• Current Optics and Photonics
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• v.1 no.2
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• pp.132-137
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• 2017

To investigate the usefulness of optical coherence tomography (OCT) for imaging lymphedema, we directly compared it to other histological methods in a mouse model of lymphedema. We performed detailed imaging of the lymphedema lesion on a mouse tail. We imaged the mouse tail in vivo with OCT and created histopathological samples. We constructed a spectrometer-based OCT system using a fiber-optic Michelson interferometer. The light was directed to 50:50 couplers that split the light into reference and sample arms. Backscattered light from a reference mirror and the sample produced an interference fringe. An OCT image of the lymphedema model revealed an inflammatory reaction of the skin that was accompanied by edema, leading to an increase in the light attenuation in the dermal and subcutaneous layers. Similar to OCT image findings, histological biopsy showed an inflammatory response that involved edema, increased neutrophils in epidermis and subdermis, and lymphatic microvascular dilatation. Furthermore, the lymphedema model showed an increase in thickness of the dermis in both diagnostic studies. In the mouse tail model of lymphedema, OCT imaging showed very similar results to other histological examinations. OCT provides a quick and useful diagnostic imaging technique for lymphedema and is a valuable addition or complement to other noninvasive imaging tools.

• Current Optics and Photonics
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• v.2 no.5
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• pp.453-459
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• 2018

We have developed a high-performance signal-processing and image-rendering heterogeneous computation system for optical coherence tomography (OCT) on mobile processor. In this paper, we reveal it by demonstrating real-time OCT image processing using a Snapdragon 800 mobile processor, with the introduction of a heterogeneous image visualization architecture (HIVA) to accelerate the signal-processing and image-visualization procedures. HIVA has been designed to maximize the computational performances of a mobile processor by using a native language compiler, which targets mobile processor, to directly access mobile-processor computing resources and the open computing language (OpenCL) for heterogeneous computation. The developed mobile image processing platform requires only 25 ms to produce an OCT image from $512{\times}1024$ OCT data. This is 617 times faster than the naïve approach without HIVA, which requires more than 15 s. The developed platform can produce 40 OCT images per second, to facilitate real-time mobile OCT image visualization. We believe this study would facilitate the development of portable diagnostic image visualization with medical imaging modality, which requires computationally expensive procedures, using a mobile processor.

• Journal of the Korean Society of Visualization
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• v.10 no.2
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• pp.25-31
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• 2012

High-performance smartphones, equipped with a digital camera and an application software, can render conventional bench-top laboratory instruments mobile at affordable costs. As the smartphone-based devices are portable and wireless, they have wide applications especially in providing point-of-care (POC) tests in resource-constrained areas. We developed a hand-held diagnostic system, Mobile SmartScope, which consists of a small optical unit integrated with a smartphone. The performance of the SmartScope was favorably compared with that of conventional light microscopy in detecting and quantifying red blood cells. We also evaluated the fluorescence detection limit of the SmartScope incorporated with a blue light-emitting diode and appropriate optical filters by using fluorescently labeled microbeads for intensity calibration.

• Proceedings of the Korean Society of Computer Information Conference
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• 2011.06a
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• pp.367-368
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• 2011

본 논문에서는 PON(Passive Optical Network)망의 장애진단을 위한 임베디드 네트워크 제어기를 설계하고 구현하였다. 본 연구에서 구현한 임베디드 네트워크 제어기는 PON망의 가장 말단인 수용가의 인터넷 공유기에 부착되어 수용가의 인터넷 선로장애를 진단할 수 있도록 구현함으로서 인터넷 서비스 제공자(ISP)의 NMS가 점검할 수 없는 영역까지 장애를 진단할 수 있다. 또한, 임베디드 네트워크 제어기는 PON망의 장애진단 뿐만 아니라 수용가의 가전제품 전원제어나 다양한 센서를 부착하여 제어할 수 있도록 제작하여 간단한 홈오토메이션 제어기로 활용할 수 있도록 설계하였다.

• Imaging Science in Dentistry
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• v.51 no.2
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• pp.107-115
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• 2021

Purpose: This study aimed to demonstrate the presence of dental caries through a photoacoustic imaging system with visible and near-infrared wavelengths, highlighting the differences between the 2 spectral regions. The depth at which carious tissue could be detected was also verified. Materials and Methods: Fifteen permanent molars were selected and classified as being sound or having incipient or advanced caries by visual inspection, radiography, and optical coherence tomography analysis prior to photoacoustic scanning. A photoacoustic imaging system operating with a nanosecond pulsed laser as the light excitation source at either 532 nm or 1064 nm and an acoustic transducer at 5 MHz was developed, characterized, and used. En-face and lateral(depth) photoacoustic signals were detected. Results: The results confirmed the potential of the photoacoustic method to detect caries. At both wavelengths, photoacoustic imaging effectively detected incipient and advanced caries. The reconstructed photoacoustic images confirmed that a higher intensity of the photoacoustic signal could be observed in regions with lesions, while sound surfaces showed much less photoacoustic signal. Photoacoustic signals at depths up to 4 mm at both 532 nm and 1064 nm were measured. Conclusion: The results presented here are promising and corroborate that photoacoustic imaging can be applied as a diagnostic tool in caries research. New studies should focus on developing a clinical model of photoacoustic imaging applications in dentistry, including soft tissues. The use of inexpensive light-emitting diodes together with a miniaturized detector will make photoacoustic imaging systems more flexible, user-friendly, and technologically viable.

