• 약학회지
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• 제30권6호
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• pp.288-293
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• 1986

Effects of phenobarbital on the pharmacokinetics of griseofulvin were studied in rats. Phenobarbital was administered orally for five days at the dose of 75mg/kg/day. Absolute bioavailability of oral griseofulvin was significantly(p<0.005) reduced but total clearance(CL$_s$ was not changed by phenobarbital pretreatment. Absorption rate constant(K$_a$ and maximum plasma concentration(C$_{max}$) were significantly(p<0.05) reduced, and time to reach maximum plasma concentration(T$_{max}$) of griseofulvin was significantly(p<0.05) increased by phenobarbital pretreatment. Changed pharmacokinetics of griseofulvin seemed not to be due to induced enzyme activity by phenobarbital but to reduced GI absorption of griseofulvin.

• Journal of Photoscience
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• 제3권2호
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• pp.71-76
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• 1996

Anil K. Singh, Mrunalini M. Kapil, Department of Chemistry, Indian Institute of Technology Bombay - 400076, INDIA Purple membrane (PM, $\lambda$$_{max}$ 570 nm) of H. halobium on treatment with sulphuric acid changes its colour to blue ($\lambda$$_{max}$ 608 nm). The purple chromophore can be regenerated from the blue chromophore by exogeneous addition of anions such as CI$^-$ and HPO$_4^{2-}$. Chloride ion is found to be more effective than the dibasic phosphate ion in regenerating the purple chromophore. Nevertheless, one thing common to the anion regeneration is that both CI$^-$ and HPO$_4^{2-}$ show marked pH effect. At pH 1.0 the efficiency of regeneration of the purple chromophore is greater than at pH 2.0, for the same anion concentration. Fluorescence and circular dichroic studies indicate that the proteins do not undergo drastic changes at the secondary' or tertiary structure level and the native structure is preserved during this transition. However, chromophoric-site interactions between retinal and the apoprotein are affected during this colour transition. A molecular mechanism is advanced for this transition.

• KSBB Journal
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• 제19권2호
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• pp.143-147
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• 2004

휘발성 황화합물 중 생물학적으로 가장 난분해성으로 알려 져 있는 DMS에 대한 분해능이 우수한 신균주를 분리. 동정 하여 Gordonia sihwaniensis PKL-1로 명명하였다. 이 균주는 D DMS 초기농도가 35 mg/L 이상일 때에도 우수한 분해능을 보였고, 회분식 배양에서 최대 비분해속도 $\upsilon_{max}$ 없는 0.0016 mg/(mg-protein).hr이 었고, 최적 의 온도와 pH는 각각 $25^{\circ}C$ 와 pH는 7이였다.

• Korean Journal of Mathematics
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• 제28권4호
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• pp.931-942
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• 2020

For a polynomial $P(z)={\sum_{{\nu}=0}^{n}}\;a_{\nu}z^{\nu}$ of degree n having all its zeros in |z| ≤ k, k ≥ 1, it was shown by Rather and Dar [13] that ${\max_{{\mid}z{\mid}=1}}{\mid}P^{\prime}(z){\mid}{\geq}{\frac{1}{1+k^n}}\(n+{\frac{k^n{\mid}a_n{\mid}-{\mid}a_0{\mid}}{k^n{\mid}a_n{\mid}+{\mid}a_0{\mid}}}\){\max_{{\mid}z{\mid}=1}}{\mid}P(z){\mid}$. In this paper, we shall obtain some sharp estimates, which not only refine the above inequality but also generalize some well known Turán-type inequalities.

• Kyungpook Mathematical Journal
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• 제61권1호
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• pp.23-32
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• 2021

Let D be an integral domain with quotient field K, X an indeterminate over D, ∗ a star operation on D, and Cl∗ (D) be the ∗-class group of D. The ∗w-operation on D is a star operation defined by I∗w = {x ∈ K | xJ ⊆ I for a nonzero finitely generated ideal J of D with J∗ = D}. In this paper, we study two star operations {∗} and [∗] on D[X] defined by A{∗} = ∩P∈∗w-Max(D) ADP [X] and A[∗] = (∩P∈∗w-Max(D) AD[X]P[X]) ∩ AK[X]. Among other things, we show that Cl∗(D) ≅ Cl[∗](D[X]) if and only if D is integrally closed.

