• Korean Journal of Food Science and Technology
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• v.47 no.4
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• pp.499-503
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• 2015

We investigated the anti-obesity effects of ethanolic extract (ID1216) of Polygonatum sibiricum rhizome and its potential underlying mechanism in an animal model. ID1216 treatment decreased body weight gain and white adipose tissue weight in the prevention study. The mRNA levels of sirtuin-1 (SIRT1), peroxisome proliferator-activated receptor ${\gamma}$ coactivator-$1{\alpha}$ ($PGC1{\alpha}$), and peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) significantly increased in the epididymal white adipose tissue of ID1216-administered mice. The stimulation effects of ID1216 on these gene expressions were also observed in a cell-based assay using differentiated 3T3-L1 adipocytes. In addition, similar to orlistat, ID1216 treatment improved weight gain and reduced epididymal fat in the treatment model. These results suggest that ID1216 has potential as an anti-obesity agent by modulating the expression of genes related to thermogenesis, lipid metabolism and fatty acid oxidation.

• Microbiology and Biotechnology Letters
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• v.17 no.1
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• pp.69-73
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• 1989

Cellular autolytic enzyme was isolated from the supernatant fluid of exponentially growing cuiture of Cl. butyricum ID-113. The autolysin was partially pruified by ammonium sulfate fractionation, chromatography on DEAE-Sephadex A-50 and gel filtration through Sephadex G-200. This autolytic enzyme lysed SDS-treated cell wall fractions of Cl. butyricum ID, but not whole cells at all. Its optimum pH and temperature were 5.0 and 37$^{\circ}C$, respectively. This enzyme was relatively stable at neutral pH, but sensitive to heat treatment. Enzyme activity was not influenced by the addition of various divalent cation, but inhibited by Cu$^{++}$.

• Korean Journal of Computational Design and Engineering
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• v.18 no.3
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• pp.200-210
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• 2013

It has become important to manage plant data effectively and to share these data among different organizations that are located in different places and participate in a variety of lifecycle phases. ISO 15926 is an international standard for integration of lifecycle data for process plants including oil and gas facilities. This standard consists of several parts providing a generic data model, reference data, and implementation methods. iRINGTools is a tool developed for the exchange of plant design data. This tool supports the implementation methods specified in ISO 15926. In this paper, the exchange of plant design data using iRINGTools is investigated. For this, sample P&ID data was modeled and data exchange experiment was performed. From the experiment, a data exchange procedure based on ISO 15926 is established and design data types that can be practically exchanged using ISO 15926 were identified.

• Journal of the Korean Society of Systems Engineering
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• v.13 no.2
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• pp.49-56
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• 2017

Implementation of Model-based Systems Engineering(MBSE) depends on a model supporting efficient communication among engineers from various domains. And SysML is designed to create models supporting MBSE but unfortunately, SysML itself is not practical enough to be used in real-world engineering projects. SysML is designed to express generic systems and requires specialized knowledge, so a model written in SysML is less capable of supporting communication between a systems engineer and a sub-system engineer. Domain Specific Languages(DSL) can be a great solution to overcome the weakness of the standard SysML. A SysML based DSL means a customized SysML for a specific engineering domain. Unfortunately, current researches on SysML Domain Specific Language(DSL) for the plant engineering industry are still on the early stage. So as the first step, we have developed our own SysML based Piping & Instrumentation Diagram (P&ID) creation environment and P&ID itself of a specific plant system, using a widely used SysML authoring tool called MagicDraw. P&ID is one of the most critical output during the plant design phase, which contains all information required for the plant construction phase. So a SysML based P&ID has a great potential to enhance the communication among plant engineers of various disciplines.

• Microbiology and Biotechnology Letters
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• v.17 no.1
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• pp.63-68
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• 1989

The optimum conditions for cellular autolysis in Clostridium butyricum ID-113 have been investigated. Cellular autolysis was optimal at pH 1.0 in 0.05 M potassium phosphate buffer and at 37$^{\circ}C$. The rate of cellular autolysis depended on the age of culture. The most rapid cellular autolysis occurred in the cells of mid-exponentially growing cultures, but cellular autolysis decreased sharply when the cultures entered the stationary phase. A growing culture of Cl. butyricum ID-113 was induced to autolyze and lost its turbidity spontaneously in the hypertonic NaCl, sucrose, or glucose medium. The autolytic enzyme activity was found In the autolysate of cells and the supernatant of the culture.

