• Title/Summary/Keyword: P19

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A Study on the Factors Affecting Practice Associated with COVID-19 among Adolescents (청소년의 COVID-19 예방행위에 영향을 미치는 요인)

  • Ha, Young-Sun;Na, Yoon-Joo
    • Journal of the Korea Convergence Society
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    • v.12 no.7
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    • pp.349-359
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    • 2021
  • This study was aimed to investigate the factors influencing COVID-19 practice of COVID-19 knowledge, COVID-19 attitude, COVID-19 perceived risk among adolescents. A descriptive study design was used. Participants were 164 high school students in D and K city. The data were collected from October 26 to November 6 2020. Collected data were analyzed by t-test, one-way ANOVA, Pearson's correlation coefficient, multiple regression using SPSS WIN 21.0 program. Results: The influential factor for COVID-19 practice was COVID-19 attitude (β=0.28, p<.001). It was found that satisfaction with peer relationship (β=-0.05, p=.493), economic status (β=-0.08, p=.270), subjective health status (β=-0.06, p=.438), COVID-19 knowledge (β=0.04, p=.571), COVID-19 perceived risk (β=0.05, p=.126) had no significant effect on COVID-19 practice. In order to develop a program to increase the COVID-19 practice for youth, it is necessary to prepare a plan to improve the attitude of COVID-19.

Influencing Factors on Health-related Quality of Life among female cancer survivors based on COVID-19 Infection Experience (코로나19 감염경험 유무에 따른 여성 암생존자의 건강관련 삶의 질 영향요인)

  • Mijung Kim
    • Journal of Industrial Convergence
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    • v.21 no.3
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    • pp.129-138
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    • 2023
  • This study aimed to examine factors associated with health-related quality of life among female cancer survivors based on COVID-19 infection experience. A sample of 137 female cancer survivors was recruited from November 2022 to January 2023. The collected data were analyzed by descriptive statistics, independent t-test, Pearson correlation coefficient, and multiple regression ways using SPSS 25.0 program. As a result, age (𝛽=.20, p<.05), depressive mood (𝛽=-.29, p<.01) and anxiety (𝛽=-.39, p<.001), and social support (𝛽=.35, p<.001) were associated with health-related quality of life in the group having experience with COVID-19 infection (F=26.932, p<.001). On the contrary, the non-experienced COVID-19 infection group showed age (𝛽=.22, p<.001), anxiety (𝛽=-.54, p<.001), and prevention behaviors for COVID-19 infection (𝛽=.25, p<.001) were significant factors(F=64.937, p<.001). Tailed intervention is needed to improve health-related quality of life in female cancer survivors as a high-risk group for COVID-19, considering associated factors.

Genetic Transformation of Chlamydomonas reinhardtii with the RNAi Suppressor p19 Gene of Tombus Virus (Tombus 바이러스의 RNAi Suppressor p19 유전자에 의한 Chlamydomonas reinhardtii의 형질전환)

  • Jeong, Won-Joong;Liu, Jang-Ryol;Cerutti, Heriberto
    • Journal of Plant Biotechnology
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    • v.34 no.4
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    • pp.307-312
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    • 2007
  • Chlamydomonas reinhardtii was transformed with the coding sequence of the Tombus virus gene p19 to determine whether the gene functions as an RNAi suppressor in C. reinhardtii. Transformants were confirmed to have 1 to several copies of p19 gene in their chromosomes. When an RNAi strain of C. reinhardtii generated by transforming the inverted repeat (IR) sequence homologous to the 3'UTR region of the MAA7 gene was re-transformed with the gene p19, MAA7 transcript levels of transformants fluctuated and proliferation of trans-formants on the medium containing 5-FI was suppressed. Overall results suggest that p19-mediated silencing suppression works at a low level in C. reinhardtii because of difference in codon usage resulting in weak P19 expression unless p19-mediated silencing suppression in C. reinhardtii works in a different manner from higher plants.

Influence of Fatigue and Role-Overload on Depression in Nurses Caring for COVID-19 Patients (COVID-19 환자를 간호하는 간호사의 피로와 역할과부담이 우울에 미치는 영향)

  • Gong, Eun-Jeong;Kim, Jinhee
    • The Journal of the Korea Contents Association
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    • v.22 no.7
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    • pp.432-442
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    • 2022
  • This study aimed to investigate depression, fatigue, and role-overload in nurses caring for COVID-19 patients and identify factors affecting depression. Data were collected from 142 nurses caring for COVID-19 patients at four designated COVID-19 hospitals using self-report questionnaires, from September 8, 2020, to September 17, 2020. The subjects' scores for depression, fatigue, and role-overload were 14.51±9.54, 3.19±0.64, and 3.30±0.64 points, respectively. Depression was positively correlated with fatigue (r=.40, p<.001) and role-overload (r=.30, p<.001), and fatigue was positively correlated with role-overload (r=.54, p<.001). Factors affecting depression included fatigue (β=.23, p=.014), health status (moderate: β=.28, p=.001; unhealthy: β=.26, p=.002), and hospital type (university hospital: β=.18, p=.024). The explanatory power (R2) of the model was 28.1%. In order to manage the nurse's depression level, a strategy for lowering the fatigue level and a strategy for improving the nurse's health statue are needed.

