• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6177-6186
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• 2015

Sensitivity and specificity are the two most important indicators in selection of medical imaging devices for cancer screening. Breast images taken by conventional or digital mammography, ultrasound, MRI and optical mammography were collected from 2,143,852 patients. They were then studied and compared for sensitivity and specificity results. Optical mammography had the highest sensitivity (p<0.001 and p<0.006) except with MRI. Digital mammography had the highest specificity for breast cancer imaging. A comparison of specificity between digital mammography and optical mammography was significant (p<0.021). If two or more breast diagnostic imaging tests are requested the overall sensitivity and specificity will increase. In this literature review study patients at high-risk of breast cancer were studied beside normal or sensitive women. The image modality performance of each breast test was compared for each.

• Journal of the Optical Society of Korea
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• v.10 no.1
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• pp.42-47
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• 2006

M-mode imaging of the in vivo murine myocardium using optical coherence tomography (OCT) is described. Application of conventional techniques (e.g. MRI, Ultrasound imaging) for imaging the murine myocardium is problematic because the wall thickness is less than 1.5 mm (20 g mouse), and the heart rate can be as high as six hundred beats per minute. To acquire a real-time image of the murine myocardium, OCT can provide sufficient spatial resolution ($10{\mu}m$) and imaging speed (1000 A-scans/s). Strong light scattering by blood in the heart causes significant light attenuation, which makes delineation of the endocardium-chamber boundary problematic. To measure the thickness change of the myocardium during one heart beat cycle, a myocardium edge detection algorithm is developed and demonstrated.

• Journal of Mechanical Science and Technology
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• v.18 no.7
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• pp.1236-1245
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• 2004

In this study, an optical imaging method was developed for the measurements of the sizes and velocities of droplets in sprays. Double-exposure single-frame spray images were captured by the imaging system. An image processing program was developed for the measurements of the sizes and positions of individual particles including separation of the overlapped particles and particle tracking and pairing at two time instants. To recognize and separate overlapping particles, the morphological method based on watershed segmentation as well as separation using the perimeter and convex hull of image was used consecutively. Better results in separation were obtained by utilization of both methods especially for the multiple or heavily-overlapped particles. The match probability method was adopted for particle tracking and pairing after identifying the positions of individual particles and it produced good matching results even for large particles like droplets in sprays. Therefore, the developed optical imaging method could provide a reliable way of analyzing the motion and size distribution of droplets produced by various sprays and atomization devices.

• Journal of the Optical Society of Korea
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• v.12 no.4
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• pp.262-268
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• 2008

A compact imaging spectrometer (COMIS) for use in the STSAT3 microsatellite is currently under development. It is scheduled to be launched into a low Sun-synchronous Earth orbit (${\sim}700km$) by the end of 2010. COMIS was inspired by the success of CHRIS, which is a small hyperspectral imager developed for the ESA microsatellite PROBA. COMIS is designed to achieve nearly equivalent imaging capabilities of CHRIS in a smaller (65 mm diameter and 4.3 kg mass) and mechanically superior (in terms of alignment and robustness) package. Its main operational goal will be the imaging of Earth's surface and atmosphere with ground sampling distances of ${\sim}30m$ at the $18{\sim}62$ spectral bands ($4.0{\sim}1.05{\mu}m$). This imaging will be used for environmental monitoring, such as the in-land water quality monitoring of Paldang Lake, which is located next to Seoul, South Korea. The optics of COMIS consists of two parts: imaging telescope and dispersing relay optics. The imaging telescope, which operates at an f-ratio of 4.6, forms an image (of Earth's surface or atmosphere) onto an intermediate image plane. The dispersion relay optics disperses the image and relay it onto a CCD plane. All COMIS lenses and mirrors are spherical and are made from used silica exclusively. In addition, the optics is designed such that the optical axis of the dispersed image is parallel to the optical axis of the telescope. Previous efforts focused on manufacturing ease, alignment, assembly, testing, and improved robustness in space environments.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.403.1-403.1
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• 2014

