• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.392.2-392.2
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• 2002

Cytotoxic activity against the P388 cell line was seen in a crude extract of Anisotome lyallii. A bioactivity guided isolation led to the isolation of a deterpene. which displayed strong Cytotoxic activity against the P388 cell line (IC50 2.3 $\mu$g/ml), as well as antimicrobial activity against Bacillus subtilis. The structure of de terpene 1 was elucidated by spectroscopic methods. (omitted)

• 동의생리병리학회지
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• 제24권6호
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• pp.950-955
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• 2010

In this study, we prepared CheonJeongKiBo-Dan(7 oriental medicinal plants, 7OMP: Astragalus Membranaceus root, Panax Ginseng root, Glycyrrhiza Glabra (licorice) root, Schizandra Chinensis fruit, Polygonatum Odoratum, Rehmannia Glutinosa root, Paeonia Albiflora root) by extracting them in one reactor and studied its efficacies on skin. UV irradiation has been suggested as a major cause of photoaging in skin. In order to investigate protective effects against UV-B induced cellular damage, 7OMP was extracted with 70% ethanol and dissolved in DMSO. The protective effect was detected by MTT assay, reactive oxygen species (ROS) generation, phosphorylation of ATR and p53 in human dermal fibroblast cell system after UV-B irradiation. 7OMP reduced UV-B-induced cellular damage in HDFs cells, and inhibited ROS generation. UV-B-induced toxicity accompanying ROS production and the resultant DNA damage are responsible for activation of ATR, p53 and Bad. In this study, 7OMP hampered phosphorylations of ATR and p53 in human dermal fibroblasts. Therefore, 7OMP may be protective against UV-induced skin photoaging.

• 한국패션뷰티학회지
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• 제5권1호
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• pp.1-7
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• 2007

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.391.3-392
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• 2002

Melanin is a main pigment found in skin. hair and eyes, and tyrosinase plays an important role in the process of melanin polymer biosynthesis. Caesalpinia sappan L.(C. sappan) has been commonly used in Oriental folk medicines to promote blood circulation and as analgesic as well as remedy for thrombosis. This present study was designed to investigate the effect of ethyl acetate extract from C. sappan on melanogenesis in Melan-a cells. (omitted)

• 한방안이비인후피부과학회지
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• 제24권2호
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• pp.68-78
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• 2011

Objective : The purpose of this clinical research was to investigate the effects of herbal cosmetics containing Momordica charntia L. extracts on the anti-wrinkle and whitening effects. Methods : A total of 25 subjects who visited Daegu Hanny Oriental Medical Center from November 1st, 2010 to December 31th, 2010 were included in this study. In this study, we observed change of R1, R2, R3, R4, R5 for using products, change of average melanin content and pigmental area, analysis results of subjective wrinkle improvement, Analysis results of subjective whitening improvement. Statistical analysis was performed by using paired t-test and wilcoxon signed ranks test. Statistical significance was achieved if the probability was less than 5%(p<0.05) Results : Statistically, herbal cosmetics containing Momordica charntia L. extracts showed siginificant effect on change of R1, R2, R3, R4, R5 for using products, change of average melanin content and pigmental area, analysis results of subjective wrinkle improvement, Analysis results of subjective whitening improvement(p<0.05). And satisfaction after using herbal cosmetics was near good. Conclusions : Considering the above results, we have concluded that herbal cosmetics containing Momordica charntia L. extracts have the remarkable effects on the anti-wrinkle and whitening effects.

• 동의생리병리학회지
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• 제25권4호
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• pp.608-613
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• 2011

The aqueous Green tea comes to be used with the Oriental medicine plant, it has the numerous health benefits, including antioxidant, anti-inflammatory, and anti- carcinogenic properties. Epidermal progenitor cells give rise to multiple skin lineages: hair follicle, sebaceous gland and the overlying interfollicular epidermis. Sebocytes are the cells of the sebaceous gland, which synthesize and accumulate lipid dropolets. In order to determine the effect of Green tea on lipid production, several experiments were performed in SZ95 cells (sebocytes). We found that Green tea increased lipid droplets compared with control in a dose-dependent manner. Human sebaceous glands produce sebum, a lipid mixture of squalene, wax esters, triglycerides, cholesterol esters, and free fatty acids that is secreted onto the skin. Therefore, to investigate the effects of Green tea on intracellular lipid levels, we treated SZ95 cells with Green tea, and then examined cholesterol and triglyceride levels. After treatment of the cells with Green tea, the cholesterol and triglyceride levels of SZ95 cells were increased significantly in a dose-dependent manner.

• 대한한방피부미용학회지
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• 제1권1호
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• pp.145-157
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• 2005

Oriental cosmetics is based on oriental medical theory. In oriental medicine, skin reflects the condition of internal organ(臟腑) and qi-hyul(氣血). The oriental dermatology and aesthetics aim at the development of health and beauty using herbal medicine, acupuncture, chuna(推拿), qigong(氣功), and diet. And the oriental dermatology and aesthetics are related the branch of oriental medicine, such as oriental gynecology and oriental internal medicine.

