• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 제3회 추계심포지움
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• pp.49-57
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• 1995

Protein kinase C (PK-C) represents a central element transducing signals generated by a broad range of pathways which produce the lipid second messenger sn-1,2-diacylglycerol (DAG) directly or indirectly. Many dominant oncogenes have proven to function, at least in part, through this pathway Likewise, this pathway is involved in expression of other aspects of the transformed phenotype, such as tumor invasion or multidrug resistance. As expected from its broad role in cell signaling, PK-C Is also important in a range of other physiological and pathophysiological processes, including inflammation, differentiation, and nerve function.

• International Journal of Quality Innovation
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• 제6권2호
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• pp.31-45
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• 2005

The target costing technique, mathematically discussed by Sauers, only uses the $C_p$ index along with Taguchi loss function and ${\bar{X}}-R$ control charts to set up goal control limits. The new specification limits derived from Taguchi loss function is linked through the $C_p$ value to ${\bar{X}}-R$ control charts to obtain goal control limits. This study further considers the reflected normal loss function as well as the $C_{pk}$ index along with its lower confidence interval in forming goal control limits. With the use of lower confidence interval to replace the point estimator of the $C_{pk}$ index and reflected normal loss function proposed by Spiring to measure the loss to society, this modified and improved target costing technique would become more robust and applicable in practice. Finally, an example is provided to illustrate how this modified and improved target costing technique works.

• 품질경영학회지
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• 제26권1호
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• pp.48-60
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• 1998

This paper proposes a fourth generation index $C_{psk}$, constructed from $C_{psk}$, by introducing the factor｜$\mu$-T｜ in the numerator as an extra penalty for the departure of the process mean from the preassigned target value T. The motivation behind the introduction of $C_{psk}$ is that when $T\neqM$ process shifts away from target are evaluated without respect to direction. All indices that are now in use assume normally distributed data, and any use of the indices on non-normal data results in inaccurate capability measurements. In this paper, a new process capability index $C_{psk}$ is introduced for non-normal process. The Pearson curve and the Johnson curve are selected for capability index calculation and data modeling the normal-based index $C_{psk}$ is used as the model for non-normal process. A significant result of this research find that the ranking of the six indices, $C_{p}$, $C_{pk}$, $C_{pm}$, ${C^*}_{psk}$, $C_{pmk}$, $C_{psk}$in terms of sensitivity to departure of the process median from the target value from the most sensitive one up to the least sensitive are $C_{psk}$, $C_{pmk}$, ${C^*}_{psk}$,$C_{pm}$, $C_{pk}$, $C_{p}$.

• 산업경영시스템학회지
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• 제40권1호
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• pp.41-49
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• 2017

Process quality control, which prevents problems and risks that may occur in products and processes, has been recognized as an important issue, and SPC techniques have been used for this purpose. Process Capability Index (PCI) is useful Statistical Process Control (SPC) tool that is measure of process diagnostic and assessment tools widely use in industrial field. It has advantage of easy to calculate and easy to use in the field. $C_p$ and $C_{pk}$ are traditional PCIs. These traditional $C_p$ and $C_{pk}$ were used only as a measure of process capability, taking into account the quality variance or the bias of the process mean. These are not given information about the characteristic value does not match the target value of the process and this has the disadvantage that it is difficult to assess the economic losses that may arise in the enterprise. Studies of this process capability index by many scholars actively for supplement of its disadvantage. These studies to evaluate the capability of situation of various field has presented a new process capability index. $C_{pm}$ is considers both the process variation and the process deviation from target value. And $C_{pm}{^+}$ is considers economic loss for the process deviation from target value. In this paper we developed an improved Expected Loss Capability Index using Reflected Normal Loss Function of Spring. This has the advantage that it is easy to realistically reflect the loss when the specification is asymmetric around the target value. And check the correlation between existing traditional process capability index ($C_{pk}$) and new one. Finally, we propose the criteria for classification about developed process capability index.

• 방사선산업학회지
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• 제17권2호
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• pp.127-134
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• 2023

Pharmacokinetic (PK) data provide pivotal information in drug development, and they are usually first studied in the preclinical stage using various animals. However, quite often, animal PK data may not match with human PK, especially in metabolites. Thus, most regulatory agencies in the world make it mandatory to obtain metabolite information using ¹⁴C radiolabeled drug in human for small molecule drug candidates. However, such studies are expensive and time consuming and they are usually done at the end of Phase II trials using ~3.7 MBq of ¹⁴C labeled drug in a limited number of human subjects. Introduction of accelerator mass spectrometry (AMS) in this kind of study has revolutionized it. Since AMS can measure ¹⁴C level as close as natural abundance, it can quantify the amounts of ¹⁴C labeled drugs and their metabolites produced in human body that consumes less than the amount of 0.0037 MBq of ¹⁴C labeled drug, a very safe level of radioactive dose in human. Therefore, it is now possible to conduct human ¹⁴C studies safely in early clinical trials without spending hefty amount of money and time. Korea Radioisotope Center for Pharmaceuticals(KRICP) at Korea Institute of Biological and Medical Sciences(KIRAMS) has established an AMS facility in 2018, housing a 0.5MV AMS manufactured at the US National Electrostatics Corps (NEC). The AMS instrument has been validated using various standard samples that have been prepared at Lawrence Livermore National Laboratory in the US, a worldly reputable provider of AMS standards. In this paper, we present a mass balance study for acetaminophen in rats using AMS and prove that the study results are equivalent with those of literature, which shows the AMS facilities at KRICP has successfully installed and be ready to be used in the various PK studies using ¹⁴C labelled compounds for new drug development.