In conventional far-field microscopy, two objects separated closer than approximately half of an emission wavelength cannot be resolved, because of the fundamental limitation known as Abbe's diffraction limit. During the last decade, several super-resolution methods have been developed to overcome the diffraction limit in optical imaging. Among them, super-resolution optical fluctuation imaging (SOFI) developed by Dertinger et al [1], employs the statistical analysis of temporal fluorescence fluctuations induced by blinking phenomena in fluorophores. SOFI is a simple and versatile method for super-resolution imaging. However, due to the uncontrollable blinking of fluorophores, there are some limitations to using SOFI for several applications, including the limitations of available blinking fluorophores for SOFI, a requirement of using a high-speed camera, and a low signal-to-noise ratio. To solve these limitations, we present a new approach combining SOFI with speckle pattern illumination to create illumination-induced optical fluctuation instead of blinking fluctuation of fluorophore.. This technique effectively overcome the limitations of the conventional SOFI since illumination-induced optical fluctuation is possible to control unlike blinking phenomena of fluorophore. And we present the sub-diffraction resolution image using SOFI with speckle illumination.

• Journal of the Optical Society of Korea
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• v.14 no.2
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• pp.77-89
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• 2010

Digital holography (DH) is a potentially disruptive new technology for many areas of imaging science, especially in microscopy and metrology. DH offers a number of significant advantages such as the ability to acquire holograms rapidly, availability of complete amplitude and phase information of the optical field, and versatility of the interferometric and image processing techniques. This article provides a review of the digital holography, with an emphasis on its applications in biomedical microscopy. The quantitative phase microscopy by DH is described including some of the special techniques such as optical phase unwrapping and holography of total internal reflection. Tomographic imaging by digital interference holography (DIH) and related methods is described, as well as its applications in ophthalmic imaging and in biometry. Holographic manipulation and monitoring of cells and cellular components is another exciting new area of research. We discuss some of the current issues, trends, and potentials.

• Journal of the Optical Society of Korea
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• v.20 no.1
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• pp.8-12
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• 2016

In this paper, we theoretically and experimentally analyze the impact of speckle size of pseudo-thermal light source on ghost imaging. A larger size of speckle can bring improvements in SNR and visibility. At the same time, the edge blur of the retrieved image will become more serious. We also present a setup which can mitigate the edge blur of larger speckle while maintaining the advantages of higher SNR and visibility by changing the speckle size of the object beam with a concave lens.

• Journal of the Microelectronics and Packaging Society
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• v.21 no.4
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• pp.25-31
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• 2014

Bioimaging has advanced the field of nanomedicine, drug delivery, and tissue engineering by directly visualizing the dynamic mechanism of diagnostic agents or therapeutic drugs in the body. In particular, wide-field, planar, near-infrared (NIR) fluorescence imaging has the potential to revolutionize human surgery by providing real-time image guidance to surgeons for target tissues to be resected and vital tissues to be preserved. In this review, we introduce the principles of NIR fluorescence imaging and analyze currently available NIR fluorescence imaging systems with special focus on optical source and packaging. We also introduce the evolution of the FLARE intraoperative imaging technology as an example for image-guided surgery.

• Journal of the Optical Society of Korea
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• v.20 no.2
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• pp.228-233
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• 2016

In this paper, we propose a nonlinear maximum average correlation height (MACH) filter for information authentication of photon counting double random phase encryption (DRPE). To enhance the security of DRPE, photon counting imaging can be applied because of its sparseness. However, under severely photon-starved conditions, information authentication of DRPE may not be implemented successfully. To visualize the photon counting DRPE, a three-dimensional imaging technique such as integral imaging can be used. In addition, a nonlinear MACH filter can be utilized for helping the information authentication. Therefore, in this paper, we use integral imaging and nonlinear MACH filter to implement the information authentication of photon counting DRPE. To verify our method, we implement optical experiments and computer simulation.

• Journal of the Optical Society of Korea
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• v.15 no.3
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• pp.300-304
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• 2011

Optical microscopes are widely used for medical imaging these days, but biopsy is a lengthy process that causes many problems during the ex-vivo imaging procedure. The endo-microscope has been studied to increase accessibility to the human body and to get in-vivo images to use for medical diagnosis. This research proposes a multi-modal confocal endo-microscope for bio-medical imaging. We introduce the design process for a small endoscopic probe and a coupling mechanism for the probe to make the multi-modal confocal endo-microscope. The endoscopic probe was designed to decrease chromatic and spherical aberrations, which deteriorate the images obtained with the conventional GRIN lens. Fluorescence and reflectance images of various samples were obtained with the proposed endo-microscope. We evaluated the performance of the proposed endo-microscope by analyzing the acquired images, and demonstrate the possibilities of in-vivo medical imaging for early diagnosis.