Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
권호 표지

Immunomodulatory Effects of phellinus linteus Extracts on Liver Damage Induced by Carbon Tetrachloride in Rats.

상황버섯 추출물이 사염화탄소로 간 손상이 유발된 흰쥐에서의 면역조절 효과

  • An, Chi-Sun (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Choi, Se-Young (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Jin, Hai-Lan (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Jeon, Yun-Hui (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Hur, Sun-Jin (College of Biomedical & Health Science, Department of Life Science, Konkuk University) ;
  • Kim, Ick-Hee (Department of Surgery, School of Medicine, Konkuk University) ;
  • Park, Geum-Duck (Suheung Capsule Company) ;
  • Jeoung, Young-Jun (Suheung Capsule Company) ;
  • Lim, Beong-Ou (College of Biomedical & Health Science, Department of Life Science, Konkuk University)
  • 안치선 (건국대학교 의료생명대학 생명과학부) ;
  • 최세영 (건국대학교 의료생명대학 생명과학부) ;
  • 김해란 (건국대학교 의료생명대학 생명과학부) ;
  • 전윤희 (건국대학교 의료생명대학 생명과학부) ;
  • 허선진 (건국대학교 의료생명대학 생명과학부) ;
  • 김익희 (건국대학교 의과대학) ;
  • 박금덕 (서흥캅셀) ;
  • 정용준 (서흥캅셀) ;
  • 임병우 (건국대학교 의료생명대학 생명과학부)
  • Published : 2009.06.30
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Abstract

The purpose of this study evaluated the immunoregulatory effect of phellinus linteus ethanol (PLE) extracts on liver damage on carbon tetrachloride ($CCl_4$) induced in rats. Four-week old Male Sprague-Dawley rats were divided into the three experimental groups randomly; Control group, $CCl_4$ group, $CCl_4$ + PLE group. We found that effect of PLE on $IFN-\gamma$, STAT1 and pSTAT1 was decrease in vivo. Several genes were demonstrated to be IL-4 inducible prior to the discovery of STAT6. IL-4, STAT6 and pSTAT6 decreased significantly lower in $CCl_4$ + PLE than the $CCl_4$ group. Our data indicated that cytokine protein production were increased in $CCl_4$ group with $CCl_4$ + PLE group. In our data indicate that IgA levels in MLN lymphocytes were low, while IgE was high in $CCl_4$ + PLE group compared with $CCl_4$ group. Therefore, the results of this study show that PLE can be proposed to protect the liver against $CCl_4$-induced immunoregulatory activity in rats.

Keywords

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