• 혜화의학회지
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• 제22권1호
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• pp.79-90
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• 2013

Objectives : With increasing interests in hair cosmetic to keep their scalp and hair healthy we must have much more information about the oriental medical cosmetic goods. Methods : Shampoos which contain herbal ingredients are commonly used to stopping their hair loss, alopecia. On the basis of oriental pharmacology, we analyzed several shampoos which have herbal ingredients and thought about the oriental cosmetic methods for a hair loss. Results : We found that many herb based shampoos are developed on the basis of the principle of oriental medicine. In addition, the interest in oriental medical cosmetic methods that used the principles of the oriental medical science has been increased and cosmetic goods based on the oriental medicine have a positive market. Conclusions : With many possibilities for the oriental medical cosmetic methods, clinical records to prove scientific facts are urgently needed. In addition, the oriental medical cosmetic methods based on oriental medicine to examine scalp and hair should be offered.

• 대한화장품학회지
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• 제30권1호
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• pp.93-102
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• 2004

최근 고기능성과 식물성이라는 세계적인 화장품 트렌드 속에서 우리의 옛것을 받아들여 ‘온고지신(溫故知新)’의 의미를 되새기게 하는 ‘한방(韓方) 화장품’이 우리나라 화장품 시장의 새로운 흐름으로 자리잡고 있는 추세이다. 바야흐로 한방 전성시대를 맞고 있으며 한방 화장품 브랜드의 활발한 출시와 함께 유통 다각화도 두드러져 한방 화장품 시장은 급성장할 것으로 전망되고 있다. 이에 본 연구는 최근 신브랜드의 출시로 급성장하고 있는 국내 한방 화장품 시장을 점검해 보고, 여성 소비자들의 화장품 구매행동을 통해 한방 화장품이 어떻게 인식되고 있으며 앞으로 어떻게 육성, 발전시켜 나가야 할 것인가를 조사했다. 서울과 경기도에 거주하는 19세 이상 60세 이하의 성인 여성 소비자를 대상으로 설문조사를 실시했으며, 총 430부의 설문지를 배포해 그중 350부를 분석에 이용했다. 수집된 자료는 SPSS 프로그램을 이용하여 분석했다. 분석 방법으로는 연구대상자의 일반적 특성을 파악하기 위해 빈도와 백분율을 산출했으며, 여성들의 한방 화장품 사용실태, 한방 화장품에 대한 만족도, 한방 화상품의 개선점에 대한 인식을 살펴보기 위해 Cronbach's $\alpha$ 신뢰도 검증, $\chi$$^2$(Chi-square) 검증과 빈도분석, t-test(검증), 그리고 One-way ANOVA를 실시했다. 위의 결과를 토대로 본 연구에서는 한방 화장품의 시장 현황과 사용실태에 대한 기초 정보 제공을 통해 소비자의 요구를 보다 직접적으로 파악, 한방 화장품 시장에 대한 마케팅 전략 수립시 기초 자료가 될 것으포 사료된다.있음을 시사하고 있다.trex를 적절히 혼합하여 항균력을 향상시키고 광범위하게 사용할 수 있는 이상적인 혼합비(Manuka oil : Citrex)를 구하였는데 Escherichia coli에 대해서는 75 : 25이었고 Staphylococcusureus에 대해서는 25 : 75 이었다.asogastic tuhe를 삽입하였으며 (83.3%), 삽입하지 않은 16명 (16.7%)은 늦게 내원이 10명, 삽입 실패 4명, 기타 2명이었다. 6) 기관절개술이 요구된 경우는 호흡기장애가 있었던 17명 (17.7%)이었으며 분비물의 축적이 6명 (35.3%), 상기도폐쇄가 11명 (64.7%)이었다. 7) 조기 식도경 검사를 시행한 11명 (11.5%)중 48시간이내가 6명 (54.5%)으로 가장 많았다. 조기 식도경검사 결과 ; 점막에 중증도의 궤양이 8명 (72.7%)으로 대부분을 차지하였고 점막의 종창과 부식 정도가 비교적 경하였던 6명 (54.5%)은 입원 가료가 필요하지 않아서 곧 경구 음식 투여를 시작하였으나 입원 가료가 필요했던 중(重)증의 경우 그 입원 일수는 평균 4주간 이었다. 8) 본 병원에 처음 내원하여 치료를 받은 22명중 Nasogastric tube를 넣은 기간은 평균 11.6일 이었으나 최근에는 tube를 삽입하여둔 기간은 대체로 입원기간과 일치하며 이는 조기 식도경 검사를 시행하여 병변의 정도에 따라 결정하였다. 9) 대부분의 경우에서 Steroid를 투여하였으며 투여하지 않거나 투여가 지연된 경우는 47명 (48.9%)으로서 내용별 분류를 보면 (1) 약물의 종류로 인한 경우(산성, 미상) 12명, (2) 경(輕)하다고 인정된 경우 9명,

• 약학회지
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• 제56권4호
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• pp.268-273
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• 2012

This study was to explore the lipogenic effect by ethanol extract of ponciri fructus (EPF) and possible molecular mechanisms in sebocyte. When SZ95 sebocyte cell line were treated with the EPF, lipid droplets were accumulated in the majority of cells. EPF increased expression of sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) in the SZ95 cells. EPF augmented expression of PPAR-${\beta}$ and PPAR-${\gamma}$ but not that of PPAR-${\alpha}$. These results suggest that EPF induces lipogenesis in SZ95 cells through SREBP-1, PPAR-${\beta}$ and PPAR-${\gamma}$ activations.