• Journal of Veterinary Science
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• 제19권6호
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• pp.725-734
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• 2018

Ovaries of 21 bitches presented with gynecopathies were surgically removed and histologically examined. Standard histological, as well as immunohistochemical, classification of 193 cystic structures resulted in the classification of 72 cysts of subsurface epithelial structures (SES), 61 follicular cysts (FCs), 38 cystic rete ovarii (CRO), 13 lutein cysts (LCs), and 9 non-classifiable cysts (NCCs). In addition to the histological classification, results were interpreted according to subject medical history, clinical examination outcome, and macroscopic observations during ovariohysterectomy. Dogs with ovarian cysts (OCs) and associated reproductive perturbations were mostly nulliparous, of large breed, and had an average of $9.5{\pm}3$ years. Prolonged or shortened inter-estrus intervals of past heats, however, seemed to be relatively low-risk factors for the development of OCs in dogs. Furthermore, we provide histological observations of a rarely seen canine LC including a degenerated oocyte in the central cavity.

• Journal of Yeungnam Medical Science
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• 제29권2호
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• pp.73-76
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• 2012

More and more children are becoming obese and overweight due to several factors that include a high energy density in the diet (a high fat intake) and low energy expenditure. Consequently childhood obesity is becoming a significant health problem. Fat tissue releases many cytokines such as resistin, tumor necrosis factor-${\alpha}$, leptin, interleukin-6. These adipocytokines induce obesity-related insulin resistance. Insulin resistance is a key component of obesity-related metabolic problems such as hypertension, type 2 diabetes mellitus, dyslipidemia, non-alcoholic steatohepatitis, acanthosis nigricans and polycystic ovarian syndrome. This review article focused on insulin resistance and its related metabolic diseases.

• 산업식품공학
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• 제15권1호
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• pp.1-5
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• 2011

Codonopsis lanceolata L. (Campanulaceae) has long been used in traditional Korean medicine to treat bronchitis, cough, and inflammatory diseases, however, the efficacy of anti-tumor activities remains to be defined. In this study the effects of Codonopsis lanceolata (C. lanceolata) on proliferation, migration and adhesion in lung (A549, H1299) and ovarian cancer (SKOV-3) cells were investigated. To assess and compare the pharmacological effects and production places of C. lanceolata, the ethanolic extracts of C. lanceolata from different places in Korea (Hongseong, Yecheon, Yeongwol, Yanggu, Gangjin, and Hoengseong) were prepared. The extract from Hoengseong county did have only marginal anti-proliferative activity in all the cell lines tested, however, other extracts had little or no effect on cell proliferation. The extracts from Hongseong, Gangjin or Hoengseong county had partial anti-migratory activity in lung cancer cells, but not in ovarian cancer cells. In addition, the extract from Hoengseong county had partial anti-adhesive activity in ovarian cancer cells, however, other extracts did not affect cell adhesion in both lung and ovarian cancer cells. Taken together, these findings provide the first description of anti-tumor efficacy of C. lanceolata from different production places in Korea, and suggest that C. lanceolata from Hoengseong county may have therapeutic potential in lung and ovarian cancers.

• 대한수의학회지
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• 제26권1호
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• pp.163-174
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• 1986

The 587 Holstein cows which calved from January 1983 to December 1984 at an integrated dairy farm in Chung-nom province were examined for the incidence of reproductive disorders and their conception rate after treatment. The results obtained were as follows; 1. The incidence of reproductive disorders was 47.9% (281 heads) among 587 heads which calved. 1) As number of calvings increased, the incidence of reproductive disorders decreased. 2) The cows which calved in spring and summer showed significantly higher incidence of reproductive disorders than those which calved in autumn and winter (p<0.05). 3) Among reproductive disorders, ovarian, uterine, cervical and vaginal diseases figured 54.3%, 43.7%, 0.9% and 0.6%, respectively. 4) Among individual genital diseases, endometritis (40.3%) occurred most frequently. 2. Among 281 heads with reproductive disorders, 216 heads(76.9%) conceived after treatment. 1) After treatment of reproductive disorders, the conception rate by number of calvings was in range from 69.6% to 87.5%. 2) The cows which calved in summer and winter showed significantly higher conception rate after treatment of reproductive disorders than those which calved in spring and autumn (P<0.05). 3) The conception rates after treatment of the cows with ovarian, uterine, cervical and vaginal diseases were 66.5%, 81.2%, 33.3% and 50.0% respectively. 4) The cows with endometritis showed the highest conception rate after treatment (85.9%).

