YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Ponciri Fructus Extract Induces Lipogenesis through Transcription Factor SREBP-1 Activation

지실 추출물의 전사인자 SREBP-1 활성에 의한 지질 생성 촉진

  • Kim, Dae-Sung (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine) ;
  • Jeon, Byoung-Kook (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine) ;
  • Mun, Yeun-Ja (Dept. of Anatomy, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Ghang-Tai (Coreana Cosmetics Ltd., R&D Center) ;
  • Lee, Kun-Kuk (Coreana Cosmetics Ltd., R&D Center) ;
  • Woo, Won-Hong (Dept. of Anatomy, College of Oriental Medicine, Wonkwang University)
  • 김대성 (원광대학교 한의학전문대학원) ;
  • 전병국 (원광대학교 한의학전문대학원) ;
  • 문연자 (원광대학교 한의과대학) ;
  • 이강태 (코리아나화장품 기술연구소) ;
  • 이건국 (코리아나화장품 기술연구소) ;
  • 우원홍 (원광대학교 한의과대학)
  • Received : 2012.07.09
  • Accepted : 2012.08.23
  • Published : 2012.08.31
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Abstract

This study was to explore the lipogenic effect by ethanol extract of ponciri fructus (EPF) and possible molecular mechanisms in sebocyte. When SZ95 sebocyte cell line were treated with the EPF, lipid droplets were accumulated in the majority of cells. EPF increased expression of sterol regulatory element-binding protein-1 (SREBP-1) and fatty acid synthase (FAS) in the SZ95 cells. EPF augmented expression of PPAR-${\beta}$ and PPAR-${\gamma}$ but not that of PPAR-${\alpha}$. These results suggest that EPF induces lipogenesis in SZ95 cells through SREBP-1, PPAR-${\beta}$ and PPAR-${\gamma}$ activations.

Keywords

References

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