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Anti-tumor Effects of Codonopsis Lanceolata Extracts on Human Lung and Ovarian Cancer  

Cho, Young-Rak (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University)
Kim, Soo Hyeon (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University)
Yoon, Hyun Jae (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University)
Hong, Sam Yeol (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University)
Ko, Hee-Young (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University)
Park, Eun-Hee (Department of Food Science and Biotechnology, School of Biotechnology and Bioengineering, Kangwon National University)
Kim, Myoung-Dong (Department of Food Science and Biotechnology, School of Biotechnology and Bioengineering, Kangwon National University)
Seo, Dong-Wan (Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University)
Publication Information
Food Engineering Progress / v.15, no.1, 2011 , pp. 1-5 More about this Journal
Abstract
Codonopsis lanceolata L. (Campanulaceae) has long been used in traditional Korean medicine to treat bronchitis, cough, and inflammatory diseases, however, the efficacy of anti-tumor activities remains to be defined. In this study the effects of Codonopsis lanceolata (C. lanceolata) on proliferation, migration and adhesion in lung (A549, H1299) and ovarian cancer (SKOV-3) cells were investigated. To assess and compare the pharmacological effects and production places of C. lanceolata, the ethanolic extracts of C. lanceolata from different places in Korea (Hongseong, Yecheon, Yeongwol, Yanggu, Gangjin, and Hoengseong) were prepared. The extract from Hoengseong county did have only marginal anti-proliferative activity in all the cell lines tested, however, other extracts had little or no effect on cell proliferation. The extracts from Hongseong, Gangjin or Hoengseong county had partial anti-migratory activity in lung cancer cells, but not in ovarian cancer cells. In addition, the extract from Hoengseong county had partial anti-adhesive activity in ovarian cancer cells, however, other extracts did not affect cell adhesion in both lung and ovarian cancer cells. Taken together, these findings provide the first description of anti-tumor efficacy of C. lanceolata from different production places in Korea, and suggest that C. lanceolata from Hoengseong county may have therapeutic potential in lung and ovarian cancers.
Keywords
Codonopsis lanceolata; ovarian cancer; lung cancer;
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