• BMB Reports
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• 제46권7호
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• pp.338-345
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• 2013

microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by targeting the 3'-untranslated region of multiple target genes. Pathogenesis results from defects in several gene sets; therefore, disease progression could be prevented using miRNAs targeting multiple genes. Moreover, recent studies suggest that miRNAs reflect the stage of the specific disease, such as carcinogenesis. Cystic diseases, including polycystic kidney disease, polycystic liver disease, pancreatic cystic disease, and ovarian cystic disease, have common processes of cyst formation in the specific organ. Specifically, epithelial cells initiate abnormal cell proliferation and apoptosis as a result of alterations to key genes. Cysts are caused by fluid accumulation in the lumen. However, the molecular mechanisms underlying cyst formation and progression remain unclear. This review aims to introduce the key miRNAs related to cyst formation, and we suggest that miRNAs could be useful biomarkers and potential therapeutic targets in several cystic diseases.

• Clinical and Experimental Reproductive Medicine
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• 제29권3호
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• pp.195-200
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• 2002

Objective : To investigate the expression of apoptosis related proteins and apoptotic cells on the human ovarian follicles. Materials and Methods: Thirty five Formalin-fixed paraffin-embedded human ovarian tissue blocks were selected from the surgical pathology files of the department of pathology, College of Medicine, Yonsei University, for the period from 1996 to 1998. All specimen were from premenopausal women aged from $32{\sim}45$. Ovarian tissues were collected from the patients performing hysterectomy for benign uterine diseases. Immunohistochemical staining was performed for the detection of DNA fragmented cell, Bcl-2, Bax, Fas and Fas-ligand. Results: Bcl-2 and bax were not expressed on the surrounding cells and oocyte of the primary, primordial and preantral follicles. Fas and Fas-ligand (Fas-L) were not expressed on the surrounding cells on the primordial and primary follicles. But expressed on the surrounding granulosa cells and oocyte in the primordial and primary follicles. In the healthy follicles, Bcl-2 was expressed on the granulosa cells, however, Bax was not expressed. DNA fragmented cells were expressed on the inner granulosa cell layer of atretic follicles. Conclusion: Fas, Fas-ligand, and Bax may be responsible for the follicular atresia and Bcl-2 may be involved in the follicular survival in the human ovary.

• 한국가축번식학회지
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• 제25권3호
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• pp.207-217
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• 2001

1999년 5월부터 2000년 5월까지 김제시 관내 32농가 가임암소 836두를 대상으로 번식장애 진단 및 치료를 수행하였다. 번식장애는 직장검사와 초음파 진단기(SA 600, Medison, 5.0MHz rectal linear transducer)를 이용하여 진단한 후 유형별로 분류하였다. 번식장애 치료는 자궁질환우는 자궁세정 또는 질세정을 실시하였고, 개체에 따라 호르몬 처치를 하였다. 난소질환우는 난소질환의 유형에 따라 호르몬 처치를 하고 초음파 소견에 따라 자궁 또는 질세정을 병행하여 실시하였다. 1. 번식장애 대상우 102두중 15두는 임신으로 판정되어 번식장애우는 87두로 가임암소 836두에 대해 10.4%의 번식장애 발생율을 나타내었다. 2. 번식장애는 자궁질환, 난소질환, 자궁과 난소질환 혼합형, 황체존재 무발정형의 4가지로 분류하였다 번식장애우로 분류된 87두중 자궁질환은 33두 37.9%, 난소질환은 30두 34.5%, 자궁과 난소질환 혼합형은 16두로 18.4%, 황체존재 무발정은 8두로 9.2%를 나타내었다. 3 번식장애우 87두중 시험중 번식장애와 함께 병발질환인 요질과 발굽질환이 심하여 번식우로 활용하기가 어렵다고 판단되어 7두를 도태 유도하였다. 4. 번식장애우 87두중에 7두는 도태되었고 치료두수 80두에 대한 치료결과 발정발현우는 74두로 92.5%의 발정발현율을 보였으며, 수태우는 56두로 70.0%의 수태율을 나타내었다. 5. 번식장애 유형별 치료결과는 자궁질환우 32두에 대한 치료후 발정발현우는 31두로 96.8%, 수태우는 23두로 71.9%의 수태율을 나타내었고, 난소질환우는 25두에 대한 치료후 발정발현우는 22두로 55.0%, 수태우는 16두로 64.0%이었으며, 혼합형중 15두에 대하여 발정발현우는 13두로 86.7%, 수태우는 9두로 60.0%의 수태율이었으며, 황체존재 무발정우 8두에 대한 치료후 발정 및 수태 모두 8두에 나타나 발정발현율 및 수태율이 100.0%이었다. 6. 번식장애우의 분만후 경과시기에 따른 발생 여부는 전체 87두중 분만후 0~30일이 2두 2.3%, 30~60일이 6두 6.9%, 60~90일이 12두 13.8%, 90~120일이 18두 20.7%, 120일 이상이 49두로 56.3%로서 분만후 시일이 경과할수록 번식장애우의 발생율이 높은 경향을 보였다. 7. 번식장애우에 번식질환과 함께 병발된 질환을 조사한 결과 번식장애우 87두중 병발질환이 있는 번식장애우는 18두로 20.7%를 나타내었다. 이러한 병발질환을 유형별로 보면 발굽질환우는 5두, 관절질환우는 5두, 뇨질 6두, 직장질루 2두로 나타났다. 병발질환우 18두에 대한 사지질환우는 10두로 55.6%이었다. 8. 번식장애농가 12농가중 7농가가 번식기록 관리를 하지 않았고(58.3%), 또한 5 농가가 운동장이 없거나 활용하지 않아(41.7%) 이러한 요인도 번식장애 발생과 연관이 있다고 판단되었다. 이상의 결과 직장검사에 의존해서 번식장애를 판단하기보다는 초음파 검사와 병행을 할 때 정확한 진단이 이루어질 수 있고 적절한 치료가 이루어져 높은 치료효과를 보일 수 있을 것으로 판단된다. 그리고 번식기록 미비와 운동장의 활용이 적다는 것도 번식장애를 발생시킬 수 있는 사양관리상의 조건이 될 것으로 생각되어 이에 대한 개선방향이 세워져야 할 것으로 판단된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6749-6754
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• 2014