Factors Influencing Preventive Behavior against Coronavirus Disease 2019(COVID-19) among Nursing Students (간호대학생의 코로나19 감염예방행위 영향요인)

  • Jun, Hye Jung;Hong, Younseo;PARK, HYEIN;Seo, Ah Young;Yang, Chaewon
    • Journal of Korean Public Health Nursing
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    • v.37 no.1
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    • pp.54-65
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    • 2023
  • Purpose: The purpose of this study is to identify the factors influencing COVID-19 infection prevention behavior of nursing students. Methods: Data collection is from December 17 to October 22, 2021. One hundred and ninety-seven nursing students participated in this study. Data were analyzed using an independent t-test, ANOVA, correlation coefficient, scheffé test, and multiple regression analysis. Results: COVID-19 knowledge (r=.49, p<.001), attitude (r=.41, p<.001), and COVID-19 risk perception (r=.40, p<.001) were related to COVID-19 infection prevention behaviors. The factors influencing COVID-19 preventive behaviors were identified as knowledge (𝛽=.28, p<.001), attitude (𝛽=.25, p<.001), risk perception (𝛽=.18, p=003), 2th grade (𝛽=.19, p=.011), 3th grade (𝛽=.21, p=.006), 4th grade (𝛽=.20, p=.008), and gender (𝛽=.12, p=.033). Conclusion: The results of this study can be used for the development of health policies suitable for community infectious disease prevention behaviors and the development of infectious disease educational intervention programs.

Knowledge and preventive health behavior of Coronavirus disease 19 (COVID-19) among nursing students (간호대학생의 코로나 19에 대한 지식과 예방적 건강행위에 관한 연구)

  • Park, Sung Hee;Byun, Eun Kyung;Seo, Young Seung
    • The Journal of the Convergence on Culture Technology
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    • v.7 no.2
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    • pp.281-289
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    • 2021
  • The purpose of this study was to investigate the level of knowledge, preventive health behavior of the COVID-19 among nursing students. Data were collected from 190 nursing female students in B city and analyzed by t-test, ANOVA, Pearson correlation coefficient using SPSS/WIN 22.0. The degree of knowledge about COVID-19 in nursing female students was 9.18±1.95. The degree of preventive health behaviors on COVID-19 in nursing female students was 3.62±0.30. There were significant differences in knowledge about COVID-19 with respect to age(F=5.981, p=.001), grade(r=6.376, p<.001), college life satisfaction(F=3.632, p=.007). There were significant differences in preventive health behavior of the COVID-19 with respect to age(F=4.018, p=.008), grade(F=2.719, p=.046), health state(F=3.845, p=.005) college life satisfaction(F=3.875, p=.005), clinical experience satisfaction/expectation(F=4.337, p=.002), necessity COVID 19(t=2.801, p=.006). Through this research can be used as basic data by COVID 19 infection control education of nursing students.

Correlation among Wearing Masks Because of COVID-19, Makeup Satisfaction and Goal-oriented Attitude (코로나19로 인한 마스크 착용과 메이크업만족도, 목표지향적 태도의 상관관계)

  • Kim, Su-Young;Li, Shun-Hua
    • Journal of Convergence for Information Technology
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    • v.10 no.12
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    • pp.156-165
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    • 2020
  • 330 Korean adult women were examined the correlation between degree of makeup and makeup satisfaction before/after wearing masks due to COVID-19 and the moderating effect of mandatory/voluntary goal-oriented attitude toward makeup. The study found that lip makeup(p<.001) was significant variable in makeup satisfaction before COVID-19, and eyebrow makeup(0<.002) was significant after COVID-19. Although moderating effect of mandatory goal-oriented attitude, which works between degree of makeup before/after COVID-19 and makeup satisfaction was not significant, but moderating effect of voluntary goal-oriented attitude appeared to be significant before(p<.000) and after(p<.000) COVID-19. And the degree of makeup after COVID-19 was lower than before(p<.000). If one believe that makeup is for one's own satisfaction, degree of makeup can be significant effect on the makeup satisfaction, but actual behavior has shown that degree of makeup has decreased since wearing masks because of COVID-19. I hope this research will be used as marketing material for beauty and cosmetics industry.

