• Korean Journal of Remote Sensing
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• v.22 no.4
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• pp.265-274
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• 2006

Extracting ground points is the kernel of DTM generation being considered as one of the most popular LIDAR applications. The previous extraction approaches can be mostly characterized as a point based approach, which sequentially examines every individual point to determine whether it is measured from ground surfaces. The number of examinations to be performed is then equivalent to the number of points. Particularly in a large set, the heavy computational requirement associated with the examinations is obviously an obstacle to employing more sophisticated criteria for the examination. To reduce the number of entities to be examined and produce more robust results, we developed an approach based on features rather than points, where a feature indicates an entity constructed by grouping some points. In the proposed approach, we first generate a set of features by organizing points into surface patches and grouping the patches into surface clusters. Among these features, we then attempt to identify the ground features with the criteria based on the attributes of the features. The points grouped into these identified features are labeled ground points, being used for DTM generation afterward. The Proposed approach was applied to many real airborne LIDAR data sets. The analysis on the results strongly supports the prominent performance of the proposed approach in terms of not only the computational requirement but also the quality of the DTM.

• Journal of the Korean Society of Marine Environment & Safety
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• v.24 no.4
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• pp.489-495
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• 2018

In this paper, we designed and fabricated WLAN / UWB communication antennas operating at 3.3 [GHz] and 5 [GHz] bands in order to effectively use the high-speed communication network system that improved antenna miniaturization, gain and radiation pattern. Microstrip patch antennas were chosen to improve the bandwidth. The slot width, length, and transmission line width were calculated using the theoretical formula for each step. Simulation results show that the return loss is -14.053 [dB] at 3.3 [GHz] and -13.118 [dB] at 5 [GHz]. The gain showed a value of 2.479 [dBi] at 3.3 [GHz] and a value of 3.317 [dBi] at 5 [GHz]. After optimizing it with the CST Microwave Studio 2014 program, which can be 3D-designed, Based on these results, we investigated the performance of antennas by measuring their characteristics. In recent years, WLAN, which is a variety of wireless technologies that are continuously developing, and UWB, which is a communication technology which is increasing in frequency band due to an increase in demand of the technology users, is used for a high speed wireless communication system. Communication seems to be possible.

• YAKHAK HOEJI
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• v.42 no.1
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• pp.25-30
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• 1998

This study was designed to compare the absorption fraction and extent of ketoprofen gels and a matrix typed ketoprofen plaster patch. 3g (90mg as ketoprofen) of the two gels whi ch has oleohydrogel or hydrogel as a base, respectively, and 3 pieces of plaster patches (90mg as ketoprofen) were, applied in the area of 210$cm^2$ on forearm in 12 volunteers by cross over design. Blood samples were collected serially up to 24 hours and the plasma concentrations of ketoprofen were analyzed by HPLC using flurbiprofen as an internal standard. The detection limit of the assay was 1ng/ml of ketoprofen in plasma. The pharmacokinetic parameters (e.g. $AUC_{24hr}$, $AUMC_{24hr}$, MRT, Fraction Absorbed) were calculated from the plasma concentrations time data of each volunteer. The oleo-hydrogel showed significantly higher absorption fraction and extent of ketoprofen than the current hydrogel. The mean plasma concentrations of the oleo-hydrogel were increased to 98.46${\pm}$23.15ng/ml by 6 hour after application, and increased futher to 100.61${\pm}$18.65ng/ml at 24 hour. On the other hand, those of the hydrogel were increased 17.61${\pm}$18.65ng/ml at 5 hour to 34.68${\pm}$9.65ng/ml at 24 hour gradually. Therefore the plasma concentrations of oleo-hydrogel at each measured time were 3~7 times greater than those of the hydrogel with statistical significance. The $AUC_{24hr}$ (1797.26${\pm}$52.09ng.h/ml) of the oleo-hydrogel was 3.5 times greater (P<0.05) than that (516.17${\pm}$104.52ng.h/ml) of the hydrogel. The plaster patches showed higher bioavailability ($AUC_{24hr}$ 2877.37${\pm}$578.27ng.h/ml) than the olea-hydrogel ($AUC_{24hr}$ 1797.26${\pm}$52.09ng.h/ml) without statistical significance. But the absorption fraction of the oleo-hydrogel was rather higher than that of the plaster patches during the first 6 hours after administration. These results suggest that newly developed ketoprofen gel which is used oleo-hydrogel as a base would show excellent skin permeation on topical application for the corresponding clinical indications and could be absorbed as well as plaster patches.

