$ group with $CCl_4$ + PLE group. In our data indicate that IgA levels in MLN lymphocytes were low, while IgE was high in $CCl_4$ + PLE group compared with $CCl_4$ group. Therefore, the results of this study show that PLE can be proposed to protect the liver against $CCl_4$-induced immunoregulatory activity in rats.
Keywords
Phellinus linteus; $CCl_4$; Nitric Oxide; IL-4; $IFN-\gamma$; STAT1/STAT6;
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Times Cited By KSCI : 5  (Citation Analysis)
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