• Korean Journal of Acupuncture
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• v.28 no.3
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• pp.63-71
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• 2011

Objectives : The aim of this study is to develop the system and evaluate the optical analytical technique that reflects acupoint pigmentation and extravasated blood by cupping. Methods : We designed the system able to express XYZ coordinate on local skin color. To evaluate measurement-accuracy, we compared with 24 Color Checker Chart by standardized Commission Internationale de l'Eclairage. After confirming the performance of system, we experimented with cupping which was 80 kPa negative pressure for 1 minute on left/right BL13. The X, Y and Z values were converted to R, G and B, $L^*$, $a^*$ and $b^*$, Erythema Index (E.I.), and Melanin Index (M.I). We compared and analyzed two cases on before/after cupping. Results : The R, G and B values which were converted by X, Y and Z values had high linearity as a high level of R-square (R: 0.969, G: 0.996, and B: 0.992). Moreover, we confirmed that it was possible to quantitatively analyzed the change in skin color by cupping using R, G, B, $L^*$, $a^*$, $b^*$, E.I., and M.I. Conclusions : Therefore, we proposed the new analytical technique for objectifying the oriental medical diagnostic method using cupping and optical sensing technique.

• Archives of Plastic Surgery
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• v.42 no.5
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• pp.626-629
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• 2015

Peripheral nerve injuries remain a challenge for reconstructive surgeons with many patients obtaining suboptimal results. Understanding the level of injury is imperative for successful repair. Current methods for distinguishing healthy from damaged nerve are time consuming and possess limited efficacy. Confocal laser endomicroscopy (CLE) is an emerging optical biopsy technology that enables dynamic, high resolution, sub-surface imaging of live tissue. Porcine sciatic nerve was either left undamaged or briefly clamped to simulate injury. Diluted fluorescein was applied topically to the nerve. CLE imaging was performed by direct contact of the probe with nerve tissue. Images representative of both damaged and undamaged nerve fibers were collected and compared to routine H&E histology. Optical biopsy of undamaged nerve revealed bands of longitudinal nerve fibers, distinct from surrounding adipose and connective tissue. When damaged, these bands appear truncated and terminate in blebs of opacity. H&E staining revealed similar features in damaged nerve fibers. These results prompt development of a protocol for imaging peripheral nerves intraoperatively. To this end, improving surgeons' ability to understand the level of injury through real-time imaging will allow for faster and more informed operative decisions than the current standard permits.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.2
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• pp.42.2-42.2
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• 2019

Korea Astronomy and Space Science Institute (KASI) has been developing a next-generation coronagraph (NGC) in cooperation with NASA to measure the coronal electron density, temperature, and speed using four different filters around 400 nm. To demonstrate technology for the measurement through the 2017 total solar eclipse across the USA, KASI organized an expedition team to demonstrate the coronagraph measurement scheme and the instrumental technology. The observation site was in Jackson Hole, Wyoming, USA. We built an eclipse observation system, so-called Diagnostic Coronal Experiment (DICE), which is composed of two identical telescopes to improve a signal to noise ratio. The observation was conducted with 4 wavelengths and 3 linear polarization directions according to the planned schedule in a limited total eclipse time of about 140 seconds.Polarization information of corona from the data was successfully obtained but we failed to get the coronal electron temperature and speed information due to a low signal-to-noise ratio of the optical system. In this study, we report the development of DICE and observation results. TSE observation and analysis by using our own developed instrument gave an important lesson that a coronagraph should be carefully designed to archive the scientific purpose. This experience through TSE observation will be very useful for a success of NASA-KASI joint missions called the Balloon-borne Investigation of the Temperature and Speed of Electrons in the Corona (BITSE) and COronal Diagnostic EXperiment (CODEX).

• Journal of Biomedical Engineering Research
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• v.11 no.2
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• pp.277-282
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• 1990

A workstation for archiving and communication of medical records is developed for clinical use in hospital. In this system, handwritten diagnostic reports, medical recording papers such as ECG and EEG etc., and ultrasound images are stored in optical disks instead of papers. This system improves medical service owing to speedy diagnosis by fast finding the patient's medical chart, and curtails the cost of archiving medical charts economically. If this system can be combined with already developed MPACS, then integrated medical image di- agnosis will be possible.

• Journal of Internet Computing and Services
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• v.8 no.2
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• pp.67-76
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• 2007

Data used for the SFP module are stored in A0 and A2 memory area based on the SFP-MSA standard. In this paper the auto set-up program for SFP module has been designed and implemented. In order to make the Digital Diagnostic Monitoring Interface, the specific value has been written into the designated register via RS232 communication channel in the LD Driver IC. The Agilent VEE is used as a programming language for factory automation, and optical characteristics of SFP module and SFP-MSA standard are main structure of the implementation. The implemented program has been applied to the manufacturing field and the system gains a higher effect than the result of 6-Sigma.