The effect of COVID-19 Stress on Premenstrual Syndrome in Female College Students: Mediating Effects of Depression and Coping with Premenstrual syndrome (여대생의 코로나19 스트레스가 월경전증후군에 미치는 영향: 우울과 월경전증후군 대처의 매개효과)

  • Na Won An
    • Journal of the Korean Applied Science and Technology
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    • v.40 no.3
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    • pp.462-475
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    • 2023
  • This study is descriptive research to identify the effect of COVID-19 stress on premenstrual syndrome in female college students and the mediating effect of depression and coping with premenstrual syndrome. The data were collected through an on-line survey for 20 days from November 11 to November 30, 2021, targeting female college students attending C College located in S city. As a result of analyzing a total of 161 data, COVID-19 stress was positively correlated with premenstrual syndrome(r=.383, p<.001) and depression(r=.436, p<.001), and coping with premenstrual syndrome had a positive correlation only in premenstrual syndrome(r=.190, p=.016). As a result of verifying the mediating effect of depression and coping with premenstrual syndrome between COVID-19 stress and premenstrual syndrome, COVID-19 stress had a significant direct effect on premenstrual syndrome(β=4.907, p=.002), and depression(β=6.780, p<.001), and depression had a significant direct effect on premenstrual syndrome(β=.383, p=<.001), coping with premenstrual syndrome had a direct effect on premenstrual syndrome(β=4.292, p=.030) respectively. The indirect effect of verifying the mediating effect in the relationship between COVID-19 stress and premenstrual syndrome confirmed that there was a statistically significant effect only in the path via depression(95% CI, 1.282 to 4.140). Therefore, it is necessary to develop an intervention strategy to reduce depression and alleviate premenstrual syndrome symptoms by controlling related stress, such as COVID-19 stress, in preparation for the outbreak of new infectious diseases and pandemic situations such as COVID-19.

$p19^{ras}$ Accelerates $p73{\beta}$-mediated Apoptosis through a Caspase-3 Dependent Pathway

  • Jang, Sang-Min;Kim, Jung-Woong;Choi, Kyung-Hee
    • Animal cells and systems
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    • v.13 no.4
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    • pp.399-403
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    • 2009
  • $p19^{ras}$ is an alternative splicing variant of the proto-oncogene c-H-ras pre-mRNA of $p21^{ras}$. In contrast to $p21^{ras}$, $p19^{ras}$ does not have a C-terminal CAAX motif that targets the plasma membrane and is localized to both the cytoplasm and nucleus. We found that $p19^{ras}$ activated the transcriptional activity of $p73{\beta}$ through protein-protein interactions in the nucleus. p73 is known to play an important role in cellular damage responses such as apoptosis. Although p73 is a structural and functional homologue of p53, p73-mediated apoptosis has not yet been clearly elucidated. In this study, we demonstrate that the interaction between $p19^{ras}$ and $p73{\beta}$ accelerated $p73{\beta}$-induced apoptosis through a caspase-3 dependent pathway. Treatment with DEVD-CHO, a caspase inhibitor, also strengthened $p73{\beta}$-mediated apoptosis through a caspase-3 dependent pathway. Furthermore, the enhanced transcriptional activity of endogenous $p73{\beta}$ by treatment with Taxol was amplified by $p19^{ras}$ overexpression, which markedly increased caspase-3 dependent apoptosis in the p53-null SAOS2 cancer cell line. Our findings indicate a functional linkage between $p19^{ras}$ and p73 in caspase-3 mediated apoptosis of cancer cells.

Prediction of Covid-19 confirmed number of cases using SARIMA model (SARIMA모형을 이용한 코로나19 확진자수 예측)

  • Kim, Jae-Ho;Kim, Jang-Young
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.26 no.1
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    • pp.58-63
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    • 2022
  • The daily number of confirmed cases of Coronavirus disease 2019(COVID-19) ranges between 1,000 and 2,000. Despite higher vaccination rates, the number of confirmed cases continues to increase. The Mu variant of COVID-19 reported in some countries by WHO has been identified in Korea. In this study, we predicted the number of confirmed COVID-19 cases in Korea using the SARIMA for the Covid-19 prevention strategy. Trends and seasonality were observed in the data, and the ADF Test and KPSS Test was used accordingly. Order determination of the SARIMA(p,d,q)(P, D, Q, S) model helped in extracting the values of p, d, q, P, D, and Q parameters. After deducing the p and q parameters using ACF and PACF, the data were transformed and schematized into stationary forms through difference, log transformation, and seasonality removal. If seasonality appears, first determine S, then SARIMA P, D, Q, and finally determine ARIMA p, d, q using ACF and PACF for the order excluding seasonality.