• 대한수학회지
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• 제58권3호
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• pp.643-702
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• 2021

Fix ℤ/2 is the prime field of two elements and write 𝒜₂ for the mod 2 Steenrod algebra. Denote by GL_d := GL(d, ℤ/2) the general linear group of rank d over ℤ/2 and by ${\mathfrak{P}}_d$ the polynomial algebra ℤ/2[x₁, x₂, …, x_d] as a connected unstable 𝒜₂-module on d generators of degree one. We study the Peterson "hit problem" of finding the minimal set of 𝒜₂-generators for ${\mathfrak{P}}_d$. Equivalently, we need to determine a basis for the ℤ/2-vector space $$Q{\mathfrak{P}}_d:={\mathbb{Z}}/2{\otimes}_{\mathcal{A}_2}\;{\mathfrak{P}}_d{\sim_=}{\mathfrak{P}}_d/{\mathcal{A}}^+_2{\mathfrak{P}}_d$$ in each degree n ≥ 1. Note that this space is a representation of GL_d over ℤ/2. The problem for d = 5 is not yet completely solved, and unknown in general. In this work, we give an explicit solution to the hit problem of five variables in the generic degree n = r(2^t - 1) + 2^ts with r = d = 5, s = 8 and t an arbitrary non-negative integer. An application of this study to the cases t = 0 and t = 1 shows that the Singer algebraic transfer of rank 5 is an isomorphism in the bidegrees (5, 5 + (13.2⁰ - 5)) and (5, 5 + (13.2¹ - 5)). Moreover, the result when t ≥ 2 was also discussed. Here, the Singer transfer of rank d is a ℤ/2-algebra homomorphism from GL_d-coinvariants of certain subspaces of $Q{\mathfrak{P}}_d$ to the cohomology groups of the Steenrod algebra, $Ext^{d,d+*}_{\mathcal{A}_2}$ (ℤ/2, ℤ/2). It is one of the useful tools for studying these mysterious Ext groups.

• 대한한방내과학회지
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• 제27권4호
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• pp.895-904
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• 2006

Objectives : In the present study, the author intended to investigate whether two oriental medical prescriptions named Socheongryongtang-ga-seoggo (SCTS) and Prescription D (P-D) significantly affect mucin release from cultured hamster tracheal surface epithelial (HTSE) cells. Materials and Methods : Confluent HTSE cells were metabolically radiolabeled with 3H-glucosamine for 24 hrs and chased for 30 min in the presence of SCTS or P-D to assess the effect of each agent on 3H-mucin release. Possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase (LDH) release. Also, the effects of SCTS and P-D on contractility of isolated tracheal smooth muscle were investigated. Results : SCTS did not affect mucin release from cultured HTSE cells, without cytotoxicity. However, P-D significantly increased mucin release from cultured HTSE cells. with significant cytotoxicity. SCTS inhibited Ach-induced contraction of isolated tracheal smooth muscle. P-D also inhibited Ach-induced contraction of isolated tracheal smooth muscle. Conclusions : The author suggests that the effects of SCTS and P-D with their components should be further investigated and it is valuable to find, from oriental medical prescriptions, novel agents which might regulate mucin secretion from airway goblet cells.

• 한국작물학회:학술대회논문집
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• 한국작물학회 1990년도 춘계 학술대회지
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• pp.118-119
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• 1990

• 약학회지
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• 제39권1호
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• pp.78-84
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• 1995

Based on Computer graphics molecular modeling method, quinolone derivatives as DNA-gyrase inhibitors formed stable DNA-intercalation complex with deoxycytidilyl-3',5'-deoxy guanosine[d($C_{p}G)_{2}$] dinucleotide. When d($C_{p}G)_{2}$ and d($A_{p}T)_{2}$, were compared in order to find out which DNA could form more stable DNA-Drug complex based on interaction energy($\Delta$E) and DNA-Drug complex energy, d($C_{p}G)_{2}$ resulted in lower energy than d($A_{p}T)_{2}$.

• Bulletin of the Korean Chemical Society
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• 제32권11호
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• pp.4005-4010
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• 2011

We investigated thermal behavior of spin-coated films of P(HB-co-HHx)/PEG blends by using infraredreflection absorption (IRRAS) spectroscopy and 2D correlation spectroscopy. Based on 2D IRRAS correlation spectra, we could determine the sequence of spectral intensity changes with increasing temperature that PEG band changes first and then a band for crystalline component of P(HB-co-HHx) changes before a band for amorphous component. The intensities of bands for PEG and amorphous P(HB-co-HHx) were changed greatly as PEG weigh % of P(HB-co-HHx)/PEG blends increased. Transition temperatures of P(HB-co-HHx)/PEG blends were successfully determined by 2D gradient mapping method. The transition temperature of spincoated films of 98/2 and 90/10 P(HB-co-HHx)/PEG blends and 80/20 P(HB-co-HHx)/PEG blend determined by 2D gradient map are, respectively, about 137.5 and $132.5^{\circ}C$. Furthermore, P(HB-co-HHx)/PEG blends show an additional transition temperature that have been interpreted in terms of different lamellar thicknesses in spin coated films.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2003년도 제24회 학술발표회 초록집
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• pp.68-68
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• 2003