• Journal of Life Science
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• v.31 no.7
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• pp.662-670
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• 2021

Interstitial cells of Cajal (ICCs) are the pacemaking cells in the gastrointestinal (GI) muscles that generate the rhythmic oscillation in membrane potentials known as slow waves. In the present study, we investigated the effects of mirtazapine, a noradrenergic and serotonergic antidepressant, on pacemaking potential in cultured ICCs from the murine small intestine. The whole-cell patch-clamp configuration was used to record pacemaker potential in cultured ICCs. Mirtazapine induced pacemaker potential depolarizations in a concentration-dependent manner in the current clamp mode. Y25130 (a 5-HT3 receptor antagonist), RS39604 (a 5-HT4 receptor antagonist), and SB269970 (a 5-HT7 receptor antagonist) had no effects on mirtazapine-induced pacemaker potential depolarizations. Also, methoctramine, a muscarinic M₂ receptor antagonist, had no effect on mirtazapine-induced pacemaker potential depolarizations, whereas 4-diphenylacetoxy-N-methyl-piperidine methiodide (4-DAMP), a muscarinic M₃ receptor antagonist, inhibited the depolarizations. When guanosine 5'-[β-thio] diphosphate (GDP-β-S; 1 mM) was in the pipette solution, mirtazapine-induced pacemaker potential depolarization was blocked. When an external Ca²⁺ free solution or thapsigargin, a Ca²⁺-ATPase inhibitor of the endoplasmic reticulum, was applied, the generation of pacemaker potentials disappeared, and under these conditions, mirtazapine induced pacemaker potential depolarizations. In addition, protein kinase C (PKC) inhibitor, calphostin C, and chelerythrine inhibited mirtazapine-induced pacemaker potential depolarizations. These results suggest that mirtazapine regulates pacemaker potentials through muscarinic M₃ receptor activation via a G protein-dependent and an external or internal Ca²⁺-independent PKC pathway in the ICCs. Therefore, mirtazapine can control GI motility through ICCs.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.4
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• pp.437-445
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• 2018

In this study, we analyzed two components, sulforaphane and PF-3758309 to prove that the mixed composition of them has more effective antioxidant and whitening functions compared to each component. We analyzed the cellular toxicity of each component and also the mixed composition to find the safe concentration level for cell viability. From the single component treatment, we discovered that sulforaphane was safe up to $10{\mu}M$, and PF-3758309 up to 100 nM. Combination treatment of $10{\mu}M$ sulforaphane and 1 nM PF-3758309 did not affect the cell viability. The LPS-stimulated NO generation was significantly reduced by the mixed composition of sulforaphane and PF-3758309. Melanogenesis by ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH) was also inhibited by the mixed composition. In order to confirm the possibility as the cosmetic material, we carried out clinical studies for the mixed composition samples. Skin safety evaluation using patch test was judged to be unstimulated, skin whitening effect was increased, and melanin deposition was suppressed by treatment of mixed composition samples. These results provide us with the opportunity for applying it into the development of new functional cosmetics.

• Korean Journal of Environment and Ecology
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• v.33 no.3
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• pp.292-302
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• 2019

This study conducted a hierarchy analysis based on a questionnaire survey of experts in park management, ecosystem survey, and ecological environment planning to establish evaluation items and a weighing value of each item to develop ecological connectivity in Baekdudaegan mountain range neighboring the Taebaeksan National Park using the AHP approach. We selected four high-level evaluation indexes and 13 low-level evaluation indexes through literature review and interview with the people in the field and calculated weights for each question through the consistency analysis. The analysis showed that increasing the ecological value was the most important item with the index of 0.474 among the high-level evaluation items, followed by the mitigation of human-nature conflict at 0.247, participation by local residents at 0.165, and the economic perspective at 0.114. Among the low-level evaluation indexes, the movement route of wildlife was the highest at 0.116, followed by the connectivity of landscape ecological patch at 0.112, and functional habitat at 0.099. The comparison of the evaluation items in each working group and the weight factors showed that the movement route of wildlife was the most important at 0.116 in ecosystem survey, the functional habitat was the most important at 0.110 in park management, and the regional preservation and distribution of resources was the most important at 0.123 in ecological environment planning. The results of this study is useful to identify evaluation items for developing ecological network with a diverse source of the actual environmental data in the Taebaeksan National Park.