• 대한수학회보
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• 제59권3호
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• pp.685-695
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• 2022

The minimum number of complete bipartite subgraphs needed to partition the edges of a graph G is denoted by b(G). A known lower bound on b(G) states that b(G) ≥ max{p(G), q(G)}, where p(G) and q(G) are the numbers of positive and negative eigenvalues of the adjacency matrix of G, respectively. When equality is attained, G is said to be eigensharp and when b(G) = max{p(G), q(G)} + 1, G is called an almost eigensharp graph. In this paper, we investigate the eigensharpness and almost eigensharpness of lexicographic products of some graphs.

• Nonlinear Functional Analysis and Applications
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• 제27권3호
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• pp.691-700
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• 2022

Let p(z) be a polynomial of degree n having no zero inside the unit circle. Then for 0 < r ≤ 1, the well-known inequality due to Rivlin [Amer. Math. Monthly., 67 (1960) 251-253] is $$\max\limits_{{\mid}z{\mid}=r}{\mid}p(z){\mid}{\geq}{\(\frac{r+1}{2}\)^n}\max\limits_{{\mid}z{\mid}=1}{\mid}p(z){\mid}$$. In this paper, we generalize as well as sharpen the above inequality. Also our results not only generalize, but also sharpen some known results proved recently.

• Archives of Pharmacal Research
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• 제19권5호
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• pp.386-389
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• 1996

The in vivo behaviour of phenylephrine hydrochloride in different vehicles like gels of Carbopol $907^circledR$, Carbopol $934P^circledR$ and latex system of cellulose acetate hydrogen phthalate(CAHP) was evaluated by measuring the reduction in intraocular pressure and the mydriatic activity. The parameters that haave been utilised to assess the performance of the formulations were the area under the curve (AUC), the maximum mydriasis $(I_{max})$, ethe time of maximum response $(T_{max})$ and the duration of activity (D). The influence of viscosity and mucoadhesion on the bioavailability parameters has also been investigated. Carbopol 934P and CAHP formulations showed prolonged duration of action and greater AUC compared to Carbopol 907 aqueous solution(P<0.05).

• Nonlinear Functional Analysis and Applications
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• 제29권2호
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• pp.451-460
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• 2024

If a₀ + Σⁿ_ν=μ a_νz^ν, 1 ≤ µ ≤ n, is a polynomial of degree n having no zeroin |z| < k, k ≥ 1 and p'(z) its derivative, then Qazi [19] proved $$\max_{{\left|z\right|=1}}\left|p\prime(z)\right|\leq{n}\frac{1+\frac{{\mu}}{n}\left|\frac{a_{\mu}}{a_0} \right|k^{{\mu}+1}}{1+k^{{\mu}+1}+\frac{{\mu}}{n}\left|\frac{a_{\mu}}{a_0} \right|(k^{{\mu}+1}+k^{2{\mu}})}\max_{{\left|z\right|=1}}\left|p(z)\right|$$ In this paper, we not only obtain the L^r version of the polar derivative of the above inequality for r > 0, but also obtain an improved L^r extension in polar derivative.

• Archives of Pharmacal Research
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• 제29권1호
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• pp.102-107
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• 2006

The aim of present study is to investigate the effect of naringin on the pharmacokinetics of verapamil and its major metabolite, norverapamil in rabbits. The pharmacokinetic parameters of verapamil and norverapamil were determined after administering verapamil (9 mg/kg) orally to rabbits in the pretreated with naringin (1.5, 7.5, and 15 mg/kg). Naringin pretreatment significantly altered the pharmacokinetic parameters of verapamil. Compared with the control group (given verapamil alone), the $K_a,\;C_{max}$ and AUC of verapamil were significantly (p<0.05 or p<0.01) increased in the pretreatment of naringin, However there were no significant change in $T_{max}\;and\;t_{1/2}$ of verapamil. Consequently, pretreatment of naringin significantly (p<0.05, p<0.01) increased the AB% of verapamil significantly in a dose dependent manner (p<0.05 or p<0.01 ), and elevated the RB% of verapamil by 1.26- to 1.69-fold. the MR of verapamil were significantly (p<0.05) increased in the pretreatment of naringin, implying that pretreatment of naringin may effectively inhibit the CYP3A4-mediated metabolism of verapamil. In conclusion, pretreatment of naringin enhanced the oral bioavailability of verapamil. Based on these results, the verapamil dosage should be adjusted when given with naringin or a naringin-containing dietary supplement.