• 한국균학회지
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• 제9권3호
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• pp.153-155
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• 1981

Attempts were made to investigate on sterols of Cryptoporus volatus (Pk.) Hubb.. Its carpophores were collected in Gyeong Gi Province and extracted with a mixture of chloroform and methanol. From the extract eight spots were detected by T.L.C.. One of the spots was identified as ergosterol by T.L.C., G.L.C. and chemical tests.

• 한국의학물리학회지:의학물리
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• 제25권3호
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• pp.185-192
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• 2014

이 연구의 목적은 본원이 보유하고 있는 선형가속기들의 출력 특성을 Shewhart-type Chart, EWMA Chart, 공정능력지수 $C_p$와 $C_{pk}$을 이용한 통계적 분석으로 품질보증에 대한 결과를 평가하고자 한다. 측정값은 의학물리사에 의하여 2012년 9월부터 2014년 4월까지 매월 측정된 각각 치료기들(21EX, 21EX-S, Novalis Tx)의 출력측정값을 사용하였다. 치료기들의 출력 특성은 IAEA TRS-398의 가이드라인을 따랐으며, 측정 에너지는 광자선 6 MV, 10 MV, 15 MV와 전자선 4 MeV, 6 MeV, 9 MeV, 12 MeV, 16 MeV, 20 MeV였다. 매월 측정하여 교정한 출력특성에 대한 통계학적 분석이며, 가중인자와 측정값의 관리한계의 폭은 ${\lambda}=0.10$, L=2.703로 계산되었으며, 공정능력 $C_p$와 $C_{pk}$는 모든 선형가속기(21EX, 21EX-S, Novalis Tx)의 모든 에너지에서 1이상이었다. Shewhart-type Chart를 통하여 출력선량의 측정값의 큰 변화점을 찾을 수 있었고, EWMA Chart를 통하여 출력선량의 측정값의 미세한 변화점을 알아 볼 수 있었다. 본원의 치료기의 공정능력지수 $C_p$와 $C_{pk}$를 통하여 21EX가 2.384와 2.136, 21EX-S가 1.917과 1.682, Novalis Tx가 2.895와 2.473으로 Novalis Tx가 가장 안정적이고 정확한 출력특성을 나타내고 있었다.

• Biomolecules & Therapeutics
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• 제19권2호
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• pp.248-254
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• 2011

Biotransformation of pharmacologically inactive lactone prodrug simvastatin (SV) into pharmacologically active simvastatin ${\beta}$-hydroxy acid (SVA) exhibits inter-species differences due to variations in amount and activity of esterase enzymes. In this study, we investigated the pharmacokinetics (PK) of SV and its metabolite SVA following oral doses of SV from controlled-release (CR) tablets and immediate-release (IR) tablets in rodent and canine animal models that features different esterase activity. In rat PK study, no SV was detected in plasma for both formulations due to rapid hydrolysis of SV into SVA by plasma esterase. Besides, no significant differences in PK parameters of SV or SVA were observed between both species. In dog PK study, the relative oral bioavailability of CR tablets in terms of SV was 72.3% compared to IR tablets. Regarding formulation differences in dogs, CR tablets exhibited significantly lower $C_{max}$ (p<0.05), and higher $T_{max}$ (p<0.01) and MRT (p<0.01) for both SV and SVA compared to IR tablets. Accordingly, CR tablets of SV with prolonged drug release profiles in both species might be a potential candidate for a more effective delivery of SV with reduced side effects. Besides, similar PK parameters of SV and SVA in both species despite variation in enzyme activities suggested involvement of equally potent biotransformation pathways in these animal species.

• 대한수학회보
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• 제43권4호
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• pp.723-735
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• 2006

In [2] it was shown that a 1-generator quasi-cyclic code C of length n = ml of index l over $\mathbb{Z}_4$ is free if C is generated by a polynomial which divides $X^m-1$. In this paper, we prove that a necessary and sufficient condition for a cyclic code over $\mathbb{Z}_pk$ of length m to be free is that it is generated by a polynomial which divides $X^m-1$. We also show that this can be extended to finite local rings with a principal maximal ideal.

• 음성과학
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• 제15권4호
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• pp.43-60
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• 2008

Instrumental studies (e.g., aerodynamic, EPG, and EMMA) have shown that the first of two stops in sequence can be articulatorily reduced in time and space sometimes; either gradient or categorical. The current EMMA study aims to examine possible factors_linguistic (e.g., speech rate, word boundary, and prosodic boundary) and paralinguistic (e.g., natural context and repetition)_to induce gradient reduction of $C_1$ in /pk/ cluster sequences. EMMA data are collected from five Seoul-Korean speakers. The results show that gradient reduction of lip aperture seldom occurs, being quite restricted both in speaker frequency and in token frequency. The results also suggest that the place assimilation is not a lexical process, implying that speakers have not fully developed this process to be phonologized in the abstract level.