• Journal of Life Science
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• v.29 no.9
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• pp.1010-1015
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• 2019

The interstitial cells of Cajal (ICCs) are the pacemaker cells in the gastrointestinal (GI) tract. In the present study, the effects of olanzapine, an atypical antipsychotic agent, on pacemaker potentials in cultured ICCs from the small intestine of the mouse were investigated. The whole-cell patch-clamp configuration was used to record pacemaker potentials from cultured ICCs. Olanzapine produced pacemaker depolarizations in a concentration-dependent manner in current clamp mode. Methoctramine, a muscarinic $M_2$ receptor antagonist, did not inhibit olanzapine-induced pacemaker depolarizations, whereas 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) muscarinic $M_3$ receptor antagonist did inhibit it. When guanosine 5'-[${\beta}$-thio] diphosphate (GDP-${\beta}$-S; 1 mM) was in the pipette solution, olanzapine-induced pacemaker depolarization was blocked. Also, low $Na^+$ solution externally eliminated the generation of pacemaker potentials and inhibited the olanzapine-induced pacemaker depolarizations. Additionally, the nonselective cation channel blocker, flufenamic acid, inhibited the olanzapine-induced pacemaker depolarizations. Pretreatment with U-73122, an active phospholipase C (PLC) inhibitor, also eliminated the generation of pacemaker potentials and suppressed the olanzapine-induced pacemaker depolarizations. These results suggested that olanzapine modulates the pacemaker potentials through muscarinic $M_3$ receptor activation by G protein-dependent external $Na^+$ and PLC pathway in the ICCs. Therefore, olanzapine could affect intestinal motility through ICCs.

• Composites Research
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• v.32 no.1
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• pp.37-44
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• 2019

The reinforcement effect of micro-bolt for a bonded scarf joint was investigated. Three scarf ratios of 1/10, 1/20, and 1/30 were considered to examine the effect of scarf patch configuration on joint strength. To maintain the same density of micro-bolt, 16, 32, and 48 bolts were installed in the scarf joint specimens with scarf ratios of 1/10, 1/20, and 1/30, respectively. Tests were also carried out on the joints that are bonded with only adhesive and that are fastened with only micro-bolts to obtain reference values. The average failure loads of the adhesive joints with scarf ratios of 1/10, 1/20, and 1/30 were 29.7, 39.6, and 44.8 kN, respectively. In case of micro-bolt reinforcement, the failure loads at the same scarf ratios were 28.4, 37.2, and 40.1 kN, respectively, which corresponds to 96, 94, and 90% of the pure adhesive joint failure loads. In the case of using only micro-bolts, the failure loads were only 13-25% of the average failure loads of pure adhesive joints. Fatigue test was also conducted for the joints with scarf ratio of 1/10. The results show that the fatigue strength of hybrid joints using both adhesive and microbolts together slightly increased compared to the fatigue strength of adhesive joint, but the rate of increase was small to 2-3%. Through this study, it was confirmed that the reinforcement effect of micro-bolt is negligible in the scarf joints where shear stress is dominating the failure, unlike in the structure where peel stress is dominant.

• Journal of Adhesion and Interface
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• v.20 no.1
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• pp.23-28
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• 2019

In this study, the micro- and nano-particles were used and their shapes were transferred into the polydimethylsiloxane (PDMS) film to fabricate the dry adhesives and their properties were investigated. The Cu nanoparticles of the sizes of 20 nm, 40 nm and 70 nm and the polymethylmethacrylate (PMMA) beads of the size of $5{\mu}m$ were used to transfer their images and the resultant properties of the dry adhesives were compared. The effects of particle size and materials on the mechanical property, tensile adhesion strength, light transmittance, surface morphology, water contact angle were studied. The dry adhesives obtained from the transfer process of Cu nanoparticles with the size of 20 nm resulted in the enhancement of tensile adhesion strength more than 300% compared to that of the bare PDMS. The formation of nanostructure of large surface area on the surface of the PDMS film by the Cu nanoparticles may responsible for the improvement. This study suggests that the use of nanoparticles during the fabrication of PDMS dry adhesives is easy and effective and could be applied to the fabrication of the medical patch.

• The Journal of the Korea Contents Association
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• v.21 no.2
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• pp.499-506
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• 2021

Hackers' cyber attack techniques are becoming more sophisticated and diversified, with a form of attack that has never been seen before. In terms of information security vulnerability standard code (CVE), about 90,000 new codes were registered from 2015 to 2020. This indicates that security threats are increasing rapidly. When new security vulnerabilities occur, damage should be minimized by preparing countermeasures for them, but in many cases, companies are insufficient to cover the security management level and response system with a limited security IT budget. The reason is that it takes about a month for analysts to discover vulnerabilities through manual analysis, prepare countermeasures through security equipment, and patch security vulnerabilities. In the case of the public sector, the National Cyber Safety Center distributes and manages security operation policies in a batch. However, it is not easy to accept the security policy according to the characteristics of the manufacturer, and it takes about 3 weeks or more to verify the traffic for each section. In addition, when abnormal traffic inflow occurs, countermeasures such as detection and detection of infringement attacks through vulnerability analysis must be prepared, but there are limitations in response due to the absence of specialized security experts. In this paper, we proposed a method of using the security policy information sharing site "snort.org" to prepare effective countermeasures against new security vulnerability attacks.