• Journal of the East Asian Society of Dietary Life
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• v.21 no.3
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• pp.463-470
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• 2011

The objective of this study was to examine the effects of a fruit diet and exercise on body composition and hematological parameters in female collegians according to their uncoupling protein 2 (UCP2) genotypes. Nine subjects were recruited from the SahmYook University. 4 subjects carried the ID genotype, 5 the DD genotype, and none of the subjects carried the II genotype. After 10 days of the program, BMI were significantly decreased (p<0.05) in the ID genotype and the DD genotype. Mean total energy intake from fruit diet was 888.1 kcal. Fat mass and % body fat were significantly decreased (p<0.05) in subjects with the ID genotype. Hemoglobin level was significantly increased (p<0.05) in subjects with the DD genotype. This study provided evidence that fruit diet and exercise could decrease the BMI in subjects with the ID and DD genotypes and increase the hemoglobin level in those with the DD genotype.

• Proceedings of the KIEE Conference
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• 2002.07b
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• pp.1172-1174
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• 2002

An adaptive fuzzy P + ID controller for variable speed operation of BLDC motor drives is presented in this paper. Generally, a conventional PID controller is most widely used in industry due to its simple control structure and ease of design. However, the PID controller suffers from the electrical machine parameter variations and disturbances. To improve the tracking performance for parameter and load variations, the controller proposed in this paper is constructed by using an adaptive fuzzy logic controller in place of the proportional term in a conventional PID controller. For implementing this controller, only one additional parameter has to be adjusted in comparison with the PID controller. An adaptive fuzzy controller applied to proportional term to achieve robustness against parameter variations has simple structure and computational simplicity. The controller based on optimal fuzzy logic controller has an self-tuning characteristics with clustering. Computer simulation results show the usefulness of the proposed controller.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.969-972
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• 2005

This paper presents a GA-fuzzy $P^2ID$ control system for the flexible-joint robot arm. This controller is designed based on the parameter adjustment using fuzzy logic and genetic algorithms. According to the simulations, the better performance has been achieved acquired that the robot moved smoothly and met its required objectives. The results of comparison between 8 parameters and 10 parameters can be conclusion that the 10 parameters have setting time little than 8 parameters. In usability can be use 8 or 10 parameters these one.

• Toxicological Research
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• v.31 no.2
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• pp.137-149
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• 2015

Human hepatocytes, with complete hepatic metabolizing enzymes, transporters and cofactors, represent the gold standard for in vitro evaluation of drug metabolism, drug-drug interactions, and hepatotoxicity. Successful cryopreservation of human hepatocytes enables this experimental system to be used routinely. The use of human hepatocytes to evaluate two major adverse drug properties: drug-drug interactions and hepatotoxicity, are summarized in this review. The application of human hepatocytes in metabolism-based drug-drug interaction includes metabolite profiling, pathway identification, P450 inhibition, P450 induction, and uptake and efflux transporter inhibition. The application of human hepatocytes in toxicity evaluation includes in vitro hepatotoxicity and metabolism-based drug toxicity determination. A novel system, the Integrated Discrete Multiple Organ Co-culture (IdMOC) which allows the evaluation of nonhepatic toxicity in the presence of hepatic metabolism, is described.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.23 no.4
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• pp.695-707
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• 2013

DHT(Distributed Hash Table) networks such as Kademlia are vulnerable to the ID mapping attack caused by the voluntary DHT mapping structure where the location of a node is solely determined by itself on the network topology. This causes security problems such as eclipse, DRDoS and botnet C&C on DHT networks. To prevent ID mapping attacks, we propose a non-voluntary DHT mapping scheme and perform analysis on NAT compatibility, attack resistance, and network dynamicity. Analysis results show that our approach may have an equivalent level of attack resistance comparing with other defense mechanisms and overcome their limitations including NAT compatibility and network dynamicity.