Background: There are limited data in the literature related to concomitant genital or extra-genital organ pathologies in patients with borderline ovarian tumors (BOTs). The aim of this study was to evaluate our experience with 183 patients to draw attention to the accompanying organ pathologies with BOTs. Materials and Methods: One hundred eighty-three patients with BOTs, diagnosed and/or treated in our center between January of 2000 and March of 2013 were evaluated retrospectively. Data related to age, tumor histology, lesion side, disease stage, accompanying incidental ipsilateral and/or contralateral ovarian pathologies, treatment approaches, and follow-up periods were investigated. Incidental gynecologic and non-gynecologic concomitant organ pathologies were also recorded. Results: The mean age at diagnosis was 40.6 years (range: 17-78). Ninety-five patients (51%) were ${\leq}40$ years. A hundred and forty-seven patients (80%) were at stage IA of the disease. The most common type of BOT was serous in histology. Non-invasive tumor implants were diagnosed in 4% and uterine involvement was found 2% among patients who underwent hysterectomies. There were 12 patients with positive peritoneal washings. Only 17 and 84 patients respectively had concomitant ipsilateral and concomitant contralateral incidental ovarian pathologies. The most common type of uterine, appendicular and omental pathologies were chronic cervicitis, lymphoid hyperplasia and chronic inflammatory reaction. Conclusions: According to our findings most of accompanying pathologies for BOT are benign in nature. Nevertheless, there were additional malignant diseases necessitating further therapy. We emphasize the importance of the evaluation of all abdominal organs during surgery.

• Journal of Digestive Cancer Research
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• 제10권2호
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• pp.112-116
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• 2022

Idiopathic inflammatory myopathy (IIM) is known for its association with malignant diseases. Moreover, various solid organ malignancies, such as ovarian, breast, lung, esophageal, stomach, and colorectal cancers, have been reported to occur with IIM. Furthermore, its relationship with hematologic malignancies, including non-Hodgkin lymphoma, myeloma, and leukemia, has been reported. However, to date, IIM related to pancreatic cancer has scarcely been reported, particularly in patients with polymyositis (PM). Therefore, here we report a case of PM developed immediately after the diagnosis of pancreatic ductal adenocarcinoma.

• 대한유전성대사질환학회지
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• 제22권2호
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• pp.46-52
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• 2022

Inborn errors of metabolism (IEM) are very rare and genetically transmitted diseases and have man y different symptoms related with multisystemic involvement. More rarely, endocrinopathies can be an early and first symptom of IEM, but presents with signs of later complications in adolescent or adulthood. The mechanisms of endocrine dysfunction in IEM are poorly understood. Hypogonadotropic hypogonadism is common in hemochromatosis, adrenoleukodystrophy, galactosemia, and glycogen storage disease. Many girls with classic galactosemia are at high risk for premature ovarian insufficiency (POI), despite an early diagnosis and good control. Mitochondrial diseases are multisystem disorders and are characterized by hypo- and hypergonadotrophic hypogonadism, thyroid dysfunction and insulin dysregulation. Glycogen storage disorders (GSDs), especially type Ia, Ib, III, V are assocciated with frequent hypoglycemic events. IEM is a growing field and is not yet well recognized despite its consequences for growth, bone metabolism and fertility. For this reason, clinicians should be aware of these diagnoses and potential endocrine dysfunction.