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제43권5호
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• pp.324-330
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• 2017

Objectives: There are only a limited number of studies on cyclin D1 and p63 expression in oral squamous cell carcinoma (OSCC) and leukoplakia. This study compared cyclin D1 and p63 expression in leukoplakia and OSCC to investigate the possible correlation of both markers with grade of dysplasia and histological grade of OSCC. Materials and Methods: The study included a total of 60 cases, of which 30 were diagnosed with OSCC and 30 with leukoplakia, that were evaluated immunohistochemically for p63 and cyclin D1 expression. Protein expression was correlated based on grades of dysplasia and OSCC. Results: Out of 30 cases of OSCC, 23 cases (76.7%) were cyclin D1 positive and 30 cases (100%) were p63 positive. Out of 30 cases of leukoplakia, 21 cases (70.0%) were cyclin D1 positive and 30 (100%) were p63 positive (P<0.05). Conclusion: The overall expression of cyclin D1 and p63 correlated with tumor differentiation, and increases were correlated with poor histological grades, from well-differentiated to poorly-differentiated SCC. Increased cyclin D1 and p63 expression was associated with the severity of leukoplakia. Based on these results cyclin D1 and p63 products can be a useful tool for improved leukoplakia prognosis.

• Journal of Microbiology and Biotechnology
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• 제32권6호
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• pp.740-748
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• 2022

As circ_UBE2D2 has been confirmed to have targeted binding sites with multiple miRNAs involved in septic acute kidney injury (SAKI), efforts in this study are directed to unveiling the specific role and relevant mechanism of circ_UBE2D2 in SAKI. HK-2 cells were treated with lipopolysaccharide (LPS) to construct SAKI model in vitro. After sh-circ_UBE2D2 was transfected into cells, the transfection efficiency was detected by qRT-PCR, cell viability and apoptosis were determined by MTT assay and flow cytometry, and expressions of Bcl-2, Bax and Cleaved-caspase 3 were quantified by western blot. Target genes associated with circ_UBE2D2 were predicted using bioinformatics analysis. After the establishment of SAKI rat model, HE staining and TUNEL staining were exploited to observe the effect of circ_UBE2D2 on tissue damage and cell apoptosis. The expression of circ_UBE2D2 was overtly elevated in LPS-induced HK-2 cells. Sh-circ_UBE2D2 can offset the inhibition of cell viability and the promotion of cell apoptosis induced by LPS. Circ_UBE2D2 and miR-370-3p as well as miR-370-3p and NR4A3 have targeted binding sites. MiR-370-3p inhibitor reversed the promoting effect of circ_UB2D2 silencing on viability of LPS-treated cells, but shNR4A3 neutralized the above inhibitory effect of miR-370-3p inhibitor. MiR-370-3p inhibitor weakened the down-regulation of NR4A3, Bax and Cleaved caspase-3 and the up-regulation of Bcl-2 induced by circ_UB2D2 silencing, but these trends were reversed by shNR4A3. In addition, sh-circ_UBE2D2 could alleviate the damage of rat kidney tissue. Circ_UBE2D2 mitigates the progression of SAKI in rats by targeting miR-370-3p/NR4A3 axis.

• 충청수학회지
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• 제25권3호
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• pp.543-552
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• 2012

In this paper, we will show that if ${\mu}$ is a Borel measure on the unit disk D such that ${\int}_{D}\frac{d{\mu}(z)}{(1-\left|z\right|^2)^{p\alpha}}$ < ${\infty}$ where 0 < ${\alpha},{\rho}$ < ${\infty}$, then a bounded sequence of functions {$f_n$} in the $\alpha$-Bloch space $\mathcal{B}{\alpha}$ has a convergent subsequence in the space $D_p({\mu})$ of analytic functions f on D satisfying $f^{\prime}\;{\in}\;L^p(D,{\mu})$. Also, we will find some conditions such that ${\int}_D\frac{d\mu(z)}{(1-\left|z\right|^2)^p$.

• 대한수학회지
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• 제44권4호
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• pp.863-872
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• 2007

Let D be an integral domain with quotient field K, A a nonempty set of height-one maximal t-ideals of D, F$({\Lambda})={I{\subseteq}D|I$ is an ideal of D such that $I{\subseteq}P$ for all $P{\in}A}$, and $D_F({\Lambda})={x{\in}K|xA{\subseteq}D$ for some $A{\in}F({\Lambda})}$. In this paper, we prove that if each $P{\in}A$ is the radical of a finite type v-ideal (resp., a principal ideal), then $D_{F({\Lambda})}$ is a weakly Krull domain (resp., generalized weakly factorial domain) if and only if the intersection $D_{F({\Lambda})}={\cap}_{P{\in}A}D_P$ has finite character, if and only if $F({\Lambda})$ is a t-splitting set of ideals, if and only if $F({\Lambda})$ is v-finite.